OWITH.ai: Cutting Through the Noise in AI and Tech
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Explore " bci" with insightful episodes like "OWITH.ai: Cutting Through the Noise in AI and Tech", "The Rise of Brain Computer Interfaces (BCI) that Can Compete with Rogue Super-AIs, w/ Trent McConaghy", "Brain-Computer Interfaces | Jaimie Henderson", "The Brain Implant That Sidesteps The Competition" and "The Fine Art of Mutt Boa Selective Breeding" from podcasts like ""OWITH.ai - Only What's Important to Hear around AI and Tech", "AI-Curious with Jeff Wilser", "From Our Neurons to Yours", "Fixing the Future" and "Holdback Rack Podcast"" and more!
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If AI gets super intelligent and super powerful, will it be benevolent? Or will it want to crush us like ants?
Perhaps they’ll be benevolent. Maybe they’ll be “aligned” with our interests. But if not? What should we do? How can we prepare for this nightmarish scenario?
Trent McConaghy has a plan. McConaghy has been working in AI for decades, both as an entrepreneur and as a researcher, and he’s widely respected in the field.
And he recently gave a speech to the “existential-risk” (x-risk) group at NASA about how, to prepare humanity for this all-powerful AI…We need to become more than humans. Specifically, we need to embrace the idea of Brain-Computer Interface, or BCI.
BCI, says McConaghy, can even help unshackle us from the constraints of being a flesh-and-blood human. In a literal mind-meld with computers, we could be 1,000 times smarter and live longer.
This sounds like deep sci-fi, but McConaghy lucidly breaks down the vision in a way that’s step by step, easy to understand, and almost feels…plausible?
Whether you agree with the theory or not, McConaghy’s thoughts are FASCINATING and he makes for a wildly engaging conversation about the future of AI. I’m confident that anyone even remotely interested in AI — or sci-fi — will find his thought experiments intriguing.
Among many other sweeping and futuristic topics, we cover:
Why economic incentives make AGI (or “ASI,” for Artificial Super Intelligence) is perhaps more likely than we think (13:50); Why we might soon be like an anthill compared to god-like entities of Artificial Smart Intelligence (23:00); whether these all-powerful ASIs will protect human rights (26:00); why we need a “more competitive substrate” that helps us be more than human and hyper-boost our intelligence (29:00); how creating powerful Brain-Computer-Interfaces is more grounded and less sci-fi-ish than you might think (35:00); how we will some day —maybe soon — be able to just think of videos and use telepathy to send to friends (45:00); why the human “bio-stack” won’t be enough and we’ll need a synthetic solution (53:00); the dangers of “bike shedding” the risks of ASI (59:30); how BCI could plausibly go mainstream (61:30); why when we’re 94 years old we might switch from our “bio-stack brain” and migrate to our “silicon-stack” side (65:00).
So join us on a futuristic and fascinating journey….
McConaghy’s presentation to the existential-risk group at NASA:
https://drive.google.com/file/d/1tLK1sBCMNuJTNX8Pi99iDmLzFiIsUOk5/view
McConaghy’s Medium article that breaks down the BCI theory:
https://medium.com/@trentmc0/bci-acc-a-path-to-balance-ai-superintelligence-80bb6f32e39c
McConaghy on Twitter/X:
https://twitter.com/trentmc0
Ocean Protocol, the blockchain-powered AI ecosystem that McConaghy founded:
https://oceanprotocol.com
My article about AI and blockchain where I first interviewed McConaghy, and he shares a part of this theory (which got me fascinated in the first place):
https://www.coindesk.com/consensus-magazine/2023/09/21/is-crypto-ai-really-a-match-made-in-heaven/
And finally Jeff Wilser (me) on Twitter/X:
https://twitter.com/jeffwilser
Imagine being trapped in your own body, unable to move or communicate effectively. This may seem like a nightmare, but it is a reality for many people living with brain or spinal cord injuries.
Join us as we talk with Jaimie Henderson, a Stanford neurosurgeon leading groundbreaking research in brain-machine interfaces. Henderson shares how multiple types of brain implants are currently being developed to treat neurological disorders and restore communication for those who have lost the ability to speak.
We also discuss the legacy of the late Krishna Shenoy and his transformative work in this field.
Learn more
Henderson's Neural Prosthetics Translational Lab
BrainGate Consortium – "Turning thought into action"
Commentary on Neuralink's brain-interfacing technology by Wu Tsai Neurosciences Institute Faculty Scholar Paul Nuyujukian (WIRED, 2023; NBC Bay Area, 2024)
Brain Implants Helped 5 People Recover From Traumatic Injuries (New York Times, 2023)
Brain to text technology is about more than Musk (Washington Post, 2023)
The man who controls computers with his mind (New York Times Magazine, 2022)
Software turns ‘mental handwriting’ into on-screen words, sentences (Stanford Medicine, 2021)
Learn about the work of the late Krishna Shenoy
Krishna V. Shenoy (1968–2023) (Nature Neuroscience, 2023)
Krishna Shenoy, engineer who reimagined how the brain makes the body move, dies at 54 (Stanford Engineering, 2023)
Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.
Learn more about the Wu Tsai Neurosciences Institute at Stanford and follow us on Twitter, Facebook, and LinkedIn.
We've all seen impressive demos of prototype brain implants being used by paralyzed patients to interface with computers, but none of those implants have entered general clinical use. Biomedical device company Synchron is close to actually coming to market with its stentrode technology, promising less spectacular results than some of its competitors, but making up for that with ease of use and implant longevity. Synchron's co-founder Tom Oxley talks with IEEE Spectrum senior editor Eliza Strickland about the new tech, and you can read more in our January issue article by Emily Waltz.
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We’re back with Part II of our two-part series on Connectomics!
In part one we speculated on the legal and ethical implications of emerging technologies in the connectomics field. In part two, we don our lab coats and take a deep dive into the latest research tools, from fixation protocols for the preservation of neural tissue, to multimodal imaging techniques, to the machine intelligence designed to interpret massive data sets and reconstruct the vast neural circuits that make up the connectome.
Our guests are:
In this episode, Ken and Robert from part one return to the pub, and we are also joined by Jeremy Maitin-Shepard, an engineer and researcher at Google, who shares insights into some of the machine intelligence modalities being used to decode previously uncharted neural networks. Check out Jeremy’s recent paper on BioRxiv, as well as his published work at Google.
If you missed part one, you can listen and explore the show notes here. Cheers!
Show Notes:
0:00 | Intro
1:03 | Kenneth Hayworth, PhD
1:12 | Robert McKintyre, CEO, Nectome
1:17 | Jeremy Maitin-Shepard, PhD
1:51 | Setting the record straight
3:09 | The nucleotide sequence of bacteriophage φX174
4:22 | Frozen Zoo at San Diego Zoo
12:01| Glutaraldehyde and reduction techniques for immunolabeling
17:39 | SWITCH Framework
19:14 | Population Responses in V1 Encode Different Figures by Response Amplitude
Permeabilization-free en bloc immunohistochemistry for correlative microscopy
19:57 | Synaptic Signaling in Learning and Memory
Structure and function of a neocortical synapse
Engineering a memory with LTD and LTP
Synapse-specific representation of the identity of overlapping memory engrams
20:28 | Ultrastructure of Dendritic Spines
Structure–stability–function relationships of dendritic spines
24:25 | Reconstructing the connectome
24:32 | Connectomics Research Team at Google
24:55 | Google x HHMI: Releasing the Drosophila Hemibrain Connectome
28:38 | Serial Block-Face Scanning Electron Microscopy
29:22 | Automated Serial Sections to Tape
29:45 | Mapping connections in mouse neocortex
30:59 | A connectome and analysis of the adult Drosophila central brain
32:14 | Expansion Microscopy
34:37 | The future of connectomics
49:49 | Mice and rats achieve similar levels of performance in an adaptive decision-making task
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Welcome back to Neurotech Pub!
In this first installment of two episodes on Connectomics, host and Paradromics CEO Matt Angle kicks off a lively discussion on the rapidly accelerating research in the mapping, preservation, and reconstruction of the human connectome. We explore the ethical and legal ramifications of disruptive technology, and some of the unique challenges faced when driving innovation in emerging industries.
Our guests are:
As an exciting new development since the recording of this episode, Nita recently published a book, The Battle for Your Brain, which examines many topics in neuroethics, from Connectomics to Brain-Computer Interfaces. It is currently available on Amazon.
Keep an eye out for part two in this series, which will take a deep dive into the latest technical and engineering innovations in the connectomics ecosystem. Coming soon!
Please be advised that this episode contains a brief discussion of assisted suicide in a medical setting.
Show Notes:
0:00 | Episode Intro
1:16 | Nita A. Farahany, JD, PhD
1:21 | Kenneth Hayworth, PhD
1:27 | Robert McKintyre, CEO, Nectome
1:56 | Meeting of the minds
2:53 | Aldehyde-stabilized cryopreservation wins final phase of brain preservation prize
3:56 | The Brain Preservation Foundation
4:09 | Documentary series on the Brain Preservation Foundation
5:21 | Letter of Support for Aldehyde Stabilized Cryopreservation (and ‘next steps’ caveats)
5:51 | Nita's 2018 Neuroethics Ted Talk
5:54 | International Neuroethics Society
6:25 | Connectomics & new paths in neuroscience
8:10 | Allen Institute for Brain Science
8:47 | A connectome and analysis of the adult Drosophila central brain
9:33 | A visual intro to synaptic imaging in connectomics
10:28 | The structure of the nervous system of the nematode Caenorhabditis elegans
11:16 | Mouse Connectome Project at CIC
14:59 | Cryonics controversy
19:00 | Death, taxes, and synapses
20:51 | Uniform Law Commission
21:08 | The Uniform Determination of Death Act
24:25 | Watch Altered Carbon on Netflix
25:49 | Understanding the “Loss of Chance” Doctrine
37:13 | Understanding Physician-Assisted Death, or ‘Death with Dignity’
40:21 | Euthanasia in the Netherlands
46:01 | Autonomy, Dignity, and Consent to Harm, Rutgers Law Review
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Naturally, tech layoffs are top-of-mind for many of us. Despite comparisons to the dot-com bubble, what we’re seeing right now is different. Here’s what the tech and media layoffs really tell us about the economy.
In praise of analog technology: why Millennials and Gen Z are springing for paper maps.
Make Time, a way of “rethinking the defaults of constant busyness and distraction so you can focus on what matters every day,” was developed in response to always-on Silicon Valley culture.
Wifi routers can now be used to detect the physical positions of humans and map their bodies in 3D. Terrifyingly dystopian or interestingly practical? Why not both?
In recent accessibility news, a brain-computer interface (BCI) that converts speech-related neural activity into text allows a person with paralysis due to amyotrophic lateral sclerosis (ALS) to communicate at 62 words per minute, nearly 3.5 times faster than before. From the abstract: “These results show a feasible path forward for using intracortical speech BCIs to restore rapid communication to people with paralysis who can no longer speak.” 
Shoutout to Lifeboat badge winner Holger for their answer to Sort an array containing numbers using a 'for' loop.
Welcome back to Neurotech Pub! In this episode we’re talking about sleep–why we sleep, how sleep works on a neurophysiological level, and some of the emerging sleep technologies that are about to revolutionize this essential neural activity.
Our guests are Amy Kruse, PhD, General Partner at Prime Movers Lab, Ram Gurumoorthy, PhD, Founder and CTO of Stimscience & Somnee, and Luis de Lecea, PhD, Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine.
This episode also features a video introduction to sleep stages by Paradromics Intern Zoe Lalji. This is essential viewing if you’re unfamiliar with the stages of sleep and want to follow along later in the episode.
Cheers!
