drug delivery

(4:00) - Wearable patch can painlessly deliver drugs through the skin

This episode was brought to you by Mouser, our favorite place to get electronics parts for any project, whether it be a hobby at home or a prototype for work. Click HERE to learn about how wearable technology has been making its way into the medical industry.

(3:00) - 3D printing with bacteria-loaded ink produces bone-like composites

This episode was brought to you by Mouser, our favorite place to get electronics parts for any project, whether it be a hobby at home or a prototype for work. Click HERE to learn about how additive manufacturing is being leveraged in the medical industry from bone replacement to dental guides!

Lipid nanoparticles have been around for decades, but they took a spotlight in the delivery of the COVID19 mRNA-based vaccines. This chemical cage can fuse with cell membranes and deliver a specific payload to a cell. While the delivery to specific cells is routine, are there ways to improve the system to have more specific therapeutic benefit. Dr. John Lewis of Entos discusses lipid nanoparticle chemistry and new formulations that exhibit enhanced capacity to target specific locations and deliver payloads more effectively. We also discuss the current therapies that may benefit from the new technologies. 

A new generation of drug delivery technology is emerging, with new refillable, absorbable, and dissolvable drug delivery systems making their way through clinical trials and into the market. Large pharmaceutical companies, biotech firms, and device startups alike are all developing innovative alternatives to intravitreal injection.

These systems are important for improving compliance and, as a result, patient outcomes. The ability to extend treatment duration also alleviates some of the patient and physician burden that comes with regular injections.

To explore the latest advances in the ocular drug delivery space and their impact on patients and clinics, OIS brought together an A team of medical, venture capital, and industry experts.

Listen to this podcast to hear our panel discuss: 

• Do longer-lasting therapies, injectables, and resorbables represent a new bar for existing technologies?
• What’s in development at Bausch + Lomb, Aerie Pharmaceuticals, and Allergan/Abbvie?
• How will these new delivery systems change the dynamics in the clinic?
• What should companies starting to commercialize keep in mind to ensure success?

(3:00) - Starfish-inspired Robot ⭐️🤖

(11:30) - Drones With Bird-like Legs🚁🦅

Episode 49 was brought to you by Mouser Electronics, Farbod & Daniel’s favorite electronics distributor. Click here to watch the video of Grant Imahara at Carnegie Mellon University discussing biorobotics.

(1:55) - Dragonfly on Titan: 

Dragonfly is the sequel to the Cassini mission from 1997 whose goal was to study the moon of planet Saturn; Titan. Titan’s earth-like features - like it’s atmosphere - has piqued the interest of researchers for years. We hope to better understand the origins of our planet in addition to the formation of biological beings by studying this moon. 

(8:13) - Machine Learning Discovers New Sequence For Drug Delivery: 

Duchenne Muscular Dystrophy (DMD) is a disease that takes a severe toll on the patients that are impacted leading to an average life expectancy of ~26 years. So, when Spectra Therapeutics announced in 2019 that they had developed a drug capable of addressing the faulty proteins the world rejoiced; however, the proposed drug suffers from weak cell membrane penetration which is essential for this treatment technique and that is where this MIT research comes into play. This group has developed a model to analyze experimental data about cell penetrating peptides and formulate the best possible solutions for scientists to test with.

(16:30) - NeckFace: 

Non-verbal cues like our facial features can tell people a lot about how we feel but wouldn’t it be great if we could observe those subconscious cues as well? That is one of the primary goals of NeckFace which has been developed by researchers at Cornell University to continuously monitor and record our facial expressions using a neck brace or a necklace. The device can either be used to teleconference while in motion or record facial data to analyze mood changes throughout the day which can be valuable for gauging mental health.

Robert Niichel, Founder/CEO of SmartTab, explores the concept of personalized wireless drug delivery, including its advantages, barriers, and current status. We also discuss the future of digital medicine, the Internet of Medical Things, AI, and much more!

To find out more about Impetus: https://www.meetwithimpetus.com

Natalie Yeadon LinkedIn: https://www.linkedin.com/in/natalieyeadon/

Impetus Digital Website: https://www.impetusdigital.com/

Impetus Digital LinkedIn: https://www.linkedin.com/company/impetus-digital/

Impetus Digital Twitter: https://twitter.com/impetus_digital

Impetus YouTube: https://www.youtube.com/ImpetusDigital

Robert Niichel: https://www.linkedin.com/in/robert-niichel-54a48038/

SmartTab: https://www.santencanada.ca/

Impetus Digital has been delivering best-in-class virtual and hybrid meetings, events, and programs for global life science companies since 2008. We work closely with clinical, market access, medical affairs, marketing, medical education, and many other departments to virtualize their internal and external stakeholder meetings, such as advisory boards, learning programs, working groups, and congress engagement initiatives. We partner with clients at all stages of the product life cycle, from R&D to loss of exclusivity.

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To learn more about Impetus, our services, and our tools: https://www.meetwithimpetus.com

Natalie Yeadon LinkedIn: https://www.linkedin.com/in/natalieyeadon/

Impetus Digital Website: Home Page

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Twitter: impetus_digital

YouTube: Impetus Digital

This podcast was recorded on February 23rd, 2021

In Episode 1 of the Xtalks Life Science Podcast, Sarah discusses a new condition called “Mask-Associated Dry Eye” and Ayesha talks about Droplet Micron, an innovative insulin needle.

 Tune into this episode to hear a clip from Sarah’s interview with Dr. Richard Hom, optometric director at Anthem Blue Cross and Blue Shield, who talks about the impact of prolonged screen time on eye health. And hear from Anu Rajora, director of medical marketing at HTL-STREFA, the company behind the innovative Droplet Micron insulin needle, who explains why technology needs to make it easier for patients to adhere to medication schedules.

Read the full articles here:

Why Mask-Associated Dry Eye Won’t Necessarily Boost Restasis Sales

Patient Centricity in Insulin Delivery: Improving the Injection Experience with Droplet Micron

For more life science and medical device content, visit the Xtalks Vitals homepage.

Follow Us on Social Media

Twitter: @Xtalks, @XtalksMedDevice
Instagram: @Xtalks
Facebook: https://www.facebook.com/Xtalks.Webinars/
LinkedIn:https://www.linkedin.com/company/xtalks-webconferences
YouTube: https://www.youtube.com/c/XtalksWebinars/featured

This week we veer off the beaten path to bring you a unique panel discussion with industry leaders from Allergan, Santen, Genentech, and Aerie Pharmaceuticals. Each share expertise on drug development technologies and discusses insights on some of the hurdles they have had to overcome to successfully roll out products in pharma.

In 2016, the Australian Government joined a global movement by approving the use of medicinal cannabis. Now in 2020, cannabis prescriptions are rising, but many patients are still turning to the unregulated and therefore unreliable black market.

In this episode, David speaks with chemical engineer and Curtin University academic, Professor Neil Foster, and Little Green Pharma Chief Operating Officer Paul Long, who have been working together on research into cannabis to help make the regulated products safer, more accessible, and more affordable.

Professor Foster from the WA School of Mines: Minerals, Energy and Chemical Engineering and his team developed a new drug delivery system called ARISE (Atomised Rapid Injection for Solvent Extraction) and under a new partnership, Curtin has provided an exclusive worldwide licence to Little Green Pharma for the system.

• What is ARISE technology? (1:05)
• How prohibition impacted medicinal cannabis adoption and research, and other challenges (4:08)
• Can you get high off medicinal cannabis? The difference between THC and CBD (6:10)
• Legitimate medicinal cannabis vs black market cannabis (10:51)
• Who’s using medicinal cannabis and what illnesses does it treat? (12:39)
• Where we’re heading in the future for medical cannabis research and uptake (16:30)
• How much does it cost to access medicinal cannabis? (23:00)

Learn more

• New micro drug delivery system reduces side effects, costs
• Curtin and Little Green Pharma partner on medicinal cannabis
• Medicinal Cannabis
• Little Green Pharma (ASX:LGP) launches new “Classic” medicinal cannabis product

Got any questions or suggestions for future topics?

Email thefutureof@curtin.edu.au.

Curtin University supports academic freedom of speech. The views expressed in The Future Of podcast may not reflect those of the university.

Music: OKAY by 13ounce Creative Commons — Attribution-ShareAlike 3.0 Unported — CC BY-SA 3.0 Music promoted by Audio Library

You can read the full transcript for the episode here

This is the 14th episode of 16 Minutes, our weekly-ish news show where we quickly cover the top headlines of the week, the a16z Podcast way: what’s real, what’s hype from our vantage point in tech. This week, we cover the following news -- with a16z experts general partner Julie Yoo and market dev partner Venkat Mocherla from the bio team, and former CSO/ a16z security operating partner Joel de la Garza -- in conversation with Sonal Chokshi:

1. UPS drones deliver prescriptions -- For the first time ever, drones delivered prescription medication directly to residential homes and retirement homes in North Carolina this month; but why don't we already get drugs by delivery? And what's the significance of pharma as a node in the healthcare system?
2. Apple opens health records to vets -- Apple and the Department of Veterans Affairs announced recently that veterans can now access their health information on their iPhones; why is (or isn't) this significant, and wherefore the promise of EHRs (electronic health records)?!
3. hackers can use lasers to command voice devices -- Security researchers were able to send laser-powered “light commands” to smart assistants (including products like Amazon’s Alexa, Apple’s Siri, Facebook’s Portal, and Google Assistant) to take full control over them at specific distances; how worried should we be, and how does this affect the future of a voice-enabled world?

Relevant/ related links:

• on healthcare delivery and the pharma industry:
  • software eats care delivery by Julie Yoo
  • science, business, and innovation in pharma with Vas Narasimhan, Jorge Conde, Vijay Pande, and Sonal Chokshi
• on hacks of all kinds:
  • https://a16z.com/tag/hacked/