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    bci

    Explore " bci" with insightful episodes like "OWITH.ai: Cutting Through the Noise in AI and Tech", "The Rise of Brain Computer Interfaces (BCI) that Can Compete with Rogue Super-AIs, w/ Trent McConaghy", "Brain-Computer Interfaces | Jaimie Henderson", "The Brain Implant That Sidesteps The Competition" and "The Fine Art of Mutt Boa Selective Breeding" from podcasts like ""OWITH.ai - Only What's Important to Hear around AI and Tech", "AI-Curious with Jeff Wilser", "From Our Neurons to Yours", "Fixing the Future" and "Holdback Rack Podcast"" and more!

    Episodes (46)

    OWITH.ai: Cutting Through the Noise in AI and Tech

    OWITH.ai: Cutting Through the Noise in AI and Tech
    Good morning from OWITH.ai: the podcast that gives you only what's important to hear in AI and tech world.The author disagrees with the claim made on the All-In podcast that Sora has "learned physics on its own." They argue that Sora is not a reliable guide to how the world works, but rather a semi-reliable guide to how the world looks. The author points out that Sora's physics engine lacks object permanence and does not accurately model physical entities or obey the laws of physics. The videos created by Sora often depict unrealistic scenarios such as objects passing through each other or changing size spontaneously, due to its focus on image prediction rather than physics. The author acknowledges Sora's impressive video synthesis capabilities but believes claims about its ability to model the world are confused and inaccurate..Transitioning to the discussion of the emerging neurotech industry focusing on brain-computer interfaces (BCIs) that enable direct communication between the brain and external devices. It mentions two types of BCIs - invasive and non-invasive, with companies like Neuralink, Kernel, and Synchron leading the field. The potential of BCIs to revolutionize human-computer interactions is highlighted, with examples of recent advancements such as Neuralink receiving FDA approval for human trials. Other key players in the industry include Blackrock Neurotech, Synchron, Kernel, OpenBCI, and Precision Neuroscience. Despite the promising applications of BCIs in healthcare and technology, challenges related to safety, security, and accessibility remain to be addressed before widespread adoption. The text emphasizes the need for continued research and development efforts to ensure the efficacy and ethical implications of BCIs as they move towards mainstream acceptance..Shifting gears, Elon Musk has filed a lawsuit against OpenAI and Sam Altman, citing breaches of contract and fiduciary duty. Musk is concerned about OpenAI's shift from a non-profit, open-source AI lab to a for-profit, closed-source company, particularly after the alleged achievement of AGI with the GPT-4 algorithm. The lawsuit aims to force OpenAI to return to its original non-profit status and address concerns about unfair business practices. Musk's motivations appear to be driven by concerns about AI safety, threats to his other ventures like Tesla, and personal issues related to Altman's actions. The lawsuit highlights the potential risks associated with non-profits transitioning to for-profit models in the tech industry. The outcome of the lawsuit could have significant implications for OpenAI's future direction and partnerships..Moving on to discuss the challenges faced by creators in the current creator economy, with a decline in lucrative deals from big brands and an increase in pitches from low-rent merchants. Creators are feeling frustrated with the influx of requests to create advertorial videos for TikTok's e-commerce initiative, Shop, which is not as profitable as traditional brand deals. Despite this, some creators are optimistic that quality content creation will lead to a rebound in brand partnerships. The text also touches on other tech news, including Elon Musk suing OpenAI, Facebook discontinuing its news tab, WhatsApp winning a legal battle against spyware vendor NSO Group, and Google removing apps from its Play Store in India for non-compliance with billing policies...In a recent development, Elon Musk has filed a lawsuit against OpenAI, alleging that the organization has strayed from its original non-profit mission and is now operating as a closed-source subsidiary of Microsoft. Musk is not seeking monetary compensation but rather wants OpenAI to return to its original mission of benefitting humanity. The lawsui

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    The Rise of Brain Computer Interfaces (BCI) that Can Compete with Rogue Super-AIs, w/ Trent McConaghy

    The Rise of Brain Computer Interfaces (BCI) that Can Compete with Rogue Super-AIs, w/ Trent McConaghy

    If AI gets super intelligent and super powerful, will it be benevolent? Or will it want to crush us like ants?

    Perhaps they’ll be benevolent. Maybe they’ll be “aligned” with our interests. But if not? What should we do? How can we prepare for this nightmarish scenario?

    Trent McConaghy has a plan. McConaghy has been working in AI for decades, both as an entrepreneur and as a researcher, and he’s widely respected in the field. 

    And he recently gave a speech to the “existential-risk” (x-risk) group at NASA about how, to prepare humanity for this all-powerful AI…We need to become more than humans. Specifically, we need to embrace the idea of Brain-Computer Interface, or BCI. 

    BCI, says McConaghy, can even help unshackle us from the constraints of being a flesh-and-blood human. In a literal mind-meld with computers, we could be 1,000 times smarter and live longer. 

