How to Live to 200 Podcast

Phil White – Health and Fitness Writer

Today’s guest is an Emmy-nominated writer and the co-author of Waterman 2.0, The 17 Hour Fast, Game Changer, and Unplugged. Besides being an all around great person, Phil’s work has been a staple of modern athletes and fitness experts. Beginning with Unplugged, he’s helped a new generation re-engage with nature by spending less time indoors and more time outside.

A modern mountain man with a different approach to building a healthy lifestyle, Phil flips the focus from what you’re doing during exercise periods to what you’re doing in the remaining 22 hours of your day. Too many of us really put our focus on maximizing our exercise patterns but then lose sight of the benefits that come outside of the gym. Phil really breaks down the mindset and lifestyle changes that allow you to unlock your potential.

In addition to talking through his expertise in healthy living, we dive into a few pro tips, including:

• Why the 17-hour fast program works
• Superior breathing techniques he uses during workouts
• How he winds down for sleep

If you haven’t already, add Phil’s books to your summer reading list. We hope you enjoy the conversation as much as we did! Please don’t forget to share the podcast with your friends, family, and colleagues.

We hope you enjoy!

About Phil White

• philwhitebooks.com
• Phil White on Twitter
• Phil on Amazon

Show Links

• Waterman 2.0
• MobilityWOD
• Kelly Starrett
• Ready to Run
• James Levine / Mayo Clinic / NEAT
• Rogue Fidget Bar
• StandUp App
• Gut smashing Kelly Starrett
• Dom d'Agostino
• Dr. Rhonda Patrick – Found My Fitness
• Patrick McKeown (Oxygen Advantage)
• XPT
• Art of Breath
• Buteyko breathing
• Wim Hof

Dr. Will Cole — Functional Medicine Expert and Ketotarian

We’re back! Our guest today is Dr. Will Cole, a functional medicine expert and the author of the book Ketotarian, a book about the secrets of Vegan and fat adapted dieting. In addition to writing a ground-breaking book, Dr. Cole specializes in investigating underlying factors and creating tailored health programs for chronic conditions such as thyroid issues, autoimmune, hormonal dysfunctions, digestive disorders, diabetes, heart disease and fibromyalgia.

In this episode, we discuss what functional medicine means, some of the key markers of the “inflammation spectrum” for which you can test, and key principles of Ketotarian-ism.

• Dr. Cole’s fasting protocol
• What are the best ways to measure ketosis
• What are people looking for when they’re suffering from inflammation

This episode is a fascinating new perspective on the hottest trend in dieting. We hope you enjoy the conversation as much as we did! Please don’t forget to share the podcast with your friends, family, and colleagues.

We hope you enjoy!

About Dr. Will Cole

• drwillcole.com
• Dr. Cole on Twitter
• Dr. Cole on Instagram

Show Links

• Cytokine model of cognitive function
• Inflammation blood marker tests:
• Hs-CRP
• Homocysteine
• Ferritin
• Galangal broth
• beta-Hydroxybutyric acid
• Ketonix
• OMAD
• The Power of Now and A New Earth by Eckhart Tolle
• Headspace
• Calm

Bob Troia Aka “Quantified Bob” – Technology Entrepreneur, Biohacker, and Self-Quantification Geek

Today’s guest is Bob Troia - or “Quantified Bob” as he calls himself. Bob is not the average health and fitness geek; he’s a geek’s geek. With a background as a software engineer, Bob takes personal data analysis to a whole new level. As you’ll quickly learn, he takes his tracking very seriously.

In this episode, we talk about the API Bob’s built for his personal data, the underlying software architecture, his tracking strategy, and some of the data analysis tools he uses to make sense of the massage amounts of data he’s collecting. If you love to geek-out on apps and tools as much as we do, Bob has you covered. He gives us an inside look at exactly what he uses, how he uses it, and why it’s important.

Not only do we dive into the super geeky stuff—which we love—we also cover a wide-ranging list of topics that can be applied to anyone looking to live a longer, healthier life, including:

• What environmental factors he monitors and manages (e.g. air quality, water quality, and the electromagnetic radiation)
• How Bob uses data to personalize his diet
• What it means to build a biohacking gym
• Why Bob thinks Epigenetics are more important than Genetics
• And of course, all of the wonderful data tracking and analyzing tools your heart desires

This episode was a tech-lovers dream. We hope you enjoy the conversation as much as we did! Please don’t forget to share the podcast with your friends, family, and colleagues.

