Host: Mario R. Nacinovich, Jr., MSc
Guest: Charles P. Gerba, MD

With rates of monkeypox continuing to rise, what do we need to know about this disease? And how easily can it spread from one person to another? Tune in to hear from renowned microbiologist, Dr. Charles Gerba, a Professor of Environmental Science at the University of Arizona as he explores these topics with Mario Nacinovich.

Host: Mario R. Nacinovich, Jr., MSc
Guest: Julia Bilinska, MD
Guest: Aatish Patel, MD

Monkeypox continues to spread around the globe, and its clinical manifestations can differ from what we’ve seen. What are the newest symptoms of this disease? Learn more about these manifestations from Drs. Aatish Patel and Julia Bilinska from Guy's and St. Thomas' NHS Foundation Trust in London as they talk about their research with Mario Nacinovich.

Guest: Amy Mgonja, PharmD, BCGP, CPPS

Training pharmacists to administer vaccines can reduce barriers to immunizations and improve patient care. Here to discuss the ApHA Pharmacy-Based Immunization Delivery Program and the important role that pharmacists play in educating and vaccinating patients is Dr. Amy Mgonja, clinical consultant pharmacist at Dawa Rx Consulting.

Host: John Russell, MD
Guest: Randy Young, MD

As monkeypox continues to spread across non-endemic countries, how can we detect it in our patients? And what’s being done to stop the spread? Guest and fellow ReachMD Host Dr. Randy Young, a pulmonary disease and critical care medicine physician, joins Dr. John Russell to discuss what physicians should be looking for and how this virus has impacted public health.

Host: John Russell, MD
Guest: Amesh Adalja, MD

Monkeypox is not something we’re used to seeing in non-endemic countries like North America and Europe. Yet its spreading has some experts scratching their heads. Dr. Amesh Adalja, a Senior Scholar at the Johns Hopkins Center for Health Security at the Bloomberg School of Public Health, shares with Dr. John Russell what clinicians need to know about monkeypox amid the global outbreak in non-endemic countries.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Heather Moday, MD

When we say the words behavior, diet, habits, and environment, chances are you don't think of the body's immune system. But based on recent research, all of those factors play a role in influencing immune function. So how can we keep them in mind and boost our immunity in the face of prevalent diseases, including COVID-19? Find out with Dr. Charles Turck as he speaks with Dr. Heather Moday, author of The Immunotype Breakthrough: Your Personalized Plan to Balance Your Immune System, Optimize Health, and Build Lifelong Resilience.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Emily Carroll, JD, MSW

The No Surprises Act aims to protect consumers from surprise medical bills. But how exactly does it go about doing that, and what’s the current status of its implementation? Joining Dr. Charles Turck to share progress and challenges associated with the No Surprises Act is Ms. Emily Carroll, a senior legislative attorney for the American Medical Association's Advocacy Resource Center.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Emily Carroll, JD, MSW

The No Surprises Act aims to protect consumers from surprise medical bills. But how exactly does it go about doing that, and what’s the current status of its implementation? Joining Dr. Charles Turck to share progress and challenges associated with the No Surprises Act is Ms. Emily Carroll, a senior legislative attorney for the American Medical Association's Advocacy Resource Center.

Host: Charles Turck, PharmD, BCPS, BCCCP
Guest: Emily Carroll, JD, MSW

The No Surprises Act aims to protect consumers from surprise medical bills. But how exactly does it go about doing that, and what’s the current status of its implementation? Joining Dr. Charles Turck to share progress and challenges associated with the No Surprises Act is Ms. Emily Carroll, a senior legislative attorney for the American Medical Association's Advocacy Resource Center.

Host: Matt Birnholz, MD
Guest: Peng Zhang, PhD

Oxygen: It's the third most abundant element in our universe. From healthcare to industrial needs, we know oxygen's uses to be far-reaching, but could there still be more therapeutic potential yet?

In an in-depth conversation with Dr. Matt Birnholz, Dr. Pang Zheng presents new evidence of oxygen's potential uses within the healthcare industry.

Host: John Russell, MD
Guest: Meredith Wadman, BM, BCh, M.S.

Until the late 1960s, tens of thousands of American children suffered crippling birth defects if their mothers had been exposed to rubella, popularly known as German measles, while pregnant; there was no vaccine and little understanding of how the disease devastated fetuses.

In June 1962, a young biologist in Philadelphia, using human tissue samples sent from Sweden, produced a line of cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a massive German measles epidemic, the vaccine that would one day wipe out homegrown rubella was introduced. This vaccine has since protected more than 150 million people in the United States, and its development method has also led to other vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles, and adenovirus.

Host Dr. John Russell chats with Meredith Wadman, author of The Vaccine Race: Science, Politics, and the Human Costs of Defeating Disease, about the story of both the science of this urgent race and the political and ethical controversies that nearly ended it prematurely.

Host: Matt Rosenberg, MD
Guest: Aiden Harrington, ANP, CNM

Current CDC Treatment Guidelines include transgender men and women as special populations. These guidelines recommend risk assessment based on current anatomy and sexual behaviors and screening for asymptomatic STIs based on the patient's history and sexual practices.

At a recent live event recorded in Chicago, moderator Dr. Matt T. Rosenberg welcomes Aiden Harrington, ANP, CNM from Howard Brown Health in Chicago, Illinois. Topics covered include health risks in the LGBTQ community, STI screening and treatment, and how to discuss sexuality with your patients.

Host: John Russell, MD

Do pets help prevent allergies? Does the 5-second rule actually exist? And is dirt really good for a child’s immune system?

Host Dr. John Russell talks with Jack Gilbert, Ph.D., Professor of Surgery at the University of Chicago and Director of the Microbiome Institute. Dr. Gilbert is author of the book Dirt is Good, answering questions about the potential benefits of exposure to germs and bacteria. He and Dr. Russell sift through common misconceptions about microbiomes to better understand their actual risks and benefits for the body's immune system, explaining its role in disease and health.

Host: Kathy King, RDN

Lyme disease is one of the most puzzling illnesses on the planet. Anyone who has suffered from its debilitating symptoms knows the frustrations of trying to find a cure.

Joining host Kathy King is Dr. Bill Rawls, physician and author of the book Unlocking Lyme: Myths, Truths and Practical Solutions for Chronic Lyme Disease. Dr. Rawls, who overcame Lyme disease himself, gives a comprehensive, practical review of clinical approaches.

Host: Matt Birnholz, MD
Guest: Robert McNally, MD

From the Villanova Health Summit's Speaker Event, host Dr. Matt Birnholz speaks with guest Dr. Robert McNally, President, and CEO of GeoVax, Inc. They discuss the challenges that biotech companies face when bringing vaccines through clinical trials, and the long-term project being conducted by his colleagues to deliver an HIV vaccine to market.

Host: Ana Maria Rosario
Guest: David Gandell, MD

Genital Herpes Simplex Virus (HSV) infection is a major public health problem. A dramatic upsurge in genital HSV infections have been documented from several prominent studies, making recognition, treatment, and patient counseling strategies more important than ever.

Joining host, Ana Rosario at the Women's Health Annual Visit in Deerborn, MI, is Dr. David Gandell, Clinical Professor of Obstetrics and Gynecology at the University of Rochester and attending phsyician at Strong Memorial Hospital.

Microbial colonization and lung function in adolescents with cystic fibrosis.

Hector A, Kirn T, Ralhan A, Graepler-Mainka U, Berenbrinker S, Riethmueller J, Hogardt M, Wagner M, Pfleger A, Autenrieth I, Kappler M, Griese M, Eber E, Martus P, Hartl D.

J Cyst Fibros. 2016 May;15(3):340-9. doi: 10.1016/j.jcf.2016.01.004. Epub 2016 Feb 5.

Abstract

With intensified antibiotic therapy and longer survival, patients with cystic fibrosis (CF) are colonized with a more complex pattern ofbacteria and fungi. However, the clinical relevance of these emerging pathogens for lung function remains poorly defined. The aim ofthis study was to assess the association of bacterial and fungal colonization patterns with lung function in adolescent patients with CF. Microbial colonization patterns and lung function parameters were assessed in 770 adolescent European (German/Austrian) CF patients in a retrospective study (median follow-up time: 10years). Colonization with Pseudomonas aeruginosa and MRSA were most strongly associated with loss of lung function, while mainly colonization with Haemophilus influenzae was associated with preservedlung function. Aspergillus fumigatus was the only species that was associated with an increased risk for infection with P. aeruginosa.Microbial interaction analysis revealed three distinct microbial clusters within the longitudinal course of CF lung disease. …

A phase 3, multi-center, multinational, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of levofloxacin inhalation solution (APT-1026) in stable cystic fibrosis patients.

Flume PA, VanDevanter DR, Morgan EE, Dudley MN, Loutit JS, Bell SC, Kerem E, Fischer R, Smyth AR, Aaron SD, Conrad D, Geller DE,Elborn JS.

J Cyst Fibros. 2016 Jul;15(4):495-502. doi: 10.1016/j.jcf.2015.12.004. Epub 2016 Feb 4.

Abstract

RATIONALE:

For patients with cystic fibrosis (CF), the use of inhaled antibiotics has become standard of care to suppress chronic Pseudomonas airways infection. There are limited antibiotic options formulated and approved for inhaled use and antibiotic efficacies attenuate over time, making additional inhaled antibiotic classes desirable. APT-1026 (levofloxacin inhalation solution, LIS) is a fluoroquinolone in development for management of chronic P. aeruginosa airways infection in patients with CF.

OBJECTIVES:

To compare the safety and efficacy of a 28-day course of treatment with LIS 240mg or placebo BID in persons ≥12years old with CF and chronic P. aeruginosa infection.

METHODS:

A multinational, randomized (2:1), double-blinded study of LIS and placebo over 28days in CF patients ≥12years with chronic P. aeruginosa infection. Time to exacerbation was the primary endpoint. FEV1 (% predicted) and patient-reported …

Host: Matt Birnholz, MD

In the ongoing global campaign to prevent, treat, and cure HIV and AIDS, there have been countless therapeutic approaches targeting the HIV virus and everything it interacts with on the path to infection. But after decades of relentless infectivity claiming over 25 million lives, what if we could one day simply edit and delete the HIV virus right out of existence?

Joining Dr. Matt Birnholz to discuss a novel research effort to leverage gene editing technology in the fight against HIV is Dr. Kamel Khalili, Professor and Chair of the Department of Neuroscience, Director of the Center for Neuro-virology, and Director of the Comprehensive Neuro-AIDS Center at the Lewis Katz School of Medicine at Temple University.

[Read the Article]

Recent outbreaks of vaccine-preventable diseases in the United States have prompted clinicians, public health officials and the public to pay closer attention to the growing phenomenon of vaccine refusal. A new study looks at the role of vaccine refusal and the risk of measles and pertussis. In recent years, a substantial proportion of US measles cases occurred in people who were intentionally unvaccinated. Vaccine refusal was also found to be associated with an increased risk of pertussis in some populations.

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