mhc

TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Links for this episode

• MicrobeTV Discord Server
• First gene therapy for hemophilia A approved (FDA)
• Luxurna, gene therapy for vision loss (FDA)
• Anti-RSV monoclonal antibody approved (FDA)
• Trial of single-dose Nirsevimab (NEJM)
• Letters read on TWiV 1028
• Timestamps by Jolene. Thanks!

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Dickson – Phoenix hits 110 degrees for the 19th day in a row, setting national record
Brianne – James Webb Telescope One Year Anniversary Photo
Kathy – Drone awards photos
Alan – WHO Film Festival winners
Vincent – Thinking, Fast and Slow by Daniel Kahneman

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David – The Mass Extinction Debates: A Science Communication Odyssey

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Pamela Bjorkman and Andy Mehle

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Bjorkman laboratory
• Mehle laboratory
• Finding the groove (Nat Immunol)
• Structure of HLA-A2 (Nat Immunol)
• Mosaic RBD nanoparticles (Science)
• Influenza virus PB2 627 (J Virol)
• ANP32B or not to be (eLife)
• Influenza virus compartmentalization (Nat Commun)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Listen to a fascinating update about genetic signals, familial risk and the work that's being done to understand how psoriasis and psoriatic arthritis develop from leading dermatologist and geneticist Dr. James T. Elder, Kirk D. Wuepper Professor of Molecular Genetic Dermatology, University of Michigan, Department of Dermatology. This episode is supported by unrestricted educational grants from Amgen, Bristol Myers Squibb, Janssen and Novartis. 

Join us in our 5-Part Mini-Series as we delve into the depths of Title Management. In this episode we cover the Abandoned Mobile Home Process @ Snickfish, and how you can start processing your titles on abandoned homes!

The immunophiles discuss T cell antigen discovery by trogocytosis - the transfer of membrane patches among cells in close contact.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

Subscribe (free): iTunes, Google Podcasts. RSS, email

Become a patron of Immune!

Links for this episode

• Trogocytosis for T cell antigen discovery (Nat Methods)
• Trogocytosis (J Immunol)
• Orphan T cell receptors (Cell)
• Letters read on Immune 18
• Time stamps by Jolene. Thanks!

Weekly Science Picks

Steph- Scientists rise up against statistical significance
Cindy- Why I quit my PhD and returned
Vincent- The Law and Vaccine Resistance

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv