Triangulation (Audio)

In a wide-ranging conversation, Leo Laporte talks with Dr. George Church about the history and future of genome sequencing. Dr. Church explains why he is very excited about how they made an organism resistant to all viruses- both known and unknown.  

They also talk about: 

• How Dr. Church made sequencing affordable (from $3BN to $600)
• Where are we on sequencing the entire human genome, and why would we even want to?
• How close are we to reversing aging?
• Should we use gene therapy to double the human lifespan?
• Why genetically engineering cold-resistant elephants could be important for climate change, and what about ultimately bringing back the Mammoth?
• He explains the difference between the hype and reality of CRISPR
• sequencing, synthesis, and delivery
• What are the privacy concerns about companies sharing your genome?
• They discuss the controversy and benefit of reconstructing old viruses like the 1918 flu and even inventing new viruses.

Dr. Church is a professor of genetics at Harvard Medical School and a pioneer in personal genetics. He is credited with developing the first methods for sequencing the first genome and also the CRISPR technology. He created several companies, including Nebula Genomics and Veritas Genetics.

Host: Leo Laporte

Guest: Dr. George Church

Download or subscribe to this show at https://twit.tv/shows/triangulation.

New York Times bestselling author Daniel Suarez returns to talk with Leo Laporte about the second book in his 'Delta-v' novel series, 'Critical Mass,' where a group of pioneering astropreneurs must overcome never-before-attempted engineering challenges to rescue colleagues stranded at a distant asteroid—kicking off a new space race in which Earth's climate crisis could well hang in the balance. 

Get 'Critical Mass': https://amzn.to/3Yjb9xu

Host: Leo Laporte

Guest: Daniel Suarez

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Writer/activist Cory Doctorow and scholar Rebecca Giblin join Leo Laporte to talk about their latest book Chokepoint Capitalism: How Big Tech and Big Content Captured Creative Labor Markets and How We'll Win Them Back. They argue that we're in a new era of "chokepoint capitalism," with exploitative businesses creating insurmountable barriers to competition that enable them to capture value that should rightfully go to others.

Get "Chokepoint Capitalism": https://chokepointcapitalism.com

Host: Leo Laporte

Guests: Cory Doctorow and Rebecca Giblin

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Tripp Mickle joins Leo Laporte to discuss his new book, "After Steve: How Apple Became a Trillion-Dollar Company and Lost Its Soul". They discuss the shift in Apple's dynamic and approach to products after the passing of Steve Jobs from a company of innovation with Jony Ive, to a company of efficiency under Tim Cook.

Host: Leo Laporte

Guest: Tripp Mickle

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Amy Webb joins Leo Laporte to discuss her new book, "The Genesis Machine." Webb explains synthetic biology, tells the story of golden rice, and shares a glimpse of the future and the changes we can expect.

Get "The Genesis Machine": https://amzn.to/3BC7K2t

Host: Leo Laporte

Guest: Amy Webb

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Leo Laporte interviews Andy Weir, author of "The Martian," about his new book, "Project Hail Mary." The discussion starts out spoiler-free with a chat about making the book into a film, how Andy Weir approached writing this book, and the time he confused Ryan Reynolds and Ryan Gosling. After a loud and apparent spoiler warning (at 32:04), the two continue their chat by discussing "Project Hail Mary" in depth. Weir shares a bit about the science behind the book, the characters he's created, and other stories he's working on.

Project Hail Mary: https://amzn.to/3hLcStp
The Martian: https://amzn.to/3v9LUiU
Artemis: https://amzn.to/3vahYDf

Host: Leo Laporte

Guest: Andy Weir

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Jason Howell is joined by TWiT's studio engineer to talk about his time as the drummer and founder of the progressive rock band Cairo, creating the Virtual Live Show, and how the intersection of music and tech has evolved.

Cairo on YouTube: https://www.youtube.com/JeffBrockmanDirector

Virtual Live Show on Twitter: https://twitter.com/virtualliveshow

Host: Jason Howell

Guest: Jeff Brockman

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Flynn Coleman, writer, and international human rights attorney, joins Denise Howell to talk about her book A Human Algorithm: How Artificial Intelligence Is Redefining Who We Are. Flynn argues that we must instill values, ethics, and morals into our robots, algorithms, and other forms of AI by developing and implement laws, policies, and oversight mechanisms to protect us from tech's insidious threats.

Get "A Human Algorithm": https://amzn.to/2rIqgH6

Host: Denise Howell

Guest: Flynn Coleman

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Stephen Wolfram is a computer scientist who designed Mathematica, Wolfram Alpha, and the Wolfram Language. He talks to Mikah Sargent about translating between human language, mathematics, and programming languages, how computational language works, and how he has spent his life trying to build computational intelligence up.