About Bob

• Bob on Twitter
• quantifiedbob.com

Show Links

• Precision Xtra Glucose and Ketone Monitoring Kit
• CorSense
• ARX Fit
• PEMF
• Epigenetic clock
• Chronomics
• HACKD Fitness
• NanoVi
• Statwing
• Plotly
• Zenobase
• gyroscope

Wade Lightheart – Natural National Body Building Champion and Author

Life finds a way to nudge us in the right direction. Wade Lightheart is a wonderful example of how fate positions people on a life-changing path. Wade is a 3-time Natural National Bodybuilding Champion, advisor, and author. His latest book, “Staying Alive in a Toxic World”, details his natural approach to achieve incredible health results, regardless of your individual circumstances. But Wade’s journey to natural bodybuilding was set long ago, when as a young-adult, Wade experienced three pivotal events that forever shaped his health and fitness future.

In today’s podcast, we learn about Wade’s journey to bodybuilding and the near-encyclopedic knowledge he’s accumulated for enzymes, amino acids, digestion, and physical and mental performance. We really cover a lot of ground in this episode. We spend a while diving into the details of his meditation practice, learning about the machine he uses to customize his water intake, and much more, including:

• How climate impacts raw diet
• Wade’s daily diet and nutrition regimen
• How Wade sustains energy on a reduced protein diet
• How Wade integrates “cheat days” into his diet
• What dietary changes Wade recommends for strength vs. endurance
• What are the key benefits Wade derives from amino acids
• The differences between amino acids and enzymes
• Why Wade recommends using a journal
• Travel-ready superfoods
• What is the storage capacity of water
• The 5 types of water Wade uses every day

This episode is an eye-opening look into the little details we often overlook. We hope you enjoy the conversation as much as we did! Please don’t forget to share the podcast with your friends, family, and colleagues.

About Wade

• Wade’s Twitter
• BioOptimizers
• wadelightheart.net

Show Links

• Masszymes.com
• GlutenGuardian
• HCL Breakthrough
• P3-OM
• Viome
• Activation Oils
• Autobiography of a Yogi
• Water the Great Mystery
• Kangen Water
• Cells, Gels, and the Engines of Life by Gerald H. Pollack
• 10 Dogmas of Science
• The Awesome Health Podcast
• Ben Greenfield
• Bulletproof Radio
• The Tim Ferriss Show
• The Joe Rogan Experience
• Dr. Rhonda Patrick
• Thorp Institute
• Aniracetam
• Lion's Mane

Ivan Liachko – Co-founder & CEO at Phase Genomics

Today’s guest is Ivan Liachko. Ivan is Co-Founder and CEO of a fascinating University of Washington spinout, Phase Genomics. With 20 years of experience and a Ph.D. in Genetics, Ivan is a leading expert in genetic/genomic research. Ivan and his teams at Phase Genomics have developed a new genomic discovery that, among other things, can help lead to longer lives and new drug developments.

In this episode, we learn all about Lil Bub and how the internet famous cat’s poop helped Ivan discover entirely new organisms. In addition to some incredible discussions about the microbiome, we discuss parabiosis, genomic sequencing, and interesting future-facing technologies. Throughout our conversation, we cover a lot of valuable info, including:

• What Ivan learned from Lil Bub
• What is Parabiosis for poop transplants
• What Ivan recommends for chronic issues
• The difference between genome and metagenome
• How Ivan imagines tech helping in the near future

This episode is really scientific and you know what, we think it’s fantastic. Please don’t forget to share the podcast with your friends, family, and colleagues. If you enjoy this episode, be sure to check out the episodes with Alex Jiao of Silene Biotech and Leen Kawas of M3 Biotechnology.

About Ivan

• Ivan Liachko Twitter
• Phase Genomics

Show Links

• Lil Bub
• AnimalBiome
• FMT
• 16s sequencing
• Illumina
• Pacific Biosciences
• Oxford Nanopore Technologies

Stephan Guyenet – Neuroscientist and Author

Our guest today is Stephan Guyenet, Ph.D. Stephan has spent a long time in the neuroscience research world studying neurodegenerative disease and the neuroscience of body fatness. In other words, he knows why it’s so hard to stick to your New Year’s resolution. He’s the author of The Hungry Brain, a book detailing the complex relationship between hormones, habits, and overeating.

During our conversation, we run the gamut on all aspects of body weight optimization, from drivers to set points and metabolic rate. Stephan has such a deep passion for the intricate connections that inhibit our ability to lose weight and stay healthy. Throughout our conversation, we cover a lot of really practical details, including:

• What key factors cause us to overeat and what we can do to stay balanced
• What your metabolism actually does and why it matters so much for weight maintenance
• Who is “Uncle Fat” and what he tells us about the traditional America diet
• What foods Stephan keeps in his backpack to stay healthy and energized while hiking
• What health advice Stephan disagrees with at the moment

Given the time of year, this conversation is incredibly topical, so we hope you find it helpful in your annual pursuit of a happier, healthier you. Please don’t forget to share the podcast with your friends, family, and colleagues.