    This sounds like deep sci-fi, but McConaghy lucidly breaks down the vision in a way that’s step by step, easy to understand, and almost feels…plausible?

    Whether you agree with the theory or not, McConaghy’s thoughts are FASCINATING and he makes for a wildly engaging conversation about the future of AI. I’m confident that anyone even remotely interested in AI — or sci-fi — will find his thought experiments intriguing. 

    Among many other sweeping and futuristic topics, we cover:

    Why economic incentives make AGI (or “ASI,” for Artificial Super Intelligence) is perhaps more likely than we think (13:50); Why we might soon be like an anthill compared to god-like entities of Artificial Smart Intelligence (23:00); whether these all-powerful ASIs will protect human rights (26:00); why we need a “more competitive substrate” that helps us be more than human and hyper-boost our intelligence (29:00); how creating powerful Brain-Computer-Interfaces is more grounded and less sci-fi-ish than you might think (35:00); how we will some day —maybe soon — be able to just think of videos and use telepathy to send to friends (45:00); why the human “bio-stack” won’t be enough and we’ll need a synthetic solution (53:00); the dangers of “bike shedding” the risks of ASI (59:30); how BCI could plausibly go mainstream (61:30); why when we’re 94 years old we might switch from our “bio-stack brain” and migrate to our “silicon-stack” side (65:00). 

    So join us on a futuristic and fascinating journey….

    McConaghy’s presentation to the existential-risk group at NASA:
    https://drive.google.com/file/d/1tLK1sBCMNuJTNX8Pi99iDmLzFiIsUOk5/view

    McConaghy’s Medium article that breaks down the BCI theory:
    https://medium.com/@trentmc0/bci-acc-a-path-to-balance-ai-superintelligence-80bb6f32e39c

    McConaghy on Twitter/X:
    https://twitter.com/trentmc0

    Ocean Protocol, the blockchain-powered AI ecosystem that McConaghy founded:
    https://oceanprotocol.com

    My article about AI and blockchain where I first interviewed McConaghy, and he shares a part of this theory (which got me fascinated in the first place):
    https://www.coindesk.com/consensus-magazine/2023/09/21/is-crypto-ai-really-a-match-made-in-heaven/

    And finally Jeff Wilser (me) on Twitter/X:
    https://twitter.com/jeffwilser

    Brain-Computer Interfaces | Jaimie Henderson

    Brain-Computer Interfaces | Jaimie Henderson

    Imagine being trapped in your own body, unable to move or communicate effectively. This may seem like a nightmare, but it is a reality for many people living with brain or spinal cord injuries.

    Join us as we talk with Jaimie Henderson, a Stanford neurosurgeon leading groundbreaking research in brain-machine interfaces. Henderson shares how multiple types of brain implants are currently being developed to treat neurological disorders and restore communication for those who have lost the ability to speak. 

    We also discuss the legacy of the late Krishna Shenoy and his transformative work in this field.

    Learn more
    Henderson's Neural Prosthetics Translational Lab

    BrainGate Consortium – "Turning thought into action"

    Commentary on Neuralink's brain-interfacing technology by Wu Tsai Neurosciences Institute Faculty Scholar Paul Nuyujukian (WIRED, 2023; NBC Bay Area, 2024)

    Brain Implants Helped 5 People Recover From Traumatic Injuries (New York Times, 2023)

    Brain to text technology is about more than Musk (Washington Post, 2023)

    The man who controls computers with his mind (New York Times Magazine, 2022)

    Software turns ‘mental handwriting’ into on-screen words, sentences (Stanford Medicine, 2021)


    Learn about the work of the late Krishna Shenoy

    Krishna V. Shenoy (1968–2023) (Nature Neuroscience, 2023)

    Krishna Shenoy, engineer who reimagined how the brain makes the body move, dies at 54 (Stanford Engineering, 2023)

    Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

    Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.

    The Brain Implant That Sidesteps The Competition

    The Brain Implant That Sidesteps The Competition

    We've all seen impressive demos of prototype brain implants being used by paralyzed patients to interface with computers, but none of those implants have entered general clinical use. Biomedical device company Synchron is close to actually coming to market with its stentrode technology, promising less spectacular results than some of its competitors, but making up for that with ease of use and implant longevity. Synchron's co-founder Tom Oxley talks with IEEE Spectrum senior editor Eliza Strickland about the new tech, and you can read more in our January issue article by Emily Waltz.