Host: Mikah Sargent

Guest: Stephen Wolfram

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsors:

• capterra.com/triangulation
• LastPass.com/twit

Margaret O'Mara, Professor of History at the University of Washington, joins Mikah Sargent to talk about her book The Code: Silicon Valley and the Remaking of America. They dive into the behind-the-scenes history of Silicon Valley, including how the Cold War shaped what Stanford University is today, shine a light on some of the unsung heroes like Ann Hardy and David Morgenthaler, and the legacy of Steve Jobs.

Get "The Code": https://amzn.to/32ozIwm

Host: Mikah Sargent

Guest: Margaret O'Mara

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

• LastPass.com/twit

Scott Petry is the CEO of Authentic8. He talks to Leo Laporte about his work on the Newton, how he saved the world from spam, and his plan to make your browser safe.

Host: Leo Laporte

Guest: Scott Petry

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Brett Frischmann is the Charles Widger Endowed University Professor in Law, Business and Economics, Villanova University and joins Denise Howell to discuss his book, co-authored with Evan Selinger, 'Re-Engineering Humanity.' They talk about what's happening to our lives as society embraces big data, predictive analytics, and smart environments.

Host: Denise Howell

Guest: Brett Frischmann

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

• capterra.com/triangulation

Famed writer, comedian, and actor John Hodgman (though not nearly as those two corgis from Instagram) returns to join Mikah Sargent to discuss his latest book Medallion Status: True Stories from Secret Rooms. They examine status, fame, and identity; and dive into how to make the perfect hard-boiled egg, how a nude scene with an oboe relates to vulnerability, and how celebrity has evolved.

Get "Medallion Status": https://amzn.to/36picuc

Host: Mikah Sargent

Guest: John Hodgman

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

• ZipRecruiter.com/triangulation

Yancey Strickler is the co-founder and former CEO of Kickstarter and joins Jason Howell to talk about his new book, This Could Be Our Future: A Manifesto for a More Generous World. They discuss the crowdfunding platform's transition into a public-benefit corporation, leading to Yancey's book, which details a philosophy and framework for building a society that looks beyond "financial maximization" and more towards other values like community, purpose, and sustainability.

Buy "This Could Be Our Future": https://amzn.to/2JlMhkx

Host: Jason Howell

Guest: Yancey Strickler

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

• LastPass.com/twit

Jeri Ellsworth returns to talk with Jason Howell about Tilt Five's holographic tabletop gaming system, what happened with her previous augmented reality startup castAR, and the how the AR/VR space has evolved and where it's going.

Tilt Five on Kickstarter: http://twit.to/tiltfive

Host: Jason Howell

Guest: Jeri Ellsworth

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Ruha Benjamin, Associate Professor of African American Studies at Princeton University, joins Mikah Sargent to talk about her new book 'Race After Technology: Abolitionist Tools for the New Jim Code.' They discuss how emerging technologies can reinforce and amplify racial biases and ways we could solve this problem.

Buy "Race After Technology": https://amzn.to/2Bj8ICE

Host: Mikah Sargent

Guest: Ruha Benjamin

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Mikah Sargent talks with professor Kate O'Neill about her new book, 'Waste' and what we can do about the ever-growing amount of trash each of us produces. They discuss what happens to much of our e-waste and how tech companies could work proactively, including the right-to-repair. One big issue is how China changed recycling world-wide, complicating the recycling industry and what happens next. Some solutions to this problem include finding alternatives to plastic and developing a global solution to our waste problem. Mikah and Kate also coin the term "Garbology."

Buy 'Waste': https://amzn.to/2luYrPt

Host: Mikah Sargent

Guest: Kate O'Neill ("Waste" author)

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

• LastPass.com/twit

Best known for developing the sleep-aid app White Noise, Todd Moore is an app developer, founder and CEO of TMSOFT, and author of Tap, Move, Shake. Todd joins Ant Pruitt to discuss his advice for app devs, the differences in developing for iOS and Android, and working on new platforms like AR/VR and virtual assistants.

Get White Noise: https://www.tmsoft.com/white-noise/

Buy "Tap, Move, Shake": https://amzn.to/2nPfyw4

Host: Ant Pruitt

Guest: Todd Moore

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

• capterra.com/triangulation

Shel Israel is a writer, consultant, and expert on how technology is shaping humanity. He talks with Denise Howell about how the development of Artificial Intelligence is affecting driving, education, and even dentistry. 

Host: Denise Howell

Guest: Shel Israel

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsor:

• ZipRecruiter.com/triangulation

Jono Bacon is the author of 'People Powered: How Communities can Supercharge your Business, Brand, and Teams.' He talks with Leo Laporte about how to grow your community by facilitating safe, constructive feedback.

Host: Leo Laporte

Guest: Jono Bacon

Download or subscribe to this show at https://twit.tv/shows/triangulation.

Sponsors:

• ZipRecruiter.com/triangulation
• capterra.com/triangulation