About Stephan

• Stephan Guyenet Twitter
• stephanguyenet.com
• The Hungry Brain

Show Links

• Leptin and Ghrelin
• Non-excercise activity thermogensis
• Direct calorimetry
• Wilbur Atwater
• Respirometry
• Doubly labeled water
• Uncle Fat Monkey

Stephan Guyenet – Neuroscientist and Author

Our guest today is Stephan Guyenet, Ph.D. Stephan has spent a long time in the neuroscience research world studying neurodegenerative disease and the neuroscience of body fatness. In other words, he knows why it’s so hard to stick to your New Year’s resolution. He’s the author of The Hungry Brain, a book detailing the complex relationship between hormones, habits, and overeating.

During our conversation, we run the gamut on all aspects of body weight optimization, from drivers to set points and metabolic rate. Stephan has such a deep passion for the intricate connections that inhibit our ability to lose weight and stay healthy. Throughout our conversation, we cover a lot of really practical details, including:

• What key factors cause us to overeat and what we can do to stay balanced
• What your metabolism actually does and why it matters so much for weight maintenance
• Who is “Uncle Fat” and what he tells us about the traditional America diet
• What foods Stephan keeps in his backpack to stay healthy and energized while hiking
• What health advice Stephan disagrees with at the moment

Given the time of year, this conversation is incredibly topical, so we hope you find it helpful in your annual pursuit of a happier, healthier you. Please don’t forget to share the podcast with your friends, family, and colleagues.

About Stephan

• Stephan Guyenet Twitter
• stephanguyenet.com
• The Hungry Brain

Show Links

• Leptin and Ghrelin
• Non-excercise activity thermogensis
• Direct calorimetry
• Wilbur Atwater
• Respirometry
• Doubly labeled water
• Uncle Fat Monkey

Dr. Maggie Ney – Co-Director of the Women’s Clinic and Licensed Naturopathic Doctor

Today’s episode is one of a kind. It’s a long overdue discussion on a topic that takes a backseat far too often - women’s health. To help us understand and explore this topic, we enlisted naturopathic doctor and co-director of the Women’s Clinic at Akasha, Dr. Maggie Ney.

Dr. Ney’s expertise is in healthy aging for women, with a special focus on hormone balancing. Her interest in this particular area is both incredibly relevant and highly personal. Having previously struggled with her own hormonal imbalance issues as a teenager, her enthusiasm is deeply rooted.

In our conversation with Dr. Ney, we cover a lot of really interesting topics ranging from recommendations for pregnant women to why she thinks hormone replacement therapy is critical after menopause and the what latest treatments for women’s sexual health. The conversation answers many important questions, including:

• Why she’s focused on women’s health
• What Maggie recommends for stress reduction
• How diet can impact your menstrual cycle
• What are the differences in fasting between men and women
• What changes has Maggie seen in women getting pregnant
• What Maggie recommends for women entering menopause
• What is the Mona Lisa Touch

This conversation covers so much important information; we can’t recommend it enough. Be sure to check out the incredible lightning round at the end of the episode, where Maggie shares specific advice for women of different age groups. We hope you enjoy the episode and share it with your friends, family, and colleagues.

About Dr. Ney

• Dr. Ney’s Website
• Dr. Ney’s Blog

Show Links

• Chaste tree
• Rhodiola
• Ashwagandha
• Headspace
• Calm
• Glo
• The Women’s Health Initiative
• PRP
• Mona Lisa Touch
• Upgrade Labs
• Oura ring
• Muse
• Younger by Sara Gottfried
• The Hormone Cure by Sara Gottfried
• Dirty Genes by Ben Lynch
• Longevity Diet by Valter Longo
• The End of Alzheimer’s by Dale Bredesen
• Wheat Belly by William Davis
• Eat Fat Get Thin by Mark Hyman

Matt Kaeberlein – Longevity Expert

Our guest today is Matt Kaeberlein, Ph.D., a globally recognized researcher and expert in the biology of aging. Dr. Kaeberlein’s research is based around the premise that understanding the molecular mechanisms of aging will lead to interventions that slow the onset and progression of age-related chronic conditions, such as cancer, diabetes, kidney disease, heart disease, Alzheimer’s and others. Dr. Kaeberlein received his Ph.D. from the Massachusetts Institute of Technology in 2002 advised by Leonard Guarente, and did his post-doctoral work with Stanley Fields in the Department of Genome Sciences at the University of Washington.

