biomedical engineering

What happens to the human body in deep space? Neil deGrasse Tyson, Chuck Nice and Gary O’Reilly explore tissue engineering, Wolverine & Deadpool’s healing style, and the science to help humans adapt to long-term space travel with biomedical engineer Ronke Olabisi.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: 
https://startalkmedia.com/show/engineering-humans-for-deep-space-with-ronke-olabisi/

Thanks to our Patrons Micheal Morey, Kristoff Vidalis, Adir Buskila, Yanir Stein, Randombot38, James Komiensky, Richard Clark, Daniel Helwig, Kayleigh Sell, and KENNY SMART for supporting us this week.

Mark Skylar-Scott is one of the world’s foremost experts on the 3D printing of human tissue, cell by cell. It’s a field better known as bioprinting. But Skylar-Scott hopes to take things to a level most never imagined. He and his collaborators are working to bioprint an entire living, working human heart. We’re printing biology, Skylar-Scott tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

• Skylar-Scott Lab

Connect With Us:

• Episode Transcripts >>> The Future of Everything Website
• Connect with Russ >>> Threads or Twitter/X
• Connect with School of Engineering >>> Twitter/X

Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode, guest Mark Skylar-Scott and his work bioprinting the heart.

(00:02:15) What is Bioprinting & Tissue Engineering?

Explanation of bioprinting and its distinction from traditional 3D printing. Overview of the technology and its applications in tissue engineering and how to get the cells for this purpose.

(00:06:37) Engineering the Cells of the Heart

The 11 different cell types of the heart that are being created, and the steps involved in printing them, scaffolding them, and how they form tissue.

(00:12:23) Building Hearts: Size and Growth Considerations

The scale of bio-printed hearts, potential strategies for growth and integration, & technical challenges in controlling cell growth and development. 

(00:15:05) Scaling Up Cell Production

The importance of scaling up cell production for efficient experimentation. Exploration of the transition from laboratory research to clinical implementation. 

(00:18:40) Vascularization: The Key to Functional Bioprinted Organs

Critical importance of creating a comprehensive vascular network & the challenges of integrating capillaries and ensuring nutrient delivery to all cells. 

(00:23:00) Ethical Considerations in Bioprinting

Examination of the ethical issues surrounding the use of human cells in bioprinting, focusing on consent and the potential for inequality in access due to cost.

(00:26:12) The Future of Bioprinting: Timeline and Field Dynamics

Projections about the timeline for the clinical application of bio-printed organs and the state of collaborative competition within the fabrication field. 

(00:28:28) Conclusion

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads or Twitter/X

Connect with School of Engineering >>> Twitter/X

(0:50) - AI agents help explain other AI systems

(3:13) - Aided by AI, New Catheter Design Prevents Bacterial Infections

This episode was brought to you by Mouser, our favorite place to get electronics parts for any project, whether it be a hobby at home or a prototype for work. Click HERE to learn more about the type of medical devices that can benefit the most from additive manufacturing!

(1:00) - Scientists 3D-print hair follicles in lab-grown skin

(3:55) - Soft robotic, wearable device improves walking for individual with Parkinson's disease

This episode was brought to you by Mouser, our favorite place to get electronics parts for any project, whether it be a hobby at home or a prototype for work. Click HERE to learn more about how exoskeleton are being utilized today to give people superhuman powers!

Guest: Dr. Joseph Dituri, Clinical Researcher, U. S. Navy Saturation Diving Officer (Ret), World Record Holder (Living underwater)

On Linkedin | https://www.linkedin.com/in/joseph-dituri-ph-d-5099789/

On Twitter | https://twitter.com/drdeepsea?lang=en

On Instagram | https://www.instagram.com/drdeepsea/

Website | https://drdeepsea.com/

_____________________________

Host:  Marco Ciappelli, Co-Founder at ITSPmagazine [@ITSPmagazine] and Host of Redefining Society Podcast & Audio Signals Podcast

On ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/marco-ciappelli
_____________________________

This Episode’s Sponsors

Are you interested in sponsoring an ITSPmagazine Channel?
👉 https://www.itspmagazine.com/sponsor-the-itspmagazine-podcast-network

_____________________________

Episode Introduction

Hello, listeners and readers! Welcome back to the Audio Signals Podcast, where we explore the intersection of technology, storytelling, and the human spirit. I'm your host, Marco Ciappelli, and today we embark on an extraordinary journey beneath the waves with our special guest, Dr. Joseph Dituri.

In this episode, "Living Undersea for 100 Days with Dr. Joseph Dituri," we dive deep into a narrative that merges the frontiers of science and the art of storytelling. As you've journeyed with us through our previous episodes, you know we're passionate about not just the stories themselves but the storytellers who bring them to life. Today's story is about pushing boundaries, exploring the unknown, and the profound implications of such endeavors on society and our collective future.

Dr. Dituri, a retired United States Navy diver and special operations officer, shares his incredible experience of living underwater for a full 100 days. This feat isn't just about endurance or adventure; it's a testament to human curiosity and our relentless pursuit of knowledge. After retiring from a distinguished military career, Dr. Dituri turned his focus to biomedical engineering, specifically addressing the challenges of traumatic brain injuries in service members. His undersea mission, however, goes beyond medical research. It's a clarion call to explore our oceans, understand their mysteries, and recognize their critical role in our planet's health.

As we navigate through Dr. Dituri's journey, we uncover the stark contrasts in funding and attention between space exploration and oceanic research. Despite oceans covering 70% of our planet and being vital to our survival, they remain largely unexplored and undervalued. Dr. Dituri's endeavor under the waves is a stark reminder of the untapped potential lying in the depths of our oceans – potential that could hold the keys to solving some of humanity's most pressing challenges.

During his time underwater, Dr. Dituri engaged with over 5,000 students across 15 countries, not just sharing his knowledge but igniting a spark of curiosity and wonder in the next generation. His experiences highlight the importance of storytelling in science, making complex concepts accessible and exciting, and inspiring future explorers and scientists.

Join us in this captivating episode as we unravel the stories of the deep, the significance of undersea exploration, and how Dr. Dituri's journey is shaping the narrative around oceanic research and its critical role in our world. This is more than just a tale of adventure; it's a story about our relationship with the vast, mysterious world beneath the waves and how understanding it better can change our future.

_____________________________

Resources

Mission complete: USF’s Dr. Deep Sea resurfaces after living underwater for 100 days, setting new world record: https://www.usf.edu/news/2023/mission-complete-usfs-dr-deep-sea-resurfaces-after-living-underwater-for-100-days-setting-new-world-record.aspx

Florida scientist resurfaces after living underwater for record 100 days: https://www.pbs.org/newshour/science/florida-scientist-resurfaces-after-living-underwater-for-record-100-days

How (and why) this man plans to live underwater for 100 days:  https://www.npr.org/2023/03/07/1161325332/joseph-dituri-science-dr-deep-sea-underwater-marine

Meet 'Dr. Deep Sea,' the scientist who broke the record for the longest time living underwater: https://www.livescience.com/planet-earth/rivers-oceans/meet-dr-deep-sea-the-scientist-who-broke-the-record-for-the-longest-time-living-underwater

_____________________________

For more podcast stories from Audio Signals: 
https://www.itspmagazine.com/audio-signals

Watch the video version on-demand on YouTube: https://www.youtube.com/playlist?list=PLnYu0psdcllS0aVY7qlwHxX3uiN7tqqsy

Are you interested in sponsoring an ITSPmagazine Channel?
👉 https://www.itspmagazine.com/sponsor-the-itspmagazine-podcast-network

Guest: Dr. Joseph Dituri, Clinical Researcher, U. S. Navy Saturation Diving Officer (Ret), World Record Holder (Living underwater)

On Linkedin | https://www.linkedin.com/in/joseph-dituri-ph-d-5099789/

On Twitter | https://twitter.com/drdeepsea?lang=en

On Instagram | https://www.instagram.com/drdeepsea/

Website | https://drdeepsea.com/

_____________________________

Host:  Marco Ciappelli, Co-Founder at ITSPmagazine [@ITSPmagazine] and Host of Redefining Society Podcast & Audio Signals Podcast

On ITSPmagazine | https://www.itspmagazine.com/itspmagazine-podcast-radio-hosts/marco-ciappelli
_____________________________

This Episode’s Sponsors

Are you interested in sponsoring an ITSPmagazine Channel?
👉 https://www.itspmagazine.com/sponsor-the-itspmagazine-podcast-network

_____________________________

Episode Introduction

Hello, listeners and readers! Welcome back to the Audio Signals Podcast, where we explore the intersection of technology, storytelling, and the human spirit. I'm your host, Marco Ciappelli, and today we embark on an extraordinary journey beneath the waves with our special guest, Dr. Joseph Dituri.

In this episode, "Living Undersea for 100 Days with Dr. Joseph Dituri," we dive deep into a narrative that merges the frontiers of science and the art of storytelling. As you've journeyed with us through our previous episodes, you know we're passionate about not just the stories themselves but the storytellers who bring them to life. Today's story is about pushing boundaries, exploring the unknown, and the profound implications of such endeavors on society and our collective future.

Dr. Dituri, a retired United States Navy diver and special operations officer, shares his incredible experience of living underwater for a full 100 days. This feat isn't just about endurance or adventure; it's a testament to human curiosity and our relentless pursuit of knowledge. After retiring from a distinguished military career, Dr. Dituri turned his focus to biomedical engineering, specifically addressing the challenges of traumatic brain injuries in service members. His undersea mission, however, goes beyond medical research. It's a clarion call to explore our oceans, understand their mysteries, and recognize their critical role in our planet's health.

As we navigate through Dr. Dituri's journey, we uncover the stark contrasts in funding and attention between space exploration and oceanic research. Despite oceans covering 70% of our planet and being vital to our survival, they remain largely unexplored and undervalued. Dr. Dituri's endeavor under the waves is a stark reminder of the untapped potential lying in the depths of our oceans – potential that could hold the keys to solving some of humanity's most pressing challenges.

During his time underwater, Dr. Dituri engaged with over 5,000 students across 15 countries, not just sharing his knowledge but igniting a spark of curiosity and wonder in the next generation. His experiences highlight the importance of storytelling in science, making complex concepts accessible and exciting, and inspiring future explorers and scientists.

Join us in this captivating episode as we unravel the stories of the deep, the significance of undersea exploration, and how Dr. Dituri's journey is shaping the narrative around oceanic research and its critical role in our world. This is more than just a tale of adventure; it's a story about our relationship with the vast, mysterious world beneath the waves and how understanding it better can change our future.

_____________________________

Resources

Mission complete: USF’s Dr. Deep Sea resurfaces after living underwater for 100 days, setting new world record: https://www.usf.edu/news/2023/mission-complete-usfs-dr-deep-sea-resurfaces-after-living-underwater-for-100-days-setting-new-world-record.aspx

Florida scientist resurfaces after living underwater for record 100 days: https://www.pbs.org/newshour/science/florida-scientist-resurfaces-after-living-underwater-for-record-100-days

How (and why) this man plans to live underwater for 100 days:  https://www.npr.org/2023/03/07/1161325332/joseph-dituri-science-dr-deep-sea-underwater-marine

Meet 'Dr. Deep Sea,' the scientist who broke the record for the longest time living underwater: https://www.livescience.com/planet-earth/rivers-oceans/meet-dr-deep-sea-the-scientist-who-broke-the-record-for-the-longest-time-living-underwater

_____________________________

For more podcast stories from Audio Signals: 
https://www.itspmagazine.com/audio-signals

Watch the video version on-demand on YouTube: https://www.youtube.com/playlist?list=PLnYu0psdcllS0aVY7qlwHxX3uiN7tqqsy

Are you interested in sponsoring an ITSPmagazine Channel?
👉 https://www.itspmagazine.com/sponsor-the-itspmagazine-podcast-network

Join us in this episode of Humans of AI as we sit down with Youssef Hosni, a rising star in the AI research community and a prominent figure in both academia and industry.

Dive deep into the world of artificial intelligence with us as we explore three main highlights of this episode:

• The Transition from Academia to Industry: Youssef shares his unique journey from biomedical engineering to the forefront of AI research, revealing key insights for those aspiring to make a similar transition.
• The Importance of Efficient Machine Learning: Youssef discusses the future of AI, emphasizing the need for efficient, less resource-intensive models, particularly in the realm of self-driving cars and other practical applications.
• The Power of Tools like ChatGPT: Discover how Youssef leverages cutting-edge AI tools like ChatGPT in his research and educational endeavors, enhancing productivity and innovation.

Don't miss out on these compelling insights from a leading voice in AI. Tune in, learn, and be inspired! Subscribe now and join the conversation on how AI is shaping our world.

In this episode, I have the distinct pleasure of hosting Dr. Marco Altini, PhD, a luminary in the realm of digital health and wearable technology. An Italian researcher and entrepreneur, Dr. Altini's expertise spans across computer science and biomedical engineering. He's not just an academic; Marco has transformed his knowledge into actionable insights for athletes and health enthusiasts alike. As the co-founder of HRV4Training, he's played a pivotal role in leveraging heart rate variability analysis to optimize training and recovery, bridging the gap between science and real-world applications.

Our conversation dives deep into the advancements in wearable technology and their profound impact on health and fitness monitoring. We explore the innovative mobile app, HRV4Training, and how it empowers users to harness their heart rate variability data to enhance their fitness and overall well-being. Furthermore, we delve into Marco's research related to sleep monitoring and the broader implications of his scientific findings. His insights offer a fascinating perspective on the confluence of technology, physiology, and health.

So, whether you're an athlete, a health enthusiast, or simply someone curious about the future of digital health, this episode promises a wealth of knowledge. Join us as we decode the science behind wearable technology and its transformative potential. Listen in!

Key Points From This Episode:

Timing of stressors is crucial for health and performance [00:00:00]
Understanding stress and body response [00:05:13]
Balance stress and prioritize health [00:11:05]
Understanding stress and its effects [00:17:34]
Balance subjective perception and data [00:27:42]
Wearable device data has limitations [00:29:02]
Baseline physiological stress changes [00:37:58]
Transparency is key for accuracy [00:41:56]
HRV measures stress response [00:51:25]
HRV is a useful tool [00:52:05]
Prioritize sleep, exercise, and nutrition [00:59:37]
Modify stress response for improvement [01:09:21]
Timing of stressors is crucial [01:11:32]
Listen to your body's data [01:17:28]

Links Mentioned in Today’s Episode:

Click HERE to save on BiOptimizers Magnesium

HRV4Training

Oura Ring

Cubitt (10% OFF)

BioStrap

Marco Altini

Marco Altini (LinkedIn)

Marco Altini (Instagram)

Kanazawa University NanoLSI Podcast:Heat and manipulate, one cell at a time 

Transcript of this podcast

Hello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Satoshi Arai at the Kanazawa University NanoLSI.

The research described in this podcast was published in ACS Nano in June 2022

Kanazawa University NanoLSI website

https://nanolsi.kanazawa-u.ac.jp/en/

Heat and manipulate, one cell at a time

Researchers at Kanazawa University report in ACS Nano the development of a nanoparticle that acts as a heater and a thermometer.  Inserting the nanoparticle in living cells results in a heat spot that, by switching it on and off, enables the controlled modulation of local cellular activities.

Being able to heat nano-sized regions in biological tissues is key to several biomedical applications.  Indeed, many biological processes are temperature-sensitive, and the ability to locally modify temperature provides a way to manipulate cellular activity.  A notable purpose is the destruction of cancer cells by heating them.  Beside the need for an in-tissue local heating mechanism, it also important to be able to instantaneously measure the generated temperature.  Satoshi Arai from Kanazawa University and colleagues have now engineered a nanoparticle that is both a nanoheater and a nanothermometer at the same time.  They successfully showed that the insertion of a single, controllable heat spot in tissue can be very effective in modifying cellular function.

The nanoparticle, called “nanoHT” by the scientists — an abbreviation of “nanoheater-thermometer” — is essentially a polymer matrix embedding a dye molecule (called EuDT) used for sensing temperature, and another dye molecule (called V-Nc) for releasing heat.  The latter happens through the conversion of light into thermal energy (the photothermal effect, which is also exploited in solar cells): shining a near-infrared laser (with a wavelength of 808 nanometer) onto V-Nc results in fast heating, with a stronger increase in temperature for higher laser power.

The temperature sensing is based on the thermal fluorescence effect of EuDT.  When irradiated with light of one wavelength, the molecule emits light at another wavelength — that is, it fluoresces.  The higher the temperature, the less intense the fluorescence becomes.  This inverse relationship can be used to measure temperature.  Arai and colleagues tested the performance of nanoHT as a thermometer, and established that it can determine temperatures with a resolution of 0.8 °C and less.

So what could you use this nanoHT for?

The researchers then performed experiments with a type of human cells called HeLa cells.  They looked at the effect of heating through nanoHT, and found that at a temperature increment of about 11.4 °C, the heated HeLa cells died after only a few seconds.  This finding suggests that nanoHT could be used to induce cell death in cancer cells.

Arai and colleagues also studied how nanoHT can be used to affect the behavior of muscles.  They introduced the nanoparticle into a myotube, a type of fiber present in muscle tissue.  Upon heating the myotube by approximately 10.5 °C, the muscle tissue contracted.  The procedure worked reversibly; letting the myotube cool again led to muscle relaxation.

The work of Arai and colleagues shows that local heating at a subcellular scale by means of nanoHT enables the controlled manipulation of a single cell’s activity.  Regarding applications, the scientists believe that – to quote them from their paper -  “the targeted application of nanoHT has a diverse and versatile range of capabilities to regulate cellular activities that w

NanoLSI Podcast website

About 54 million Americans and 936 million patients globally suffer from sleep apnea and 80% of cases go undiagnosed. Today’s guest is fixing that problem.

Chris Fernandez co-founded EnsoData in June 2015 to use AI to make sleep studies more efficient, cost effective, and accurate.

Since then, he and the team have raised more than $30M from an exceptional group of investors including Zetta Venture Partners, M25 Ventures, and Inspire Medical Systems.

Chris received his bachelors and masters degrees from the University of Wisconsin-Madison in Biomedical and Medical Engineering. He also wrote one of the most thoughtful perspectives on the entrepreneurial journey when he handed over the reigns to new CEO Justin Mortara last November. At 8,200 words, it may also be one of the longest.

Listen and learn...

1. What led Chris to care about solving sleep problems
2. How EnsoData overcame being "a solution in search of a problem"
3. How AI and machine learning can be applied to sleep apnea
4. How being incubated by Y Combinator helped launch EnsoData
5. How to use brainwaves to train AI models to diagnose sleep issues
6. When we'll get "smart rooms" that adjust the environment to optimize for healthy sleep
7. How Chris and the team control for the impact of AI bias
8. How to improve the quality of your sleep... from an expert
9. What led Chris to replace himself as CEO

References in this episode...

• Gordon Wilson, Rain Neuromorphics CEO, on AI and the Future of Work
• Why We Sleep by Matt Walker
• Stanford Professor Dr. William Dement and the origins of sleep science

Dr. Ross Uhrich, DMD, MBA, is Program Manager, Advanced Research Projects Agency for Health ( ARPA-H - https://arpa-h.gov/people/ross-uhrich/ ), which is focused on advancing high-potential, high-impact biomedical and health research that cannot be readily accomplished through traditional research or commercial activity, accelerating better health outcomes targeting society's most challenging health problems. Under the ARPA-H portfolio, Dr. Uhrich is responsible for the recently launched Novel Innovations for Tissue Regeneration in Osteoarthritis ( NITRO - https://arpa-h.gov/engage/programs/nitro/ ) program which seeks to develop new ways of helping the human body repair its own joints, with the goal of revolutionizing treatment for osteoarthritis — a common and often very painful condition where bones and cartilage break down. Dr. Uhrich joined ARPA-H in March 2023 from Walter Reed National Military Medical Center (WRNMMC) and the Uniformed Services University of the Health Sciences, where he worked as a board-certified oral and maxillofacial surgeon and assistant professor of surgery. In addition to these roles, he spent 12 years with the U.S. Navy, finishing his tenure as a Lieutenant Commander. Throughout his career, Dr. Uhrich has cared for thousands of members of the U.S. Armed Forces at various healthcare facilities, including the USS Gerald R. Ford , Naval Health Clinic Quantico, and WRNMMC, and served as an oral and maxillofacial surgery consultant to Congress. He also treated patients at Charleston Area Medical Center, R Adams Cowley Shock Trauma Center, and Suburban Hospital. Dr. Uhrich holds a doctorate in dental medicine from the University of Pennsylvania, an MBA from the University of Virginia, and completed his surgical residency at WRNMMC. He also has a Bachelor of Science in Biomedical Engineering from Yale University.