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    The Science of Testosterone || Carole Hooven

    enMarch 09, 2023

    Podcast Summary

    • Shopping deals at Ross and UPS store services, plus a discussion on testosterone and behaviorLearn about discounted brands at Ross during spring, UPS store assistance for packing and shipping, and the science behind testosterone's impact on behavior, emphasizing the role of genetics and culture.

      This podcast episode discusses various topics including deals at Ross, UPS store services, and the science of testosterone. At Ross, listeners can expect to find familiar brands at discounted prices during spring. The UPS store offers packing and shipping assistance, promising to be open and ready to help during the holiday season. In the main discussion, Dr. Carol Hoven, a Harvard Evolutionary Biologist, shares her research on testosterone and its role in explaining sex differences in behavior, such as higher rates of physical violence and risk-taking in males. However, she also emphasizes the importance of genetics interacting with culture in shaping behavior. Overall, this episode offers insights into various topics, from shopping deals to scientific research.

    • A college fascination with neurotransmitters and the brain led to a career studying human behavior and its evolution.A college curiosity about neurotransmitters sparked a lifelong career exploring the biological basis of human behavior and its evolutionary origins.

      The speaker's passion for understanding the biological basis of human behavior began with her fascination with neurotransmitters and the brain during her senior year of college. This discovery led her to travel, take additional classes, and eventually pursue a career studying the evolution of human behavior and the commonalities and differences between humans and nonhuman animals. Her experiences observing chimpanzees in Uganda further fueled her interest in sex differences and the role of testosterone. Evolutionary biology, she explains, provides an ultimate explanation for why we are the way we are, and she is fascinated by both the proximal (what's happening in the body) and ultimate (evolutionary) explanations for behavior. Her dissertation work took place in Kibali National Park in Uganda.

    • Understanding mental rotation for problem-solving and intelligenceMental rotation ability, the ability to rotate mental images of objects, is crucial for complex problem-solving and human intelligence. Research suggests sex differences in mental rotation test scores, and understanding the underlying processes can provide insights into human cognition.

      Mental rotation ability, a key aspect of spatial cognition, is an important factor in problem-solving and intelligence. This ability, which allows us to rotate mental images of objects in our heads, is related to the neural architecture used for physical object manipulation. The speaker, who studied mental rotation for her master's thesis, emphasized the significance of understanding the processes involved in complex problem solving and the potential influence of sex differences on test scores. She also mentioned her work with advisors Coslyn, Sternberg, and Gray, and their research on the multiple steps and processes involved in problem solving. The speaker's first scientific publication was on sex differences and mental rotation ability. Overall, mental rotation is a crucial aspect of cognition, and understanding its role can provide valuable insights into human intelligence and problem-solving abilities.

    • Sex difference in mental rotation tasksThe large sex difference in mentally rotating 3D objects may be due to the specific test used, rather than an inherent difference between men and women.

      The largest sex difference in cognitive abilities is found in tasks related to mentally rotating three-dimensional objects. However, the reason for this difference is not fully understood. Researchers have consistently found this large sex difference in tasks like the Shepherd and Metzler paper and pencil test, but when other tests are used, the sex difference is smaller. The large sex difference may be due to the specific test being used rather than an inherent difference between men and women. For instance, men might be faster and more accurate in making decisions about whether two objects are different, while women are more likely to say they are the same. This doesn't mean that men are better at mental rotation, but rather that the Shepherd and Metzler test may not fully capture the actual ability to rotate objects in the brain. Mental rotation is a skill we use in our daily lives, such as packing luggage, that we often don't even realize we are using. It's important to keep in mind that while there may be inherent differences between men and women, the specific tests used can greatly impact the results.

    • Testosterone's Role in Shaping Sex Differences: Cognitive AbilitiesTestosterone influences cognitive abilities as part of sex differences, but the exact mechanism is unclear. It communicates about energy availability in the body, affecting behavior.

      Testosterone, a reproductive hormone, plays a role in shaping sex differences, including cognitive abilities. However, the relationship between testosterone and cognition is less clear compared to its effects on sexual competitive and aggressive behavior. Testosterone is produced in response to various signals in the body and interacts with receptors on cells to regulate functions, including energy availability. In the brain, testosterone communicates about the energy situation in the body, affecting behavior. The exact mechanism through which testosterone impacts cognitive abilities and provides reproductive advantages is less understood. Nonetheless, testosterone's role in shaping sex differences is an essential area of research in understanding the complex relationship between hormones and behavior.

    • Hormones shape behaviors for survival and reproductionHormones like estrogen and testosterone have long-term effects, shaping behaviors and physical traits for survival and reproduction, with testosterone's in utero effects on the brain being permanent.

      Hormones play a crucial role in coordinating physical energy with behaviors needed for survival and reproduction. The steroid hormones, particularly estrogen and testosterone, have long-term effects, including coordinating puberty, growth, and reproductive system development, both in utero and during adolescence. Testosterone's in utero effects on the brain are permanent and shape various behaviors in adulthood. It also coordinates the development of physical traits that enable male animals to reproduce. These effects are on average, and there is overlap between males and females, but there are also fluctuations and changes throughout life. Additionally, hormones like testosterone and the "cuddle hormone" can interact in complex ways, leading to a range of behaviors. Men and women both take physical risks, but they tend to do so in different contexts, with men more likely to risk their lives to save strangers and women more likely to risk their lives for their families.

    • Cultural norms have a greater impact on male violence than testosterone levelsCultural norms and laws play a significant role in shaping male violence rates, not just hormones or genetics.

      While testosterone plays a role in male violence, cultural norms have a more significant impact on the rates of male violence across populations. Testosterone, a hormone responsible for many masculine traits, gets a lot of attention due to its link to extreme male violence, but it's essential to acknowledge the positive aspects of testosterone and its interaction with culture. Some cultures have lower rates of male violence, and it's not due to genetic differences or testosterone levels alone but rather the cultural norms and laws that exist within those societies. The gene-hormone interactions are complex, and while there are differences in testosterone receptors across populations, cultural differences cannot be entirely explained by genetic differences. The power to change cultural norms lies with us, making it a crucial area of focus to reduce male violence. However, the topic of male violence and its relationship to hormones, genes, and culture is complex and can lead to sensitive discussions, such as the debate around trans women competing in male sports.

    • The Interplay of Biology and Culture in SportsBiology and culture influence sports advantages, with testosterone contributing to male physical advantages. However, the degree of impact varies and requires academic freedom, open dialogue, and equal access to information for fair policy-making.

      The interaction of biology and culture plays a significant role in determining advantages in various domains, including sports. Testosterone, a male hormone, contributes to physical differences between men and women, resulting in inherent advantages for males in terms of size, strength, and speed. However, the degree to which these advantages translate into cultural disadvantages or advantages depends on the specific context. In sports, the emphasis is on having an advantage over others, making it challenging to determine how to accommodate trans women fairly. While the scientific consensus suggests that testosterone is the primary source of the advantage, the solution lies in fostering academic freedom, promoting open dialogue, and ensuring equal access to information for all parties involved in the policy-making process. Ultimately, a democratic society should allow for the exchange of facts and diverse viewpoints to arrive at a reasonable and inclusive solution.

    • Transgender athletes and sports: Complex scientific and ethical questionsRespecting diverse perspectives, acknowledging potential athletic advantages, and ensuring a safe and inclusive environment are crucial in the ongoing debate surrounding transgender athletes and sports.

      The debate surrounding transgender athletes competing in sports categories raises complex scientific and ethical questions. Some argue for an open category, while others advocate for protecting specific categories based on biological sex. Research indicates that individuals who experience male typical levels of testosterone during puberty have an athletic advantage over those who did not. However, there is a lack of conclusive evidence on whether this initial advantage is lost after taking testosterone blockers and transitioning to the female category. Additionally, there are potential long-term health concerns associated with taking these hormones. It's crucial to respect diverse perspectives and experiences while acknowledging the need for more research on this topic. Ultimately, the goal should be to create a safe and inclusive environment for all individuals, particularly those with gender dysphoria, while ensuring fairness in competitive sports.

    • The Complexity of Using Puberty Blockers in Young PeopleThe use of puberty blockers in young people involves serious consequences, including infertility and the inability to experience orgasms. While some argue it helps prevent painful puberty, others suggest allowing natal puberty can lead to self-discovery. Evidence-based conversations are crucial.

      The use of puberty blockers in young people, particularly in Europe, is a complex issue with serious and irreversible consequences. These consequences include infertility and the inability to experience orgasms. While some argue that these interventions can help prevent the painful process of puberty, others contend that allowing young people to progress through their natal puberty can lead to the discovery of their sexual orientation and gender identity. The decision to use puberty blockers is often made out of fear and the belief that not affirming a child's gender identity could lead to suicide, but there is little evidence to support this claim. It's essential to have open and clear conversations about this issue based on evidence rather than political ideologies. Gender affirming care is not just about taking puberty blockers but also includes psychological support and exploring various options to help individuals navigate their gender identity. Unfortunately, the narrative around this issue is often polarized, and what's needed is an evidence-informed approach.

    • The complex considerations of gender transitioning and medical interventionsContinued research, open dialogue, and a nuanced approach are necessary for understanding and addressing the complexities of gender transitioning and medical interventions.

      The discussion surrounding gender transitioning and the associated medical interventions involves complex considerations and a wide range of perspectives. While some people believe that transitioning is the right choice for some individuals, others argue for more caution and research. There are significant variations in the quality and approach of medical care, and the lack of a transparent and open environment for debate among medical professionals can hinder progress. From an evolutionary biology perspective, the focus on the sex binary makes sense, but from a psychological perspective, understanding gender as a complex phenomenon on a spectrum is crucial. The ongoing debate highlights the need for continued research, open dialogue, and a nuanced approach to this complex issue.

    • Understanding the Complexity of Trans ExperiencesRecognize the complexity of trans experiences, respect individual lived experiences, and acknowledge that there's no one-size-fits-all approach to supporting the trans community.

      The experience of being trans goes beyond a single definition or mechanism. While some individuals identify as trans and seek hormonal treatment during adolescence, others may not express their gender identity until later in life. It's crucial to recognize that gender dysphoria, the feeling of not aligning with one's gendered body or societal expectations, is distinct from being trans. The complexity of these experiences can lead to misunderstandings and unproductive debates. It's essential to listen to and respect each other's lived experiences, acknowledging that there is no one-size-fits-all approach to understanding and supporting the trans community. Additionally, research suggests that prenatal exposure to hormones may have lasting effects on brain development, which can influence gender identity. Understanding this complexity and respecting individual experiences is essential for fostering a more inclusive and supportive society.

    • Open-minded communication and respect are key to productive discussions, even when dealing with controversial topics like sex and gender.Maintain open communication and respect for differing perspectives, clarify sex and gender concepts, and uphold academic freedom to express facts.

      Open-minded communication and respect for differing perspectives are essential for productive discussions, especially in academic settings. However, asserting biological facts can be met with resistance and even backlash, particularly when it comes to topics like human behavior and gender. The speaker, an evolutionary biologist, shared her personal experience of facing controversy and discomfort for stating that there are two sexes, despite the importance of acknowledging the distinction between sex and gender identity. It's crucial to clarify these concepts and avoid making assumptions about someone's beliefs based on their statements. The academic freedom to express opinions and facts should be upheld, and discussions should be grounded in facts and respect for all parties involved.

    • Understanding the Science of Gender and SexExplore the science behind gender and sex with compassion and openness, recognizing the importance of factual information and potential future advancements.

      The discussion emphasized the importance of understanding the science behind gender and sex, while also approaching the topic with compassion and openness. The speaker expressed concern over the suppression of scientific research and the impact of ideological divisions on people's willingness to engage in compassionate and open discussions. They also touched upon the role of hormones, particularly testosterone, in shaping gender development. The speaker also shared their fascination with the hormone and mentioned their new book on the subject. Ultimately, the conversation underscored the need for a fact-based, compassionate approach to understanding gender and sex. The speaker also hinted at the potential for future scientific advancements in this field, but emphasized the importance of continuing to grapple with the science and its implications for people's rights and policies.

    • Explore solutions for financial wellness and new adventuresDiscover personalized financial insights with Facet's free quiz, find land for unique experiences on Land.com, and embark on cultural adventures with Viking.

      There are solutions available to help manage financial wellness and explore new adventures, despite feeling overwhelmed. For those struggling with financial planning, Facet's free financial wellness quiz offers a starting point and personalized insights (facet.com). Meanwhile, for those longing for wide-open spaces and unique experiences, Land.com provides access to various types of land for sale, catering to diverse interests in hunting, fishing, and more (land.com). Lastly, Viking offers a chance to explore Europe in comfort and luxury, with all-inclusive, adult-only voyages that focus on cultural enrichment and destination-focused dining (viking.com). These resources aim to make the impossible feel possible, whether it's improving financial health or embarking on an adventure.

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    Gender Differences in Resident Evaluation

    Show Notes for Podcast Nine of seX & whY

    Host: Jeannette Wolfe

    Guests: Dr. Dan O’Connor, Dr. Anna Mueller

    Topic: Gender Differences in Resident Evaluation

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    • Women received more discordant feedback about ways to do things better in areas in which they struggled especially surrounding issues about autonomy and leadership
    • Evaluators perceived that women were less likely than men to receive feedback appropriately.
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    • Reinforce a sense of belief in ability and of belonging

     Stay tuned for next month in which we will tackle feedback.

    Dayal, A., O’Connor, D. M., Qadri, U., & Arora, V. M. (2017). Comparison of Male vs Female Resident Milestone Evaluations by Faculty During Emergency Medicine Residency Training. JAMA Internal Medicine, 177(5), 651. https://doi.org/10.1001/jamainternmed.2016.9616

    Mueller, A. S., Jenkins, T. M., Osborne, M., Dayal, A., O’Connor, D. M., & Arora, V. M. (2017). Gender Differences in Attending Physicians’ Feedback to Residents: A Qualitative Analysis. Journal of Graduate Medical Education, 9(5), 577–585. http://www.jgme.org/doi/10.4300/JGME-D-17-00126.1

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    MRI study about political views- evaluated how individuals with definitive political views may process contradictory information differently than individuals with more flexible mindsets.  Kaplan, J. T., Gimbel, S. I., & Harris, S. (2016). Neural correlates of maintaining one’s political beliefs in the face of counterevidence. Scientific Reports, 6, 39589. Retrieved from http://dx.doi.org/10.1038/srep39589

    Thoracic surgery study that suggests that male surgical fellows may actually receive more advanced operative experience than their female matched peers

    Meyerson, S. L., Sternbach, J. M., Zwischenberger, J. B., & Bender, E. M. (2017). The Effect of Gender on Resident Autonomy in the Operating room. Journal of Surgical Education, 74(6), e111–e118. https://doi.org/10.1016/j.jsurg.2017.06.014

    JAMA study perceiving gender differences in implicit bias in academic medicine

    Jagsi  R, Griffith  KA, Jones  R, Perumalswami  CR, Ubel  P, Stewart  A.  Sexual harassment and discrimination experiences of academic medical faculty.  JAMA. 2016;315(19):2120-2121. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526590/

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    Andrea Forsland is the Founder & CEO of Cognixion, the Assisted Reality company based in Santa Barbara, California and Toronto, Ontario. Cognixion ONE is a brain-computer interface that is integrated with an augmented reality display. It has wide-ranging implications as the foundational technology for a future metaverse where our mind and body are immersed in the user experience. Their primary focus is ensuring that the future of AR is universally accessible with the help of biological sensors and intuitive user interfaces and designed to assist millions of people with complex disabilities using their face, eyes, and now brain as a direct control interface for mobile and AR, and is addressing the needs of a half billion people worldwide with physical and communication challenges. Cognixion is recognized as a top 21 neurotech startup to watch, recently won the Red Dot Best of the Best Award for AR/VR and was nominated for the Red Dot Luminary Award, the Edison Award, and Singularity Global Grand Challenge, and is led by luminaries including the creator Siri, and signal processing sensor fusion for the Tricorder Xprize winner, plus multiple patents in the areas of natural user interfaces and brain-computer interface for augmented reality. 

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    Linktr.ee: https://linktr.ee/cognixion

    Cognixion LinkedIn: https://www.linkedin.com/company/cognixion

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    The Neurocareers podcast is brought to you by The Institute of Neuroapproaches (https://www.neuroapproaches.org/) and its founder, Milena Korostenskaja, Ph.D. (Dr. K), a neuroscience educator, research consultant, and career coach for students and recent graduates in neuroscience and neurotechnologies. As a professional coach with a background in the field, Dr. K understands the unique challenges and opportunities facing students in this field and can provide personalized coaching and support to help you succeed.

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    Dynamical workspace reconfiguration under cognitive load

    Dynamical workspace reconfiguration under cognitive load
    A movie of dynamic network changes during performance of zero- and two-back working memory tasks. Bottom row, Changes in key workspace parameters as a function of trial duration for zero-back (red lines) and two-back (blue lines) versions of the task: from left to right, global efficiency, local efficiency or clustering, physical distance, and proportion of intramodular edges. Red bar, Interquartile range of response latencies. L, Left; R, right; F, front.