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    Why dementia could start in your blood vessels with Dr. William Li

    enMay 23, 2024

    Podcast Summary

    • Heart health impacts brain health, especially in agingImproving heart health through diet and reversing blood vessel damage can potentially reduce dementia risk

      Heart health and brain health are closely connected, especially as we age. Dementia, a common threat to brain health, is not inevitable and can be influenced by the condition of our heart. Dr. William Lee, a world-renowned heart health specialist, explains that dementia is linked to blood vessel damage, and this damage can be reversed. Additionally, mental health impacts cardiovascular disease, and improving diet can help combat memory loss. The connection between the brain and heart is complex, and it's essential to understand that different types of dementia exist. This connection is not a new discovery, but it's a topic that is gaining more attention due to its significance in preventing and treating various brain conditions. So, taking care of our heart can lead to better brain health and potentially reduce the risk of developing dementia.

    • Understanding Dementia and the Role of Blood VesselsCaring for blood vessels inside the brain, which form a vast network, is essential for maintaining brain health and potentially preventing dementia.

      Dementia is characterized by various symptoms including memory loss, cognitive problems, difficulty speaking, and executive function issues. These symptoms can be linked to the health of our blood vessels, as the brain relies on these vessels to bring oxygen and nutrients to brain cells. When these blood vessels become damaged or blocked, the brain's ability to function optimally is compromised, potentially leading to dementia. It's important to take care of our blood vessels, as they form a vast network inside our brain, and their health directly impacts brain health. This connection between blood vessels and dementia opens up possibilities for prevention and treatment, offering a glimmer of hope amidst the fear of this condition. So, tending to the health of our blood vessels, particularly the 400 miles inside our brain, is crucial for maintaining brain health and potentially preventing dementia.

    • Maintaining Healthy Blood Vessels for Brain HealthHealthy blood vessels are crucial for brain health, delivering essentials and protecting sensitive structures. Damage from risk factors can lead to serious health issues, so maintaining them is vital.

      The health of our blood vessels plays a crucial role in maintaining a healthy brain and preventing conditions like stroke and dementia. The brain relies on a complex network of blood vessels to deliver oxygen, nutrients, and protect sensitive structures. Damage to these blood vessels, such as leaks, clots, or blockages, can lead to serious health issues. It's essential to maintain healthy blood vessels by avoiding risk factors like high blood pressure, heart disease, and poor lifestyle choices. The blood-brain barrier, a filter made of blood vessels, protects the brain from harmful substances and infections. Therefore, keeping our blood vessels healthy is key to preserving brain function and overall health.

    • The Brain's Recycling and Rebooting Process During SleepSleep is essential for the brain's recycling and toxin removal process, involving both the circulatory system and a hidden 'sewer system' in the brain. Poor sleep impedes this process, leading to a buildup of toxins and potential conditions like dementia.

      The brain is the most crucial organ in the human body, and its health and functioning are prioritized above all else by evolution. The brain requires a constant supply of oxygen and nutrients to function optimally, and during sleep, it undergoes a recycling and rebooting process that involves both the circulatory system (blood vessels) and a hidden "sewer system" (lymphatic channels) in the brain. This system drains out toxins that accumulate during the day, ensuring the brain remains healthy. Poor quality sleep can impede this process, leading to a buildup of toxins and a "brain foggy" feeling. This recycling and toxin removal process is crucial for preventing conditions like dementia, which are linked to the accumulation of toxins in the brain.

    • Heart-Brain Connection: Pumping for Optimal Brain Function and Emotional BondMaintaining heart health is crucial for optimal brain function and emotional well-being, as the heart delivers essential nutrients and oxygen, and the two organs communicate through hormones.

      The health of our heart and brain are deeply connected. Our heart acts as a pump, delivering oxygen and nutrients to the brain, making it crucial for optimal brain function. A weak heart can lead to weak circulation and ultimately, a weak brain. Moreover, the heart and brain communicate through hormones, creating a strong emotional connection between the two. The lymphatic system, responsible for draining the brain, is also linked to heart health. Poor quality sleep, which hinders the glymphatic system's ability to drain the brain, can negatively impact heart function and breathing. Thus, taking care of our cardiac health is essential for maintaining cognitive and mental well-being.

    • Vascular dementia: Narrowed blood vessels lead to cognitive impairmentsA 10% reduction in blood flow can cause cognitive decline, highlighting the importance of maintaining good vascular health to reduce the risk of vascular dementia

      Vascular dementia, caused by the narrowing of blood vessels supplying the brain, is the most common form of dementia. This condition, often overlooked, can lead to cognitive impairments such as memory problems, difficulty in executing tasks, and even dementia itself. The brain, our most energy-consuming organ, relies heavily on a consistent blood flow to function optimally. A reduction as small as 10% in blood flow can cause noticeable cognitive decline. This connection between heart health and brain health highlights the importance of maintaining good vascular health to reduce the risk of developing vascular dementia. The narrowing of blood vessels is a common thread in cardiovascular diseases, making heart disease and brain disease interconnected issues.

    • Understanding the body's natural defenses against dementiaEating a balanced diet, reducing inflammation, and caring for gut health can optimize the body's defenses against dementia, debunking the myth that it's an inevitable part of aging

      Our bodies are naturally designed to maintain healthy blood sugar levels and protect our brains from circulation and dementia problems. We can optimize this process by eating a balanced diet, reducing inflammation, and taking care of our gut health. The misconception that dementia is an inevitable part of aging is being debunked by scientific research, which is revealing the complex ways our body's defenses work together to keep our brains healthy throughout our lives. It's important to understand that our lifestyle choices can influence these defenses and either support or hinder their ability to protect our brains.

    • Blood vessel health and brain functionImprove blood vessel health through circulation, preventing leakages and clots, reducing inflammation, managing stress, and ensuring better sleep and mental health to potentially reduce dementia risk.

      The health of our blood vessels, which start forming early in development, plays a crucial role in brain health. The endothelial cells lining our blood vessels are responsible for smooth blood flow and maintaining the structural strength of the vessels. Our diet and lifestyle choices can impact the integrity of this lining and the walls of the blood vessels. By focusing on factors like circulation, protecting against leakages and blood clots, lowering inflammation, managing stress, and ensuring better sleep and mental health, we can potentially reduce the risk of developing dementia. The formation of blood vessels is compared to a garden hose, with the thick wall ensuring strength and the smooth endothelial lining allowing for uninterrupted blood flow.

    • Protecting and maintaining the health of our endotheliumDamaging factors like smoking, toxic exposures, and ultra-processed foods can harm the endothelium, leading to blood clots and narrowed blood vessels. EPCs repair and regenerate damaged blood vessel linings, emphasizing the importance of protecting and maintaining the health of our endothelium to prevent vascular diseases.

      Just as a freshly prepared ice skating rink allows for smooth circulation, a healthy endothelium, the lining of our blood vessels, ensures unobstructed blood flow from the heart to all organs. However, damage to the endothelium from factors like smoking, toxic exposures, and ultra-processed foods can make the lining rough and scuffed up, leading to blood clots and narrowed blood vessels. This can ultimately result in conditions like stroke and vascular dementia. EPCs, or endothelial progenitor cells, act as cellular seamstresses, repairing and regenerating damaged blood vessel linings. Understanding this process and taking steps to protect and maintain the health of our endothelium is crucial for preventing vascular diseases.