Show Notes:
00:00 | Episode intro with Matt Angle and Amy Kruse
1:07 | StimScience in Fast Company
5:05 | Learned Motor Patterns Are Replayed in Human Motor Cortex during Sleep
6:43 | Connect with Prime Movers Lab
7:01 | PML on Medium
7:45 | Introduction to Sleep Stages
References:
Check out Zoe’s nonprofit organization, ALS Heroes, and her Ted Talk
12:24 | Pulling all-nighters
12:50 | Amy Kruse, PhD
13:00 | Ram Gurumoorthy, PhD
13:07 | Stimscience, now Somnee
13:30 | Luis de Lecea, PhD
18:26 | Gordon Rule, PhD
18:40 | Knights of the Old Republic II: The Sith Lords (2004)
19:50 | Why do we sleep?
20:26 | Sleep drives metabolite clearance from the adult brain
20:35 | Sleep & DNA Repair
22:13 | Neural Activity can cause DNA damage
23:22 | Jerry Seigal
24:26 | DARPA Sleep Research
24:55 | Fur seals and sleep
25:08 | How do Whales and Dolphins Sleep Without Drowning?
25:54 | Putting Humans in Stasis Is the Best Way of Getting Us to Mars
27:36 | Sleep and Mortality
28:09 | The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices
28:27 | Giulio Tononi, MD, PhD
28:45 | Sleep, Memory, and Plasticity
28:52 | Sleep Cognition and Memory
29:00 | Sleeping up and down the phylogenetic tree
29:05 | Actually...worms do sleep
29:20 | Decoding sleep
29:36 | Fruit flies and their mini sleeps
29:44 | Mapping sleep in the brain
30:35 | Hypocretin-positive neurons
31:17 | Clearly Matt slept through his midterm... again
31:57 | The hypocretins/orexins: integrators of multiple physiological functions
32:05 | Stress-sleep interactions
33:30 | The Science of Narcolepsy
35:08 | Equivalence of sleep deprivation and intoxication | Additional reference
36:21 | Sleep Pressure: Homeostatic Sleep Drive
40:38 | EEG Visualization of electrodermal activity during sleep
44:08 | Circuitry of Sleep Stages
45:00 | Regional slow waves and spindles in human sleep | Local sleep in awake rats
48:00 | Emerging Sleep Technologies
1:00:56 | Hypothalamus and Sleep
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“What about the future are you trying to determine? Is it a specific kind of technology? A cultural behavioral pattern? A system of running companies? A way of feeding people? Language evolution? Where in society today are people asking the hard questions or making some new discoveries?”
In high school, I would spend every week reading Omni magazine in the school library. Today I often read Science Daily. Both of these sources of information play huge inspirations into the questions I ask about the future.
In this episode I talk about Amy Webb’s book (that shares the same name as the title of this episode) and delve into her six-step methodology, offering my viewpoint for each step. I use my own Janey McCallister sci-fi mystery novels as an example and some of the decision making process for that series.
In this episode, you will learn the following:
1) Where do you look for inspiration in writing the future?
2) What are you trying to determine about the future?
3) How can Amy Webb’s six step methodology help your writing?
ABOUT THE HOW TO WRITE THE FUTURE PODCAST
The How To Write The Future podcast is for science fiction and fantasy writers who want to write positive futures and successfully bring those stories out into the marketplace. Hosted by Beth Barany, science fiction novelist and creativity coach for writers.
Tips for fiction writers!
This podcast is for you if you have questions like:
This podcast is for readers too if you’re at all curious about the future of humanity.
RESOURCES
Amy Webb, The Signals Are Talking: https://books2read.com/thesignalsaretalkingwebb ; and her organization: Future Today Institute: https://futuretodayinstitute.com/
SCIENCE DAILY: https://www.sciencedaily.com/news/
TALK TO A WRITING COACH
https://writersfunzone.com/blog/talk-to-a-writing-coach/
SHOW PRODUCTION BY Beth Barany
SHOW NOTES SUPPORT from Kerry-Ann McDade
--
CONNECT
Contact Beth: https://writersfunzone.com/blog/podcast/#tve-jump-185b4422580
Email: beth@bethbarany.com
LinkedIn: https://www.linkedin.com/in/bethbarany/
CREDITS
EDITED WITH DESCRIPT: https://get.descript.com/0clwwvlf6e3j
MUSIC: Uppbeat.io
DISTRIBUTED BY BUZZSPROUT: https://www.buzzsprout.com/?referrer_id=1994465
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The Panel:
Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn.
Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram.
Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin.
00:00 | Intro
0:14 | Neurotech Pub Episode 13: BCI Pioneers Part I
0:47 | Neurotech Pub Episode 10: Business Models in Neurotech
1:30 | BCI & Identity
1:30 | New Yorker - Do Brain Implants Change Your Identity?
2:09 | The Utah Array (Blackrock Neurotech)
16:05 | Learn more about Hector in Part 1
17:14 | Talking Form Factors
18:36 | CerePlex System
22:36 | Support Systems in BCI Adoption
38:35 | Get in Touch
38:54 | The Ian Burkhart Foundation
39:13 | Book Ian as a speaker
39:25 | North American Spinal Cord Injury Consortium (NASCIC)
40:04 | Where to find Ian
40:19 | Contact Nathan
40:25 | Nathan on Instagram, LinkedIn, and Twitter
40:32 | Nathan's NFTs on OpenSea
Links to Jan’s lab photos and how to get in touch can be found here
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In this very special two part series in collaboration with Blackrock Neurotech, Paradromics CEO Matt Angle and Blackrock Creative Director Taryn Southern co-host a discussion with BCI research pioneers Jan Scheuermann, Ian Burkhart, and Nathan Copeland. In part one, we discuss their personal journeys to becoming BCI pioneers, implant experiences with the Utah Array, their time in the lab, and some of their current projects. Learn more about Jan, Ian, and Nathan below and stay tuned for part two, coming in July 2022!
The Panel:
Jan Scheuermann is an author and public speaker, and self-styled “professional lab rat.” She has spoken at DARPA, the Johns Hopkins Applied Physics Laboratory, and the National Convention of the ALS Association about her experience as a BCI trial participant at UPitt. She is the author of a fictional mystery novel, Sharp as a Cucumber, available on Amazon. You can find out more about Jan and book her for public speaking events on her website or connect with her on LinkedIn.
Ian Burkhart is the President of the Ian Burkhart Foundation, which provides equipment not typically covered by insurance that improves independence for those with spinal cord injuries. He is also the Vice President of the North American Spinal Cord Injury Consortium, an advocacy organization that brings individuals with lived experience together with researchers to improve research, care, cure, and policy. In addition, Ian consults on medical device development and user interaction. Ian’s latest project is the BCI Pioneers Coalition, a platform to connect BCI users, researchers, industry, and other stakeholder groups to discuss the future of Brain Computer Interfaces. You can visit him on his website or connect with him on LinkedIn, Twitter, and Instagram.
Nathan Copeland is a neurotechnology consultant, speaker, and digital artist. He has spoken at numerous conventions around the world about his experiences in the lab and has been featured in many prominent publications including, but not limited to, Wired, MIT Tech Review, NPR, Fortune, and the Atlantic. He is the creator of the first BCI NFTs, available on OpenSea. You can connect with Nathan on Instagram, Twitter, and Linkedin.
00:00 | Intro
6:10 | Who came first?
7:07 | Jan Scheuermann
7:18 | Tim Hemmes & the UPitt/UPMC Team
8:05 | New Yorker profile of Jan and the UPitt team
8:55 | View Jan’s photos from the lab
10:10 | Nathan Copeland
13:00 | Parietal Cortex
13:22 | Saccade Movements
14:12 | The Pioneer Experience
16:04 | Neuro Life Study | Additional Reference | Interview with Ian | Archives of PMR
18:15 | Mirror Therapy
23:50 | Jan in the Pilot Seat
25:07 | Ian's Experience in the Car Simulator
25:53| Thinking About Thinking
31:24 | Jan's novel, Sharp as a Cucumber
37:37 | View Jan’s photos from the lab
38:04 | Andy Schwartz
38:45 | Nathan's NFTs
43:22 | Nathan's Instagram
45:03 | 15 Minutes of Fame
45:12 | A Presidential Greeting
45:45 | Jan on 60 Minutes
45:54 | Jan in SciAM
46:00 | Book Jan as a keynote speaker
46:32 | SfN
47:05 | Investment in BCI
47:17 | The Ian Burkhart Foundation
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Welcome back to Neurotech Pub!
This episode is part two of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD, Mark Schnitzer, PhD, and Jacob Robinson, PhD. Last time we talked about optical recording methods, but in this episode we focus on optical stimulation methods.
Cheers!
Check out video and full transcript here: https://www.paradromics.com/podcast/episode-12-mind-control-with-lasers
00:00 | Intro
1:37 | Aspirational Papers
1:56 | Packer Lab
2:10 | What is the claustrum?
2:30 | Ian's paper (but only part of it!)
3:02 | Two-Photon Bidirectional Control and Imaging In Vivo
3:29 | Inferring Spikes from Calcium Imaging
5:45 | Neuropixels are now in humans
7:12 | Paper by Pachitariu et al
7:55 | Ian Oldenburg
10:02 | Kaufman Lab
11:21 | Cortical activity in the null space: permitting preparation without movement
12:08 | Motor cortical dynamics shaped by multiple distinct subspaces during naturalistic behavior
12:33 | Tickling Cells with Light
14:41 | Light-activated ion channels for remote control of neuronal firing
14:50 | Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons
15:20 | Millisecond-timescale, genetically targeted optical control of neural activity
16:03 | Red-shifted Opsins
16:52 | eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications
17:26 | Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor
18:16 | Neural Dust
18:41 | Wireless magnetothermal deep brain stimulation
19:05 | Neural Stimulation Through Ultrasound
19:20 | Methods and Modalities: Sculpting Light
21:35 | Recent advances in patterned photostimulation for optogenetics
22:50 | Two-photon microscopy is now over 30 years old (Denk 1990)
25:22 | Optical Recording State of the Art
27:06 | Challenges of Deep Tissue 2-Photon Imaging
28:21 | Deisseroth Lab
28:29 | Temporal Precision of Optical Stimulation
29:09 | Simultaneous all-optical manipulation and recording
30:40 | Targeted Ablation in Somatosensory Cortex
33:29 | Commercially Available Fast Opsins
34:41 | Recent paper from Deisseroth Lab
41:17 | Cortical layer–specific critical dynamics triggering perception
42:21 | The Utah Array from Blackrock Neurotech
44:52 | Principles of Corticocortical Communication
50:43 | The Cost of Cortical Computation
51:27 | Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex (2013) | Spatiotemporal convergence and divergence in the rat S1 "barrel" cortex (1987) | Diverse tuning underlies sparse activity in layer 2/3 vibrissal cortex of awake mice (2019)
52:56 | Gollisch and Meister 2008
53:22 | Spike Timing-Dependent Plasticity (STDP)
1:05:09 | Neurotech Pub Episode 11 - Let There Be Light
1:05:20 | Forecasting the Future
1:05:41 | Temporally precise single-cell-resolution optogenetics
1:06:16 | Large Scale Ca++ Recordings from Vaziri Lab
1:07:11 | Cohen Lab
1:07:19 | All Optical Electrophysiology
1:14:19 | Emiliani et al 2015
1:16:33 | All-Optical Interrogation of Neural Circuits
1:16:53 | Mice Strains @ Jackson Lab
1:17:00 | The Allen Institute
1:20:39 | Neuroscience and Engineering Collaborations
1:18:39 | Nicolas Pegard
1:18:47 | Adesnik Lab
1:24:41 | Shenoy, Sahani, and Churchland 2013
1:24:52 | Dimensionality reduction for large-scale neural recordings
1:25:17 | Matlab: Understanding Kalman Filters
1:25:58 | Two-photon excitation microscopy
1:26:37 | Emiliani Lab Holography course
1:26:57 | Optics by Eugene Hecht
1:28:05 | Intro to Optics Course
1:29:41 | What the Heck Is a Claustrum?
