nerve

Someone can get on your nerves. You can have nerves of steel. Heck, they can even be frayed! But have you ever wondered what nerves actually are? If so, you've come to the right place! 

This week, our dear friend and contributor Deboki Chakravarti (@okidoki_boki) stops by to join the fun, and Ceri hosts for the first time ever! Don't miss it!

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A big thank you to Patreon subscribers Garth Riley and Tom Mosner for helping to make the show possible!

Follow us on Twitter @SciShowTangents, where we’ll tweet out topics for upcoming episodes and you can ask the science couch questions! 

While you're at it, check out the Tangents crew on Twitter: Ceri: @ceriley Sam: @im_sam_schultz Hank: @hankgreen

[Truth or Fail]

Electric rays/low voltages to treat painful nerves

https://www.mjrheum.org/assets/files/792/file60_974.pdf

https://arthritis.ca/living-well/2019/women,-arthritis-and-neuropathic-pain

https://my.clevelandclinic.org/health/treatments/15840-transcutaneous-electrical-nerve-stimulation-tens

https://www.nhs.uk/conditions/transcutaneous-electrical-nerve-stimulation-tens/

Mouse tail galvanoscope (sciatic nerve)

https://books.google.com/books?id=SJNMAQAAMAAJ&pg=PA309&lpg=PA309

https://micro.magnet.fsu.edu/optics/olympusmicd/galleries/brightfield/mousetail.html

https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=85&contentid=p01382

Electrically stimulating tastebuds 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1307523/

http://longevity3.stanford.edu/design-challenge-winners-announced/

[Trivia Question]

Glaucoma retinal nerve fiber layer

https://link.springer.com/article/10.1007/s00417-022-05619-4

[Fact Off]

C. elegans auditory nerves

https://www.sciencedaily.com/releases/2022/02/220223103054.htm

https://www.eurekalert.org/news-releases/928925

[Ask the Science Couch]

Paresthesia aka pins and needles 

https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=1&ContentID=58

https://www.ninds.nih.gov/Disorders/All-Disorders/Paresthesia-Information-Page

https://www.racgp.org.au/afp/2015/march/paraesthesia-and-peripheral-neuropathy

https://journals.sagepub.com/doi/abs/10.1177/0305735610362950

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384201/

https://journals.sagepub.com/doi/10.1177/107385840200800209

[Butt One More Thing]

Sciatic butt nerve

https://www.scielo.br/j/acb/a/rwFj4BBy4p35XbfKDLNFLkx/?lang=en

https://www.mayoclinic.org/diseases-conditions/sciatica/symptoms-causes/syc-20377435#:~:text=The%20sciatic%20nerves%20branches%20from,one%20side%20of%20your%20body.

https://my.clevelandclinic.org/health/diseases/12792-sciatica

John Waupsh, Co-Founder, Nerve

Historically, banks offered services tailored to their local geographies. Today’s banking communities aren’t defined by rivers and railroads but by the shared experience and goals of their customers. Nerve is a mobile app that merges data from streaming revenue sources, aiming to meet the unique business needs of music professionals. Robin Amlôt of IBS Intelligence speaks to John Waupsh, Co-Founder of Nerve.

In this mini episode, Hillary dives into the anatomy of carpal tunnel syndrome. You will learn about the parts of the body that are involved in carpal tunnel syndrome, common causes, symptoms, and solutions. 

The articles below were used as a reference for this episode. 
https://orthoinfo.aaos.org/en/diseases--conditions/carpal-tunnel-syndrome/
https://www.ncbi.nlm.nih.gov/books/NBK546607/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558235/ https://my.clevelandclinic.org/health/diseases/4005-carpal-tunnel-syndrome

You can connect with Hillary on Instagram @theanatomynerdpodcast or feel free to send her an email at theanatomynerdpodcast@gmail.com 

The Center for Medical Education's new course title EMCert Module Mastery has been designed to guarantee participants a passing grade on the new MyEMCert exams from ABEM.  This episode comes from the Trauma Module and discusses head and neck trauma.

Cranial Nerve function and testing, neurologic examinations, head trauma, Coup-Contrecoup head injuries, skull fractures, Basilar skull fractures, Epidural Hematoma, Subdural Hematoma, Brain Herniation, ICP treatments, Traumatic Seizures, Axonal Injuries, Pediatric Head Trauma, Neck Injuries, Foreign Bodies, Carotid Artery Dissections, etc...

To learn more, visit https://ccme.org/emcertmodule

Í þessu framhaldi af síðasta þætti tala þrír lyfjafræðinemar áfram um eitur og mögulega efnavopn eða eitthvað lol sem gæti kannski hafa mögulega orðið að lyfjum. Eða hvað?

Í þessum þætti fara þrír lyfjafræðinemar í það hvernig sum eitur urðu að lyfjum. Fyrri hluti.

Und da wären wir auch schon: Das Finale von RuPaul’s Drag Race All Stars 6 ist hier! Einerseits verging diese Staffel wie im Flug, andererseits fühlt es sich an als würden wir diese Queens schon das ganze Jahr über begleiten. Doch jetzt haben wir die finalen Vier und nur eine kann gewinnen. Wer das ist, entscheidet die letzte Challenge, eine Strophe zu dem neuen Country Song „This Is Our Country“ zu schreiben, zu singen und live zu performen. Beim All Star Hall of Fame Eleganza Extravaganza Runway zeigen sich alle nochmal von ihrer besten Seite, bis es dann schließlich zum großen Lip Sync um die Krone geht. Am Ende haben wir einen neuen Champion. Wer das ist, und wie Geeo und Max das Finale und die Staffel fanden, erfahrt ihr natürlich hier bei The Gayze.

Mit großer Freude können wir verkünden: Unsere griechische Lieblingstante ist zurück! Nach drei Folgen ist Geeo wieder dabei und er kommt nicht allein, denn auch der Special Guest Host Martin gesellt sich in dieser Episode von The Gayze dazu. Zusammen mit Max entsteht so die dreifache Reviewpower. Gebraucht wird diese für die vorletzte Folge von All Stars 6, in der sich entscheidet, wer in das große Finale einzieht, diesmal aber auch wirklich. Welche Queen schafft es sich mit ihrem Charisma, Uniqueness, Nerve, and Talent Monologue in die Herzen der Judges und somit direkt ins Finale zu reden? Für welche Queen ist der lange Weg leider so kurz vorm Ziel vorbei? Und warum wäre Geeo fast nicht rechtzeitig wieder zurück? Alle Antworten gibt es natürlich in dieser Episode.

We kick off with a fresh helping of rap from certified barmen Nerve and JK-47 and you'll hear what it sounds like when a Sydney solo artist takes her queen energy to the next level on a song made in a castle.

A SPECIAL ANNOUNCEMENT!!!

To whom it may concern, we have made it even easier for you to support our work via the cashapp! Please send your donations once, monthly or annually to EBisrael and we will send you back a cashapp receipt for your taxes! Whatever you can afford would be greatly appreciated, as it would assist us in adding an even greater library of content for you and all you love to enjoy whenever you like! We love you and thankyou in advance for your support!

A motor nerve is a nerve located in the central nervous system (CNS), usually the spinal cord, that sends motor signals from the CNS to the muscles of the body. This is different from the motor neuron, which includes a cell body and branching of dendrites, while the nerve is made up of a bundle of axons.

Psalm 139:13-16 KJV

13 For thou hast possessed my reins: thou hast covered me in my mother's womb.

14 I will praise thee; for I am fearfully and wonderfully made: marvellous are thy works; and that my soul knoweth right well.

15 My substance was not hid from thee, when I was made in secret, and curiously wrought in the lowest parts of the earth.

16 Thine eyes did see my substance, yet being unperfect; and in thy book all my members were written, which in continuance were fashioned, when as yet there was none of them.

A SPECIAL ANNOUNCEMENT!!!

To whom it may concern, we have made it even easier for you to support our work via the cashapp! Please send your donations once, monthly or annually to EBisrael and we will send you back a cashapp receipt for your taxes! Whatever you can afford would be greatly appreciated, as it would assist us in adding an even greater library of content for you and all you love to enjoy whenever you like! We love you and thankyou in advance for your support!

In higher vertebrates (reptiles, birds, mammals) there are 12 pairs of cranial nerves: olfactory (CN I), optic (CN II), oculomotor (CN III), trochlear (CN IV), trigeminal (CN V), abducent (or abducens; CN VI), facial (CN VII), vestibulocochlear (CN VIII), glossopharyngeal (CN IX), vagus (CN X), accessory (CN XI), and hypoglossal (CN XII). Lower vertebrates (fishes, amphibians) have 10 pairs. A 13th pair, a plexus (branching network) known as the terminal nerve (CN 0), is sometimes also recognized in humans, though whether it is a vestigial structure or a functioning nerve is unclear.

Cranial nerves are made up of motor neurons, sensory neurons, or both. They are named for their function or structure; for example, the trigeminal nerve consists of three primary branches, while the vestibulocochlear nerve serves the organs of equilibrium and hearing. The vagus nerve is one of the most important; it extends to many of the organs in the chest and upper abdomen.

Psalm 139:13-16 KJV

13 For thou hast possessed my reins: thou hast covered me in my mother's womb.

14 I will praise thee; for I am fearfully and wonderfully made: marvellous are thy works; and that my soul knoweth right well.

15 My substance was not hid from thee, when I was made in secret, and curiously wrought in the lowest parts of the earth.

16 Thine eyes did see my substance, yet being unperfect; and in thy book all my members were written, which in continuance were fashioned, when as yet there was none of them.

Ever wonder what a Confidence Man meets LCD Soundsytem lovechild might sound like? You'll hear that from a Melbourne newcomer as well as the Aus-indie crossover of BUGS and Ball Park Music.

Nerve makes his case for having the best bars in the country and meet King Stingray, the children of Yothu Yindi carrying the torch with their Yolgnu surf rock

Let Dave Ruby Howe (triple j Unearthed’s Music Director) give you the hot scoop on five of his favourite Unearthed uploads this week. Listen up as he serves slices of new music from The Nights, Nerve, Chymes, Ms. Thandi and The Lulu Raes.

Travel the parasympathetic pathways of cranial nerves 7 and 9 to review how the salivary glands are innervated. 

A few months ago, I briefly mentioned on a podcast that I discovered that by taking a specific blend of nutrients to support my vagus nerve, I was able to completely get rid of morning constipation. Today, my podcast guest, Dr. Diana Driscoll, is the individual who actually designed that blend, and who knows a heckuva lot about the vagus nerve and its interplay with our bodies.

Dr. Diana Driscoll is an optometrist who had always been healthy - she was also a bit of an exercise fanatic who also geeked out with nutrition. But despite this history, she was struck down by an illness that few understood and was disabled for over a decade. Ultimately, she was diagnosed with something called POTS (Postural Orthostatic Tachycardia Syndrome) - a disorder of the autonomic nervous system and was told there was no cure for this mysterious condition.

When her children also became ill and doctors had no answers, she formed Genetic Disease Investigators to formally study these conditions. Dr. Driscoll is considered to be “the patients researcher”, bypassing notoriously slow academic research institutions to get answers quickly.

Twelve years later, she is now the director of POTS Care – the only POTS Clinic focused on searching for the underlying cause of POTS, and treating it at its source. She has received two patents to date, and is now not only helping patients who are ill -- she is reaching out to healthy folks who want to improve their quality of life and maximize their health, even into old age. Dr. Driscoll graduated summa cum laude from both The University of Houston College of Optometry and The University of Texas at Austin. She is a geek, through and through.

She is a member of the International Society of Neurovascular Disease, the American Headache Society, the Medical Advisory Board for EDS Network C.A.R.E.S, the American Optometric Association, the Tear Film and Ocular Surface Society, and served as a medical advisor for the Ehlers-Danlos National Foundation.   Her peer-reviewed medical abstracts include those involving vascular abnormalities in the fundus of POTS patients, the etiology of left ventricular diastolic dysfunction, and the use of acetazolamide in multiple sclerosis.

She is the author of “The Driscoll Theory” and “Your Eyes and EDS”, and was the chief author of the “Ophthalmology Medical Resource Guide” for Ehlers-Danlos National Foundation. 

Dr. Driscoll is the recipient of numerous awards for patient advocacy and continues to donate her time to help others across the globe through her online forum and videos on YouTube. Her work in chronic inflammation, the autonomic nervous system, collagen disorders, and organ dysfunction can help others live their best life, as well as have their best body and mind.

