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    antibiotic

    Explore " antibiotic" with insightful episodes like "#398: Demystifying Mushrooms: Medicinals and Psychedelics with Nick Zemp", "Gut Check: Exploring Viome's Biological Insights to Optimizing Health", "Full Episode - 1677", "What's the impact of antibiotic resistant bacteria?" and "#006 - Journal club - آنتی بیوتیک در پره ترم - علل انسفالوپاتی نوزادی - آنمی بارداری" from podcasts like ""Vitality Radio Podcast with Jared St. Clair", "Living Lucky Podcast with Jason and Jana Banana", "Kelly and Ramya", "Kelly and Ramya" and "انکوباتور"" and more!

    Episodes (30)

    #398: Demystifying Mushrooms: Medicinals and Psychedelics with Nick Zemp

    #398: Demystifying Mushrooms: Medicinals and Psychedelics with Nick Zemp

    When you hear the word mushroom, do you think, food? Medicine? Or a hallucinogenic trip? The truth is, mushrooms can be beneficial as all of these things, but understanding the difference is very important. On this episode of Vitality Radio, Jared interviews Nick Zemp to break down the many benefits and uses of mushrooms. You’ll learn the latest research on psilocybin and psychedelics, as well as medicinal mushrooms including Lion’s Mane, Reishi, and Cordyceps, so that you can decide how to best put mushrooms to use for yourself.


    Nick is a Chinese & Western Herbalist, Aromatherapist, educator, an avid naturalist and gardener, and currently does research evaluating the efficacy of dietary supplements and herbs for Better Being Co/Solaray. He’s been studying, teaching, and practicing herbal medicine for over 20 years. He has a passion for sharing both traditional wisdom and science based approaches to living healthier and happier.


    Jared also shares another Homeopathic Minute from his series of quick, easy to digest information on single homeopathic remedies. Today’s remedy is Apis Mellifica.


    Products:

    Vitality Nutrition Organic Greens and Shrooms

    Pure Essence Lion’s Mane

    Solaray Fermented Reishi

    Solaray Cordyceps


    Additional Information:

    #370: Fermentation 101: What It Is, The Many Benefits of Fermented Foods, and How They Differ From Probiotics!

    ***Emotional Vitality episodes
    ***Be sure to listen to Wednesday’s podcasts this year for Jared’s Homeopathic Minute to learn more about specific remedies.
    #393: What Is Homeopathy and How Does It Work? With Guillaume Lois

    Visit the podcast website here: VitalityRadio.com


    You can follow @vitalityradio and @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!


    Please also join us on the Dearly Discarded Podcast with Jared St. Clair.


    Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

    Gut Check: Exploring Viome's Biological Insights to Optimizing Health

    Gut Check: Exploring Viome's Biological Insights to Optimizing Health

    Join hosts Jason and Jana on a riveting journey into the mysterious yet critical domain of gut health. In this episode, they embark on a transformative adventure exploring the profound impact of gut microorganisms on our genes, hormones, and overall well-being.

    Venturing into the unconventional and eye-opening realm of Viome testing, Jason and Jana share their personal odyssey, unmasking the process of gathering biological samples (yes, including stool samples!) for analysis. Discover how these microscopic entities residing in our digestive system hold the reins to our health, akin to maintaining a finely tuned engine.

    Delving deeper, the duo navigates the repercussions of non-biological substances, focusing on the staggering effects of antibiotics on the delicate balance of our body's bacteria. Through insights gleaned from Viome's investigation into the gut microbiome and oral health, they shed light on the interconnectedness of our bodily systems.

    But it doesn't end there. Jason and Jana lay bare the stark realities of the profit-driven healthcare system, emphasizing the urgent need for widespread awareness and education concerning the food we consume. The podcast unearths the hidden truths behind what fills our grocery store shelves and its profound implications for our health.

    In a world where fortune favors the brave, the episode culminates with a powerful call to action—embracing the ethos of 'living lucky®.' Explore, learn, and be inspired by their insightful conversation, and embark on your journey toward wellness and fulfillment.

    For more inspiring stories, insights, and to explore further, visit StartLivingLucky.com and unlock the secrets to a life of vitality and positivity.