    The Fine Art of Mutt Boa Selective Breeding

    The Fine Art of Mutt Boa Selective Breeding

    Out World Reptiles https://outworldreptiles.com/ 
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    Jessica Hare - Hare Hollow Farm - Altus, OK

    Harehollowfarm.com

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    Roger and Lori Gray - Gray Family Snakes - Huntsville, Alabama

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    Eileen Jarp - Bravo Zulu - Daleville, IN

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    Christopher Shelly - B&S Reptilia - Sellersville, PA

    Morph Market - https://www.morphmarket.com/stores/bandsreptilia/

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    Justin Brill - Stoneage Ball pythons - Gresham, OR

    Morph Market -https://www.morphmarket.com/stores/stoneageballpythons/?cat=bps

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    BCI, EEG... czyli wszystko, co chcieliście wiedzieć o interfejsach mózg-komputer - prof. dr hab. Piotr Durka

    BCI, EEG... czyli wszystko, co chcieliście wiedzieć o interfejsach mózg-komputer - prof. dr hab. Piotr Durka
    Brain-Computer Interface (BCI) to system, który pozwala sterować komputerem bez użycia mięśni. BrainTech tworzy BCI oparte na elektroencefalogramie (EEG) - elektrycznym śladzie myśli rejestrowanym z powierzchni głowy. BCI interpretuje świadome intencje użytkownika z zarejestrowanych śladów i przekształca je na komendy sterujące komputerem. Jak działa interfejs mózg-komputer, czym jest elektroniczny ślad myśli i jakie są fakty i mity dotyczące odczytywania myśli i przenoszenia mózgu do cyberprzestrzeni opowiada prof. Piotr Durka, naukowiec specjalizujący się w fizyce biomedycznej, założyciel firmy BrainTech i twórca systemu PISAK. Wszystkie spotkania odbyły się w ramach konferencji “Dni Mózgu 2023”, organizowanej przez Koło Naukowe NeuroPsyche Uniwersytetu SWPS w ramach Światowego Tygodnia Mózgu. Strefa Psyche Uniwersytetu SWPS to projekt popularyzujący wiedzę psychologiczną na najwyższym merytorycznym poziomie oraz odkrywający możliwości działania, jakie daje psychologia w różnych sferach życia zarówno prywatnego, jak i zawodowego. Projekt obejmuje działania online, których celem jest umożliwienie rozwoju każdemu, kto ma taką potrzebę lub ochotę, niezależnie od miejsca, w którym się znajduje. Więcej o projekcie: https://web.swps.pl/strefa-psyche

    Your Future Self Will Thank You | Connectomics Part II

    Your Future Self Will Thank You | Connectomics Part II


    We’re back with Part II of our two-part series on Connectomics! 

    In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome. 

    Our guests are: 

    • Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC)
    • Robert McIntyre, CEO at Nectome
    • Jeremy Maitin-Shepard, PhD, Software Engineer–Connectomics at Google

    In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv, as well as his published work at Google. 


    If you missed part one, you can listen and explore the show notes here. Cheers!


    Show Notes: 


    0:00 | Intro

    1:03 | Kenneth Hayworth, PhD

    1:12 | Robert McKintyre, CEO, Nectome

    1:17 | Jeremy Maitin-Shepard, PhD


    1:51 | Setting the record straight 

    3:09 | The nucleotide sequence of bacteriophage φX174

    4:22 | Frozen Zoo at San Diego Zoo

    12:01| Glutaraldehyde and reduction techniques for immunolabeling 

    17:39 | SWITCH Framework

    19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude 

    Enhanced mirror neuron network activity and effective connectivity during live interaction among female subjects 

    Permeabilization-free en bloc immunohistochemistry for correlative microscopy 

    19:57 | Synaptic Signaling in Learning and Memory 

    Structure and function of a neocortical synapse 

    Engineering a memory with LTD and LTP 

    Synapse-specific representation of the identity of overlapping memory engrams 

    20:28 | Ultrastructure of Dendritic Spines

    Structure–stability–function relationships of dendritic spines 


    24:25 | Reconstructing the connectome 

    24:32 | Connectomics Research Team at Google 

    24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome 

    28:38 | Serial Block-Face Scanning Electron Microscopy 

    29:22 | Automated Serial Sections to Tape

    29:45 | Mapping connections in mouse neocortex

    30:59 | A connectome and analysis of the adult Drosophila central brain 

    32:14 | Expansion Microscopy


    34:37 | The future of connectomics 

    45:13 | Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons

    49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task 


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    We're in Heated Agreement Over Here | Connectomics Part I

    We're in Heated Agreement Over Here | Connectomics Part I

    Welcome back to Neurotech Pub! 


    In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries. 


    Our guests are: 


    • Nita Faraheny, JD, PhD, Everett Distinguished Professor of Law & Philosophy at Duke Law School, the Founding Director of Duke Science & Society, the Faculty Chair of the Duke MA in Bioethics & Science Policy, and principal investigator of SLAP Lab. 
    • Kenneth Hayworth, PhD, President and Co-Founder of the Brain Preservation Foundation, Senior Scientist at the Howard Hughes Medical Institute’s Janelia Farm Research Campus (JFRC)
    • Robert McIntyre, CEO at Nectome


    As an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon.


    Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon!


    Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting.


    Show Notes: 


    0:00 | Episode Intro 

    1:16 | Nita A. Farahany, JD, PhD

    1:21 | Kenneth Hayworth, PhD

    1:27 | Robert McKintyre, CEO, Nectome


    1:56 | Meeting of the minds 

    2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize

    3:56 | The Brain Preservation Foundation

    4:09 | Documentary series on the Brain Preservation Foundation

    5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats)

    5:51 | Nita's 2018 Neuroethics Ted Talk 

    5:54 | International Neuroethics Society


    6:25 | Connectomics & new paths in neuroscience 

    8:10 | Allen Institute for Brain Science

    8:47 | A connectome and analysis of the adult Drosophila central brain

    9:33 | A visual intro to synaptic imaging in connectomics

    10:28 | The structure of the nervous system of the nematode Caenorhabditis elegans 

    11:16 | Mouse Connectome Project at CIC

    14:59 | Cryonics controversy 


    19:00 | Death, taxes, and synapses 

    20:51 | Uniform Law Commission

    21:08 | The Uniform Determination of Death Act

    24:25 | Watch Altered Carbon on Netflix

    25:49 | Understanding the “Loss of Chance” Doctrine 

    37:13 | Understanding Physician-Assisted Death, or ‘Death with Dignity’ 

    40:21 | Euthanasia in the Netherlands

    46:01 | Autonomy, Dignity, and Consent to Harm, Rutgers Law Review 



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    What do the tech layoffs really tell us?

    What do the tech layoffs really tell us?

    Naturally, tech layoffs are top-of-mind for many of us. Despite comparisons to the dot-com bubble, what we’re seeing right now is different. Here’s what the tech and media layoffs really tell us about the economy.

    In praise of analog technology: why Millennials and Gen Z are springing for paper maps.

    Make Time, a way of “rethinking the defaults of constant busyness and distraction so you can focus on what matters every day,” was developed in response to always-on Silicon Valley culture.

    Wifi routers can now be used to detect the physical positions of humans and map their bodies in 3D. Terrifyingly dystopian or interestingly practical? Why not both?

    In recent accessibility news, a brain-computer interface (BCI) that converts speech-related neural activity into text allows a person with paralysis due to amyotrophic lateral sclerosis (ALS) to communicate at 62 words per minute, nearly 3.5 times faster than before. From the abstract: “These results show a feasible path forward for using intracortical speech BCIs to restore rapid communication to people with paralysis who can no longer speak.” 

    Shoutout to Lifeboat badge winner Holger for their answer to Sort an array containing numbers using a 'for' loop.

    Locked-In - Wie vollständig Gelähmte kommunizieren können

    Locked-In - Wie vollständig Gelähmte kommunizieren können
    Preisverdächtige Folge?! Beworben für den Fast Forward Science 2022/23 Award: www.fastforwardscience.de #FFSci #audiospezial Es gibt Menschen, die aufgrund einer seltenen Krankheit am ganzen Körper gelähmt sind - aber bei vollem Bewusstsein. Locked-In nennt sich dieser Zustand. Sie sind eingeschlossen in ihrem Körper, ohne Möglichkeit, mit der Außenwelt in Kontakt zu treten. Hirnforscher Niels Birbaumer versucht über 30 Jahre, für diese Menschen einen Ausweg zu finden - mit teils umstrittenen Methoden. Von Hannah Rau.

    Neuro Mapping & Napping

    Neuro Mapping & Napping

    Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity. 

    Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine.

    This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode.

    Cheers!

    Show Notes: 

    00:00 | Episode intro with Matt Angle and Amy Kruse

    1:07 | StimScience in Fast Company

    5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep

    6:43 | Connect with Prime Movers Lab

    7:01 | PML on Medium


    7:45 | Introduction to Sleep Stages

    References: 

    Stages of Sleep Overview 

    REM vs Non-REM Sleep

    Sleep Walking

    Benefits of REM Sleep

    Consequences of low REM sleep

    Importance of Deep Sleep

    Check out Zoe’s nonprofit organization, ALS Heroes, and her Ted Talk


    12:24 | Pulling all-nighters

    12:50 | Amy Kruse, PhD

    13:00 | Ram Gurumoorthy, PhD

    13:07 | Stimscience, now Somnee

    13:30 | Luis de Lecea, PhD

    18:26 | Gordon Rule, PhD

    18:40 | Knights of the Old Republic II: The Sith Lords (2004)


    19:50 | Why do we sleep?

    20:26 | Sleep drives metabolite clearance from the adult brain

    20:35 | Sleep & DNA Repair

    22:13 | Neural Activity can cause DNA damage

    23:22 | Jerry Seigal

    24:26 | DARPA Sleep Research

    24:55 | Fur seals and sleep

    25:08 | How do Whales and Dolphins Sleep Without Drowning?

