ketogenic diets

In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to the causes, treatments, and prevention of cancer are covered in this in-depth conversation.

We discuss:

• How Tom got interested in cancer research [9:00];
• Calorie-restricted ketogenic diets, fasting, and epileptic seizures [18:30];
• Otto Warburg and the Warburg effect [30:45];
• Germline mutations, somatic mutations, and no mutations [42:00];
• Mitochondrial substrate level phosphorylation: Warburg’s missing link [51:30];
• What is the structural defect in the mitochondria in cancer? [1:02:00];
• Peter’s near-death experience with the insulin suppression test while in ketosis [1:06:30];
• Insulin potentiation therapy and glutamine inhibition [1:13:15];
• The macrophage fusion-hybrid theory of metastasis [1:39:30];
• How are cancer cells growth dysregulated without a mutation? [1:47:00];
• What is the dream clinical trial to test the hypothesis that we can reduce the death rates of cancer by 50%? [2:03:15];
• How can the hypothesis be tested rigorously that structural abnormalities in the mitochondria impair respiration and lead to compensatory fermentation? [2:26:30];
• Case studies of GBM survivors [2:32:45]; and
• More.

Learn more at www.PeterAttiaMD.com

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Rhonda and I go on a Nerd Safari into the jungle of health, nutrition, fitness, performance, and longevity. We visit IGF-1 and whether there’s a tradeoff of having high or low levels. We discuss the PPARs (receptor proteins) and genetic polymorphisms. Does Rhonda think there’s any benefit in a NAD+ booster for health and longevity? Can saunas lower the risk of heart disease, dementia, and all-cause mortality? 

Rhonda is a wealth of knowledge on so many topics and was the perfect companion to dig into so many fun topics in this episode. She puts a ton of thought into her research and it really shows in this conversation.

We discuss:

• What Rhonda believes differently today than she did a few years ago [5:40];
• The paradox of GH/IGF-1 in performance and longevity [21:00];
• The role of PPAR in fat metabolism and ketogenic diets [23:00];
• The possible genetic explanations for why some patients don’t respond well to a ketogenic diet [31:00];
• The health benefits of heat and cold exposure [1:12:30];
• NAD+ [1:32:45];
• And more.

Learn more at www.PeterAttiaMD.com