1:33:53 | Cortical activity in the null space: permitting preparation without movement
1:34:33 | Neural Manifolds and Learning
1:35:19 | Locked-in Syndrome
1:36:58 | Sabatini Lab
1:37:07 | Probing and regulating dysfunctional circuits using DBS
1:39:36 | Sliman Bensmaia | Nicho Hatsopoulos
1:39:43 | The science and engineering behind sensitized brain-controlled bionic hands
1:41:20 | Michael Long's singing rodents
1:42:12 | Engram
1:43:06 | Chang Lab
1:43:19 | Tim Gardner | Michale Fee
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John Alite w/ Mike Dowd
Ex-Detective interview explaining how cops turn into mafia cops, how they go about doing their killings for the mob, and the mental stress of seeing the ghetto streets and crime amongst those living there when nobody seems to care.
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Welcome back to Neurotech Pub!
This episode is one of a two part series on optical methods for recording and stimulating neural activity. Our guests on this episode are Elizabeth Hillman, PhD, Mark Schnitzer, PhD, and Jacob Robinson, PhD. So far, our technical dives have focused mainly on direct electrical recording and stimulation of neural activity, but in this episode we deep dive into advantages that all-optical interfaces might have over electrical interfaces, and the challenges in developing them.
In addition, we talk about running highly collaborative, interdisciplinary projects that span traditional physics and engineering with biology, a theme that is ever-present in neurotech and is also highlighted in part two of this series.
Cheers!
Check out full video with transcript here: https://www.paradromics.com/podcast/episode-11-let-there-be-light
Show Notes
Latest news & publications since recording:
>> Hillman Lab: New publication on SCAPE in Nature Biomedical Engineering
>> Robinson Lab: Review article in Optica on Recent advances in lensless imaging
>> Robinson Lab: BioRxiv pre-print on in vivo fluorescence imaging
1:23 | The Heart and Soul of a Paper
2:32| Ultrasmall Mode Volumes in Dielectric Optical Microcavities
3:01 | Robinson Lab
4:01 | Hillman Lab
4:07 | Zuckerman Institute
4:15 | Schnitzer Lab
4:25 | Howard Hughes Medical Institute
4:41| Miniature Fluorescence Microscope
9:02 | Discovery of DNA Structure and Function
10:25 | Hodgkin–Huxley Equations
13:49 | Vessel Dilation in the Brain
16:03 | State of the art of Neural Optical Recording
18:03 | Long-Term Optical Access to an Estimated One Million Neurons in Mouse Cortex
24:56 | Watch the Crystal Skull video
27:45 | High-Speed Cellular-Resolution Light Beads Microscopy
29:54 | Relationship between spiking activity and calcium imaging
32:50 | Analytical & Quantitative Light Microscopy [AQLM]
32:59 | Imaging Structure & Function in the Nervous System
35:22 | NIH Brain Initiative Cell Census Network (BICCN)
35:54 | Allen Brain Atlas: Cell Types
40:17 | A Theory of Multineuronal Dimensionality, Dynamics and Measurement
46:19 | Dr. Laura Waller's DIY Diffuser Cam
50:38 | FlatCam by Robinson Lab
53:42 | Advantages of MEG
55:06| Random Access Two Photon Scanning Techniques
56:07 | Swept Confocally-Aligned Planar Excitation (SCAPE)
58:47 | Optics Systems for Implantable BCIs
1:00:43 | GCaMP - Janelia GECI reagents
1:01:33 | DARPA NESD Program
1:04:06 | SCAPE Microscopy for High-Speed Volumetric Imaging of Behaving Organisms
1:07:00 | Glial Response to Implanted Electrodes
1:07:07 | Brain Tissue Responses to Neural Implants
1:09:36 | Two Deaths in Gene Therapy Trial for Rare Muscle Disease
1:10:46 | Intrinsic Optical Signal due to Blood Oxygenation
1:11:11 | Coupling Mechanism and Significance of the BOLD Signal
1:12:10 | DARPA invests in Treating Mood Disorders
1:12:57 | Amygdalar Representations of Pain
1:13:48 | Fast Optical Signals: Principles, Methods, and Experimental Results
1:14:12 | Dr. Larry Cohen's early work in Neurophotonics
1:14:42 | Linear Systems Analysis of Functional Magnetic Resonance Imaging | Additional Resource
1:16:20 | Flavoprotein Fluorescence Imaging in Neonates | Additional Resource
1:18:02 | Pumped Probe Microscopy
1:19:26 | Biological Imaging of Chemical Bonds by Stimulated Raman Scattering Microscopy
1:19:36 | Coherent Anti-Stokes Raman Scattering microscopy (CARS)
1:19:55 | Min Lab @ Columbia
1:20:06 | Glucose Analog for Stimulated Raman Scattering
1:20:39 | Emerging Paradigms for Aspiring Neurotechnologists
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Welcome back to the Season 2 premiere of Neurotech Pub!
In this episode, host and Paradromics CEO Matt Angle sits down with fellow Founder/CEOs Carolina Aguilar, Brian Pepin, and Kunal Ghosh to talk shop about building cutting edge neurotech companies from the ground up. We dive deep into business strategies, the neurotech fundraising landscape, emerging therapeutics, and more. We also provide an insider’s view of the intersections of data, pharma, and med devices that are shaping the future of healthcare. Pour yourself a cold one and settle in!
Check out full video with transcript here: Check out video and a full episode transcript here.
00:00 | Updates & News
>> INBRAIN Neuroelectronics raised a $17M Series A
>> Rune Labs raised a $22.8 Million Series A
>> Inscopix Launched Cloud-Based Platform for Data Management and Analysis
2:15 | Meet the panel and pick up a book
1:54 | Jester King Brewery
2:25 | Rune Labs
2:50 | Neurostimulator for deep brain stimulation therapy
3:23 | INBRAIN Neuroelectronics
4:11 | Inscopix
5:24 | Ursula K. Le Guin’s 'The Dispossessed'
6:19 | Yuval Noah Harari’s 'Sapiens: A Brief History of Humankind'
6:32 | Daniel G. Miller’s 'The Tree of Knowledge'
6:40 | Jiddu Krishnamurti’s 'The Book of Life'
7:34 | Barack Obama’s 'A Promised Land,' ‘Dreams from my Father,’ & ‘The Audacity of Hope’ 7:56 | Karl Popper’s 'The Open Society and Its Enemies'
9:25 | Venture Capital in Neurotech
34:44 | Business Strategy in Neurotech
40:32 | Tom Oxley, CEO, Synchron
43:58 | Dr. Thomas Insel
44:06 | Mindstrong Mental Health Care
44:35 | Aduhelm controversy
52:25 | Galvani Bio
59:39 | Percept Neurostimulator
1:00:32 | Neuromodulation and the future of treating brain disease
1:07:21 | Software as a Medical Device FDA Guidance
1:09:12 | State of Animal Model Systems
1:14:28 | α-Synuclein in Parkinson's Disease
1:18:01 | Alto Neuroscience
1:18:36 | Flatiron Foundation
1:18:45 | Gaurdent Health
1:19:03 | Melanoma Trends & Rates
1:21:41 | The Pharma-Data-Device Ecosystem
1:21:42 | Frank Fischer, Chairman of Neuropace
1:22:28 | Neurotech Pub Season 1, Episode 9
1:26:35 | Roche acquisition of Flatiron Health & merger with Foundation Medicine
1:27:12 | Companion Diagnostics
1:28:29 | Adhulem and PET imaging
1:29:09 | Resignations at the FDA over Alzheimer’s Drug
1:29:32 | Derek Lowe’s take on the Aducanumab Approval, FDA Committee Votes, Halting the Aducanumab Trials, & The FDA Advisory Committee Briefing Document on Aducanumab
1:31:39 | Donanemab receives breakthrough therapy designation in 2021
1:36:58 | Mapping the Frontal-Vagal Pathway
1:37:09 | The Human Connectome Project
1:40:07 | Teal Organizations and Holacracy
1:41:18 | Society for Neuroscience
1:44:37 | Affymetrix (Thermo Fisher Scientific)
1:44:39 | Illumina
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