    #LivingLucky #LivingLuckyPodcast #JanaShelfer #JasonShelfer #Viome #ViomeCEO #NaveenJain #HealthOptimization #GeneExpression #GutHealth #ViomeTesting #Microbiome #WellnessInsights #PersonalizedHealth #NutritionalBalance
    Optimizing Well-being, Viome's Secret Formula, Biological Markers, Hormonal Balance, Antibiotic Effects, Oral Microbiome, Non-Biological Substances, Human Biology Insights, Lifestyle Medicine, Precision Health, Mind-Body Connection, Holistic Health Insights, Scientific Wellness, Biome Analysis, Health Awareness, Food Impact on Health


    Thanks for joining us.
    CONNECT with us in our PRIVATE COMMUNITY

    *** The Living Lucky Community is experiencing what it feels like to create a life of inspiration where dreams come true. Check it out HERE *** or at https://www.startlivinglucky.com/sendusyourdreams

    !!! SEND US A MESSAGE: Are you ready to unlock your path to a more inspired life where you're Living Lucky®? Email me directly and let's chart your course toward realizing your dreams and creating a life that fills you with daily inspiration.
    Email Jason Shelfer
    HERE

    The 4 pillars of Living Lucky
    Believe in yourself
    Believe in the people around you
    Believe in your circumstances and
    Believe that God is working through you, for you, and always conspiring in your favor.

    *Previously Recorded

    Full Episode - 1677

    Full Episode - 1677
    On our Ask a Vet segment, Danielle Jongkind talks about antibiotic resistant bacteria and how that impacts vet medicine. Why is gut health important, and how can we improve it? Let's learn more with Frances Wong on our Wellness segment. Director Andrew Kushnir chats with us about “Bad Roads,” a theatre performance enabling us to connect with the people in the Ukraine about the ongoing invasion. There are two Christmas parties being hosted by the CNIB in Nova Scotia. Community reporter, Julie Martin has the festive details. On our Woodworking segment with Jeff Thompson, we talk about mitre saws and dados. We review Women Talking, a 2018 novel by Canadian author Miriam Toews, on our monthly book club.

    #006 - Journal club - آنتی بیوتیک در پره ترم - علل انسفالوپاتی نوزادی - آنمی بارداری

    #006 - Journal club - آنتی بیوتیک در پره ترم - علل انسفالوپاتی نوزادی - آنمی بارداری

     

     

    دوستان عزیز سلام

    به ششمین اپیزود فارسی پادکست انکوباتور خوش آمدید. در این قسمت، ما 3 مقاله جالب و جدید را بررسی میکنیم. درمقاله اول به بررسی پیامد های کم خونی مادر در بارداری در مادر و نوزاد میپردازیم، سپس یک مقاله جنجالی در رابطه با آنتی بیوتیک تراپی در نوزادان پره ترم را مرور میکنیم و در نهایت در مقاله سوم به علت های انسفالوپاتی نوزادی میرسیم. امیدواریم از شنیدن این اپیزود لذت ببرید.

    1- Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study

    2- Early Antibiotic Use and Neonatal Outcomes Among Preterm Infants Without Infections

     3- Characteristics, Genetic Testing, and Diagnoses of Infants with Neonatal Encephalopathy Not Due to Hypoxic Ischemic Encephalopathy: A Cohort Study



    مریم و آیلار

     


     

    بی صبرانه منتظر شنیدن سوالات، نظرات و پیشنهادات شما از طریق آدرس ایمیل هستیم. همچنین شما می توانید از طریق اینستاگرام یا کانال تلگرام ما به آدرس @incubator_farsi ، با ما در ارتباط باشید .
    امیدواریم از این اپیزود لذت ببرید.

    There's a Fungus Among Us

    There's a Fungus Among Us
    This week, we're joined by our friend and yours, Dr. Bill Sullivan, so of course we had to talk about some of the science behind The Last of Us! We're talking about the very real cordyceps fungus, and how one species can create a zombie apocalypse while another changes the economy of the Tibetan plateau. We're also looking at Keanumycin, the bacterial substance that could save us all, without the need for any pesky fireflies. Our Guest: Bill Sullivan is a professor of pharmacology and microbiology at the Indiana University School of Medicine in Indianapolis, where he studies infectious disease and genetics. An award-winning researcher, teacher, and science communicator, Sullivan has been featured in a wide variety of outlets, including CNN, Fox & Friends, National Geographic, Scientific American, COSMOS magazine, Science Fantastic with Dr. Michio Kaku, The Naked Scientists, and The Scientist. Website (https://authorbillsullivan.com/) Twitter (https://twitter.com/wjsullivan?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor) Your Hosts: Steffie Diem (https://twitter.com/SteffiDiem) Jason Organ (https://twitter.com/OrganJM) James Reed (https://twitter.com/James_Reed3) Credits Editing-James Reed Mastering- James Reed Music: Intro and Outro- Wolf Moon by Unicorn Heads | https://unicornheads.com/ | Standard YouTube License Additional Sounds- Inside a Computer Chip by Doug Maxwell |https://www.mediarightproductions.com/ | Standard YouTube License The Science Night Podcast is a member of the Riverpower Podcast Mill (https://riverpower.xyz/) family www.scinight.com

    FAQs: Improving Empiric Antibiotic Regimens for HABP/VABP in the ICU

    FAQs: Improving Empiric Antibiotic Regimens for HABP/VABP in the ICU

    In this episode, Marion Elligsen, BScPhm, MSc, RPh, ACPR; Keith S Kaye, MD, MPH; and Andrew Shorr, MD, MPH, MBA, discuss key considerations for selecting empiric antibiotic regimens in patients with HABP/VABP in the intensive care unit, including: 

    • The role of novel β-lactam/β-lactamase inhibitor combinations
    • Use of clinical predictions scores (eg, Drug Resistance in Pneumonia [DRIP] score) to predict risk for pneumonia caused by multidrug-resistant pathogens
    • Application of rapid diagnostic testing in critically ill patients with pneumonia, including current limitations
    • Implementation of advanced antibiograms and clinical prediction scores
    • Clinical utility of biomarkers for pneumonia (eg, procalcitonin)
    • Application of updated nosocomial pneumonia classifications in clinical practice

    Faculty:
    Marion Elligsen, BScPhm, ​ MSc, RPh, ACPR​
    Practice-Based Researcher
    Sunnybrook Research Institute​
    Antimicrobial Stewardship Pharmacy Lead
    Department of Pharmacy​
    Sunnybrook Health Sciences Centre​
    Toronto, Ontario, Canada​

    Keith S. Kaye, MD, MPH
    Chief  
    Division of Allergy, Immunology and Infectious Diseases
    Professor of Medicine
    Rutgers Robert Wood Johnson Medical School
    New Brunswick, New Jersey

    Andrew Shorr, MD, MPH, MBA​
    Director
    Pulmonary and Critical Care Medicine​
    Medstar Washington Hospital Center​
    Washington, DC​

    Content based on a CME program supported by an educational grant from Merck Sharp & Dohme Corp. 

    Link to full program:
    https://bit.ly/3HaZpYw

    Link to downloadable slideset:
    https://bit.ly/3UxHoqr

    The Microbial Economy and Greenhouse Gas Mitigation

    The Microbial Economy and Greenhouse Gas Mitigation

    Time Stamps

    0:10 What is a microbial economy and how does it mitigate greenhouse gasses?
    1:09 Environmental homeostasis has gone wonkers, giving rise to climate anxiety.
    1:45 Actions that promote healthy microbial communities can restore environmental homeostasis.
    2:00 Primitive microbes diversified over half a million years to produce the first photosynthetic cyanobacteria. Plants came about 2 billion years later.
    4:45 Three points about microbial life on earth.
    6:10 Why aren’t microbes today doing more to mitigate climate change?
    6:58 Our antibiotic mindset is anti-life.
    8:02  Managing agricultural systems without regard to effects on microbial life comes with hidden costs.
    9:12  Carbon economies may soon pay growers to manage land in “climate-smart” ways that promote microbial growth.

    REFERENCES
    Environmental Problems that Affect Homeostasis offers a simple and basic introduction to homeostasis, and suggest how homeostasis might be influenced by environmental factors.
    The Emergence of Environmental Homeostasis in Complex Ecosystems Authors of this study find that "...the stability of this system will typically increase then remain constant with an increase in biological diversity...
    Using microbial community interactions within plant microbiomes to advance an evergreen agricultural revolution.  This book chapter details the importance of microbes in climate change mitigation and food system restoration.

    The Cornerstones of Healthy Food Systems Podcast Introduction by David Lucero.
    Theme music by Zakhar Valaha 

    This version was updated in summer, 2023, when we decided to remove the cornerstones.endofite.com website reference.  The only change was to remove the word cornerstones from the website reference. 

    This podcast is created and produced by End-O-Fite Enterprises LLC.

    The podcast is supported when you purchase our products and services, or when you purchase products from our affiliates. Affiliate links may be found in the show notes and on our virtual marketplace.

    Visit our market to find:

    • virtual course offerings
    • great books on any topic
    • nutritional supplements and more to keep you healthy



    Choke Me With Your CPap Hose Daddy

    Choke Me With Your CPap Hose Daddy

    LIVE FROM OUR HOTEL BED IN AUSTIN TEXAS

    This week we enjoy the sights and sounds of Austin and when we say sights and sounds, we mean it. Everything is bigger in texas but its full of Steers and Queers. Bobby and Jim talk about their issues with the capital city as well as what they like. We talked about meeting some of the amazing people and we are obsessed with the energy they bring. We harassed straight guys per usual and ended up drinking too much (and Bobby having edibles like it was candy). Jim was able to have a rendezvous with a fellow hotel guest, and Bobby tells us about his bout with a bad reaction to an antibiotic. This episode is one of the classics in our catalog, due to all the insane things that seem to happen within an hour of recording. We regret nothing. Oh, and choke me with your CPap hose Dad.

     Follow us on Instagram:
    https://www.instagram.com/shesnotdoingsowell/

    Please share with your friends and make sure you rate and subscribe!

    #gaypodcast #podcast #gay #lgbtq #queerpodcast #lgbt #lgbtpodcast #lgbtqpodcast #gaypodcaster #queer#instagay #podcasts  #podcasting #gaylife  #pride #lesbian #bhfyp #gaycomedy #comedypodcast #comedy #nyc #614 #shesnotdoingsowell #gays #Notwell #Austin #ATX #bears #cpap  #dumbGOP #bed




    Some topics: 

    • Bachelor Parties 
    • Vaping on a Plane 
    • Antibiotics 
    • Shirts and Skins
    • Austin Texas 
    • Hot Straights Ugly Gays 
    • C Diff
    • Cunny 
    • Docotor Play 
    • Radiation Seeds 
    • Doungen 
    • Near Death 
    • Craigslist 
    • Sneaking around 
    • Heartstopper 
    • Pool Party 
    • Straight guys
    • Bowling 
    • Hookups 
    • Where is Bobby's Beer 
    • Bed talk 
    • Emma's U Turns 
    • Sex 
    • Open Relationship 
    • Edibles 
    • Weed
    • Cranes 
    • ATX 
    • CPap Play 
    Support the show

    As always you can write us at nowellpodcast@gmail.com or call us at ‪(614) 721-5336‬ and tell us your Not Wells of the week


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    Help us continue to grow and create amazing content, like a live tour or just help fund some new headphones when needed. Any help is appreacited. https://www.buzzsprout.com/510487/subscribe


    #gaypodcast #podcast #gay #lgbtq #queerpodcast #lgbt #lgbtpodcast #lgbtqpodcast #gaypodcaster #queer#instagay #podcasts #podcasting #gaylife #pride #lesbian #bhfyp #gaycomedy #comedypodcast #comedy #nyc #614 #shesnotdoingsowell #wiltonmanor #notwell

    Infection Prevention in ASCs

    Infection Prevention in ASCs

     ASCA Chief Executive Officer Bill Prentice talks with Cindy Young, administrator of the Surgery Center of Farmington in Farmington, Missouri, and Rebecca Craig, chief executive officer of Harmony Surgery Center in Fort Collins, Colorado, about keeping surgical patients safe from infections. Both Young and Craig are registered nurses, CASC-certified administrators and past ASCA Board members. They currently chair ASCA’s Education and Programs Committee and Quality and Patient Safety Committee, respectively. This highly informative discussion considers sterilization of the surgical room, regulatory inspections, accreditation and the importance of antibiotic therapies in fighting and remedying common infections. 

    SCCM Pod-439 The Association Between Antibiotic Delay and Hospital Mortality

    SCCM Pod-439 The Association Between Antibiotic Delay and Hospital Mortality
    Rapid delivery of antibiotics is a cornerstone of sepsis therapy, although time targets for specific components of antibiotic delivery are unknown. Host Ludwig H. Lin, MD, is joined by Stephanie Parks Taylor, MD, to discuss the significance of time lead for suspected sepsis patients, how to use a generous time window wisely, and new and reconfigured technologies opportunities.

    SuperStructures and the looking glass

    SuperStructures and the looking glass

    You will hear the following terms used during the interview. I've included some descriptions here. 

    • Chirality – Chirality is a feature where an object can be distinguished from a mirror-image version of itself (for instance left and right gloves, or shoes). In chemistry, chirality is often due to the presence of an asymmetrical carbon atom. Chiral isomers are identified as either L-type or D-type, based on how polarized light is rotated when passing through a molecule.
    • Superstructure – In the context of this discussion “When the structures become way, way bigger than the building blocks, you can call the superstructures.” They represent massive polymers of the base construction molecules
    • Nanomaterials / Nanoparticles – A term used to describe substances where the base unit is small – between 1 nm - 100 nm along one or more dimensions
    • Amyloid beta-peptide (also known as Abeta, or Aβ) – Peptides between 36-43 amino acids long that form insoluble amyloid plaques in the brains of people suffering from Alzheimer’s disease. Although the specific role of Amyloid plaques in Alzheimer’s disease is not fully understood, it is widely accepted that they are responsible for the pathology of the disease.
    • Peptide – A short chain of 2-50 amino acids, linked by a peptide bond. A dipeptide has two amino acids in the chain, a tripeptide has three amino acids, and so on.
    • Hydrophobic pockets – When folded into a functional configuration, the amino acids of a protein can be brought into physical proximity. When the majority of amino acids surrounding an ‘opening’ in the surface of the protein are hydrophobic, it creates a region that is unattractive to hydrophilic molecules. As the majority of biological systems are water-based, this hydrophobic region stimulates other hydrophobic regions of suitable molecules to bind. This then typically leads to downstream activation or effect
    • Catalytic triads - a set of three coordinated amino acids that can be found in the active site of some enzymes. Catalytic triads are most commonly found in hydrolase and transferase enzymes.
    • Antimicrobial resistance – This is an evolutionary process where bacteria become immune to the effects of antimicrobial agents (such as antibiotics). Typically this is caused by exposure are designed to kill bacteria. To do this, the bacteria need to be exposed to the agents at sub-lethal levels. As antimicrobial agents accumulate in the environment, it is believed that this provides an opportunity for bacteria to be exposed at sub-lethal levels, which accelerates the rate at which the bacteria develops resistance to the antimicrobial.

    We discussed the drawing of Alice going through the looking glass during our discussion, you can see it at https://www.sciencephoto.com/media/995913/view/through-the-looking-glass-alice-pushes-through-the-mirror.
    Silvia also mentions an article in the journal ACS Nano, you can find that at: https://pubs.acs.org/doi/10.1021/acsnano.0c09386#

    Silvia is contactable on social media, you can find her on 
    LinkedIn https://www.linkedin.com/in/silvia-marchesan-2590712/
    On Twitter, search @MarchesanLab
    The group website is www.marchesanlab.com

     

    Our theme music is "Wholesome" by Kevin MacLeod (https://incompetech.com)
    Music from https://filmmusic.io
    License: CC BY (http://creativecommons.org/licenses/by/4.0/)

     

    Connect with me (Paul) at https://www.linkedin.com/in/paulorange/

    H.E.L. group can be found at www.helgroup.com online,
    on LinkedIn at https://www.linkedin.com/company/hel-group/ 
    on Twitter we're @hel_group, https://twitter.com/hel_group
    or search for us on Facebook

     

    Episode 93 - Tuesday Talks - Gluacoma in Dogs: A Personal "Tail"

    Episode 93 - Tuesday Talks - Gluacoma in Dogs: A Personal "Tail"

    Is your dog acting weird? Are they anxious? Blinking? Red eye? Glowing eye in lights?

    How I almost missed the signs my dog Coco had Glaucoma and what to look for in your pet. While there is no cure, there are ways to slow it down and catch it quickly before it does permanent damage, which includes blindness and or surgery.   Update included on Coco's 2nd vet visit!

    This is part 1 of a 2 part series.

    Invitation to Vets:  If you would like to be a part of the show, please contact me directly in any of the links below.

    Contact Me:
    ROSANAMODPOD@GMAIL.COM

    Buy Me:
    http://www.amazon.com/handmade/rosana-mod-shop

    Buy Me:
    https://www.ebay.com/usr/rosanamod

    Read Me:
    https://hubpages.com/@rosanamodugno

    Follow Me:
    https://www.instagram.com/rosanamod/ 

    If you love my shows, please click the PayPal link below to support it so I can bring you more interesting content!  Thank you!


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    https://paypal.me/RosanaMod?locale.x=en_US

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    Episode 50- Public service announcement: Don't forget to redose your antibiotics!

    Episode 50- Public service announcement: Don't forget to redose your antibiotics!

    In this episode, we discuss a recent article that describes delays in antibiotic redosing in the ER and how that affects mortality rates.

    Click HERE to leave a review of the podcast!

    References:
    All references for Episode 50 are found on my Read by QxMD collection

    Disclaimer: 
    The information contained within the  ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution,  seek medical advice from a licensed physician,  and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of,  any medical institutions, educational facilities, or other healthcare programs.

    Support the show

    Find ER-Rx:

    - On Instagram: @ERRxPodcast
    - On the website: errxpodcast.com
    - On YouTube

    Disclaimer:

    The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.

    A New Era of Antibiotic Discovery with James Martin

    A New Era of Antibiotic Discovery with James Martin

    Bacteria are rapidly evolving ways to resist antibiotics, causing minor infections to become life-threatening events. Compounding the problem, new antibiotics have been incredibly challenging to develop and pharma is economically disincentivized to invest in finding them. James Martin and his colleagues Joseph Sheehan and Benjamin Bratton took on this challenge, developing an extremely potent antibiotic that targets multiple different classes of bacteria. James tells the story of identifying this antibiotic, understanding its potential, and pinpointing how its structure begets its function. Describing the state-of-the art CRISPR screens, proteomics, and machine learning methods they used, James calls for a new era of antibiotic discovery to meet the impending wave of superbugs.

     

    About the Author

    • James Martin performed this work as a graduate student in Professor Zemer Getai’s lab at Princeton University.
    • James’s optimism and drive to understand a problem from all angles led him and his colleagues to develop one of the most potent antibiotics ever found.

    Key Takeaways

    • Our arsenal of antibiotics will soon be worthless, as bacteria evolve ways to get around their killing effects.
    • Adding new antibiotics to this arsenal has been slow because they are challenging to discover and they have poor return on investment.
    • Synergizing a number of new biological tools available like high throughput microscopy, CRISPR, and machine learning, new antibiotics can be developed and understood faster than ever before.
    • Applying this fresh take on antibiotic discovery, a novel drug is found that targets a wide-variety of bacteria and is difficult to evolve resistance to.

    Translation

    • Moving this extremely potent compound to the clinic will require some smart biochemistry to make it a better drug.
    • The research of James and his colleagues demonstrates a paradigm shift in how antibiotic discovery pipelines are performed to more easily and rapidly find these new drugs.

    First Authors: James Martin, Benjamin Bratton, Joseph Sheehan

    Paper: A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance

    Follow Fifty Years on Twitter!

    If you’re an author of an upcoming paper in bio or know of any interesting papers dropping soon and want to hear from the authors, drop us an email at translation [AT] fifty [DOT] vc.

    Episode 22- One-time IV antibiotics prior to discharge

    Episode 22- One-time IV antibiotics prior to discharge

    Is giving your patient a one-time dose of IV antibiotics prior to discharge helpful? Or are you doing more harm than good? Tune in this week to find out!

