chronological age

Tired of getting older? Maybe you don’t have to. This week we’re joined by Dr. Anil Bajnath as he walks us through the complexities of senescent cells. Learn about the differences of chronological age and biological age, recent findings, and much more from this week’s guest. Each Thursday, join Dr. Raja and Dr. Hadar, board certified dermatologists, as they share the latest evidence based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com.

Anil Bajnath, MD MBA is a Board-Certified Family Physician. Author of The Longevity Equation: The Step-By-Step Blueprint to Hack Your Genes, Optimize Your Health, And Master the Art of Existence. Dr. Bajnath currently serves as Adjunct Faculty with the Department of Clinical Research and Leadership at George Washington University School of Medicine and is the current course director for INTM 6205: Clinical Genomics, Proteomics, & Metabolomics. He is also the CEO and founder of the Institute for Human Optimization Precision Medicine Research Group located in Annapolis, Maryland.

His practice offers a range of services from conventional preventative screening guidelines to precision personalized healthcare modalities including individualized nutrition, genomic medicine, advanced biomarker testing, microbiome analysis, and biometric lifestyle monitoring. Dr. Bajnath additionally serves as the Chief Medical Advisor of BajnathMD™ Longevity Nutraceutical Formulas and The Longevity Insider HQ Publications. Dr. Bajnath’s primary field of interest is understanding the underlying causes of unresolved illness and formulating care plans for resolving these complex medical scenarios. He also actively researches pharmacogenomics, nutrigenomics, and the microbiome sciences.

To learn more about taking an Integrative Approach to Assessing the GI Tract, attend Dr. Bajnath's lecture at the 2023 Integrative Dermatology Symposium.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

 …you’ll learn how biological age, rather than chronological age, is the primary risk factor behind diseases like cancer, heart disease, diabetes, strokes, even Alzheimer’s. Scientific discoveries show chronological aging may be written in the epigenome, those chemical tags attached to your DNA that control the way DNA operates.

We’re finding out more about both types of aging because of scientists like Morgan Levine, Ph.D., a leading voice in the field of aging and longevity science. She focuses her research on the science of biological aging, emphasizing health span over lifespan. 

“If you take the difference between someone’s biological age and chronological age, it should predict the things we care about, the actual things we're trying to prevent—so death, disease,” she says. 

She’s an assistant professor of pathology and the Director of the Laboratory for Aging in Living Systems at Yale University School of Medicine. Her team looks at using bioinformatics to quantify the aging process and test how lifestyle and pharmaceuticals alter the rate of aging. 

She’s also a founding Principal Investigator at Altos Labs, a biotech company that focuses on cellular rejuvenation programming to restore cell health and resilience.

Today, she’s going to talk about the science of aging and longevity explored in her new book, “True Age: “Cutting-Edge Research to Help Turn Back the Clock.” Three main drivers—health behaviors, recent stressors and adversity, and genetics—determine your biological aging. She shares how to measure your own biological age and why you should track your aging regularly. 

This conversation gets into topics and makes them make sense for your own aging, like:

• Epigenetics & epigenetic clocks
• DNA methylation & telomeres
• Cell lifespan 
• Ageotypes (molecular assessment of aging)
• Phenotypic age
• The “Ceiling” effect
• The “CALERIE” trial
• Nutrition & aging (plants, fasting, ketosis)
• Fitness & aging (energy & brain health)
• Rest & relaxation (sleep & biological programming)

Morgan gives great takeaways on how you can make lifestyle changes to maintain your youthfulness—both inside and out—with low-risk, data-driven biohacking. 

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IN THIS EPISODE OF THE HUMAN UPGRADE™…

 …you’re going to discover how old you really are by taking a dive into the science of epigenetic methylation and biological aging. You’re going to find out about gene function, gene expression and what it has to do with how you age—and why it matters.

Biochemist Ryan Smith co-founded TruDiagnostic, a company focused on methylation array-based diagnostics for life extension and preventive healthcare. TruDiagnostic, a CLIA certified lab and health data company, developed the TRUAGE anti-aging test. 

From a small blood test, TruDiagnostic can tell you your biological age—how old your body acts, based on how it’s functioning (as opposed to your chronological age, which is the number of years you’ve been on Earth). 

Biological age is one of the most impactful pieces of data you can have about yourself. Age is the number one predictor of death, and your biological age matters more than the number of times you’ve been around the sun.  

For example, you could be 42, and if you take great care of yourself, your biological age may be 30… Or, if you take poor care of yourself, your biological age may be 60. 

Either way, TruDiagnostic will tell you how old you really are. And their test goes further than that. After you discover your biological age, TruDiagnostic also gives you a list of strategies to reverse aging based on your unique genetics. In other words, you get personalized anti-aging biohacks—and you can test your age over time to see if you’re getting younger, so you know whether or not your anti-aging hacks are working.

If you can turn back the clock on your biological age, you unlock the door to a longer, better life. 

It feels like the cusp of a big change in longevity research with science and data now more fully supporting this work. TruDiagnostic currently has over 30 approved clinical research studies underway investigating how epigenetic methylation changes impact how long you live and how well you age.

In this episode, you’ll also learn:

• Why men age worse than women, and what you can do about it
• The best ways to predict your biological age (hint: grip strength is one of them)
• How getting COVID changes the speed at which you age
• Why small amounts of stress are amazing for anti-aging (and the right ways to stress your body and brain so you age in reverse)

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