• Contracted a virus during a missions trip to Costa Rica, but she was unable to kick it
  • Difficulty breathing
  • Poor sleep
  • Racing heart
  • Poor digestion
  • Developed a tremor
  • Memory loss
  • Difficulty handling any type of stress
• Her kids began to develop similar symptoms
• Treatment included more exercise; but nothing worked
• Was disabled due to fatigue for over a decade

• "Layers of discovery" over the course of several years
• Diana's blog
• The Driscoll Theory
• Abnormal inter cranial pressure
• Inflammation was a factor
• The exaggerated symptoms actually made it easier to discover the causes
• Genetics play a large role (her children experienced the same symptoms)
• Started by looking at the eyes (great window into systemic illness)

• POTS is not a disease, it's a symptom
• There was no specific diagnosis for her condition
• Dysfunction of the autonomic nervous system
• ALS/Parkinson's begin with POTS symptoms
• Astronauts get POTS while in space, due to the lack of gravity

• The abnormal inter cranial pressure is indicative of a poorly functioning vagus nerve
• When symptoms occur simultaneously (difficulty breathing, racing heart, gut dysfunction, etc.) it could be the vagus nerve
• Ileocecal valve is linked to POTS and nerve function
  • Vagus nerve controls the function of the valve
• Gastro motility linked to migrating motor complex (cleaning up digestive system)
  • Triggered by signals from the vagus nerve

• A kidney stone turned up 3 days after being cleared for kidney stones
• The doctor confirmed the ileocecal valve was problematic
• A surgeon refused to open the valve
• Two parts of vagus nerve: preganglionic (extremely long) and postganglionic (extremely short)
• Diana tried to stimulate the postganglionic nerve
• The vagus nerve is a nicotinic acido cholinergic nerve (nicotine is the imitator of the vagal neurotransmitter)
• She put a nicotine patch over the side of the ileocecal valve
  • Within hours, the symptoms began to subside
• This changed the way Diana viewed the cause of the problem:
  • It wasn't an autoimmune condition affecting the receptors
  • It was either a preganglionic vagus nerve or a neurotransmitter problem
• Ultimately nicotine was not a viable long-term solution

• Parasym Plus (use code GREENFIELD for 10% off on all products)
• Established goals:
  • Use supplements already deemed safe by the FDA
  • Wanted it to work in spite of genetic issues
  • Stimulate postganglionic nerve just as nicotine did
  • Cross the blood-brain barrier to help cognition
• Vagus nerve problems can be mistaken for acetylcholine production issues and vice versa
• CHAT gene provides instructions for making a protein called choline acetyltransferase
• It needed to account for nutrient malabsorption
• Finding the right balance between stimulation and overstimulation of the vagus nerve was a challenge
• Parasym is not a stool softener or a laxative; it allows a normal bowel movement by making the vagus nerve work properly
• Primary ingredients: Huperzine, Acetyl-L-carnitine, Alpha glycerylphosphorylcholine
• Onnit Alpha Brain (use BEN for a 10% discount)
• Diana was able to acquire a patent because of the unique blend (and balance) of ingredients; it's not just another nootropic

• Pupil size is an indicator of the condition of the autonomic nervous system
  • The sympathetic and parasympathetic nervous systems are out of balance, resulting in large pupil sizes
  • High sensitivity to light
  • Pupils responded more consistently than HRV

• Need to look for symptoms; there's no codified way of testing for problems
• Genetic tests can identify issues to a limited degree
• BravermanTest.com 
• BoundlessBook.com

• Some will always need help
• Feeling "good enough" can be deceptive
• Vagus nerve is the anti-inflammatory pathway of the body
• Reasons typical stimulants of the vagus nerve won't work:
  • Damage to the nerve
  • Genetic issues
  • Some inflammatory psydochines block the release of acetylcholine

-Parasym Plus (use code GREENFIELD for 10% off on all products!)

-Huperzine

-Tianchi

-Diana's blog at PrettyIll.com

-The POTSCare.com website

-Book: The Driscoll Theory  by Dr. Diana Driscoll

-My podcast with Dr. Sarah Myhill "The Ultimate Guide To Beating Chronic Fatigue With Specific Vitamins, Minerals, Biohacks & More – A Conversation With Dr. Sarah Myhill."

-The LUCY nicotine gum Ben chews

-Onnit Alpha Brain (use BEN for a 10% discount)

-Qualia Focus and Qualia Mind

-BravermanTest.com 

-BoundlessBook.com

-My podcast on "32 Ways To Support The Vagus Nerve"

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