    References:

    Mueller K, McCammon C, Skrupky L, Fuller BM. Vancomycin use in patients discharged from the emergency department: a retrospective observational cohort study. J Emerg Med. 2015; 49 (1): 50-57 

    Disclaimer: 
    The information contained within the  ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution,  seek medical advice from a licensed physician,  and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of,  any medical institutions, educational facilities, or other healthcare programs.

    Support the show

    Find ER-Rx:

    - On Instagram: @ERRxPodcast
    - On the website: errxpodcast.com
    - On YouTube

    Disclaimer:

    The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.

    Episode 17- The Emergency Medical Minute meets ER-Rx

    Episode 17- The Emergency Medical Minute meets ER-Rx

    In case you missed it, last week Dr. Nick Tsipis from the Emergency Medical Minute discussed a few rapid-fire ER topics with our host, Adis Keric. Check out the full episode here or on the Emergency Medical Minute podcast!

    *Correction to figures quoted on anticoagulation reversal pricing. High-dose Andexxa regimen maxes out around $60,000 and Kcentra maxes out at $6,000. So there is still a massive price difference, but not as high as quoted in the audio.

    References:

    Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia. J Respir Crit Care Med. 2019; 200 (7): e45-67

    Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013 ;41(1): 263-306

    Connolly SJ, Milling Jr., Eikelboom JW, et al. Andexanet alfa for acute major bleeding associated with Factor Xa inhibitors. N Engl J Med. 2016; 375:1131-41

    Disclaimer: 
    The information contained within the  ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution,  seek medical advice from a licensed physician,  and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of,  any medical institutions, educational facilities, or other healthcare programs.

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    Disclaimer:

    The information contained within the ER-Rx podcast episodes, errxpodcast.com, and the @errxpodcast Instagram page is for informational/ educational purposes only, is not meant to replace professional medical judgement, and does not constitute a provider-patient relationship between you and the authors. Information contained herein may be accidentally inaccurate, incomplete, or outdated, and users are to use caution, seek medical advice from a licensed physician, and consult available resources prior to any medical decision making. The contributors of the ER-Rx podcast are not affiliated with, nor do they speak on behalf of, any medical institutions, educational facilities, or other healthcare programs.

    End of Shift Podcast: Sepsis in the ED

    End of Shift Podcast: Sepsis in the ED

    In this episode, Eric and Joe do a deep dive on sepsis with Dr. Rob Stenstrom, Sepsis and Infections Lead for the EM Network. They discuss the most practical definition of sepsis in the ED and which diagnostic score to use. They find the bottom line on serum lactate, fluid treatment, and blood cultures and antibiotic timing. Rob answers questions on which pressor to use, central access timing, and the status of novel therapies. Plus, is there a genetic predisposition to developing sepsis?

    Sepsis Stats

    • 1 in 18 deaths in Canada involve Sepsis
    • 30% of Canadians hospitalized with sepsis die within 1 month.

    Related links

    End of Shift Hosts

    Eric Angus
    Eric Angus is an emergency physician and trauma team leader at Lions Gate Hospital. He is married with 15-year-old twins. His nonmedical interests include origami, meditation, mountain biking, skiing, rock climbing, just generally being outside, and drinking wine. He has a diploma in mountain medicine and volunteers for ski patrol and the North Shore Rescue team. He is an ATLS instructor. He dabbles in stoicism and Buddhist philosophies.

    Joe Haegert
    Joe Haegert practices emergency and trauma medicine at the Royal Columbian Hospital in New Westminster, British Columbia. He is a talented teacher, engaging speaker, and devoted clinician. He lives in South Surrey with his wife Sandy and managed to raise three children without much incident. Known for his unflagging enthusiasm, Joe enjoys all aspects of the outdoors and recently has taken to turning wooden burls into all manner of bowls and tables.

    Disclaimer
    The discussion within the End of Shift podcast may be graphic, and some listeners may find the language and content disturbing. The views and opinions expressed in this podcast are those of the participants and do not necessarily reflect the official policy or position of the BC Emergency Medicine Network.

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