Dr. Kaeberlein’s expertise in dietary restriction, longevity genes for therapeutics, aging in dogs, and Rapamycin really shines in this conversation. We were lucky enough to really explore his background while sharing our collective love of dogs. The conversation explores many areas, including:

• What is the difference between calories restriction and dietary restriction
• What are the biggest challenges with the science
• How Matt thinks about tailored dietary advice
• Why Matt launched the Dog Aging Project
• What we can learn from his research with dogs
• What is Rapamycin and why he’s so interested in its effects

This conversation was incredibly illuminating and really fun. We hope you enjoy the episode and share it with your friends, family, and colleagues.

About Matt

• Matt Kaeberlein
• Matt Kaeberlein Twitter

Show Links

• Next Generation sequences
• Metabolomics
• Epigenetic clocks
• Calorie Restriction Society
• TAME Trial
• Rapamycin
• Daniel Promislow
• Dog Aging Project
• Acarbose
• NIA Interventions Testing Program
• Shock center of excellence
• George M. Martin
• Rapalog Everolimus

Our guest today needs no introduction. It is the one and only Aubrey de Grey, a leading biomedical gerontologist, computer scientist, author, and entrepreneur whose work in longevity research is widely known and regularly referenced by many in the industry. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics, Inc. In many respects, Aubrey is one of the most prominent, if not provocative figures in longevity science.

What makes Aubrey so provocative? Well, aside from his exceptionally long beard, he is the leading advocate of the controversial view that technology may one day enable humans to control the aging process and live well into our hundreds, or even thousands. As much as he believes this, he also knows that there are two main obstacles to achieving this utopia: money and time. While Aubrey’s research is funded by some of the biggest investors, he notes that the “pro-aging trance” has historically held them back. This conversation with Aubrey uncovers the theory of his pro-aging trance phenomena and many incredibly insightful details, including:

• How to remove senescent cells from our body
• What investments are at the top of his list
• Why investor Peter Thiel gave him $6M in funding
• What locations are hot spots for longevity research and innovation
• Where he’s seen the biggest breakthroughs
• When we can expect to benefit from his research
• What is the “pro-aging trance” and why it’s holding us back

This was a really exciting episode that gave the team a chance to hear a unique perspective. We hope you enjoy the episode and share it with your friends, family, and colleagues.

About Aubrey

• Aubrey de Grey
• Aubrey de Grey on Twitter

Show Links

• Sens.org
• Senolytics
• Unity Biotechnology
• Peter Thiel
• Insilico medicine
• Aubrey de Grey – Living to 1000 Years Old
• Ending Aging by Aubrey de Grey

Sonia Arrison – Author and Founder of 100 Plus Capital

Most of us watch reality TV shows to escape our responsibilities and indulge in something less than wholesome. Today's guest found something interesting nestled in her indulgence. While watching the Fox reality TV show The Swan, famed author and investor Sonia Arrison detected the pending human longevity revolution that was just around the corner. She began investigating the effects that increased human longevity would have on society, culminating in her book 100 Plus: How the Coming Age of Longevity Will Change Everything, From Careers and Relationships to Family and Faith.

While we at L200 are still wondering what it looks like to live to 200, Sonia literally wrote the book on what it means to live past 100. Sonia's interest in human longevity started long before her encounter with The Swan. As a young girl, she noticed that while her grandparents were aging quite well, others did not fare so well. This sparked her curiosity and set her on a lifelong journey in longevity science.

Today, Sonia and her team at 100 Plus Capital invest in some of the most innovative companies positively impacting human longevity. As an active investor, Board Member at the Thiel Foundation, and a Senior Fellow at the Fraser Institute, Sonia’s research and intuition delivers a unique perspective that proved highly-engaging in our conversation. During this podcast, we explore Sonia's investment focus, her diverse background, and her view on a number of interesting topics, including:

• What has changed since Sonia wrote her book
• Why longevity is good for economic growth
• What are the hot longevity topics at Silicon Valley cocktail parties
• What investment categories are interesting for Sonia
• Where she sees the most innovation
• How 911 changed her perspective on human health
• What Sonia thinks of the latest trends/fads (e.g. Keto, fasting)

This was an incredible episode that left our team feeling optimistic and energized. Be sure to catch the (new) lightning round at the end of the episode for Sonia’s take on the latest and greatest trends in healthy living!

About Sonia

• Sonia’s Website
• Sonia Arrison’s Twitter

Show Links

• Senolytics
• Daniel Kraft, MD
• Gerry Becker, The Economic Way of Looking at Life
• Implications of Population Aging for Economic Growth -  David canning and David Bloom
• CIA longevity factbook
• The Ocean Cleanup
• L- nutra, ProLon
• Blumio
• 5-2 diet
• Parabiosis
• Aubrey de Grey
• UCSF Memory and Aging Center
• Johnson & Johnson Anti-Aging
• Calico
• Unity Biotechnology

Leen Kawas – CEO, M3 Biotechnology

"There's work that needs to be done and we're going to do it." - Leen Kawas

Nothing better illustrates the grit, determination, and enthusiasm of today's guest, Leen Kawas. Leen is the CEO and president of M3 Biotechnology, a Seattle-based startup tackling diseases of the brain. As a leader in her field and an award-winning entrepreneur, she knows no bounds when it comes to tackling the daunting challenge of neurodegenerative diseases like Alzheimer's. As a Ph.D. student at Washington State University, Leen stumbled into an unlikely career as a startup CEO. But Leen's journey to entrepreneurship was completely unplanned.

As an immigrant from Jordan, Leen started her professional journey as a pharmacist. Not long into her career, Leen realized pharmacology didn't suit her ambitions, so she returned to academia, in pursuit of her Ph.D. at Washington State University. The opportunity to move from academia to the startup world came during her time at Washington State University. Like most great entrepreneurs, Leen saw the opportunity and felt compelled to change the status quo. Her passion, intelligence, and charisma quickly catapulted her to the role of CEO. And the rest is, as they say, history.

During our time with Leen, we explore the research behind M3 Biotechnology and find out:

• What happens to our brains as we age?
• What is a cognoscopy?
• What data points can you use to address neurodegeneration?
• What is the difference between small and large molecule treatments?

Leen's charm, wit, and ability to keep T.A. on his toes makes for an incredibly insightful and fun conversation. We hope you enjoy it as much as we did.

Note from Leen: M3 Biotechnology is introducing a new webpage and flyer to support recruitment for our NDX-1017 Phase 1 clinical trials. Please refer to our webpage at ndx-1017.com or call 1-800-839-2095 for more information. Thank you for your interest in our program and novel therapy for Alzheimer’s Disease.

About Leen

• M3 Biotechnology
• Leen Kawas Twitter

Show Links

• APOE4 gene
• Alzheimer’s Disease Neuroimaging Initiative
• Allen Institute for Brain Science
• Alzheimer’s Drug Discovery Foundation
• A-𝛽 hypothesis

Liz Parish – CEO of BioViva

On this week’s episode of the How to Live to 200 podcast, we speak with Liz Parrish, CEO of BioViva. Join us as we go on a journey as we learn about Liz’s highly controversial medical tourism trip and the experimental gene therapies she’s using to cure aging. While many of our guests explore the boundaries of accepted treatments and standards, Liz’s experimentation takes things to a new level.

As CEO of BioViva, Liz works diligently to push accelerate innovation in gene therapy while democratizing critical information about the benefits of these new, bleeding-edge therapies. During this eye-opening conversation, we learn about the diagnoses that kickstarted her entrepreneurial journey to find a cure for kids. Along the way, we get a glimpse into the experimental world of gene therapies and the exciting new trends that Liz expects to see in the next wave of medicine. In this episode, we find out:

• Why is Medical tourism big in Columbia?
• What is the process of taking experimental gene therapies?
• What results did Liz have after her gene therapies?
• What is the delivery mechanism for gene therapies?
• What is the future of telomerase injection?

If you’ve ever considered medical tourism, this episode is for you. We really enjoyed getting an in-depth look at the little-known world of medical tourism and the role it plays in pushing new treatments. Sit back, relax, and join us as we venture into the unknown.

About Liz

• BioViva
• Liz Parrish on Twitter

Show Links

• Progeria
• SENS Research Foundation
• George Church
• Sierra Sciences
• Telomerase
• SpectraCell telomere testings
• Myostatin
• Viral vector
• Integrated Health Systems
• Klotho
• PGC-1alpha
• hTERT
• Follistatin
• How to Read a Paper, Trisha Greenhalgh
• Buck Institute
• Right-to-try law
• Cochrane
• CAR T Cell Therapy
• GDF11 peptides

Ramez (Mez) Naam – Author and Futurist

Today’s guest is the famed author, entrepreneur, and futurist, Ramez (Mez) Naam. As an ex-Microsoft software engineering leader, Mez brings a unique perspective to the growing intersection between technology and wellness. After leaving Microsoft, Mez tried the more traditional technologist path and dove headfirst into building a startup. After spending a few years in the startup world, he decided to take some time away from building software to write his first book, More than Human. In many ways, that was just the beginning for Mez, as he soon found himself down the rabbit hole, exploring the science and technology at the thin line between science and fiction. Since then, he’s transitioned his passion for the bold ideas found in science fiction and the head-pounding adrenaline rush from the latest cutting-edge technologies, into an incredible career as an award-winning author and futurist. Today, Mez continues to write, speak, and play an influential role in the technology work, currently serving as a leader at the infamous Singularity University, where he focuses on energy exponential technologies.

In today’s episode, we run through some really interesting topics, touching on a mix of Mez’s vision for the future and the most recent hard science that fuels his writing. He also shares his process for finding, evaluating, and dissecting critical science and technology information. Below are a few of the highlights from our in-depth conversation:

• Where Mez looks for inspiration for futuristic technologies
• What technologies interest him most
• How digital health in the developing world will change in the next 10 years
• The dangers of self-hacking
• Why Mez thinks of the genome as spaghetti code
• Where and how human augmentation technologies will be applied in the near future
• Why certain countries are poised for genetic enhancement breakthroughs
• How rats are living to the human equivalent 200
• When can we really expect designer babies to be the standard
• Why Mez believes in a 3-minute workout

This podcast was incredibly energizing and eye-opening for our team, so we hope you enjoy it as much as we did.

About Ramez

• Personal Website
• Mez on Twitter
• Book: More Than Human
• Nexus Trilogy: Nexus, Crux, Apex
• The Infinite Resource

Show Links

• Singularity University
• StethIO
• 98point6
• Gretchen Reynolds
• Transcranial electric
• MIT Technology Review
• NewScientist
• @tferriss
• @theneurohacker
• @edyong209
• SingularityHub
• Singularity University Summits
• Charles Stross
• Ken MacLeod
• William Hertling
• Paolo Bacigalupi
• Cory Doctorow
• Neal Stephenson
• Modafinil

Tim Gray - Entrepreneur & Health Optimization Expert

Our guest this week is Tim Gray. Tim is a seriously interesting person and deeply committed biohacker/health optimization expert. As you’ll learn, Tim and T.A. met by happenstance at Baby Bathwater—an entrepreneurial event hosted in Croatia—where they quickly realized their shared enthusiasm for science, technology, and longevity. Tim’s approach to health optimization stems from his passion and commitment to everything he does; what Tim calls his “all-in or nothing” mentality.

As an entrepreneur, Tim is a specialist in psychology, neuro marketing, cognitive hypnotherapy, conversion rate optimization and SEO. His expertise in digital marketing is rooted in his own experiences as the founder of a very successful e-commerce business, and over 13 years experience of search engine marketing and psychology. He has a keen interest in body language and human behavior led him to study and gain various Oxford University recognized qualifications, including a Diploma in Cognitive Hypnotherapy (HPD), a Master Practitioner certification in NLP (Neuro Linguistic Programming) and NVQ in Business Management. His growing interest in optimal health, having a sharp and clear mind (and “biohacking”) has also led him to open the first Hyperbaric Oxygen Therapy clinic in London.

In this episode of How to Live to 200, T.A. explores some really interesting and less popular areas with Tim. We ask and answer questions on biohacking, mercury poisoning, gut bacteria, and more. Here’s a sample of what we cover:

• How Tim used the Ketogenic diet and Bulletproof Coffee to kickstart his journey to biohacking and health optimization
• Why Tim doesn’t like the term “biohacker”
• What symptoms allow him to easily detect mercury toxicity in strangers
• What tests Tim recommends to measure your mercury levels
• What foods to avoid if you’re worried about mercury toxicity
• What farm-raised salmon can do to your body and brain
• Should you have your old fillings removed?
• Tim’s personal gut microbiome optimization techniques
• What Tim data currently tracks and how he decides what to pay attention to
• How you can use Hyperbaric Oxygen Therapy to thrive
• How do you learn to enjoy your current moment while still striving for improved health

There’s so much great info packed into this episode, so don’t be surprised if you need to take a second listen to capture all of Tim’s knowledge.

About Tim

• Tim Gray’s Twitter
• London Biohacking Meetup
• Hyperbaric Oxygen Therapy

Show Links

• Hyperbaric Oxygen Therapy Center (3 highlighted links under “about”)
• Biohacker London
• healthoptimisation.com
• Baby Bathwater Institute
• IGF-1 hormone
• Living Supplements ALA
• Doctor's Data hair mineral analysis tests
• Christopher Shade's Mercury Tri-Test
• Personal Science
• BioLab Organic Acids Test
• uBiome
• Genova Diagnostics Comprehensive Digestive Stool Analysis (CDSA)
• Symprove gut bacteria supplement
• Chuckling Goat kefir
• RESTORE gut supplement
• Teemu Arina
• Oura Ring
• Aniracetam
• The Mercury Diaries, David Forsyth
• Amalgam Illness, Diagnosis and Treatment, Dr. Andy Cutler
• The Obstacle is the Way, Ryan Holiday
• Stop the Thyroid Madness, Janie Bowthorpe

Myles Spar, MD dives into MTHFR gene and the complex workings of gene expression.

Myles Spar, MD, MPH is board-certified in Internal Medicine and Integrative Medicine. Dr. Spar is also the founder of Tack180, a comprehensive assessment that uses cutting edge technologies to detect health problems before any symptoms or routine lab abnormalities appear.

Dr. Spar focuses on men's health, specifically to help men - or, more broadly, anyone who responds well to goal-oriented programs - live healthier and longer. He takes a unique approach to holistic health by integrating genetics, nutrition, sleep, mindfulness, and purpose into his practice. His practice focuses on optimizing men's overall health, instead of just checking to see if things are broken. The patient-centered approach allows him to bring positive behavior changes that support living longer and healthier.

In addition to his practice in West Hollywood, he works with Doctors Without Borders, provides free services at the Venice Family Clinic, and consults for the NBA and celebrities.  

In this episode, we answer questions on integrative health, longevity, and the philosophical aspects on modern medicine. Dr. Spar applies his knowledge to help us understand what it means to be goal-oriented, actionable, and personalized in our diet, exercise, and overall wellness. We also learn about how lifestyle, diet, and supplementation can change the way genes express themselves. You’ll also learn about the MTHFR gene and the way genes express themselves based on different factors within our lifestyle.

Tack180 is offering $250 off their complete Tack180 program for Live to 200 listeners. Use the coupon code "FP250OFF" and hit enter at check out. Consultations only available to CA residents. (Non-CA residents can do the Tack180 suite of advanced tests, but would not be able to work with Dr. Spar as he is only licensed in CA.)

About Myles

• Tack180.com
• Myles Spar's Website
• Myles Twitter

Show Links

• NQ01
• Methylation
• Whoop
• Oura Ring
• Valter Longo’s Longevity Diet
• APOE genes
• Health Nucleus
• Maca root
• Broccoli sprouts and Nerf 2
• Bulletproof EMS machine

Martin Tobias is the CEO of Bulletproof Labs, the CEO of Upgrade Labs and the co-founder of People For Cause, Element 8 Angels, and MGT Investments. He’s served on the board of directors for Cloudmark and Tippr, and co-founded numerous startups, including Kashless, Imperium Renewables, and Loudeye Technologies. He was a partner at Ignition Partners, a venture capital firm in Seattle, and previously served as an executive at Microsoft.

In addition to being an experienced technology executive, Martin is a health enthusiast and an advocate for people taking control of their own biology. Bulletproof Labs is a high-end health center with an emphasis on biohacking. Bulletproof Labs features the latest, cutting-edge workout equipment and experimental and emerging therapies, including cryotherapy, float tanks, and high-intensity interval training.

In this episode, we answer questions on biohacking and discuss the latest trends in life extension. What are telomeres? Can you regrow your telomeres? What are NAD supplements? Could nicotine be part of a healthy diet? What is a vampire facial?

About Martin

• bulletprooflabs.com
• Martin Tobias Twitter
• Martin's Personal Blog

Show Links

• Palo Alto Longevity Prize
• 40 years of Zen
• Telomere extension turns back aging clock in cultured human cells, study finds
• Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
• Nicotinamide adenine dinucleotide (NAD)
• NAD+ and sirtuins in aging and disease, Shin-ichiro Imai, Leonard P. Guarente
• BrainCheck
• Martin’s blog on NAD supplementation: DO THIS: Increase your NAD levels
• TRU NIAGEN
• Elysium Basis
• Bulletproof Labs' Body Hacks
• Bulletproof products
• Will a Nicotine Patch Make You Smarter? [Excerpt]
• Platelet-rich Plasma (PRP)
• Oura
• DO THIS: Morning Pages Hacks
• DAVID Delight Pro
• Muse

Alex Jiao is the co-founder and CEO of Silene Biotech, a stem cell biotechnology company. Alex received a degree in Biomedical Engineering from Northwestern and his Ph.D. in bioengineering from the University of Washington. He’s worked as a biomedical engineering researcher at the University of Michigan. Alex led Silene Biotech through the 2017 TechStars Seattle program.

Alex is an expert in stem cells and stem cell technology. His startup is dedicated to helping people preserve their stem cells so they can take advantage of emerging opportunities created by advances in the field. By harvesting and preserving their cells today, a 30-year old might be able to use their stem cells to reverse the aging process, cure diseases like arthritis and leukemia, and even regrow vital organs.

In this episode, we answer questions on stem cells and stem cell therapy. What are stem cells and IPS cells in the context of regenerative medicine? What can stem cells do for us? How will new technologies like CRISPR make the process better in the future?  Can stem cells cure blindness? Why should you save your stem cells when you’re young? How can you turn blood cells into beating heart cells through reprogramming, like Alex did with his own...

How to Live to 200 podcast listeners can get 20% off Silene Biotech, just CLICK HERE to receive your L200 discount. Give it a try today!

As part of the episode, we set up a Silene "popup shop" at Pioneer Square Labs where a bunch of us did blood draws and sent our cells off for safe keeping.

About Alex

• Silenebiotech.com
• Alex Jiao Twitter

Show Links

• Autologous stem cell transplants
• Cellular regeneration strategies for macular degeneration: past, present and future
• CRISPR
• Juno Therapeutics
• Facebook - New England Journal of Medicine
• Facebook - Scientific American
• Athletigen
• IPS cells
• Shinya Yamanaka
• Clinical trials in knee cartilage regeneration
• Cell Medicine - Panama Stem Cell Clinic
• Studies on Metformin and Rapamycin
• Video of Alex's beating heart cells

Gil Blander, Ph.D., Founder & Chief Science Officer of InsideTracker, joins T.A. for a conversation on blood biomarkers and performance optimization.

Gil Blander is the Chief Science Officer and co-founder of InsideTracker, company dedicated to providing personalized health and wellness recommendations through blood analytics. Gil received his Ph.D. in biology from the Weizmann Institute of Science and completed his Doctoral fellowship at MIT. Gil is widely recognized as an expert in the science of aging and leads a team of specialists in nutrition and exercise physiology.

InsideTracker is designed for people that want to enhance their performance, increase their energy levels, feel better, and maintain a healthy weight. It is widely used by a variety of professional athletes as well as everyday people interested in health optimization. By analyzing a vial of blood, Gil and his team at InsideTracker provide their customers with a personalized diet and exercise plan.

In this episode, we answer questions on nutrition and aging. What is your inner age? What are the advances we’re seeing in age tracking technology? What leads a person to get involved in this sort of work? What vitamins and supplements should people take? Should everyone follow the same diet?

We hope you enjoy!

P.S. How to Live to 200 podcast listeners can get 15% off InsideTracker by using the following code: LIVETO200. Give it a try today!

About Gil

• Insidetracker.com
• Gil Blander Twitter

Show Links

• David Sinclair
• Leonard Guarente
• Abbott iStat
• Seventh Sense Biosystems
• Mark Melancon / InsideTracker interview
• Ben Bergeron Article
• Aging 2.0
• Cold Springs Harbor Laboratory
• Paul Glenn Center for Aging (Harvard) Symposium

Richard Sprague is an experienced technology executive and biohacking enthusiast. He’s served as a high-level executive at both Apple and Microsoft, and worked for numerous startups, including WebTV Networks. He also co-founded Ensembio, a personal health tracking startup. He has a degree in computational linguistics from Stanford and an MBA from Wharton.

Recently, he’s been focused on the gut microbiome -- the ecosystem of bacteria that’s present in the intestines of every human being. Richard has been cataloging and analyzing his own gut microbiome for over a year and is working on an initiative to help others track and analyze the bacteria living inside them.

In this episode, we answer questions on the gut microbiome. Should you care about your microbiome? How can you test your microbiome? How does your microbiome change over time? Why are there differences in the microbiome between people? How can you improve your microbiome?

We hope you enjoy!

P.S. You can get your own uBiome testing using the Personal Science referral program. We recommend you use one of the Explorer kits and use “personalscience” during checkout for 15% discount.

About Richard

• richardsprague.com
• Richard Sprague Twitter

Show Links

• www.personalscience.com
• www.ubiome.com
• The Personal Science Guide to the Microbiome
• Ken Lassesen’s CFS site
• How bifidobacterium relates to sleep
• Bob’s Red Mill potato starch
• American Gut Project
• Cavities and microbes