    • Our bodies have the natural ability to repair and regenerate, including our blood vessels and brain tissueWe can regenerate parts of our brain and improve health outcomes through lifestyle choices and staying informed

      Our bodies have the natural ability to repair and regenerate, including our blood vessels and even brain tissue, thanks to endothelial progenitor cells (EPCs) stored in our bone marrow. These cells can transform into various types of cells, including those that help repair blood vessels and even brain cells. Recent research shows that we can regenerate parts of our brain, which is exciting for potential advancements in treating neurological conditions like dementia. On a practical level, making lifestyle choices that support overall health, such as those promoted by ZOE, can help improve health outcomes and potentially slow down the progression of diseases. For those already diagnosed with dementia or caring for someone with it, there may still be steps to take to support brain health and potentially slow down the disease's progression, such as maintaining a healthy diet, engaging in physical activity, and staying socially connected. Additionally, staying informed about the latest research and potential treatments can help individuals and their loved ones make informed decisions about their care.

    • Assessing brain and heart for memory issues or dementiaBrain scans by neurologists/neuroradiologists and heart checks by cardiologists with echocardiograms are essential for accurate diagnosis and effective treatment of memory issues or dementia. Early detection and addressing heart conditions can significantly improve outcomes.

      When dealing with memory issues or dementia, it's crucial to assess both the brain and the heart. A brain scan, ideally done by a neurologist or neuroradiologist, can help identify specific types of dementia, such as Alzheimer's or frontotemporal dementia. Additionally, ensuring the heart is functioning optimally by seeing a cardiologist and getting an echocardiogram is essential. These steps provide valuable information about what you're dealing with and increase the chances of effective treatment. Remember, early detection and intervention are key. Furthermore, addressing other health conditions, like diabetes, can also improve overall brain health. The progress in dementia research lies in getting as specific as possible about the underlying causes, and potential solutions may include addressing heart issues, such as valve problems or narrowed arteries.

    • Eating for Heart, Brain, and Gut HealthConsuming foods rich in polyphenols, omega-3s, and flavanols can help maintain and improve heart, brain, and gut health. A diet rich in fiber, prebiotics, and polyphenols also supports a healthy gut microbiome.

      Improving circulation and maintaining the health of our blood vessels is crucial for both brain and heart health. This can be achieved through medical interventions and lifestyle changes, including diet. Foods rich in polyphenols, omega-3s, and flavanols have been shown to help keep blood vessels healthy and improve blood flow. Dark chocolate, which contains flavonols, has even been studied for its ability to protect heart health and lower the risk of dementia. Moreover, a healthy gut microbiome, which can be supported through a diet rich in fiber, prebiotics, and polyphenols, is also linked to heart and brain health. In essence, what we eat plays a significant role in maintaining and improving our heart, brain, and gut health.

    • Exercise, gut health, and heart health for better brain healthRegular exercise, good gut health, and heart health contribute to better brain health by reducing inflammation, triggering stem cell release, and improving overall well-being.

      Maintaining good gut health, heart health, and engaging in regular exercise can significantly contribute to better brain health by reducing inflammation in the brain. This connection has been supported by scientific research, which shows that people with dementia often have high levels of inflammatory markers. Exercise is crucial as it not only improves cardiovascular health but also triggers the release of stem cells, which can help repair damaged organs, including the brain. So, even simple activities like staying in motion, walking, or dancing can make a difference. Remember, a body that stays in motion stays in motion, and the benefits extend far beyond just physical appearance.

    • The Power of Repair and Building UpExercise, sleep, gut health, and avoiding toxins can help protect against age-related decline and potentially delay or prevent dementia by stimulating repair processes in the body.

      Our bodies have an innate ability to repair and build themselves up, especially when put through physical stress. For young people looking to build muscle, this means breaking down muscles to allow for growth and repair. As we age, moderate exercise like walking can help keep the body in motion and stimulate repair processes. Additionally, getting good sleep, maintaining a healthy gut, and avoiding toxins like alcohol are essential for overall health and brain function. These habits can help protect against age-related decline and potentially delay or prevent the progression of conditions like dementia.

    • The connection between gut and heart healthImproving gut and heart health through lifestyle changes can reduce the risk of neurodegenerative diseases and improve brain function.

