The Future of Everything

Rebecca Silverman is an expert in how humans learn to read. It’s a complex process, she says. First we must connect letters and sounds to decode words in texts. Researchers know a lot about the decoding process and how to teach it. But, beyond that, we must also comprehend what the words in texts are conveying. Comprehension is complex, and researchers know much less about the comprehension process and how to teach it, Silverman tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

•  Rebecca Silverman’s Research Lab: Language to Literacy Lab

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Chapters:

(00:00:00) Introduction to Reading Challenges 

Host Russ Altman introduces guest Rebecca Sliverman and her research into the complexities of reading.

(00:03:53) Decoding vs. Comprehension 

The breakdown of reading into decoding and comprehension, the challenges associated with each, and the lifelong process of improving these skills.

(00:07:18) Variability in Learning to Read  

How children learn to read, including the impacts of linguistic comprehension, memory and socio-emotional contexts.

(00:09:55) Cross-Cultural Differences in Reading 

The variability of reading acquisition across languages and cultures, highlighting the components of reading that vary in their developmental trajectory.

(00:11:35) Research Challenges and Interventions in Reading 

Current research on the challenges of reading, particularly in identifying and supporting children with difficulties.

(00:15:03) The Role of Technology in Reading 

The impact of technology on reading, the differences between reading on paper and digital formats, and the potential of educational technology in literacy development.

(00:20:38) Importance of Family in Reading Development

How families play a role in early reading, with emphasis on storytelling and culturally relevant practices. 

(00:23:52) Challenges for Teachers in Literacy Education

Responsibilities of teachers in teaching literacy and the need for comprehensive support and training for teachers.

(00:27:44) Future Directions and the Potential of AI 

Future research on AI in literacy education, and the importance of human oversight in technological interventions.

(00:29:29) Conclusion

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Professor and cultural psychologist Michele Gelfand’s latest book, Rule Makers, Rule Breakers, explores notions of what she calls “tight” and “loose” cultures, and how each shapes us as individuals and the world around us. Tight cultures closely follow unwritten cultural norms, while those on the looser side have more latitude. Culture is complicated, she says, but understanding its nuances is key to understanding the world, Gelfand tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

• Michele Gelfand Website / Bio
• Rule Makers, Rule Breakers: How Tight & Loose Cultures Wire Our World (Michele Gelfand’s Book)
• Mindset Quiz  (Quiz on Michele’s Website)
• Threat Dictionary
• Tight-Looseness Across the 50 United States  (PNAS paper on reclassifying states from red/blue to tight/loose)
• The Culturally Intelligent Negotiator: The Impact on Cultural Intelligence (CQ) on Negotiation Sequences & Outcomes   (Michele Gelfand & Lynn Imai Study)
• Differences Between Tight and Loose Cultures: 33 Nation Study (Michele’s study published in Science on factors that predict strict and permissive social norms)
• Together From Afar: Introducing a Diary Contact Technique for Improving Intergroup Relations  (US / Pakistan Study)

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Chapters:

(00:00:00) Introduction

Russ introduces Michele Gelfand and her research on the study of culture and cultural intelligence.

(00:02:33) Defining Culture

A working definition of culture and the invisible impact of cultural norms, values, and beliefs.

(00:03:46) The Tight-Loose Spectrum

The concept of tight and loose cultures and how social norms vary across cultures.

(00:06:30) Cultural Variance within and between Societies

Variations of tight-loose norms at national, state, and organizational levels,  and the role of threat in shaping these norms.

(00:11:34) Cultural Intelligence in Global Leadership

How the tight-loose spectrum and cultural studies inform leadership, and the significance of cultural intelligence (CQ) in global interactions.

(00:18:59) Cultural Evolutionary Mismatch

Implications for global threats and societal responses.

(00:23:56) Applying Cultural Insights in Business

Insights on applying cultural understanding to improve business mergers, negotiations, and the success of expatriate assignments.

(00:26:09) Enhancing Cultural Intelligence

Improving cultural intelligence and steps individuals can take to enhance their CQ and adapt to cultural differences.

(00:28:48) Urban vs. Rural Cultural Differences

Tight-loose division in politics and societal contexts, and the cultural divide between urban and rural areas.

(00:31:19) Conclusion

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We’re taking you into our archive of over 250 episodes to re-share an interview Russ Altman did in 2022 with Stanford Medicine Professor of Surgery, Carla Pugh.  Performing surgery is profoundly complex and requires precision, dexterity and lots of practice. Dr. Pugh shares about how she’s studying the movements of skilled surgeons to better understand what makes them successful, which can in turn help to improve training for new surgeons.

Episode Reference Links:

• Technology Enabled Clinical Improvement Center
• Dr. Pugh’s Research: Use of sensors to quantify procedural idle time 

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Chapters:

(00:00:00) Introduction
Host Russ Altman introduces the episode with Dr. Carla Pugh discussing her research studying the movements of surgeons to improve surgical training.

(00:02:27) Dr. Carla Pugh's Research and Goals
Introduction of Dr. Carla Pugh and her research utilizing sensor technology to quantify physician performance and the long-term goals of her research.

(00:04:32) Wearable Sensors in Surgical Training
How wearable sensors are being used, and the reaction of surgeons to being monitored.

(00:06:21)  Expertise Identification & Universality of Movement
How idle time and motion tracking can distinguish between novice and expert surgeons  & how expert surgeons exhibit similar motion patterns.

(00:10:10) Expert vs. Novice Surgeon Behaviors
Observed differences in speed and precision between expert and novice surgeons, & working volume.

(00:12:48) Ethical Considerations
The ethical considerations of measuring surgeon performance, with a focus on
managing the careers of aging surgeons through data-driven decisions.

(00:16:03) The Role of Robotics in Surgery
The current and future roles of robots in surgery, debunking myths, setting realistic expectations & how this research can be applied.

(00:20:29) Demand for Robotic Surgery and Tech Trust
Patients' trust in technology and robots for surgery and the pitfalls of relying too much on the technology, using orthopedic surgery as a specific example.

(00:23:07) Preserving Human Skills in Medicine
Dr. Pugh elaborates the importance of capturing human surgical skills amidst the rise of automation in order to maintain a record of traditional practices.

(00:24:49) Evolution of Surgical Procedures and Techniques
The evolution of surgical procedures due to technological advancements, and how surgeons transition between different surgical technologies.

(00:27:17) Conclusion

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Mark Skylar-Scott is one of the world’s foremost experts on the 3D printing of human tissue, cell by cell. It’s a field better known as bioprinting. But Skylar-Scott hopes to take things to a level most never imagined. He and his collaborators are working to bioprint an entire living, working human heart. We’re printing biology, Skylar-Scott tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

• Skylar-Scott Lab

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Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode, guest Mark Skylar-Scott and his work bioprinting the heart.

(00:02:15) What is Bioprinting & Tissue Engineering?

Explanation of bioprinting and its distinction from traditional 3D printing. Overview of the technology and its applications in tissue engineering and how to get the cells for this purpose.

(00:06:37) Engineering the Cells of the Heart

The 11 different cell types of the heart that are being created, and the steps involved in printing them, scaffolding them, and how they form tissue.

(00:12:23) Building Hearts: Size and Growth Considerations

The scale of bio-printed hearts, potential strategies for growth and integration, & technical challenges in controlling cell growth and development. 

(00:15:05) Scaling Up Cell Production

The importance of scaling up cell production for efficient experimentation. Exploration of the transition from laboratory research to clinical implementation. 

(00:18:40) Vascularization: The Key to Functional Bioprinted Organs

Critical importance of creating a comprehensive vascular network & the challenges of integrating capillaries and ensuring nutrient delivery to all cells. 

(00:23:00) Ethical Considerations in Bioprinting

Examination of the ethical issues surrounding the use of human cells in bioprinting, focusing on consent and the potential for inequality in access due to cost.

(00:26:12) The Future of Bioprinting: Timeline and Field Dynamics

Projections about the timeline for the clinical application of bio-printed organs and the state of collaborative competition within the fabrication field. 

(00:28:28) Conclusion

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Cognitive scientist Michael Frank studies differences in how children and AI learn language. There is a “data gap” between the billions of words ChatGPT has to work with and the millions of words a toddler is exposed to. But, says Frank, children learn in a rich social context that supports their learning. He’s currently conducting the “BabyView Study,” where he puts cameras on young children's heads to help him understand their learning experience, as Frank tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

• Wordbank: An open database of children's vocabulary development
• ManyBabies
• The SAYCam
• BabyView Study

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Chapters:

(00:00) Introduction

Russ Altman, host, introduces the episode's focus on the future of language learning and guest, Michael Frank, an expert on how children acquire language

(02:05) Child Vs AI Language Acquisition

Child language acquisition and the comparison with AI systems like ChatGPT, the differences in language learning between humans and AI, including the vast data exposure AI systems have compared to children.

(05:23) Data-driven Approaches

The importance of big data in understanding language acquisition and the Wordbank database.

(08:04) The Early Stages of Language Learning

The universal aspects of language learning across different languages and cultures, specifically babbling and its evolution into language-specific sounds.

(10:30) Exploring Multimodal Language Learning

Introduction to the SAYcam project, and the BabyView study both using camera footage from children to gather multimodal information. 

(13:12) Social Learning and Language Acquisition

Insights into how social interactions and grounded contexts facilitate children's language learning. Exploration of active learning strategies in children.

(18:22) The ManyBabies Project

A Global research consortium to understand child development across cultures, their first study documented infants' global preference for infant-directed speech. Michael outlines the funding challenges

(21:28) Understanding Pragmatics and AI Common Sense

Explanation of pragmatics in language acquisition and its importance in social cognition and inference making. The connection between pragmatic language skills in children and the challenge of instilling common sense in AI systems.

(24:21) The Role of Reading in Language Learning

The benefits of reading to children for language development while still recognizing diverse learning paths and early auditory learning.

(27:54) Multilingualism and Early Learning Flexibility

The natural ease of learning multiple languages in childhood  and when and why the flexibility in language learning begins to decline.

(30:35) Conclusion

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We’re re-running an important episode on Alzheimer’s disease — a topic that touches many people. We still don’t have a complete understanding of the disease and that makes it hard to design effective therapies. In 2022, Russ Altman sat down with mechanical engineer Ellen Kuhl who offered a glimpse into the way she’s using computational modeling to help improve our understanding of Alzheimer’s disease.

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Chapters:

(00:00:00) Introduction 
Russ introduces the episode on Alzheimer's disease, highlighting its global impact, challenges treating it, and Dr. Ellen Kuhl’s research on it.

(00:02:08) The Approach and Research Methods
Ellen Kuhl discusses her lab's interdisciplinary approach, and method of using existing data to create dynamic models to study the brain's lifecycle and degeneration in Alzheimer's disease.

(00:03:46) Key Features of Alzheimer's Disease and Detection
Biomarkers of Alzheimer's, their role in brain cell death and cognitive decline, and the possibilities for early detection methods of these protein issues.

(00:07:20) How Computational Models Function
How the models integrate various data points and physics principles to comprehensively understand Alzheimer's progression.

(00:08:43) Spread of the Disease
Exploring the mechanisms of how Alzheimer's spreads from cell to cell in the brain, and the progression through the lobes of the brain, regardless of the cause genetic or trauma induced.

(00:12:33) Interdisciplinary Collaboration 
The challenges and benefits of working as a mechanical engineer in Alzheimer's research and the opportunities of a multidisciplinary approach.

(00:14:33) Alzheimer's Drug Development 
Modeling a controversial Alzheimer's drug, its potential impact, and the importance of early diagnosis for effective treatment.

(00:16:04) Transition to COVID Research and Modeling
How the Alzheimer's model was rapidly adapated to study the spread of COVID-19, drawing parallels between brain regions and city networks.

(00:18:38) Covid Modeling Learnings and Applications
How their COVID models highlighted the importance of asymptomatic transmission and helped governments with reopening strategies.

(00:20:24) Responsible Model Application 
The rampant and at times irresponsible use of  models during the pandemic, and metrics for measuring credibility of models

(00:23:59) COVID Data Sharing
The positive legacy of COVID-19, focusing on the accelerated progress facilitated by open and transparent data sharing.

(00:24:53) Model Interpretability and Closing
Insights into the importance of model interpretability and the value of reducing complexity to enhance understanding.

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Ran Abramitzky studies the economic history of immigration by tapping into now-public government records and using AI to chart changing attitudes on immigration captured in written documents and official speeches. What’s revealed is a remarkable story that often diverges from conventional wisdom. Not all streets were paved with gold, Abramitzky tells host Russ Altman, himself a descendant of immigrants, on this episode of Stanford Engineering’s The Future of Everything podcast.

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Chapters:

(00:00:00) Introduction
Host Russ Altman introduces the episode's focus on immigration myths, and the data story behind them with economist Ran Abramitzky.

(00:01:56) The Methods & Data used 
Ran explains his approach to researching immigration using quantitative methods, data sets, and text analysis.

(00:03:39) Who is an Immigrant?
A conversation on the scope of the term 'immigrant' and the focus on voluntary immigration in this work

(00:05:01) Personal Anecdotes and Immigrant Experiences
Russ & Ran discuss the truth behind opportunities presented through immigration, illustrated by Russ’s family experience. 

(00:07:11) The Rags to Riches Myth
Debunking this story, looking at the economic status of immigrants on arrival and the generational improvements, often driven by taking jobs beneath their skill levels.

(00:09:17) Cultural Assimilation
Examining the cultural assimilation of immigrants, including marriage patterns, naming children, and citizenship.

(00:10:53) Current Relevance of Historical Immigration Patterns
The consistency of historical immigration trends across nationalities and generation, despite policy changes regarding borders

(00:13:09) Crime Myths
Exploration of resistance to immigration, debunking of myths linking immigrants to increased crime rates,  incarceration data

(00:15:39) Historical and Contemporary Polarization
Examining how political rhetoric and attitudes towards immigrants have evolved over the last 150 years, focusing on polarization.

(00:18:00) Immigrant Beliefs on Immigration
Discussion on how immigrants' attitudes towards immigration change after settling in the U.S.

(00:20:34) Refugees & Ellis Island Interviews
Interviews with immigrants from Ellis Island provide insights into the experiences of refugees versus economic immigrants and the convergence of immigrant paths by the second or third generation.

(00:24:36) Impact of Research on Government Policy
The influence, or lack, of immigration research on government policy and public perception. Abramitzky shares the importance of a long-term view of immigration success.

(00:27:15) Conclusion

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We’re re-releasing a wonderful episode about the positive impact art has on individual and societal health. Guest Deborah Cullinan, vice president for the arts at Stanford, shares how including just 10-20 minutes of art in your day — whether through drawing or dancing to your favorite song — can contribute to improved health. Her insights remind us, and hopefully will remind you as well, that art plays a valuable role in both individual and societal well being. 

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Chapters:

(00:00:00) Introduction

(00:02:04) The Power & Appreciation of Art

Discussion on the societal shift and increased appreciation and demand  for art activities.

(00:05:30) Expansive Definition of Art 

Discussion on potential pushback and challenges in defining art boundaries.

(00:07:55) Art and Health 

The intersection of art and health, emphasizing its significance and the book “Your Brain on Art” and some of the neuroscience based benefits.

(00:11:33) Art in Healthcare 

Highlighting some of the programs integrating art and healthcare at Stanford including, Stanford Medicine's program "Medicine in the Muse" art programs for healthcare providers, and supporting mental health services for students.

(00:13:30) Micro Art Moments 

The potential benefits of small doses of art and demand for art programs 

(00:15:19) Fluidity in Creating and Consuming Art 

The symbiotic relationship between creators and consumers of art and the way creating makes you appreciate art more.

(00:18:04) Technology and the Arts 

(00:22:44) Exciting Art Collaborations at Stanford

(00:25:53) The Importances of Art Spaces as safe spaces and community hubs

(00:28:27) Conclusion

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As the pandemic made a doctor visit as easy as a Zoom call and computer vision proved able to distinguish a benign blemish from something more worrisome, guest Eleni Linos, MD, DrPH, grew fascinated with the many ways digital technologies will impact all of medicine, not just her specialty, dermatology. She now believes the future of digital health is the future of health, period. But much work remains to ensure those benefits extend to every sector of society. Linos previews the future of digital health for host and fellow physician Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

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Chapters:

(00:00) Introduction

Russ Altman introduces Professor Eleni Linos and they discuss a future where digital health encompasses all aspects of healthcare and how we have moved towards that. 

(02:10) Defining Digital Health

The challenge of defining digital health and envisioning a future where it integrates seamlessly into healthcare without differentiation.

(03:33) Dermatology and Digital Health

Eleni explains her interest in digital tools for dermatology, how they have been applied in dermatology and why they are useful.

(06:41) Challenges in Examining Diverse Skin Types

Addressing challenges in dermatological exams for patients with diverse skin tones and backgrounds.

(09:05) Impact on Patients and Health Disparities

Assessing patient reactions & benefits to remote interactions and studying health disparities concerning age, ethnicity, and technology literacy.

(10:56) LLMs, Digital Health, & Bias

How large language models (LLMs) like ChatGPT are used in digital health, and their biases, and the need for and how Dr. Linos is working to reduce these.

(15:24) Empathy and AI 

Dr. Linos tells a personal story about empathy demonstrated by Chat GPT, and reflects on the potential of AI to enhance patient interactions and care.

(18:47) Social Media in Public Health

Insights into leveraging social media for public health campaigns, the strategies used to influence behavioral changes in specific demographics, and how it was employed during COVID

(24:33) Challenges in Digital Medicine Education

Exploring the challenges & opportunities in preparing future clinicians for a digital medicine-infused future. 

(28:20) Stanford Center for Digital Health

The vision and purpose of the Center for Digital Health at Stanford, emphasizing the collaboration between academia, tech companies, and a global perspective to tackle future health challenges.

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To kick off 2024, we’re bringing you an episode that’s been one of our most popular. The timing is just right as many of us are headed into the new year thinking about how to live better. In this episode, Professor Helen Blau, a stem cell biologist, tells us all about how she’s recruiting stem cells to regenerate youthful muscle in older people. We’re thrilled to bring this episode out of the archives for another listen and renewed hope about possibilities ahead in the world of health.  Happy New Year from Russ and the team here at The Future of Everything. 

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Chapters:

(00:00:00) Introduction & Importance of Muscles in Aging
Host Russ Altman introduces the episode, the ways that muscles weakening with age affects us, and how guest, Professor Helen Blau’s work with stem cells  is addressing this.

(00:02:03) Regenerative Medicine & Stem Cells

The goals of regenerative medicine in enhancing the quality of life as people age. Overview of different types of stem cells and their potential.

(00:04:28) Focus on Muscle: Sarcopenia and Aging

Emphasizing the desire to age well, and the centrality of muscles in daily activities and how they atrophy with age.

(00:07:44) Approaches to Combating Muscle Aging

Lack of available drugs addressing muscle wasting and potential research directions. Targeting stem cells and mature muscle fibers for rejuvenation.

(00:09:09) Lab Discoveries and Challenges

Dr.  Blau's lab experiments to identify and maintain functional stem cells, the breakthrough in bioengineering microenvironments & it’s impact.

(00:12:41) Stem Cell Rejuvenation

Insights into rejuvenating stem cell functions through cell therapy that lead to. 

(00:14:37) Inflammatory Pathways and Stem Cell Response

Dr Blau explains the importance of the wave of inflammation for stem cells, and the discoveries this lead to. 

(00:17:55) Broad-Scale Muscle Rejuvenation

Exploring systemic alterations targeting inflammation pathways for global muscle regeneration. Identification of PGE-2 degrading enzyme and results of limiting this enzyme.

(00:21:33) Human Trials, Challenges & Drug Development

Discussion on the prospects of translating findings to human treatments and developing an oral drug

(00:24:42) Timeline and Clinical Trials

Anticipated timelines for the drug's availability for human trials and potential applications.

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Russ's curated playlist of six episodes from our archive to accompany you through the holiday season & into the new year.

Curated Episode Links:

• Is it time to rethink philanthropy? (Robert Reich) --> YouTube or Episode Page
• The future of the gut microbiome (KC Huang) --> YouTube or Episode Page
• How 3D printing is changing medicine (Joseph DeSimone) --> YouTube or Episode Page
• The future of computational linguistics (Chris Manning) --> YouTube or Episode Page
• Why physical books will always be with us (Elaine Treharne) --> YouTube or Episode Page
• A mobile app can be the gateway for helping communities improve their health and well-being (Abby King) --> YouTube or Episode Page

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Professor Michael Fischbach, tells us that the “gut biome” – that is, the complex community of bacteria that lives in our gastrointestinal tract – is what makes digesting and extracting nutrients from those meals possible. We hope you’ll tune in.

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Chapters:

(00:00:00) Introduction to Microbiome: A Primer

Host Russ Altman introduces the episode and its focus on the gut biome with guest Professor Michael Fischbach. Russ discusses the importance of bacteria & the influence of diet on maintaining a healthy microbiome, specifically yogurt

(00:04:08) The Role of Bacteria

An explanation of how bacteria are utilized by our body for digestion

(00:06:16) Antibiotics and Gut Microbiome Disruption

The repercussions of antibiotic use on the gut microbiome's composition and its effects on digestion.

(00:07:14) Bacterial Chemicals in the Body

A detailed explanation of how bacteria create chemicals that enter the bloodstream & example of one of these chemicals, of TMAO (trimethylamine N oxide) and its connection to heart disease risk. 

(00:09:48) Vegans and TMAO

Insight into a study involving vegans and their lack of TMAO production due to the absence of specific gut bacteria & its implications.

(00:12:31) Bacteria's Use of Chemicals for Survival

Dr. Fischbach explains how bacteria utilize chemicals in food due to the absence of oxygen in the gut. The concept of electrons and their role in bacterial survival.

(00:14:17) Microbial Communities

Discussion on manipulating microbial communities and the challenges associated with making precise changes. 

(00:15:22) Fecal Transplants and Community Dynamics

Insight into the success of fecal transplants in treating gut infections. Understanding the dynamics of microbial communities and their role in combating infections.

(00:18:30) Building Complex Microbial Communities

Exploring efforts to construct diverse communities and the stability of ecosystems. Early observations on the interactions between various bacterial species in complex communities

(00:21:16) Precision Fecal Transplants

Discussion on the limitations of fecal transplants and the need and potential for precision in microbial composition for treating diseases. 

(00:22:29) Microbiome Diagnostics for Disease Detection

The potential of microbiome analysis as a diagnostic tool for diseases like Crohn's, based on differences in gut community rosters. The debate around whether changes in the microbiome precede or result from diseases, as well as genetic & environmental factors.

(00:25:39) Fermented Foods and Microbiome Impact

Discussion on the potential health benefits of fermented foods and predictions about future interventions involving bacteria 

(00:26:29) Microbiome and Aging Effects

Early research on the impact of aging on the microbiome and the potential for programmed microbiome composition at different life stages.

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Professor Stephen Quake's research has helped countless patients avoid the pain and suffering that can come with invasive diagnostic testing. Russ and Stephen discuss his work to develop a number of noninvasive blood tests to help detect preterm births, genetic disorders like Down Syndrome, cancer, and organ transplant rejection. It’s an episode that reminds us of the power of good science. We hope you’ll take another listen and enjoy.

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Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode featuring Dr. Stephen Quake, highlighting his contributions to non-invasive blood tests. 

(00:00:46) Understanding DNA in Diagnostics

Introduction to the revelation of detecting DNA in the bloodstream, shedding light on various bodily processes.

(00:02:24) The Beginning of Dr. Quake’s work with Cell Free DNA

Dr. Quake tells the story of his journey into research with cell free DNA beginning with searching for a less risky alternative to an amniocentesis

(00:05:11) Impact on Prenatal Testing

The transformation in prenatal diagnostics, replacing invasive tests  & understanding the detection capabilities for prenatal genetic disorders like using cell-free DNA.

(00:06:39) Transplant Rejection Monitoring

The discovery of cell free DNA & it’s use in heart & lung transplant patients detecting early rejection & the real-life implications of this technology.

(00:10:35) Unveiling Infectious Agents

The detection of infectious agents in blood & the real life applications of this discovery

(00:14:52) Advances in Cancer Detection

Discussion shifts to cancer detection using cell-free DNA, emphasizing the important application of monitoring cancer progression and treatment efficacy. 

(00:17:18) Predicting Preterm Birth

Dr. Quake delves into the groundbreaking research predicting preterm births using cell-free RNA and DNA, sharing insights into discoveries indicating preterm birth risks and gestational age predictions and the significance of this.

(00:21:42) The Chan Zuckerberg Biohub's Mission

The origins and bold mission of Steve Quake’s current work at the Chan Zuckerberg Biohub, to cure, treat, or prevent all human diseases by the end of the century and the feasibility of such an ambitious goal. 

(00:24:03) Biohub's Research Strategy

Biohub's strategy focusing on cell biology and infectious diseases internally, while funding nearly a hundred faculty across diverse areas in Bay Area Universities.

(00:26:26) Conclusion 

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Guest Percy Liang is an authority on AI who says that we are undergoing a paradigm shift in AI powered by foundation models, which are general-purpose models trained at immense scale, such as ChatGPT. In this episode of Stanford Engineering’s The Future of Everything podcast, Liang tells host Russ Altman about how foundation models are built, how to evaluate them, and the growing concerns with lack of openness and transparency.

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Chapters:

(00:00:00) Introduction
Host Russ Altman introduces Percy Liang, who runs the Stanford Center on Foundation Models 

(00:02:26) Defining Foundation Models

Percy Liang explains the concept of foundation models and the paradigm shift they represent. 

(00:04:22) How are Foundation Models Built & Trained?

Explanation of the training data sources and the scale of training data: training on trillions of words. Details on the network architecture, parameters, and the objective function.

(00:10:36) Context Length & Predictive Capabilities

Discussion on context length and its role in predictions. Examples illustrating the influence of context length on predictive accuracy. 

(00:12:28) Understanding Hallucination

Percy Liang explains how foundation models “hallucinate”, and the need for both truth and creative tasks which requires “lying”.

 (00:15:19) Alignment and Reinforcement in Training

The role of alignment and reinforcement learning from human feedback in controlling model outputs. 

(00:18:14) Evaluating Foundation Models

The shift from task-specific evaluations to comprehensive model evaluations, Introduction of HELM & the challenges in evaluation these models. 

(00:25:09) Foundation Models Transparency Index

Percy Liang details the Foundation Models Transparency Index, the initial results and reactions by the companies evaluated by it.

(00:29:42) Open vs. Closed AI Models: Benefits & Risks

The spectrum between open and closed AI models , benefits and security impacts

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Guest Alex Konings studies fundamental links between the global cycle of water percolating into the ground and evaporating into the skies and a similar cycle of carbon moving through the world, shaping ecosystems, droughts, and fires. These cycles are inextricably bound, she says, and understanding how they function individually and in tandem is key to life on planet Earth. These important cycles may be easily overlooked but they cannot be ignored, Konings tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

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Chapters:

(00:00:00) Introductions 

Host Russ Altman introduces the episode's focus on plant water with Dr. Alex Konings.

(00:02:37) Understanding Global Carbon and Water Cycles

Dr. Konings defines and explains the global carbon and water cycles and their interconnectedness, and significance

(00:05:08) Transpiration

Detailed explanation of transpiration: the movement of water through plants, from soil to leaves and into the atmosphere. Significance of transpiration in the context of water loss and its impact on available resources.

(00:07:25) Implications of Transpiration

Discussion on how transpiration affects weather, solar energy, weather forecasts & water cycling via transpiration.

(00:10:21) Transpiration and Climate Change

Dr. Konings elaborates on the changing dynamics of transpiration in response to rising atmospheric temperatures &  how plants adapt to increased transpiration, as well as their area of research.

(00:13:48) Using Satellites to measure Plant Water Content

Explanation of how satellites utilize microwaves and radar technology to measure water content in plants & challenges associated with it.

(00:18:37) Impact of Transpiration on Droughts

Dr. Konings elaborates on how increased transpiration in higher temperature intensifies and speeds up the onset of drought conditions.

(00:21:37) Satellite Gravity Measurements for Groundwater Assessment

An explanation of how satellites can be utilized to measure groundwater by measuring the force of gravity. 

(00:22:30) Plant Water Dynamics, Fire Risk & Predictions

Dr. Konings discusses the intricate relationship between plant water dynamics and fire risk, and how satellite-derived plant water data can be utilized in fire risk assessment models.

(00:26:39) Satellite Sources and Public Data Accessibility

Insight into the satellites used for measurements & accessibility of satellite data from federal agencies for research and public use.

(00:27:51) Role in Governmental Agencies and Policy

Dr. Konings elaborates on how her measurements and research is being utilized by government bodies and the potential for it.

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We’re re-running a fascinating conversation Russ had with Zhenan Bao back in 2017 about the work she and her lab are doing to develop artificial skin. The possible applications of a material that could replicate properties of human skin range from restoring a sense of touch for amputees to creating bendable electronics. Thank you for tuning in, we hope you enjoy this episode from the archives.

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Chapters:

(00:00:00) Introduction and Understanding the Significance of Skin

Russ Altman introduces the episode, guest, Dr. Zhenan Bao, and the topic of artificial skin technology. 

(00:02:40) Exploring the Science Behind Artificial Skin

Dr. Bao explains the materials and mechanisms behind artificial skin.

(00:05:51) Practical Applications and Future Possibilities

Potential applications, including foldable cell phones, sensors on prosthetic limbs, paint, and clothing, the opportunities and concerns. 

(00:10:06) Self-Healing Properties of Artificial Skin

Dr. Bao explains the concept of self-healing materials, inspired by biological systems, enabled by shape memory materials.

(00:12:33) Exploring Applications in Energy Sources

Potential applications of flexible materials in solar cells and lithium-ion batteries, & safety concerns  and battery health monitoring using these materials.

(00:15:05) Integrating Multiple Sensory Functions

Russ asks about  the possibility of integrating various sensory functions into a single material, and Dr. Bao explains options for layering using inkjet  and 3d printing.

(00:17:56) Interface Challenges and Communicating with the Human Brain

The conversation delves into the challenges of interfacing electronic materials with the human brain.

(00:19:54) Research Motivation and Collaborative Approach

Dr. Bao shares her journey into her field of research, the collaborators she chooses and her studentès innovations.

(00:22:51) Bendable Cell Phones: A Glimpse into the Future

Insights into the future of smartphones, describing bendable devices that offer a transformative user experience.

(00:25:11) University Research and Transformative Impact

Dr. Zhenan Bao explains the focus of university research, emphasizing the importance of dreaming about the future, training the next generation, and balancing transformative impact with long-term goals.

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Space exploration and travel are two topics that are always exciting, and that have sparked a lot of enthusiasm about the future. Debbie Senesky, a previous guest on the show, researches ways to develop tiny, tough electronics that could help augment our abilities to further explore extreme environments, such as those found in space. Today we’re re-running a conversation Russ had with Debbie in 2017 on this topic.  Enjoy.

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Chapters:

(00:00:00) Introduction

Russ Altman introduces the episode, guest, Dr. Debbie Senesky and electronics for extreme environments.

(00:04:29) Challenges in Space Exploration

Dr. Senesky's insights into the challenges of space exploration, focusing on the need for tiny and tough electronics and introduces wide bandgap semiconductor materials.

(00:07:38) Operation Temperatures of New Materials

Discussion on the operational temperatures of wide band gap semiconductor materials, & contextualization of these temperatures in everyday life.

(00:10:13) Venus and it’s harsh environment

Introduction to Venus, and its unique characteristics as well as the scientific goals and reasons for studying it.

(00:13:10) History of Venus Missions and Exploration

Overview of past Venus missions, including the Venera program by Russia, and the challenges faced in engineering for these missions

(00:16:21) Engineering Challenges in Other Space Exploration

The conversation moves on to some of the other challenges posed by exploring other planets and areas of space including cold temps and power sources.

(00:18:03) Collaboration with Space Agencies

Discussion on collaborations between research labs and space agencies like NASA; Dr. Senesky explains her current area of research and opportunities for testing. 

(00:21:15) The Space Industry Renaissance and Access to Space

Russ & Debbie discuss the current boom of the space industry, the technology and developments, as well as the challenges raised by it.

(00:23:34) Nanoscale Materials and Engineering Challenges

Introduction to nanoscale materials, their production, and  their applications in space technologies. 

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Using math to improve photographs, with expert guest Gordon Wetzstein. Such methods have exploded in recent years and have wide-ranging impacts from improving your family photos, to making self-driving cars safer, to building ever-more-powerful microscopes. Somewhere in between hardware and software, he says, is the field of computational imaging, which makes cameras do some pretty amazing things. Wetzstein and host Russ Altman bring it all into focus on this episode of Stanford Engineering’s The Future of Everything podcast.

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Chapters:

(00:00:00) Introductions 

Host Russ Altman introduces the guest, Gordon Wetzstein as well as the concept of non-line-of-sight imaging.

(00:02:58) Computational Imaging 

Gordon Wetzstein explains the concept of computational imaging and the way it integrates hardware and software for optimal image capture.

(00:04:22) High Dynamic Range (HDR) Imaging  & Focal Stacking

An explanation of what HDR is and how it captures high-contrast scenes, and the similar process of focal stacking, using multiple images to create depth. 

(00:09:56) Non-Line-of-Sight Imaging 

(00:15:51) Optical Computing: Extending Hardware Capabilities 

Insights into optical computing, explaining how specially designed hardware can preprocess data for AI algorithms.

(00:18:08) Applications of Optical Computing 

Exploration of applications for optical computing in power constraint systems and increased efficiency in data centers.

(00:23:07) The Intersection of AI, Physics, and Computer Graphics 

Synergy between AI, physics, and computer graphics in creating 3D content and models. 

(00:25:47) Generative AI to Create 3D from 2D 

Exploring the challenge of generating 3D digital humans from unstructured 2D images using algorithms

(00:32:02) Challenges & Advancements in VR and AR Design 

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Almost everyone knows someone who has battled cancer. Today, on The Future of Everything, we’re re-running our episode with Professor Jennifer Cochran who is bringing some hope in this area through work she and her lab are doing to find ways to localize therapies directly to the site of cancer tumors for more efficient and effective treatment. You won’t want to miss this one, it’s full of inspiring insights that will hopefully move us toward a future of improving outcomes for cancer patients.

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Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode, highlighting the widespread impact of cancer and the need for innovative treatment methods.

(00:00:45) Traditional Cancer Treatments

Overview of conventional cancer treatments: surgery, radiation, and chemotherapy. Challenges and limitations associated with existing treatments.

(00:03:30) New Approaches to Cancer Therapy

Exploration of targeted therapies utilizing biological understanding of cancer cells. 

(00:05:46) Guided Chemotherapy Missiles

Introduction of guest Dr. Jennifer Cochran and her work developing ‘guided chemotherapy missiles’. Dr Cochran explains how they work and the benefits of them.

(00:09:04) Directed Evolution and Designer Proteins

Introduction to the concept of directed evolution, the process of driving evolution in a test tube to create designer proteins with specific properties.

(00:11:16) Utilizing Squirting Cucumber Seed Peptides for Chemotherapy

Dr. Cochran discusses how they transformed a peptide from the seeds of the squirting cucumber into a tumor-targeting agent, the challenges of the process and the current state of the research.

(00:14:56) Immunotherapy and Cancer Treatment

Introduction to immunotherapy and how these therapies work in our body to fight cancers

(00:16:45) Orchestrating Immune Responses: Combining Immunotherapy and Targeted Molecules

Dr. Cochran explains the collaboration between tumor targeting technology and immunotherapy and current developments.

(00:20:08) Making Immunotherapy Accessible: Challenges and Innovations

Dr. Cochran discusses the availability of immunotherapies for cancer patients and the need for broader accessibility.

(00:21:30) Interdisciplinary Collaboration and Technology Application

Exploration of interdisciplinary collaborative research, the challenges and opportunities.

(00:22:59) Translating Lab Discoveries into Treatments

Russ & Jennifer discuss the process and challenges of translating lab research from academia into actual drug development including “ the valley of death”

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Transformational research techniques shaping our understanding of how the brain works.

Guest Karl Deisseroth is a bioengineer and a psychiatrist who has developed two of the most transformational research techniques shaping our understanding of how the brain works — optogenetics, which allows neuroscientists to control brain cells with light, and CLARITY, a way to render the brain’s gray matter transparent yet retain all its intricate wiring for easier study.  There is a vast chasm between neuroscience and psychiatry, Deisseroth says of the reasons he felt compelled to develop technology ahead of pursuing science. It was never a trade-off of one over the other, however. It was simply where we had to go to get better at the science, Deisseroth tells fellow bioengineer and host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Chapters:
(00:00:00)  Introduction to Karl Deisseroth

Russ Altman introduces the episode and Karl Deisseroth, highlighting his roles as a professor of bioengineering and psychiatry. Explanation of Karl Deisseroth's approach to addressing challenges in neuroscience through technology development and application.

(00:03:23) Balancing Technology Development and Scientific Exploration

Discussion on the challenges of balancing technology development with scientific exploration. Karl Deisseroth's perspective on integrating technology development as a primary goal in neuroscience research.

(00:05:03) Optogenetics: Controlling Neurons with Light

Introduction to optogenetics as a method for precise control of individual cells using light. Explanation of the historical challenges in controlling neurons and the need for precise techniques.

(00:07:25) Importance of Bioengineering in Innovation

Highlighting the role of bioengineering in translating scientific ideas into practical tools. Importance of collaboration and interdisciplinary approaches in bioengineering and neuroscience.

(00:10:04) Discovering Microbial Rhodopsins and Opsins

Karl Deisseroth explains the class of proteins known as microbial rhodopsins and their genes, microbial opsins. Discussion on the historical knowledge of these proteins and their presence in biochemistry textbooks.

(00:12:50) Realizing Optogenetics in Human Brains

Karl Deisseroth discusses the practical application of optogenetics in the central nervous system of human beings. An example of a successful experiment by Karl's colleague Botond Roska, enabling a blind person to see objects.

(00:16:01) Bridging Psychiatry and Neurotechnology

Transition to discussing Karl Deisseroth's role as a practicing psychiatrist and the challenges faced in patient care. Integration of clinical experiences into scientific research and its impact on experimental design and understanding disease processes.

(00:16:54) The Intersection of Science and Medicine

Examination of the balance between clinical practice and scientific research in Karl Deisseroth's work. Importance of firsthand patient experiences in shaping research goals and addressing clinical challenges.

(00:20:25) Unraveling Brain Complexity with Optogenetics

Discussion on the complexity of the brain's parts list and challenges in categorizing cell types. Utilizing optogenetic tools to explore specific brain cell types and their functions. The intersection of clinical psychiatry, technology, and neuroscience in advancing our understanding of the brain.

(00:21:00) Integrating Optogenetics into Neuroscience

Exploration of the significance of having a detailed parts list for the brain and its impact on optogenetic research. Integrating optogenetic tools to study diverse brain functions and disorders. The evolving landscape of neuroscience research and the potential applications of optogenetics in the future.

(00:24:53) The Interconnectedness of Brain Cells

Examination of experiments recording from tens of thousands of cells while observing a thirsty mouse's behavior. Insights into the rapid and interconnected nature of the brain, lead to widespread correlations among neurons.

(00:28:05) Writing "Projections": Balancing Science and Literature

Karl Deisseroth's motivation for writing "Projections" was to share the inner worlds of psychiatric patients and communicate scientific advancements. Challenges in balancing literary creativity with scientific accuracy, capturing patients' experiences while staying grounded in truth.

(00:31:02) Receiving Feedback and Impact of "Projections"

Reflection on the reception of "Projections" and feedback received from readers, including patients with psychiatric disorders.Karl Deisseroth's satisfaction in capturing the experiences of patients and the impact of the book on diverse readers.

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