    25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars

    27:36 | Sleep and Mortality

    28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices

    28:27 | Giulio Tononi, MD, PhD

    28:45 | Sleep, Memory, and Plasticity

    28:52 | Sleep Cognition and Memory


    29:00 | Sleeping up and down the phylogenetic tree

    29:05 | Actually...worms do sleep

    29:20 | Decoding sleep

    29:36 | Fruit flies and their mini sleeps


    29:44 | Mapping sleep in the brain

    30:35 | Hypocretin-positive neurons

    31:17 | Clearly Matt slept through his midterm... again

    31:57 | The hypocretins/orexins: integrators of multiple physiological functions

    32:05 | Stress-sleep interactions

    33:30 | The Science of Narcolepsy

    35:08 | Equivalence of sleep deprivation and intoxication | Additional reference

    36:21 | Sleep Pressure: Homeostatic Sleep Drive 

    40:38 | EEG Visualization of electrodermal activity during sleep


    44:08 | Circuitry of Sleep Stages

    45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats


    48:00 | Emerging Sleep Technologies

    1:00:56 | Hypothalamus and Sleep


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    05. The Signals Are Talking

    05. The Signals Are Talking

    “What about the future are you trying to determine? Is it a specific kind of technology? A cultural behavioral pattern? A system of running companies? A way of feeding people? Language evolution? Where in society today are people asking the hard questions or making some new discoveries?”

    In high school, I would spend every week reading Omni magazine in the school library. Today I often read Science Daily. Both of these sources of information play huge inspirations into the questions I ask about the future. 

    In this episode I talk about Amy Webb’s book (that shares the same name as the title of this episode) and delve into her six-step methodology, offering my viewpoint for each step. I use my own Janey McCallister sci-fi mystery novels as an example and some of the decision making process for that series. 

     

    In this episode, you will learn the following:

    1) Where do you look for inspiration in writing the future?

    2) What are you trying to determine about the future?

    3) How can Amy Webb’s six step methodology help your writing?


    ABOUT THE HOW TO WRITE THE FUTURE PODCAST

    The How To Write The Future podcast is for science fiction and fantasy writers who want to write positive futures and successfully bring those stories out into the marketplace. Hosted by Beth Barany, science fiction novelist and creativity coach for writers.

    Tips for fiction writers!

    This podcast is for you if you have questions like:

    • How do I create a believable world for my science fiction story?
    • How do I figure out what's not working if my story feels flat?
    • How do I make my story more interesting and alive?

    This podcast is for readers too if you’re at all curious about the future of humanity.


    RESOURCES
    Amy Webb, The Signals Are Talking: https://books2read.com/thesignalsaretalkingwebb  ; and her organization: Future Today Institute: https://futuretodayinstitute.com/

    SCIENCE DAILY:  https://www.sciencedaily.com/news/

    TALK TO A WRITING COACH
    https://writersfunzone.com/blog/talk-to-a-writing-coach/ 



    SHOW PRODUCTION BY Beth Barany
    SHOW NOTES SUPPORT from Kerry-Ann McDade


    --
    CONNECT
    Contact Beth: https://writersfunzone.com/blog/podcast/#tve-jump-185b4422580
    Email: beth@bethbarany.com
    LinkedIn: https://www.linkedin.com/in/bethbarany/

    CREDITS
    EDITED WITH DESCRIPT: https://get.descript.com/0clwwvlf6e3j
    MUSIC: Uppbeat.io
    DISTRIBUTED BY BUZZSPROUT: https://www.buzzsprout.com/?referrer_id=1994465

    Maddox Grey of Outworld Reptiles - Diving Deep Into Boas

    BCI Pioneers Part II

    BCI Pioneers Part II

    The Panel: 


    Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn


    Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram


    Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin


    00:00 | Intro


    0:14 | Neurotech Pub Episode 13: BCI Pioneers Part I

    0:47 | Neurotech Pub Episode 10: Business Models in Neurotech


    1:30 | BCI & Identity


    1:30 | New Yorker - Do Brain Implants Change Your Identity?

    2:09 | The Utah Array (Blackrock Neurotech)

    16:05 | Learn more about Hector in Part 1


    17:14 | Talking Form Factors


    18:36 | CerePlex System


    22:36 | Support Systems in BCI Adoption


    38:35 | Get in Touch


    38:54 | The Ian Burkhart Foundation

    39:13 | Book Ian as a speaker

    39:25 | North American Spinal Cord Injury Consortium (NASCIC)

    40:04 | Where to find Ian

    40:19 | Contact Nathan

    40:25 | Nathan on Instagram, LinkedIn, and Twitter

    40:32 | Nathan's NFTs on OpenSea

    Links to Jan’s lab photos and how to get in touch can be found here


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    BCI Pioneers Part I

    BCI Pioneers Part I

    In this very special two part series in collaboration with Blackrock Neurotech, Paradromics CEO Matt Angle and Blackrock Creative Director Taryn Southern co-host a discussion with BCI research pioneers Jan Scheuermann, Ian Burkhart, and Nathan Copeland. In part one, we discuss their personal journeys to becoming BCI pioneers, implant experiences with the Utah Array,  their time in the lab, and some of their current projects. Learn more about Jan, Ian, and Nathan below and stay tuned for part two, coming in July 2022! 


    The Panel: 


    Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn


    Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram


    Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin


    00:00 | Intro


    6:10 | Who came first?


    7:07 | Jan Scheuermann

    7:18 | Tim Hemmes & the UPitt/UPMC Team

    8:05 | New Yorker profile of Jan and the UPitt team

    8:55 | View Jan’s photos from the lab


    10:10 | Nathan Copeland

    13:00 | Parietal Cortex

    13:22 | Saccade Movements


    14:12 | The Pioneer Experience


    16:04 | Neuro Life Study | Additional Reference | Interview with Ian | Archives of PMR

    18:15 | Mirror Therapy

    23:50 | Jan in the Pilot Seat

    25:07 | Ian's Experience in the Car Simulator


    25:53| Thinking About Thinking


    31:24 | Jan's novel, Sharp as a Cucumber

    37:37 | View Jan’s photos from the lab

    38:04 | Andy Schwartz

    38:45 | Nathan's NFTs

    43:22 | Nathan's Instagram


    45:03 | 15 Minutes of Fame


    45:12 | A Presidential Greeting

    45:45 | Jan on 60 Minutes

    45:54 | Jan in SciAM

    46:00 | Book Jan as a keynote speaker

    46:32 | SfN

    47:05 | Investment in BCI

    47:17 | The Ian Burkhart Foundation


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    Mind Control with Lasers: Optical Recording Part II

    Mind Control with Lasers: Optical Recording Part II

    Welcome back to Neurotech Pub!

    This episode is part two of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhDMark Schnitzer, PhD, and Jacob Robinson, PhD. Last time we talked about optical recording methods, but in this episode we focus on optical stimulation methods. 


    Cheers!

    Check out video and full transcript here: https://www.paradromics.com/podcast/episode-12-mind-control-with-lasers


    00:00 | Intro


    1:37 | Aspirational Papers

    1:56 | Packer Lab 

    2:10 | What is the claustrum?

    2:30 | Ian's paper (but only part of it!)

    3:02 | Two-Photon Bidirectional Control and Imaging In Vivo

    3:29 | Inferring Spikes from Calcium Imaging

    5:45 | Neuropixels are now in humans

    7:12 | Paper by Pachitariu et al 

    7:55 | Ian Oldenburg

    10:02 | Kaufman Lab

    11:21 | Cortical activity in the null space: permitting preparation without movement

    12:08 | Motor cortical dynamics shaped by multiple distinct subspaces during naturalistic behavior


    12:33 | Tickling Cells with Light

    14:41 | Light-activated ion channels for remote control of neuronal firing

    14:50 | Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons

    15:20 | Millisecond-timescale, genetically targeted optical control of neural activity

    16:03 | Red-shifted Opsins

    16:52 | eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications

    17:26 | Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

    18:16 | Neural Dust

    18:41 | Wireless magnetothermal deep brain stimulation

    19:05 | Neural Stimulation Through Ultrasound

    19:20 | Methods and Modalities: Sculpting Light

    21:35 | Recent advances in patterned photostimulation for optogenetics

    22:50 | Two-photon microscopy is now over 30 years old (Denk 1990)


    25:22 | Optical Recording State of the Art

    27:06 | Challenges of Deep Tissue 2-Photon Imaging

    28:21 | Deisseroth Lab

    28:29 | Temporal Precision of Optical Stimulation

    29:09 | Simultaneous all-optical manipulation and recording 

    30:40 | Targeted Ablation in Somatosensory Cortex 

    33:29 | Commercially Available Fast Opsins

    34:41 | Recent paper from Deisseroth Lab

    41:17 | Cortical layer–specific critical dynamics triggering perception

    42:21 | The Utah Array from Blackrock Neurotech

    44:52 | Principles of Corticocortical Communication

    50:43 | The Cost of Cortical Computation

    51:27 | Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex (2013) | Spatiotemporal convergence and divergence in the rat S1 "barrel" cortex (1987) | Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice (2019) 

    52:56 | Gollisch and Meister 2008

    53:22 | Spike Timing-Dependent Plasticity (STDP)