      Our bodies, specifically our gut and heart, are more interconnected than we once thought. We now have the power to make lifestyle changes, such as diet and exercise, which can positively impact our gut health and potentially reduce the risk of neurodegenerative diseases like Alzheimer's and Parkinson's. Additionally, our heart is not just a pump, but an endocrine organ that releases hormones that influence our brain, and vice versa. This interconnectivity means that issues with the heart, such as arrhythmias or heart failure, can easily affect the brain and lead to conditions like depression, bipolar disorder, schizophrenia, and dementia. These discoveries highlight the importance of taking care of both our gut and heart health for optimal brain function and overall wellbeing.

    • The brain and heart are deeply connectedThe brain's health depends on the heart's ability to pump blood effectively, and heart health impacts the brain's ability to cleanse itself. Lifestyle choices can damage blood vessels in the brain, but EPCs in the bone marrow can help repair them. Addressing heart health and underlying diseases may slow down or even reverse cognitive decline.

      The health of our brain and heart are deeply interconnected. The brain, with its 400 miles of blood vessels and requirement for constant oxygen and nutrient supply, relies on the heart to pump blood effectively. Additionally, the brain's lymphatic system, which cleanses the brain, can only function optimally when the heart is working well. Our bodies have evolved to prioritize blood flow to the brain, and even small reductions in blood flow can significantly impact cognitive function and potentially lead to conditions like vascular dementia. The blood vessels in the brain have a smooth lining that can be damaged by lifestyle choices, leading to reduced blood flow and potential issues. There are cells called EPCs in our bone marrow that can help repair these damaged blood vessels, but they can be overwhelmed by the damage caused by our lifestyles. Understanding the root causes of cognitive decline involves assessing both the brain and the heart, and in some cases, it may be possible to slow down or even reverse the progression of conditions like dementia by addressing heart health and other underlying diseases.

    • New research offers hope for slowing down or reversing dementiaEat a plant-based diet rich in fiber, polyphenols, and colorful foods, incorporate marine omega-3s and oily fish, maintain a healthy gut microbiome, exercise regularly, get good sleep, don't smoke, and limit alcohol consumption to potentially reduce dementia risk.

      Dementia, like other health conditions such as cancer, is not a hopeless diagnosis. New research suggests that we can not only slow down the progression of dementia but also potentially reverse it in some cases. A key factor in this is maintaining a healthy lifestyle, which includes eating a whole plant-based diet rich in fiber, polyphenols, and colorful foods, as well as incorporating marine omega-3s and oily fish. The gut microbiome plays a crucial role in this, as it can affect both heart health and brain health through inflammation. Regular exercise, even just staying in motion, is also important for heart health and reducing dementia risk. Other lifestyle factors, such as getting good sleep, not smoking, and limiting alcohol consumption, also make a difference. By making these changes, we can transform our health and potentially reduce our risk of developing dementia. For personalized guidance and support in making these lifestyle changes, consider using a service like Zoe, which combines world-leading science with individual test results to provide customized recommendations.

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    Foods for every decade of life with Dr. Federica Amati

    Did you know that even at age 70, with the right nutrition, you could potentially extend your life by 6 years?

    In today’s episode, we learn that it's never too late to change your diet for the better. Dr. Federica Amati, ZOE’s Head Nutritionist, dives into the unique nutrition needs at every life stage.

    From the golden windows of opportunity that can transform your health, to practical food recommendations for adolescence, adulthood and beyond, Dr. Amati gives tips to enhance your wellbeing.

    Dr. Federica Amati is a researcher at King’s College London and registered nutritionist. She is also lecturer and Nutrition Topic Lead at Imperial College School of Medicine. Federica empowers people with accessible, practical knowledge to make informed choices on diet and lifestyle and to improve health based on unique needs and preferences, at every stage of life.

    Follow Dr. Federica Amati on Instagram 

    If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your membership.

