parkin

Discover how to stop struggling and find fulfilment, joy, and inspiration by saying "F**k It" to the stress, problems, and chaos in your life. In this episode, UK Managing Director Michelle Pilley talks to international best-selling author John C. Parkin about how saying “f- it” can transform your life. By reminding us to stop listening to other people and start listening to ourselves, we can take a leap and unlock freedom and happiness.  You can listen to John’s newly revised audiobook, F**k It: The Ultimate Spiritual Way FREE for 14 days in the Empower You Unlimited Audio App. To download the app today, Apple users visit hayhouse.com/apple and Android users visit hayhouse.com/google. 

Today on the You Can Heal Your Life podcast, you’ll hear a chapter from international best-selling author John C. Parkin’s newly revised audiobook, F**k It: The Ultimate Spiritual Way. John introduces the concept of saying “f - it” to the problems and chaos in your life and explains the freedom and joy created by releasing other people’s judgements with these two magic words.  You can listen to the full audiobook FREE for 14 days in the Empower You Unlimited Audio App. To download the app today, Apple users visit hayhouse.com/apple and Android users visit hayhouse.com/google. 

Jon Parkin is the superintendent at the Madison County Historical Museum and Archival Library. Mr. Parkin also was an award-winning educator before retiring after 25+ years at Edwardsville High School. In this podcast, we primarily talk about the American War of Independence, but end up covering a plethora of historical topics that tie into modern politics. Hosted by Drew Bradley and Anthony Kindle.

For donations towards the Madison County Historical Museum renovations, click here https://madcohistory.org/capital-campaign/

Jon Parkin is the superintendent at the Madison County Historical Museum and Archival Library. Mr. Parkin also was an award-winning educator before retiring after 25+ years at Edwardsville High School. In this podcast, we primarily talk about the American War of Independence, but end up covering a plethora of historical topics that tie into modern politics. Hosted by Drew Bradley and Anthony Kindle.

For donations towards the Madison County Historical Museum renovations, click here https://madcohistory.org/capital-campaign/

Jon Parkin is the superintendent at the Madison County Historical Museum and Archival Library. Mr. Parkin also was an award-winning educator before retiring after 25+ years at Edwardsville High School. In this podcast, we primarily talk about the American War of Independence, but end up covering a plethora of historical topics that tie into modern politics. Hosted by Drew Bradley and Anthony Kindle.

For donations towards the Madison County Historical Museum renovations, click here https://madcohistory.org/capital-campaign/

Jim pulls another classic Bert I. Gordon film into the spotlight with 1957's "The Cyclops," starring Gloria Talbott, Lon Chaney Jr., James Craig, Tom Drake and Duncan Parkin. While looking for her finance, who crashed in a remote area of Mexico, a young woman and her expedition happen upon strange creatures and 125-foot giant. But the area has another shocking secret. Find out more on this episode of "Monster Attack!"

Jim re-visits the story of Col. Glen Manning with a look at Bert I. Gordon's cult classic from 1958, "War of the Colossal Beast," starring Sally Fraser, Russ Bender, Roger Pace and Dean Parkin. It seems Col Manning survived the fall off Boulder Dam and is terrorizing the remote countryside in Mexico. Can he be saved? His sister certainly hopes so. It is all answered for you on this episode of "Monster Attack!"

This week Laine returns and we are joined with special guest, Lance Parkin, the Director and actor involved in the new Amazon Prime Web Series, "Theo and The Professor.  Lance is quickly becoming a local fixture in the Pittsburgh film community with his involvement in organizing The Haunted Oaks and Indie Oaks Film Festival as well as cranking out quality short films and now a web series through his production company Locust Street Entertainment. 

Drp1 cuts off mitophagy

Misfolded mitochondrial proteins can be eliminated by Parkin-dependent mitophagy but how this process selectively removes damaged mitochondrial regions is unclear. Burman et al. reveal that protein aggregates in the mitochondrial matrix trigger a local accumulation of Parkin on the mitochondrial outer membrane, and that the mitochondrial fission protein Drp1 segregates these domains to prevent Parkin accumulation from spreading and directing the elimination of healthy regions of the organelle. This biosights episode presents the paper by Burman et al. from the October 2nd, 2017, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Richard Youle (NINDS, NIH). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

Join Siobhan as she rattles through a few things that you may like for xmas....