MedEvidence! Truth Behind the Data

• Understanding Lipid Issues and Cholesterol Numbers
• Understanding Lipoproteins and LDL Levels
• Breakthroughs in Heart Disease Treatment
• Cholesterol, Lipoproteins, and Heart Health
• Injectable PCS-K9 Vaccine Study Presentation

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• Diabetes and Nutrition
• Understanding Diabetes and Blood Sugar Response
• Managing Type 2 Diabetes Through Diet
• Impact of Food on Blood Sugar
• New Medications for Diabetes Management 
• Patient Safety in Research Studies

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Ever wondered how doctors navigate the murky waters when they're at odds over a diagnosis or medical question? This week's MedEvidence Monday Minute is discussing this intricate dance. Dr. Michael Koren and Kevin Geddings of WSOS St. Augustine Radio peeled back the curtain on medical disagreements and the importance of tailored healthcare plans. As we bid adieu to Heart Month, they also enlightened us on the latest heart health research, including groundbreaking cholesterol treatments, and how patients can get involved without stepping on their primary physician's toes. 

At MedEvidence, we bridge the gap between complex medical jargon and your everyday health concerns. From the nuances of medical misinformation to the evident nature of healthcare, our conversations with medical experts are an invaluable resource for anyone curious about the behind-the-scenes of medical decision-making and research. You'll come away with a deeper appreciation for the intricacies of medicine and the pivotal role of research in settling those tough debates between professionals. Join us for a thought-provoking journey into the heart of medical science, where we uncover not just the facts but the stories, people, and truths behind them.

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Discover the intricate ties between heart health and memory as we sit down with esteemed neurology expert Dr. Steven Toenjes and well-known cardiologist Dr. Michael Koren. They will give you insights that could reshape your understanding of Alzheimer's disease. The conversation transcends the traditional boundaries of amyloid PET scans and dissects the nuances of cognitive impairment. Through the compelling case scenario of Mr. Wrenchworth, they unveil the critical differences between normal age-related cognitive changes and genuine memory loss, illuminating the importance of comprehensive assessments in the face of memory concerns.

Venture with us into the realm of vascular disease and its profound influence on cognitive function, where strokes and small vessel changes play an unexpectedly significant role. We navigate through the distinguishing features of dementia varieties, spotlighting how conditions like Lewy body and frontotemporal dementia present their unique challenges. Not only do we tackle the controversies surrounding Alzheimer's hypotheses, but we also examine cutting-edge interventions and the delicate balance between their benefits and potential risks, as seen in the Aducanumab and Lecanemab trials.

Wrap up your journey with a deep dive into the emerging blood-based markers that promise to revolutionize the early detection of Alzheimer's. Dr. Toenjes and Dr. Koren scrutinize the pathological indicators of the disease and stress the imperative of modifiable risk factors, the restorative power of sleep, and the cognitive safeguarding properties of cardiovascular exercise. We conclude with a candid discussion on the controversial FDA approval of aducanumab and the essential, yet often overlooked, role of medication monitoring, particularly with treatments like Lecanemab. Join us for an episode that's not just a conversation but a gateway to understanding the future of Alzheimer's therapy.

Take Home Talking Points:

• Understanding Alzheimer's Disease and Memory Loss
• Vascular Disease and Types of Dementia
• Understanding Alzheimer's
• Cardio and Music's Impact on Brain Health
• Treatment for Cognitive Decline
• Asymptomatic Brain Hemorrhages and Medication Monitoring

Recording Date: January 26, 2024 a rebroadcast for the WJCT studio.

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Explore the groundbreaking realm of orthopedic research with a twist of humor as Dr. Michael Koren and Dr. Garry Kitay take you through the intricacies of clinical trials and medical innovations. Uncover how studies potentially revolutionize athlete recovery and understand the impact of performance-enhancing drugs in controlled environments. This episode isn't just a discussion; it's a journey through the transformative potential of rigorous research in sports medicine, where the anecdotal gives way to the empirical.

Raise your glasses as we blend the scientific with the sippable in the "ortho sipping scotch study." Drawing inspiration from the Lady Tasting Tea Experiment, a cornerstone of modern medical statistics, we humorously test our abilities to discern the order of scotch and ice, paralleling the meticulous nature of clinical trial design. Our conversation with Dr. Kitay isn't just about advancements in orthopedics; it's a toast to the fusion of history, science, and a dram of good spirits. Join us for an episode where each pour is paired with a dose of insight into the world of medical research.

Check out the full series:
✅Part 1: Innovation and Ingenuity in Medicine - Released January 31, 2024
✅Part 2: Pioneering Orthopedics and the Complex Ethics of Treating Athletes - Release February 7, 2024
✅Part 3: Laughter and Libations in the Lab Orthopedic Advances and Scotch Studies -Release February 14, 2024

Recording Date: January 17, 2024

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Unlock the secrets to a healthier heart with Dr. Michael Koren, our esteemed guide through the intricacies of cardiovascular wellness. During our conversation, Dr. Koren zeroes in on the cornerstone of cardiovascular disease prevention—managing lipids with the gold-standard: statins. While these medications are pivotal, they're not a one-size-fits-all solution. That's where innovative clinical trials come into play, offering alternative therapies for those whose cholesterol levels don't quite align, even with statins. If your heart health is a concern or you're just keen on the latest in medical breakthroughs, this dialogue with Dr. Koren is an essential listen, offering actionable insights and shining a light on the therapies that are reshaping the future of cardiology.

Recording Date: January 12, 2024

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Step into the cutting-edge world of orthopedic innovations with the renowned Dr. Garry Kitay, as we unravel the latest advancements in hand surgery tools. Ever wondered how a seemingly simple device like the hand immobilizer can revolutionize surgical precision and patient recovery? Dr. Kitay shares invaluable insights on this game-changer in the operating room, offering us a rare glimpse into how the new model propels the field forward, allowing unparalleled access and stability during intricate procedures. We also navigate the often-murky waters of medical device regulations, the FDA clearance labyrinth, and the pivotal role of informed consent — especially when it comes to off-label usage. It's a compelling narrative that exposes the intricate dance between innovation, regulation, and ethics in medical practice.

Shifting gears, we tackle the intense realm of sports medicine, where the stakes are ever high, and the operating table can feel like the last down of a championship game. Picture the pressure of surgical decisions that hold the weight of an athlete's career in their hands and the delicate dance of maintaining patient confidentiality amidst the scrutiny of the public eye. Our dialogue extends into the thorny issues of performance-enhancing substances and the ethical debates they spark, as well as the challenges in conducting research on athlete health outcomes in the wake of the COVID-19 pandemic. It's not just about the surgery; it's about the broader impact on the athlete, the sport, and society's perception of modern medicine and professional sports. Join us for a deep exploration of the intersection where surgical skill meets the ethical considerations that are reshaping the landscape of sports medicine today.

Take Home Talking Points:
✋Managing Hand Immobilizers and Patient Expectations
✋Pressure and Research in Sports Medicine

Check out the full series:
✅Part 1: Innovation and Ingenuity in Medicine - Released January 31, 2024
✅Part 2: Pioneering Orthopedics and the Complex Ethics of Treating Athletes - Release February 7, 2024
✅Part 3: Laughter and Libations in the Lab Orthopedic Advances and Scotch Studies -Release February 14, 2024

Recording Date: January 17, 2024

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Discover the future of cholesterol management with Dr. Michael Koren, fresh from his breakthrough publication in The Lancet. On our latest MedEvidence Monday Minute, Dr. Koren unveils an innovative oral medication that's set to change the game for patients resistant to traditional statins. Learn how reaching optimal cholesterol levels can shield you from heart attacks and strokes, and get a sneak peek at Dr. Koren's forthcoming insights at the American College of Cardiology meeting. If your cholesterol journey feels like an uphill battle, tune in for an exclusive opportunity to receive a complimentary cholesterol assessment at ENCORE Research Group.

Read the LANCET article discussed in this podcast.

Learning Lessons:
❤️️Cholesterol Treatment Options and Medical Updates

❤️️Preventing Heart Disease and Cardio Risk

Recording Date: February 5, 2024

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When paths converge in the realm of medicine, the result can be nothing short of extraordinary. Discover the serendipitous journey of Dr. Gary Kitay, esteemed orthopedic and hand surgeon, whose early exposure to the nuts and bolts of his father's hardware store set the stage for a career in the tactile world of orthopedics. In a revealing conversation, Dr. Michael Koren and Dr. Gary Kitay stitch together the tapestry of clinical research and personal calling, unraveling how a love for statistics and mathematics shepherded Dr. Koren's  cardiology practice while Dr. Kitay's affinity for anatomy and hands-on healing carved out his surgical niche. Their discussion peels back the layers on the immediate satisfaction of surgical successes as opposed to the patient wait-and-see of internal medicine, offering a rare glimpse into the passions that pulse through the veins of healthcare professionals.

Step inside the meticulous framework of medical device regulation and witness the birth of innovation through the lens of the FDA's classification system. We dissect the distinctions between class one, two, and three devices, illuminating the pivotal role of clinical trials in the journey from concept to patient care. With the introduction of the hand immobilizer, a deceptively simple class one device poised to redefine surgical support, we navigate the ethical maze of informed consent and the gratifying challenges that accompany the design and implementation of medical advancements. Join us as we unravel the complexities of device innovation and patient care, all the while championing the collaborative spirit that drives medicine forward.

Take Home Talking Points:
✋Orthopedic Surgeon's Innovations in Medicine

✋Regulation and Innovation in Medical Devices

Check out the full series:
✅Part 1: Innovation and Ingenuity in Medicine - Released January 31, 2024
✅Part 2: Pioneering Orthopedics and the Complex Ethics of Treating Athletes - Release February 7, 2024
✅Part 3: Laughter and Libations in the Lab Orthopedic Advances and Scotch Studies -Release February 14, 2024

Recording Date: January 17, 2024

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As we peel back the curtain on clinical trials, Dr. Koren shares how choosing the right candidates is as critical as the research itself. Ethical considerations and the integrity of the studies take center stage. If you've ever pondered the real-world impact of being part of a clinical trial or wondered about the top-tier healthcare and cutting-edge treatments participants access, our candid discussion with Dr. Koren offers those answers and more. Join us for a conversation that's as much about connecting with the community as it is about demystifying the research process—where personal health narratives meet scientific rigor.

Recording Date: January 29, 2024

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Unlock the truths behind Big Pharma's intentions. Dr. Michael Koren sheds light on a pressing issue: the preference for managing chronic illnesses over seeking cures. Kevin Geddings of WSOS St. Augustine Radio and Dr. Koren delve into the complex world of pharmaceuticals and their innovations, examining the intricate dance between disease management and the pursuit of outright cures. Dr. Koren doesn't shy away from tough topics, offering a candid look at the weight loss medication market and celebrating the remarkable success story of the hepatitis C cure.

Explore the far-reaching impact of medical advancements with us as Dr. Korn navigates through the ethical and economic quagmires tied to high-cost treatments. He brings a nuanced perspective to the table, discussing the potential and limitations of cutting-edge technologies like CRISPR for genetic conditions. Our discussion also honors the tremendous advances in public health, such as the eradication of smallpox through vaccine strategies, contrasting them with the ongoing challenges of resource allocation in modern healthcare. This episode promises a thought-provoking examination of medicine's role within our society, as we seek to understand the delicate balance between profitability and patient well-being.

Recording Date: January 25, 2024

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Have you ever wondered why diversity is needed in clinical research or why there may be unique challenges in engaging African-American communities in medical research? Dr. Michael Koren alongside Dr. Trevor Greene, peel back the layers of this complex issue. We tackle the delicate interplay between cultural sensitivity, revealing the stark differences within the Black community that influence participation in clinical trials. The episode is brimming with insights into the critical role of community leaders and relatable physicians in mending historical mistrust and laying the groundwork for progress in clinical research.

This heart-to-heart conversation traverses the shadow of the Tuskegee syphilis study, confronting its enduring impact on public trust head-on. As we recount the evolution of ethical research practices, we celebrate the advancements that have emerged from past mistakes, such as informed consent and increased transparency. A case study highlighting a 50% enrollment rate at a single site exemplifies the leaps made towards reconciling past breaches of trust. Join us for a profound discussion on the strides being taken to advance medical research and uplift community health, with Dr. Koren and Dr. Greene guiding us through the narrative of transformation and healing.

Podcast Paraphrase:
✅Diversity in Medicine
✅African-American Heart Failure Patients
✅Engage African American Community in Research
✅Clinical Research diversity needs for advancing medicine

Recording Date: August 23, 2023

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Imagine unlocking the secrets to a life that stretches joyously into the 90s and beyond – this is precisely what Dr. Michael Koren and Kevin Geddings unveil in our latest MedEvidence Monday Minute. As we navigate the converging paths of lifestyle choices and medical interventions like statins, we discover that longevity isn't just about the foods we eat or the miles we jog; it's also profoundly influenced by the strides we've made in healthcare.

This week, we're tearing down the myths associated with life-prolonging medications and exposing the truth behind statin side effects. Dr. Koren, with his wisdom and experience, breaks down why a pill isn't an adversary to a healthy lifestyle but rather an ally. Join us for a conversation on the perfect symphony of pills and practices that could have us all toasting to life's milestones well into our golden years with those we cherish.

Recording Date: January 15, 2024

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Join Dr. Carolyn Tran and Antoinette Bailey, the Diversity, Equity, and Inclusion Liaison for ENCORE Research Group, as we delve into the pivotal role that varied populations play in the landscape of healthcare studies. Antoinette and Dr. Tran engage in a candid conversation about the barriers to recruiting participants from diverse communities, shining a light on the deep-rooted concerns stemming from historical events like the Tuskegee experiment. We share the concerted efforts made to educate the public on the significant strides in clinical research governance, highlighting the Belmont Report, IRB oversight, and FDA regulations—all crucial in safeguarding participant welfare. Listen as we reveal how our commitment to transparency and patient safety in clinical trials addresses past wrongs and paves the way for a more inclusive, effective future in medical research.

Recording Date: December 6, 2023

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Discover the hidden truths of Medical Research as Dr. Michael Koren from ENCORE Research Group illuminates the intricate dance of clinical trials, delivering a masterclass on personalized patient care and informed decision-making in this week's MedEvidence Monday Minute. As I, Kevin Geddings, guide the conversation, we reveal the critical parallels between sports strategy and the leadership required to manage high-pressure situations in healthcare. This episode promises to unravel the complexity behind the scenes, offering you a rare peek into the meticulous world that shapes the medicines and treatments of tomorrow.

We're peeling back the curtain on clinical trials with stories straight from the front lines, as Dr. Koren recounts his early morning strategy for tackling potential side effects in a patient's trial participation, showcasing the expertise and dedication that is a signature of Encore Research Group Dr. Richard Myers and Dr. Valerie Hayes, our seasoned medical director and expert site manager respectively, also earn the spotlight for their roles in steering these medical explorations. Together, we navigate the nuanced layers of patient care, strategy, and innovation that define the future of medicine. Tune in and be part of a conversation that's as enlightening as it is essential for anyone interested in the cutting edge of healthcare.

Recording Date: January 8, 2024

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Embark on an enlightening exploration of systemic lupus erythematosus (SLE) with the insightful Dr. Shah on MedEvidence. We delve deep into the perplexing world of lupus, shedding light on its signature symptoms like the striking malar rash, while clarifying common misconceptions to foster a better understanding of this enigmatic condition. Beyond its cutaneous manifestations, we discuss how lupus can affect multiple organs and the significance of genetic predisposition, offering a comprehensive look at why this disease remains a formidable challenge in the medical community.

Navigating the lupus diagnosis and management maze can be as complex as the disease itself. Join us as we dissect early warning signs, from the elusive fatigue and Raynaud's phenomenon to more overt cues that may often be mistaken for less serious health issues. With Dr. Shah's guidance, we reveal the intricacies of the diagnostic process, emphasizing the necessity of a multifaceted treatment strategy. We don't hold back on discussing the potential complications of lupus, particularly when it comes to pregnancy, underscoring the critical nature of vigilant disease management.

As we move towards a future filled with medical advancements, we share a message of hope for those living with lupus. We cover the gamut of treatment options, from the tried-and-true hydroxychloroquine to the breakthrough potential of JAK inhibitors, and offer practical tips for day-to-day living with lupus. Our conversation ultimately culminates with an invitation for listeners to join forces in the ongoing quest for autoimmune disease research breakthroughs, empowering you to become an active participant in the journey towards a brighter, healthier future.

Lupus Snapshot:

📸Understanding Lupus
📸Diagnosing and Managing Lupus
📸Therapies and Tips for Lupus
📸Jack Inhibitors for Autoimmune Diseases 
📸Getting Involved in the Future

Recording Date: November 29, 2023

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Unlock the deeper meaning behind the well-worn New Year's wish of health, happiness, and prosperity with Dr. Michael Koren, whose passion for medical research offers a fresh take on these timeless hopes. As a seasoned cardiologist and research scientist, Dr. Koren joins us to dissect this classic greeting, revealing the interconnectedness of these ideals within the realm of healthcare and personal fulfillment. Get set to transform your understanding of what it truly means to extend these well-wishes as we explore the tangible ways they manifest in our lives.

During our conversation, Dr. Koren unravels how prosperity goes beyond mere wealth, touching on the rewards of clinical research participation and the profound impact that contributing to medical advancements can have on individuals and communities. He explains the dual nature of health – preventing illness and optimizing the management of chronic conditions – and how his organization, ENCORE Research Group, propels both. Most poignant is the exploration of happiness, where Dr. Koren shares the insight that true contentment comes from achievement and contribution, not just from what we possess. This episode is a heartfelt reminder of the power behind our New Year's aspirations and an invitation to pursue them with intention in all aspects of our lives.

Recording Date: January 2, 2023

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Are myths about vaccines and their DNA-altering capabilities clouding your judgement? Let us arm you with facts as we journey through the complexities of viruses and the marvels of modern immunizations. Together, we’ll navigate the intricate relationship between these microscopic invaders and the defense mechanisms of our bodies. Expect a thorough examination of how vaccines employ fragments of a virus's spike protein to elicit an immune response, a giant leap from the days of using inactivated viruses. Our discourse aims to dismantle doubts and empower you with the confidence to champion the cause of vaccine safety and efficacy in your community.

Our immune system is an unsung hero, and in this episode, we give it the spotlight it deserves. We'll explore the timeline of antibody production post-exposure, revealing the nuanced roles of IgM and IgG antibodies and the lasting protection they offer. We'll also discuss the valiant T cells and B cells, the architects of cellular immunity. By understanding how our bodies recruit these cells to fend off infections, you'll gain a newfound appreciation for the science behind the structure of antibodies and their vital role in our well-being.

Taking a step back in history, we delve into the contributions of diverse communities in the realm of vaccines—an homage to the pioneers who laid the groundwork for today's medical miracles. But it doesn't stop there; we also gaze into the crystal ball of vaccine technology, discussing the groundbreaking potential of combined flu and COVID-19 vaccines and the promising advancements that could see vaccine development times slashed to mere months. This episode is not just a celebration of medical achievements; it's a testament to the collective power of communities, like the 2,000 Northeast Florida participants in vaccine trials, whose efforts fuel the relentless pursuit of health innovation. Join us for a riveting tale of human ingenuity and resilience in the face of disease.

MedEvidence Checkup:
✅Understanding Vaccines and Viruses
✅Understanding the Immune System and Vaccines
✅The History and Production of Vaccines
✅Understanding the Process of RNA Vaccine
✅Future of Vaccines and Flu-Covid Vaccine


Recording Date: October 27, 2023

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Prepare to have your perception of cannabis transformed! In our final episode of Two Docs Talk Cannabis, Dr. Michael Koren and Dr. Erich Schramm you on an insightful journey into the complex world of cannabis research. They break down the walls of misunderstanding surrounding this Schedule I drug, shedding light on its potential reclassification, and introducing you to the game-changing pharmaceutical products derived from it. Join the Cannabis Conversations to explore this controversial field and its promising future.

Are you aware of the numerous components of marijuana and their effects? It's not as straightforward as traditional drugs, and that's where Dr. Schramm and Dr. Koren explore the concept known as the entourage effect, giving you a better understanding of the intricacies of this dynamic plant, debate the importance of the endocannabinoid system and its place within medical education. Moreover, they highlight the ever-increasing potency of THC content in modern marijuana, a crucial factor often overlooked. Join us as we demystify cannabis, reflecting on its past, analyzing its present, and predicting its future.

Listen to the entire series:

Part 1: Cannabis 101 - Released November 27, 2023

•    CBD vs. THC
•    Delta-8 and Delta-9
•    Terpenoids and Flavonoids
•    Sativa, Indica and Hybrids
•    Endocannabinoid System

Part 2: Cannabis Conversations - Types of Patients Treated - Released December 6, 2023

•    Common Conditions Treated
•    Case Studies

Part 3: Step by Step to Cannabis Certification - Released December 13, 2023

•    How does a patient get certified
•    Certification Process
•    Driving and Traveling with Cannabis
•    Health and Healing Benefits

Part 4: Rescheduling & Research of Cannabis - Released December 20, 2023

•    Schedule 1 vs 2 vs 3
•    Financial Implications
•    Research Implications

Recording Date: November 16, 2023

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Have you ever felt the frustration of a self-checkout area at a grocery store and then noticed the same in your interaction with your medical provider? With the retail industry's lessons in our minds, we turn the spotlight on the healthcare service in our conversation with Dr. Michael Koren. We navigate through the impact of service in our health care system - or the lack of it - and the dangers of relying on Dr. Google, drawing from real-life anecdotes shared by Dr. Koren. We also broach the topic of clinical trials, unearthing how service is a fundamental layer in this realm.

As we move closer to the holiday season, we continue engaging with Dr. Koren on the future of medicine. We probe into the role of technology in healthcare, the uphill battle of implementing evidence-based practices, and the vital importance of staying abreast with medical research. And as we bid adieu to this enlightening conversation, Dr. Koren sends us warm holiday wishes and you, our valued listeners. Join us for this enlightening episode and keep your ears primed for more stimulating discussions in the coming year!

Recording Date: December 18, 2023

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