immunotherapies

Almost everyone knows someone who has battled cancer. Today, on The Future of Everything, we’re re-running our episode with Professor Jennifer Cochran who is bringing some hope in this area through work she and her lab are doing to find ways to localize therapies directly to the site of cancer tumors for more efficient and effective treatment. You won’t want to miss this one, it’s full of inspiring insights that will hopefully move us toward a future of improving outcomes for cancer patients.

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads or Twitter/X

Connect with School of Engineering >>> Twitter/X

Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode, highlighting the widespread impact of cancer and the need for innovative treatment methods.

(00:00:45) Traditional Cancer Treatments

Overview of conventional cancer treatments: surgery, radiation, and chemotherapy. Challenges and limitations associated with existing treatments.

(00:03:30) New Approaches to Cancer Therapy

Exploration of targeted therapies utilizing biological understanding of cancer cells. 

(00:05:46) Guided Chemotherapy Missiles

Introduction of guest Dr. Jennifer Cochran and her work developing ‘guided chemotherapy missiles’. Dr Cochran explains how they work and the benefits of them.

(00:09:04) Directed Evolution and Designer Proteins

Introduction to the concept of directed evolution, the process of driving evolution in a test tube to create designer proteins with specific properties.

(00:11:16) Utilizing Squirting Cucumber Seed Peptides for Chemotherapy

Dr. Cochran discusses how they transformed a peptide from the seeds of the squirting cucumber into a tumor-targeting agent, the challenges of the process and the current state of the research.

(00:14:56) Immunotherapy and Cancer Treatment

Introduction to immunotherapy and how these therapies work in our body to fight cancers

(00:16:45) Orchestrating Immune Responses: Combining Immunotherapy and Targeted Molecules

Dr. Cochran explains the collaboration between tumor targeting technology and immunotherapy and current developments.

(00:20:08) Making Immunotherapy Accessible: Challenges and Innovations

Dr. Cochran discusses the availability of immunotherapies for cancer patients and the need for broader accessibility.

(00:21:30) Interdisciplinary Collaboration and Technology Application

Exploration of interdisciplinary collaborative research, the challenges and opportunities.

(00:22:59) Translating Lab Discoveries into Treatments

Russ & Jennifer discuss the process and challenges of translating lab research from academia into actual drug development including “ the valley of death”

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads or Twitter/X

Connect with School of Engineering >>> Twitter/X

We speak to Simblified fan (!) and microbiologist Avraneel Paul on a whole bunch of things related to what happens inside our body! Viruses and bacteria, how vaccines work, how those WBC badasses keep us safe, and so on. Along the way, we also speak about exciting advancements like CRISPR, and explore philosophical questions like whether Covid has changed the field... And what a day in the life of a scientist looks like. There's loads of trivia, loads of simblification and a few bad jokes as well in this two-part episode. We hope you like it and have renewed appreciation for scientists (and your body!) after it!

Add one part news, one part bad jokes, one part Wikipedia research, one part cult references from spending too much time on the internet, one part Wodehouse quotes, and one part quality puns, and you get Simblified.

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In our second episode of the “Immuno Oncology Talks”, Associate Professor Evren Alici, from the Karolinska Institutet in Sweden, was invited to discuss NK cell-based cancer immunotherapies, accompanied by his colleague Professor Hans-Gustaf Ljunggren. The primary focus of Professor Alici´s research is on novel NK cell-based therapies, and includes generation and testing of genetically engineered NK cells, like chimeric receptor and CAR-NK cells. Associate Professor Alici is also co-director of the NextGenNK Competence Center (https://ki.se/en/research/nextgennk).

For more information please visit:
Sanofi Immuno Oncology Talks website

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