Infectious Diseases

Host: Peter Buch, MD, FACG, AGAF, FACP
Guest: Paul Feuerstadt MD, FACG, AGAF

C. difficile is a major problem in the United States. On top of that, patients who are diagnosed with this infection have the chance of getting caught in a vicious cycle of recurrence. So how can we provide our patients with the best care and work with them to give them the best treatment option? Learn more with Dr. Peter Buch as he takes a deep dive with Dr. Paul Feuerstadt, Assistant Clinical Professor of Medicine at Yale-New Haven Hospital.

Host: Jennifer Caudle, DO
Guest: Victoria A. Statler, MD, MSc

Test-confirmed influenza outcomes provide a specific measure of influenza vaccine effectiveness (VE) and has helped to illustrate the potential benefit of cell-based versus egg-based vaccines.¹ So what data support improved VE from cell-based flu vaccines versus egg-based vaccines? To learn more, join Dr. Jennifer Caudle as she speaks with Dr. Victoria A. Statler, Associate Professor of Pediatrics at the University of Louisville and the Director of the Pediatric Transplant and Immunocompromised Host service at Norton Children’s Hospital.

Reference:

1. Stein AN, Mills C, McGovern, et al. Superior effectiveness of cell-based versus egg-based quadrivalent influenza vaccines against test-confirmed influenza over three consecutive seasons in the United States. Paper presented at: The Ninth European Scientific Working Group Influenza (ESWI) Influenza Conference; September 17-20, 2023: Valencia, Spain.

USA-QIVc-23-0119 01/24

Guest: Stephen I. Pelton, MD

Influenza disproportionately affects adults 65 and older as a result of increased frequency of comorbidities and immunosenescence.^1,2 And it’s also linked to neurologic, cardiovascular, and respiratory complications in high-risk groups, while potentially exacerbating underlying chronic medical conditions.^1,2 So how can adjuvanted vaccines help patients who are affected? Dive in to learn more with Dr. Stephen Pelton, Professor of Pediatrics at Boston University Chobanian and Avedisian School of Medicine.

References:

1. Pelton SI, Nguyen VH, Mould-Quevedo JF. The value of influenza vaccination in the older adult population. A stochastic model estimation of the benefit of vaccination to prevent the severe outcomes in the U.S. Poster presented at: IDWeek 2023; October 11-15; Boston, MA.
2. Pelton SI, Mould-Quevedo JF, Nguyen VH. The impact of adjuvanted influenza vaccine on disease severity in the US: a stochastic model. Vaccines. 2023; 11(10):1525. https://doi.org/10.3390/vaccines11101525

USA-FLUD-23-0011 12/23

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Wendy Wright, DNP
Guest: Elias Chahine, PharmD, FCCP, FASCP

While the flu may seem benign to some, it may result in up to 710,000 hospitalizations and up to 52,000 deaths every year.¹ So how are current and concerning trends in declining flu vaccinations being addressed? To hear the latest updates and recommendations, join Dr. Charles Turck as he speaks with Dr. Wendy Wright, Owner and Family Nurse Practitioner at Wright & Associates Family Healthcare in New Hampshire, and Dr. Elias Chahine, Professor of Pharmacy Practice at Palm Beach Atlantic University in West Palm Beach, Florida and Clinical Pharmacy Specialist at Wellington Regional Medical Center.

Reference:

1. Disease Burden of Influenza. Centers for Disease Control and Prevention. https://www.cdc.gov/flu/about/burden/index.html. Updated October 4, 2022. Accessed November 28, 2023.

USA-CRP-23-0043 01/24

Host: Jeffrey Kwong, DNP, MPH

Managing co-occurring conditions in patients with HIV can be challenging. But by taking certain steps—like updating management guidelines, screening for complications, and implementing prevention strategies—we can overcome those challenges and improve the way we care for HIV patients with co-occurring conditions. Here to discuss those strategies is Dr. Jeffrey Kwong, a Professor in the Division of Advanced Nursing Practice at Rutgers University School of Nursing. He also spoke about this exact topic at the 2023 Annual ANAC conference in his session, titled “Managing Co-Occurring Conditions: A Clinical Update.”

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: William R. Short, MD, MPH, AAHIVS

As of January 2023, the breastfeeding guidelines for HIV patients were updated, and they now recommend supporting the parent’s choice through shared decision-making. Joining Dr. Charles Turck to share what these new guidelines look like in practice and key counseling strategies for HIV patients is Dr. William Short. Dr. Short is an Associate Professor of Medicine and Infectious Disease at the University of Pennsylvania in Philadelphia, and he also spoke about this exact topic at the 2023 ANAC conference in his session, titled “New Recommendations for Infant Feeding for Persons with HIV in the United States.”

Host: Rachel Denyer, MD

About one in every three people living with HIV has a positive hepatitis B core antibody. But how frequently does hepatitis B reactivation occur after a patient with HIV switches to an antiretroviral regimen that has no hepatitis B activity? Find out with Dr. Rachel Denyer as she shares key data she presented at IDWeek 2023 in the session titled “Hepatitis B Reactivation in Persons with HIV with Positive Hepatitis B Core Antibody After Switching to Antiretroviral Therapy Without Hepatitis B Activity.”

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Stuart M. Levitz, MD

Treating fungal infections can be difficult due to the limited treatment options available, but could antifungal vaccines help change that? To catch us up on the progress being made in immunotherapeutic and vaccine strategies, Dr. Charles Turck speaks with Dr. Stuart Levitz about the “Antifungal Vaccines: Where Are We At?” session he presented at IDWeek 2023.

Host: Jeffrey Freiberg, MD, PhD

The field of infectious diseases is always evolving thanks to new research studies, data, and treatment options. To help us catch up on some of these essential updates, Dr. Jeffrey Freiberg is here to give us an overview of the “What's Hot in ID in Clinical Science” session he helped develop for IDWeek 2023.

Host: Jay Fishman, MD

With a global shortage of human organs, xenotransplantation offers a potential new way to save lives. But what are the immunologic barriers? Tune in as Dr. Jay Fishman, Director of Transplant Infectious Diseases and Compromised Host Program at Massachusetts General Hospital, recaps his session from the 2023 IDWeek.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Keith C. Ferdinand, MD, FACC, FAHA, FASPC, FNLA

Vaccines are essential in reducing death and disability related to influenza, but unfortunately, not all patients have equal access to these life-saving resources. In fact, many barriers exist, like misinformation and lack of public awareness and education. That’s why Dr. Charles Turck speaks with Dr. Keith Ferdinand about ways we can break down barriers and improve vaccination rates among members of racial and ethnic minority communities.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: John Russell, MD
Guest: Darvin Scott Smith, MD

Hospitals and health systems face several economic and logistical challenges due to low rates of flu vaccination. Fortunately, there are policies, programs, and initiatives that can be implemented in health system environments and at the community level to increase flu vaccination rates. Learn more with Drs. Darvin Scott Smith and John Russell. Dr. Smith is an Infectious Disease Consultant of Public Health Works, LLC in Northern California, and Dr. Russell is a family medicine physician at Jefferson Health System in Abington, Pennsylvania.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Darvin Scott Smith, MD

There are several benefits associated with using real-world evidence to assess vaccine effectiveness, especially in the context of flu vaccines. Find out why and what the real-world evidence says about the effectiveness of flu vaccines with Dr. Charles Turck and Dr. Darvin Scott Smith. Dr. Smith is an infectious disease consultant of Public Health Works, LLC in Northern California.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Jill Foster, MD

The clinical and economic burden associated with the flu is particularly heavy for our youngest patients. Learn more about this burden and how influenza vaccines can help reduce it with Dr. Charles Turck and Dr. Jill Foster, Professor in the Department of Pediatrics and the Director of the Division of Pediatric Infectious Diseases at the University of Minnesota Medical School in Minneapolis.

Host: Mary Katherine Cheeley, PharmD, BCPS, CLS, FNLA
Guest: Steve Grinspoon, MD

The risk of cardiovascular disease is twice as great among patients living with HIV, and this could partly be due to traditional risk factors, along with nontraditional risk factors. Here to discuss the results from the REPRIEVE study with Dr. Mary Katherine Cheeley is Dr. Steve Grinspoon, Co-Principal Investigator and Professor of Medicine at Harvard Medical School in Boston.

Host: Mary Katherine Cheeley, PharmD, BCPS, CLS, FNLA
Guest: Sarah Bauerle Bass, PhD, MPH, FSBM

Although the rate of new HIV diagnoses in the United States is steadily declining, people in prisons are still disproportionately living with the virus, which is why researchers at Temple University are now developing an app aimed at improving HIV prevention and substance use treatment access for incarcerated women in Philadelphia. To learn more about this research, Dr. Mary Katherine Cheeley is joined by Dr. Sarah Bauerle Bass, Associate Professor of Social and Behavioral Sciences and the Director of Risk Communication Laboratory at Temple University.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Kamel Khalili, PhD

Scientists at Temple University’s Lewis Katz School of Medicine have identified a novel gene-editing strategy aimed at eliminating HIV-1 infection with no adverse effects on cell mortality. Find out how this recent discovery could get us one step closer to a cure for HIV with Dr. Charles Turck and Dr. Kamel Khalili, the Laura H. Carnell Professor in the Department of Neuroscience and Chair of the Department of Microbiology, Immunology & Inflammation.

Host: Ryan Maves, MD
Guest: Megan Conroy, MD, MA(Ed)

Respiratory syncytial virus (RSV) is most commonly recognized for the significant disease it causes in infants and young children. However, over time its prevalence in adults has increased. Tune in to learn more with Dr. Ryan Maves as he speaks with Dr. Megan Conroy, Assistant Professor of Medicine at the Ohio State University in Columbus.

This program is produced in partnership with the American College of CHEST Physicians and is supported by an educational grant from GSK.

Host: Ryan Maves, MD
Guest: Kelly Pennington, MD

It’s estimated that respiratory syncytial virus (RSV) is responsible for up to 30 percent of viral respiratory infections in the stem cell transplant population. So how can we help RSV patients achieve their best outcomes? Learn more with Dr. Ryan Maves as he speaks with Dr. Kelly Pennington, Assistant Professor of Medicine at the Mayo Clinic in Rochester, Minnesota.

This program is produced in partnership with the American College of CHEST Physicians and is supported by an educational grant from GSK.

Host: Jerome Lisk, MD
Guest: Santosh Kumar, PhD

In an effort to examine the correlation between HIV-induced aging and Alzheimer’s disease in the United States population, a team of researchers at the University of Tennessee Health Science Center are working to develop a novel drug delivery system. To learn more, Dr. Jerome Lisk is joined by Dr. Santosh Kumar to discuss his current research and the effects it could have on future treatment approaches for HIV-induced aging and Alzheimer’s disease. Dr. Kumar is a Professor in the Department of Pharmaceutical Science at the University of Tennessee.