    Follow ZOE on Instagram

    Timecodes

    00:00 Introduction

    01:17 Quickfire questions

    03:32  The first window of opportunity is before you are born

    06:04 It takes two to tango: equal roles in conception

    07:25 The science behind sperm health and diet

    09:10 What is life course nutrition?

    10:35 Why generic nutrition advice isn't enough

    13:00 Critical changes in the first 12 weeks of pregnancy

    16:25 Nutritional needs in the second trimester of pregnancy

    17:20 Preventing allergies during pregnancy

    20:30 Nutrition in childhood and adolescence

    21:00 The importance of a diverse diet for teenagers

    22:57 Children learn to eat from us: exposure is key

    25:10 The impact of ultra-processed foods on teenagers

    27:40 Do you need to eat meat to grow well?

    32:55 Lifestyle choices in your 30s affect long-term health

    36:00 Longevity supplement myths

    37:40 Gut microbiome changes in adulthood

    43:28 How to extend your lifespan through diet at any age

    46:05 Preparing for healthy aging and avoiding 'Sniper Alley'

    50:10 How to eat right in your 70s and beyond

    54:22 Protein needs as you age

    56:30 Becoming a ZOE member is like having a nutritionist in your pocket!

    59:20 Summary

    Mentioned in today's episode:


    Books:


    Is there a nutrition topic you’d like us to explore? Email us at podcast@joinzoe.com, and we’ll do our best to cover it. 

    Episode transcripts are available <a...

    What to eat to avoid osteoporosis with Prof. Cyrus Cooper and Tim Spector

    What to eat to avoid osteoporosis with Prof. Cyrus Cooper and Tim Spector

    Did you know that every 12 years, our skeletons undergo a complete transformation? 

    Osteoporosis, a condition where bones become fragile, significantly increases the risk of fractures from minor incidents, often without any noticeable symptoms. Worldwide, it affects one in three women and one in five men over fifty, leading to pain, potential disability and loss of independence.

    In today’s episode, Jonathan, Tim and Cyrus ask the question: How can understanding osteoporosis and implementing targeted lifestyle changes enhance bone health and reduce the risk of fractures?

    Cyrus Cooper is a Professor of Rheumatology at the University of Southampton, where he is also the Director of the MRC Lifecourse Epidemiology Unit and Vice-Dean of Medicine. In addition, he’s a Professor of Musculoskeletal Science at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford.

    Tim Spector is one of the world’s top 100 most-cited scientists, a professor of epidemiology, and scientific Co-Founder at ZOE. Tim trained originally in rheumatology and epidemiology. 

    Make smarter food choices for your body: zoe.com/podcast

    Follow Tim on Instagram.

    If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your personalised nutrition program.

    Follow ZOE on Instagram.

    Timecodes

    00:00 Introduction

    01:21 Quickfire questions

    03:08 What is osteoporosis?

    06:10 Why might our bones become more fragile as we age?

    08:10 Your skeleton renews itself all the time

    10:30 Does menopause cause osteoporosis?

    12:48 What's it like living with osteoporosis?

    15:16 How common is osteoporosis in males?

    16:04 What are the symptoms of osteoporosis and at what age should you get checked?

    21:40 Some chilling statistics about osteoporosis

    23:10 Common myths about the effects of calcium and vitamin D on osteoporosis

    27:50 What is the latest science on vitamin D supplementation?

    34:10 Can vitamin D and calcium ensure children’s bone density is healthy?

    34:55 Osteoporosis treatment options, including new drugs    

    37:20 The impacts of HRT on bone density

    39:30 What are the downsides to some of these treatments?

    43:00 Does physical activity help to prevent fractures?

    44:30 Lifestyle impacts: diet and nutrition

    49:40 Can exercise make your bones stronger?

    55:20 Ideal exercises to prevent osteoporosis

    57:10 Cyrus and Tim’s top 3 actions to improve bone health

    59:10 Summary

    Mentioned in today's episode:


    Relevant studies: