What happens to the human body in deep space? Neil deGrasse Tyson, Chuck Nice and Gary O’Reilly explore tissue engineering, Wolverine & Deadpool’s healing style, and the science to help humans adapt to long-term space travel with biomedical engineer Ronke Olabisi.

NOTE: StarTalk+ Patrons can listen to this entire episode commercial-free here: 
https://startalkmedia.com/show/engineering-humans-for-deep-space-with-ronke-olabisi/

Thanks to our Patrons Micheal Morey, Kristoff Vidalis, Adir Buskila, Yanir Stein, Randombot38, James Komiensky, Richard Clark, Daniel Helwig, Kayleigh Sell, and KENNY SMART for supporting us this week.

Mark Skylar-Scott is one of the world’s foremost experts on the 3D printing of human tissue, cell by cell. It’s a field better known as bioprinting. But Skylar-Scott hopes to take things to a level most never imagined. He and his collaborators are working to bioprint an entire living, working human heart. We’re printing biology, Skylar-Scott tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

• Skylar-Scott Lab

Connect With Us:

• Episode Transcripts >>> The Future of Everything Website
• Connect with Russ >>> Threads or Twitter/X
• Connect with School of Engineering >>> Twitter/X

Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode, guest Mark Skylar-Scott and his work bioprinting the heart.

(00:02:15) What is Bioprinting & Tissue Engineering?

Explanation of bioprinting and its distinction from traditional 3D printing. Overview of the technology and its applications in tissue engineering and how to get the cells for this purpose.

(00:06:37) Engineering the Cells of the Heart

The 11 different cell types of the heart that are being created, and the steps involved in printing them, scaffolding them, and how they form tissue.

(00:12:23) Building Hearts: Size and Growth Considerations

The scale of bio-printed hearts, potential strategies for growth and integration, & technical challenges in controlling cell growth and development. 

(00:15:05) Scaling Up Cell Production

The importance of scaling up cell production for efficient experimentation. Exploration of the transition from laboratory research to clinical implementation. 

(00:18:40) Vascularization: The Key to Functional Bioprinted Organs

Critical importance of creating a comprehensive vascular network & the challenges of integrating capillaries and ensuring nutrient delivery to all cells. 

(00:23:00) Ethical Considerations in Bioprinting

Examination of the ethical issues surrounding the use of human cells in bioprinting, focusing on consent and the potential for inequality in access due to cost.

(00:26:12) The Future of Bioprinting: Timeline and Field Dynamics

Projections about the timeline for the clinical application of bio-printed organs and the state of collaborative competition within the fabrication field. 

(00:28:28) Conclusion

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads or Twitter/X

Connect with School of Engineering >>> Twitter/X

In this podcast episode, MRS Bulletin’s Laura Leay interviews Hamideh Khanbareh and Vlad Jarkov of the University of Bath in the UK about an application they introduced for using piezoelectric materials in tissue engineering. The researchers fabricated a composite by combining polydimethylsiloxane with a piezoelectric material of potassium-sodium-niobate that is compatible with cell lines similar to neurons. They then studied how the composite material would interact with neural stem cells. They found that the piezolectrically activated composites allowed the cells to spread across the surface of the material and saw an increase in the amount of neurons. Usually the use of piezoelectric materials in tissue engineering requires mechanical stimulation from either movement of the body or the application of ultrasound. In this research, no additional mechanical stimulation was required. This work was published in a recent issue of Advanced Engineering Materials. 

(1:00) - Scientists 3D-print hair follicles in lab-grown skin

In this episode we chat with Dr. Aaron Dingle, a visionary in the field of tissue engineering and limb transplantation. From the University of Wisconsin, Aaron unravels the complexities of developing artificial limbs and neuroprosthetics, sharing how advancements in this area can drastically improve the lives of those with lost limbs. Fueled by impactful personal experiences and a fascination with science fiction, Dr. Dingle provides insights into the symbiotic relationship between science fiction fantasies and real-world technological innovations, reflecting on the influence of films like Star Wars on his career trajectory.

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Aaron opens up about his daily grind and long-term goals, highlighting the challenges of translating laboratory successes into clinically viable solutions. The episode is not just about science; it's about persistence, creativity, and the constant quest for knowledge. Peppered with humor and grounded in reality, our discussion offers an inside look at the tireless efforts to mend the human body through the extraordinary potential of regenerative medicine.

Dr. Aaron Dingle has a Ph.D in vascular tissue engineering from the University of Melbourne's O'Brien Institute of Microsurgery in Melbourne Australia. He is currently a Senior Scientist and Co-Director of the Microsurgery and Regenerative Medicine Lab at the University of Wisconsin in Madison, USA.

Donations:
During this episode, a donation was made to Surf Life Saving Australia.
https://slsfoundation.com.au/

Travelling Science is currently my passion project. If you enjoy the podcast and would like to support it in some way, you can make a contribution here: https://www.patreon.com/thetravellingscientist

Links:

Dr. Aaron Dingle’s Laboratory Website
https://www.surgery.wisc.edu/research/researchers-labs/microsurgery-and-regenerative-medicine-lab/

Microsurgery Website
https://microsurgeryeducation.org/

Prosthetic Hand History
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128433/

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3D printing is becoming an incredibly versatile modern tool—there’s scope  in engineering, manufacturing, architecture and design—as well as in several aspects of health care. Today we tour the Herston Biofabrication Institute—part of the Royal Brisbane and Women’s Hospital—where clinicians, academics, and industry work together in a state of the art facility.

3D printing is becoming an incredibly versatile modern tool—there’s scope  in engineering, manufacturing, architecture and design—as well as in several aspects of health care. Today we tour the Herston Biofabrication Institute—part of the Royal Brisbane and Women’s Hospital—where clinicians, academics, and industry work together in a state of the art facility.

(3:00) - 3D printing with bacteria-loaded ink produces bone-like composites

This episode was brought to you by Mouser, our favorite place to get electronics parts for any project, whether it be a hobby at home or a prototype for work. Click HERE to learn about how additive manufacturing is being leveraged in the medical industry from bone replacement to dental guides!

Andrew Ridley, Ph.D., joins Hannah to discuss Cellink's achievement in winning the New Product Award at SLAS Europe 2022. Ridley explains what 3D bioprinting is and how BIO CELLX, the innovative biodispenser from Cellink, is shaping the future of drug discovery and tissue engineering. Also, Ridley shares a glimpse into what Cellink has in store for future products and how Cellink can provide to anyone wanting to use their technology without any tissue engineering experience. 

To learn more about Cellink, visit: https://www.cellink.com/

About Andrew Ridley, Ph.D.:
Ridley is an experienced Product Manager/Sales Director with a Ph.D. focused in Molecular and Cellular Biology and has a history of working in the biotechnology industry. Skilled in molecular/cell biology with a focus on cutting-edge technologies including microfluidics and 3D bioprinting.

Stay connected with SLAS:

• Online at www.slas.org
• Facebook
• Twitter @SLAS_Org
• LinkedIn
• Instagram @slas_org
• YouTube

About SLAS:
SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building.  For more information about SLAS, visit www.slas.org.

SLAS publishes two peer-reviewed and MEDLINE-indexed scientific journals, SLAS Discovery and SLAS Technology. For more information about SLAS and its journals, visit www.slas.org/publications.

Upcoming SLAS Events:
SLAS 2022 Americas Sample Management Symposium

• September 15-16, 2022
• La Jolla, CA, USA

SLAS 2022 AI Data Pipelines for Life Sciences Symposium

• September 26-27, 2022
• Seattle, WA, USA

SLAS 2022 Bio Entrepreneurship Symposium

• 27-28 October 2022
• Brussels, Belgium

Upcoming SLAS Events:

SLAS Building Biology in 3D Symposium

• April 16-17, 2024
• Jupiter, FL, USA

SLAS Europe 2024 Conference and Exhibition

• May 27-29, 2024
• Barcelona, Spain

View the full events calendar

(1:05) - Machine Learning Understands the Human Gut

(15:43) - A  Major Step Forward in Organ Biofabrication

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As always, you can find these and other interesting & impactful engineering articles on Wevolver.com.

To learn more about this show, please visit our shows page. By following the page, you will get automatic updates by email when a new show is published. Be sure to give us a follow and review on Apple podcasts, Spotify, and most of your favorite podcast platforms!

(1:01) - Team Builds First Living Robots - That Can Reproduce

(11:30) - Tissue Engineering Using Mechanobiology And Micromanipulation

In this episode, I had the pleasure to chat with professor Stephanie Willerth at the University of Victoria, also the founder of Axolotl Biosciences.

Stephanie is not only an expert in bioprinting and bioinks in general, but also one of a few scientists in the world focusing on using 3D cell models on common but devastating neurological diseases such as GBM, Parkinson's Disease, and Alzheimer's Disease. We started with some basic concepts related to bioprinting, bioinks, organoids, and organ-on-a-chip, and some of the general current applications and ongoing researches. All of these technologies, however, require sophisticated bioink formulation to achieve structural and functional goals. Also, who are the major players in commercial bioprinting? 

Other versions of this episode: 

Website

Instagram

Axolotl Biosciences

Willerth Lab

Youtube

Past blog by prof. Willerth: 

3D Bioprinting Glioblastoma Models for Drug Screening

3D Bioprinting Personalized Brain Tissues

About Our Guest:

Dr. Willerth holds a Canada Research Chair in Biomedical Engineering at the University of Victoria where she has dual appointments in the Department of Mechanical Engineering and the Division of Medical Sciences as an Associate Professor.

She serves as the Acting Director for the Centre for Biomedical Research at the University of Victoria and on the steering committee of the B.C. Regenerative Medicine Initiative. She also served as the President of the Canadian Biomaterials Society from 2017-2018. Her honors include being named the 2018 REACH award winner for Excellence in Undergraduate Research-inspired Teaching, a Woman of Innovation in 2017, one of the 2015 Young Innovators in Cellular and Biological Engineering, and a “Star in Global Health” by Grand Challenges Canada in 2014. She spent the Fall of 2016 on sabbatical at the Wisconsin Institute for Discovery supported by the International Collaboration on Repair Discoveries International Travel Award where she wrote her book “Engineering neural tissue using stem cells” published by Academic Press.

She completed her postdoctoral work at the University of California-Berkeley after receiving her Ph.D. in Biomedical Engineering from Washington University. Her undergraduate degrees were in Biology and Chemical Engineering from the Massachusetts Institute of Technology.

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

In this live Youtube interview, I had the pleasure of getting to the co-founders (also husband and wife) for 3D Biotechnology Solutions, Ana Millás and Pedro Massaguer. 3DBS is the first Brazilian startup that brought bioprinters to its local research institutions and market, and now it is gearing up to expand its global market including that of the United States. Some of the major talking points of this episode include Ana and Pedro's early journey as biotech cofounders in Brazil, their funding strategies, market product fit, and their strategies in dealing with the local innovation ecosystem and regulatory agencies. We also dig a little deeper on their new hybrid bio fabrication bioprinter that combines electrospinning and extrusion-based bioprinting to generate unique tissue engineering capability for its customers

Follow 3DHEALS:

https://www.instagram.com/3dheals/
https://linktr.ee/3dheals

Follow our guests:

https://www.instagram.com/3dbiotechnologysolutions/

Show Notes: https://3dheals.com/made-in-brazil-interview-with-the-co-founders-of-bioprinting-startup-3d-biotechnology-solutions

More on our Guests:

Ana Millás

As a biologist, Millás holds her PhD and Master’s degree from the Department of Materials Engineering and Bioprocesses at the School of Chemical Engineering of State University of Campinas/UNICAMP. Post-doctoral degree at School of Pharmaceutical Sciences - University of São Paulo. Ana has made part of her research in internationally renowned research centers and institutions, among them, at Cornell University in the United States and Nottingham Trent University and The Electrospinning Company in UK. She has an amazing experience in the amazon forest, also experience in the textile industry. As the R&I Director at 3D Biotechnology Solutions startup, she focused her research on the development of 3D skin in vitro models, vascularized tissues and cartilage reconstruction using the technologies of electrospinning and 3D bioprinting.

Pedro Massaguer

Business Developement, is a specialist in Strategic Business Management. He completed a Master's and Doctorate in the Science and Technology Policy program at the state University of Campinas (UNICAMP). He has experience in innovative technology-based projects, business development, and strategic planning in the area of Biotechnology. He is the CEO of 3D Biotechnology solutions and also partner of In Situ Cell Therapy and Labtermo Microbiology Consultancy.

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

 Dr Yu Shrike Zhang PhD is Assistant Professor at Harvard Medical School and Associate Bioengineer at Brigham and Women's Hospital Dr. Zhang's research interests include symbiotic tissue engineering, 3D bio-printing, organ-on-a-chip technology, biomaterials, regenerative engineering, bioanalysis, nanomedicine, and biology. His scientific contributions have been recognized by over 40 regional, national and international awards. He has been invited to deliver more than 110 lectures worldwide, and has served as reviewer for more than 500 manuscripts for as many as 50 journals. Dr. Zhang is serving as Editor-in-Chief for Microphysiological Systems, and is Associate Editor for Bio-Design and Manufacturing, Nano Select, Aggregate, and Essays in Biochemistry. He is also on the Editorial Board of Biofabrication, Bioprinting, Advanced Healthcare Materials, Discover Materials, BMC Biomedical Engineering, Materials Today Bio, and Chinese Chemical Letters, the Editorial Advisory Board of Heliyon and Biomicrofluidics, the International Advisory Board of Advanced NanoBiomed Research and Advanced Materials Technologies, and the Advisory Panel of Nanotechnology. Dr. Zhang has his PhD in Biomedical Engineering from Georgia Institute of Technology / Emory, his M.S. in Bioengineering and Biomedical Engineering from Washington University in St. Louis, and his B.Eng. in Biomedical Engineering Southeast University in China.