    1:05:09 | Neurotech Pub Episode 11 -  Let There Be Light


    1:05:20 | Forecasting the Future

    1:05:41 | Temporally precise single-cell-resolution optogenetics

    1:06:16 | Large Scale Ca++ Recordings from Vaziri Lab

    1:07:11 | Cohen Lab

    1:07:19 | All Optical Electrophysiology 

    1:14:19 | Emiliani et al 2015

    1:16:33 | All-Optical Interrogation of Neural Circuits

    1:16:53 | Mice Strains @ Jackson Lab

    1:17:00 | The Allen Institute


    1:20:39 | Neuroscience and Engineering Collaborations

    1:18:39 | Nicolas Pegard

    1:18:47 | Adesnik Lab

    1:24:41 | Shenoy, Sahani, and Churchland 2013

    1:24:52 | Dimensionality reduction for large-scale neural recordings

    1:25:17 | Matlab: Understanding Kalman Filters

    1:25:58 | Two-photon excitation microscopy

    1:26:37 | Emiliani Lab Holography course

    1:26:57 | Optics by Eugene Hecht

    1:28:05 | Intro to Optics Course

    1:29:41 | What the Heck Is a Claustrum?

    1:33:53 | Cortical activity in the null space: permitting preparation without movement

    1:34:33 | Neural Manifolds and Learning

    1:35:19 | Locked-in Syndrome

    1:36:58 | Sabatini Lab

    1:37:07 | Probing and regulating dysfunctional circuits using DBS

    1:39:36 | Sliman Bensmaia | Nicho Hatsopoulos

    1:39:43 | The science and engineering behind sensitized brain-controlled bionic hands

    1:41:20 | Michael Long's singing rodents

    1:42:12 | Engram

    1:43:06 | Chang Lab

    1:43:19 | Tim Gardner | Michale Fee


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    NYPD Mafia & Gaspipe

    NYPD Mafia & Gaspipe

    The Mob, The Mafia, and The Man Season 3 Episode 20
    John Alite w/ Mike Dowd

    Ex-Detective interview explaining how cops turn into mafia cops, how they go about doing their killings for the mob, and the mental stress of seeing the ghetto streets and crime amongst those living there when nobody seems to care.

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    Let there be Light: Optical Recording Part I

    Let there be Light: Optical Recording Part I

    Welcome back to Neurotech Pub!

    This episode is one of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhDMark Schnitzer, PhD, and Jacob Robinson, PhD. So far, our technical dives have focused mainly on direct electrical recording and stimulation of neural activity, but in this episode we deep dive into advantages that all-optical interfaces might have over electrical interfaces, and the challenges in developing them. 


    In addition, we talk about running highly collaborative, interdisciplinary projects that span traditional physics and engineering with biology, a theme that is ever-present in neurotech and is also highlighted in part two of this series. 


    Cheers!

    Check out full video with transcript here: https://www.paradromics.com/podcast/episode-11-let-there-be-light


    Show Notes


    Latest news & publications since recording: 

    >> Hillman Lab: New publication on SCAPE in Nature Biomedical Engineering

    >> Robinson Lab: Review article in Optica on Recent advances in lensless imaging

    >> Robinson Lab: BioRxiv pre-print on in vivo fluorescence imaging


    1:23 | The Heart and Soul of a Paper

    2:32| Ultrasmall Mode Volumes in Dielectric Optical Microcavities

    3:01 | Robinson Lab

    4:01 | Hillman Lab

    4:07 | Zuckerman Institute

    4:15 | Schnitzer Lab

    4:25 | Howard Hughes Medical Institute

    4:41| Miniature Fluorescence Microscope

    9:02 | Discovery of DNA Structure and Function

    10:25 | Hodgkin–Huxley Equations

    13:49 | Vessel Dilation in the Brain

    16:03 | State of the art of Neural Optical Recording

    18:03 | Long-Term Optical Access to an Estimated One Million Neurons in Mouse Cortex

    24:56 | Watch the Crystal Skull video

    27:45 | High-Speed Cellular-Resolution Light Beads Microscopy

    29:54 | Relationship between spiking activity and calcium imaging

    32:50 | Analytical & Quantitative Light Microscopy [AQLM]

    32:59 | Imaging Structure & Function in the Nervous System

    35:22 | NIH Brain Initiative Cell Census Network (BICCN)

    35:54 | Allen Brain Atlas: Cell Types

    40:17 | A Theory of Multineuronal Dimensionality, Dynamics and Measurement

    46:19 | Dr. Laura Waller's DIY Diffuser Cam

    50:38 | FlatCam by Robinson Lab

    53:42 | Advantages of MEG

    55:06| Random Access Two Photon Scanning Techniques

    56:07 | Swept Confocally-Aligned Planar Excitation (SCAPE)


    58:47 | Optics Systems for Implantable BCIs

    1:00:43 | GCaMP - Janelia GECI reagents

    1:01:33 | DARPA NESD Program

    1:04:06 | SCAPE Microscopy for High-Speed Volumetric Imaging of Behaving Organisms

    1:07:00 | Glial Response to Implanted Electrodes

    1:07:07 | Brain Tissue Responses to Neural Implants

    1:09:36 | Two Deaths in Gene Therapy Trial for Rare Muscle Disease

    1:10:46 | Intrinsic Optical Signal due to Blood Oxygenation

    1:11:11 | Coupling Mechanism and Significance of the BOLD Signal

    1:12:10 | DARPA invests in Treating Mood Disorders

    1:12:57 | Amygdalar Representations of Pain

    1:13:48 | Fast Optical Signals: Principles, Methods, and Experimental Results

    1:14:12 | Dr. Larry Cohen's early work in Neurophotonics

    1:14:42 | Linear Systems Analysis of Functional Magnetic Resonance Imaging | Additional Resource

    1:16:20 | Flavoprotein Fluorescence Imaging in Neonates | Additional Resource

    1:18:02 | Pumped Probe Microscopy

    1:19:26 | Biological Imaging of Chemical Bonds by Stimulated Raman Scattering Microscopy

    1:19:36 | Coherent Anti-Stokes Raman Scattering microscopy (CARS)

    1:19:55 | Min Lab @ Columbia

    1:20:06 | Glucose Analog for Stimulated Raman Scattering


    1:20:39 | Emerging Paradigms for Aspiring Neurotechnologists


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    The #1 Secret to Successful Boa Breeding

    The #1 Secret to Successful Boa Breeding

    Hare Hollow Farm
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    Business Models in Neurotech

    Business Models in Neurotech

    Welcome back to the Season 2 premiere of Neurotech Pub!

    In this episode, host and Paradromics CEO Matt Angle sits down with fellow Founder/CEOs Carolina Aguilar, Brian Pepin, and Kunal Ghosh to talk shop about building cutting edge neurotech companies from the ground up. We dive deep into business strategies, the neurotech fundraising landscape, emerging therapeutics, and more. We also provide an insider’s view of the intersections of data, pharma, and med devices that are shaping the future of healthcare. Pour yourself a cold one and settle in!

    Check out full video with transcript here: Check out video and a full episode transcript here. 


    00:00 | Updates & News 


    >> INBRAIN Neuroelectronics raised a $17M Series A 

    >> Rune Labs raised a $22.8 Million Series A 

    >> Inscopix Launched Cloud-Based Platform for Data Management and Analysis


    2:15 | Meet the panel and pick up a book


    1:54 | Jester King Brewery  

    2:25 | Rune Labs  

    2:50 | Neurostimulator for deep brain stimulation therapy  

    3:23 | INBRAIN Neuroelectronics  

    4:11 | Inscopix  

    5:24 | Ursula K. Le Guin’s 'The Dispossessed'  

    6:19 | Yuval Noah Harari’s 'Sapiens: A Brief History of Humankind'  

    6:32 | Daniel G. Miller’s 'The Tree of Knowledge'  

    6:40 | Jiddu Krishnamurti’s 'The Book of Life'  

    7:34 | Barack Obama’s 'A Promised Land,' ‘Dreams from my Father,’ & ‘The Audacity of Hope’  7:56 | Karl Popper’s 'The Open Society and Its Enemies'


    9:25 | Venture Capital in Neurotech


    34:44 | Business Strategy in Neurotech


    40:32 | Tom Oxley, CEO, Synchron  

    43:58 | Dr. Thomas Insel  

    44:06 | Mindstrong Mental Health Care  

    44:35 | Aduhelm controversy  

    52:25 | Galvani Bio  

    59:39 | Percept Neurostimulator  

    1:00:32 | Neuromodulation and the future of treating brain disease  

    1:07:21 | Software as a Medical Device FDA Guidance


    1:09:12 | State of Animal Model Systems


    1:14:28 | α-Synuclein in Parkinson's Disease  

    1:18:01 | Alto Neuroscience  

    1:18:36 | Flatiron Foundation  

    1:18:45 | Gaurdent Health  

    1:19:03 | Melanoma Trends & Rates


    1:21:41 | The Pharma-Data-Device Ecosystem 


    1:21:42 | Frank Fischer, Chairman of Neuropace  

    1:22:28 | Neurotech Pub Season 1, Episode 9  

    1:26:35 | Roche acquisition of Flatiron Health & merger with Foundation Medicine   

    1:27:12 | Companion Diagnostics  

    1:28:29 | Adhulem and PET imaging  

    1:29:09 | Resignations at the FDA over Alzheimer’s Drug  

    1:29:32 | Derek Lowe’s take on the Aducanumab Approval, FDA Committee Votes, Halting the Aducanumab Trials, & The FDA Advisory Committee Briefing Document on Aducanumab  

    1:31:39 | Donanemab receives breakthrough therapy designation in 2021  

    1:36:58 | Mapping the Frontal-Vagal Pathway  

    1:37:09 | The Human Connectome Project  

    1:40:07 | Teal Organizations and Holacracy  

    1:41:18 | Society for Neuroscience  

    1:44:37 | Affymetrix (Thermo Fisher Scientific)  

    1:44:39 | Illumina


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