russ altman

Discover the astonishing intricacies of microbial ecosystems and their potential to improve healthcare.  Guest KC Huang is many things: A bioengineer. A microbiologist. An inventor. But mostly he’s an expert on the ecology of the human gut. He and his collaborators have developed a device that can sample bacterial DNA and create a living map of the gut microbiome from mouth to … ah, well … you know. Every step of the way, he says, we play host to trillions of guests we know very little about. It’s time we got to know them, Huang tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Chapter Timestamps:

(00:00:00) Introduction

Russ introduces the gut microbiome and its impact on health. The potential for engineering ourselves through microbiome manipulation.

(00:00:57) Overview of Gut Microbiome

Russ Altman introduces the guest, KC Huang. KC provides an overview of the gut microbiome and its impact on health and everyday life.

(00:05:21) Challenges in Studying the Gut Microbiome

KC Huang discusses the challenges in studying the gut microbiome, including the limited data and the difficulty in accessing the ecosystem.The unique interface between human cells and gut microorganisms is emphasized.

(00:07:02) Poop as a Data Source

Russ Altman humorously mentions the collection of poop for research purposes. The difficulties in studying the bowel's internal microbiome are discussed.

(00:08:53) Diversity of Gut Microorganisms

KC Huang addresses the diversity of microorganisms in the gut microbiome. The challenges of characterizing the complex ecosystem are highlighted.KC Huang corrects a common misconception about the location of the gut microbiome. The gut microbiome as an external influence on the human body is explained.

(00:10:45) The Impact of Gut Microbiome Beyond Bowel Movements

Russ Altman mentions the gut microbiome's influence on brain function, diet, exercise, and more. The far-reaching effects of the gut microbiome are introduced.KC Huang addresses the connection between the gut microbiome and brain function. The constant interaction between microorganisms and the brain is emphasized.

(00:12:22) Impact of Gut Microbiome on Sleepiness

The relationship between post-meal sleepiness and gut microbiome activity is mentioned. The gut as a source of constant growth and activity is explained.

(00:13:19) The Device for Studying the Gut Microbiome

KC Huang introduces an innovative device designed to study the gut microbiome by collecting samples at different points in the gut. The device's simplicity and capabilities for multi-dimensional analysis are highlighted.

(00:17:32) Exercise and Its Effect on Body Temperature

The role of exercise in increasing body temperature and its potential influence on the gut microbiome is explored. Possible connections between exercise, temperature, and gastrointestinal effects are mentioned.

(00:21:55 ) The Student Survey on Microbiome Therapies

KC Huang shares the results of a student survey about microbiome-based therapies, highlighting changes in perception after studying the field. The evolving excitement and uncertainty surrounding the field's future are mentioned.

(00:23:52) The Need to Embrace Ecosystem Complexity

KC Huang emphasizes the importance of embracing the complexity of the gut microbiome ecosystem. The limitations of reductionist approaches in the field are highlighted.

(00:28:20) Complexity with a Thousand Species

KC Huang explores the challenges of dealing with complex microbial ecosystems containing thousands of species. The significance of interactions between these species is discussed.

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Guest Jane Willenbring is a geoscientist who studies accelerating coastal erosion. The challenge lies not in understanding why coasts are receding today, but in determining what they looked like a thousand years ago to know how much they’ve changed — a secret revealed in coastal rocks through isotopes shaped by cosmic radiation. But measurement is only one part of the equation, she says. We must now think about erosion’s impact on humans, Willenbring tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Chapter Timestamps:

(00:00:00) Introduction by Jane Willenbring 
Jane Willenbring, a distinguished expert in coastal erosion and a professor at Stanford University, joins Russ Altman to explore "The Future of Coastal Erosion."

(00:01:42) Defining Coastal Erosion

Dr. Willenbring provides an overview of coastal erosion, explaining its causes and effects on coastlines around the world. She discusses the natural processes and human influences contributing to coastal landscape erosion.

(00:04:56) Challenges of Coastal Erosion

The conversation delves into the challenges of coastal erosion, including the impacts on infrastructure, property, and communities. Dr. Willenbring highlights the complexities of addressing erosion in different geographical regions and the importance of understanding erosion rates.

(00:06:44) Erosion Rates and Predictions

Dr. Willenbring discusses the methods used to measure erosion rates and predict future coastal changes. She explains how these predictions can guide policy and planning decisions to mitigate the impacts of erosion.

(00:10:49) Impacts on the Infrastructure 
Dr. Willenbring shared the impacts on the infrastructure and on the actual coast. Also shared all the different kinds of reasons to be concerned about the same.

(00:12:44) Interplay with Policy and Planning

The conversation shifts to the intersection of coastal erosion with policy and planning. Dr. Willenbring explores how episodic erosion events and long-term projections influence decision-making for infrastructure and land use.

(00:15:49) Building Bridges vs. Managed Retreat 
Exploration of options for addressing coastal erosion, such as building bridges.Consideration of the downsides of building bridges and hardening infrastructure. Examination of landscape "unzipping" and its implications for erosion.

(00:18:15) Sea Level Rise and Its Coastal Impact
Delve into the ways in which sea level rise affects coastlines and the Impact of flooding and potential changes in coastal shapes. Explore the significance of wide beaches in protecting coastlines.

(00:22:33) Displacement and Human Impacts 
Delve into the potential displacement caused by coastal erosion. Focus on the impact on low-income communities and indigenous villages. Reflection on the ethical considerations of policy responses.

(00:25:16) Health Implications and Infrastructure Challenges

Examining the potential health risks associated with coastal erosion.Consideration of compromised water treatment plants and their consequences.Discussion on the uncertainties and challenges of responding to erosion-related threats.

(00:26:34) Role of Vegetation in Coastal Defence

Explore the role of vegetation in protecting coastlines. Difference between invasive and native plants in coastal environments.Insights into the potential use of kelp for wave buffering.

(00:27:50) Human Activities and Cliff Stability

Examining the impact of human activities, such as irrigation, on cliff stability. Discussion on the potential consequences of excessive water use on erosion.

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Join host Russ Altman with guest Rania Awaad, M.D.,  a Clinical Associate Professor of Psychiatry at the Stanford University School of Medicine where she is the Director of the Stanford Muslim Mental Health & Islamic Psychology Lab.  Delve into the intersection of mental health and spirituality, shedding light on the importance of holistic approaches for comprehensive healing. Drawing from historical wisdom, Awaad introduces the concept of Maristans, ancient healing centers that integrate physical, mental, and spiritual therapies to offer a holistic model of care. 
As the conversation unfolds, listeners gain a deeper understanding of how these principles can be applied in modern healthcare, fostering patient-centric approaches that consider mind, body, and spirit. From addressing diverse faiths to collaboration between medical and spiritual practitioners, Awaad's insights pave the way for a future where holistic healing is at the forefront of medical practice.

Chapter Timestamps:

(00:00:00) Introduction

Rania Awaad discusses her journey in studying the connection between Islam and mental health, including historical understandings of mental illness and treatments, such as talk therapy.

(00:03:05) Special Challenges in Studying Muslim Mental Health

Professor Awaad discusses the challenges of providing mental health care to the diverse Muslim community in the United States. The impact of immigration, intergenerational trauma, and racial diversity on mental health is highlighted. Factors like acculturation, family dynamics, and historical trauma are considered.

(00:06:50) The Intersection of Faith and Mental Health

Professor Awaad shares insights into how the Islamic faith intersects with mental health. The concept of holistic health in Islam and its implications for mental health are explained. Early Muslim scholars' references to scripture in understanding and treating mental illness are discussed.

(00:13:13) Faith and Resistance to Treatment

The conversation delves into addressing resistance to medical treatment based on religious beliefs. The concept of "spiritual bypassing" is introduced, where religious frameworks are used to explain mental health issues. Professor Awaad shares her unique approach as a dual-trained psychiatrist and theologian.

(00:14:22) Transferring Knowledge to Practitioners

Russ Altman inquires how to transfer Professor Awaad's insights and dual training to other practitioners. The role of her nonprofit, Maristan, in providing training and resources is highlighted. The development of integrated psychotherapy models and training is discussed.

(00:17:09) Common Threads in Different Faiths

The discussion explores commonalities in mental health challenges and solutions across Abrahamic faiths. The potential for sharing insights and strategies among different religious communities is emphasized.

(00:19:19) The Impact of COVID-19 on Muslim Mental Health

The challenges faced by the Muslim community during the COVID-19 pandemic, especially during Ramadan, are discussed. Professor Awaad shares findings from a global study on Muslims' mental health perceptions during the pandemic.

(00:23:00) Maristan: A Place of Healing

The nonprofit organization Maristan is introduced, and its name's historical significance is explained. The role of Maristan in integrating spirituality and mental health care is discussed, along with its goal of making mental health care more accessible to all communities. While modern languages have introduced alternative terms for hospitals, the historical terminology persists in some regions.

(00:25:10) Bringing Holistic Healing to Modern Medicine

Russ Altman discusses the concept of healing centers and the need to reintroduce holistic healing into modern medicine. Professor Awaad shares her vision of Maristans serving as a model for modern healthcare, emphasizing holistic care for the mind, body, and soul.

(00:27:21) Maristans: A Model for Holistic Healing

Russ Altman reflects on the patient's desire for holistic care and the limitations of current medical practices. Professor Awaad describes the architectural and therapeutic aspects of Maristans, highlighting their use of water fountains, greenery, acoustics, and sound therapy. The contrast between Maristans and historical asylums/prisons for the mentally ill is discussed.

 

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Bad science is a big problem for society, says guest Jonathan Osborne, an expert in science education, but we don’t have to surrender to it. Beating bad science requires young people to learn three skills, Osborne says. First is an ability to size up conflicts of interest. Second, to evaluate a source’s qualifications. And third, to more rigorously question those who go against consensus. The whole goal of science is consensus, Osborne tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Chapter Timestamps:
(00:00:00) Introduction to the Episode

Welcome to this episode featuring an insightful conversation with Jonathan Osborne about the nuances of scientific argumentation and its implications for education.

(00:2:00) The state of science education

The situation is a pretty dire, and we need to act soon to make sure that we outfit the future generations with the tools they need to navigate truth and falsehoods in science.

(00:03:01) The Importance of Science Education

The role of science education in society and the need for a new approach to science education

(00:08:31) Developmental Learning Progression in Science Education

Discussion on when young people are cognitively ready to understand the challenges of science education. The Finnish curriculum in media literacy as an example.

(00:09:31) Student Attitudes and the Fundamentals of Science Education

The importance of student attitudes towards science. The role of science education in preparing students to be citizens in a rapidly changing world.

(00:11:31) The Shortcomings of Current Science Education

Critique of the current state of science education. The need for focusing on big ideas rather than just facts.

(00:14:51) The Key Stakeholders in Changing Science Education

Discussion on who holds the keys to curricular practices. The role of boards of education, textbook writers, and faculty members in shaping science education.

(00:15:21) The Challenges of Changing Science Education

Jonathan Osborne's career reflections on trying to make changes. The resistance faced from institutional conservatism. The impact of government changes on science education

(00:17:01) The Problem with Current Curriculum

Lack of opportunities for teachers to pursue their interests. The need to cut back on performance expectations. Giving teachers more freedom and agency.

(00:18:29) Misinformation and Science Education

Concerns about misinformation in science. Tools needed to help young people vet information.

(00:19:31) The Role of Scientific Argumentation

Different forms of scientific argumentation. The importance of teaching scientific argumentation to students.

(00:22:36) The Power of Storytelling in Science

The need for more stories in science education. How stories can make science more relatable and convincing.

(00:27:21)  The Urgency of Updating Science Education

The rate at which teaching standards are updated. The need for flexibility in science education standards.

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The Future of computer chip design: delve into a revolutionary approach to chip design.  A re-run of a conversation Russ had in 2021 with Priyanka Raina, an assistant professor of electrical engineering. Priya is an expert in computer chip design. Whether or not you realize it, chips are everywhere and power everything from your toaster to your car. Priya discusses the slowing pace of progress in improving chip efficiency, and how she sees a future where chip makers will need to shift away from general-purpose computer chips to task-specific chips.

Chapter Time Stamps:
(00:00:00) Introduction

Host Russ Altman introduces the episode and the guest, Professor Priyanka Raina, an expert in electrical engineering.

(00:01:15) The Traditional Chip Design Paradigm

Explore the traditional chip design process and its challenges, including long development times and limitations in reusability.

(00:04:28) The Role of Specialized Chips

Understand the emergence of specialized chips and how they target specific applications for improved performance.

(00:07:56) The Promise of Core-Grain Reconfigurable Arrays (CGRAs)

Learn about core-grain reconfigurable arrays and how they bridge the gap between specialization and adaptability.

(00:10:12) Balancing Flexibility and Specialization

Discover the concept of specialized compute units within CGRAs and how they can be tailored to various applications.

(00:13:25) Agile Hardware Design

Explore the concept of agile hardware design and how it enables faster chip development iterations.

(00:16:40) Overcoming Hardware and Software Challenges

Understand the challenges of combining adaptable hardware with rapidly changing software and applications.

(00:19:02) The Role of Compilers in Chip Design

Explore the significance of compilers in translating high-level programming into efficient hardware instructions.

(00:21:30) Adapting Compilers for CGRAs

Discover how compilers are adapted to work seamlessly with core-grain reconfigurable arrays, enabling automatic updates as hardware changes.

(00:23:40) Benefits of Agile Chip Development

Learn about the potential benefits of agile chip development, including reduced time-to-market and adaptability to evolving applications.

(00:26:15) Revolutionizing Chip Development with CGRAs

Discuss how CGRAs can reshape the landscape of chip design, offering a new approach to balancing specialization and adaptability.

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Today we're rerunning a conversation Russ had in 2020 with Mykel Kochenderfer, a professor of Aeronautics and Astronautics at Stanford University.

Mykel's research has impacted anyone who has been on a plane recently for any kind of travel. His research led to the creation of a program known as the Airborne Collision Avoidance System, or ACAS X , which as he explains in more detail, is a critical tool in keeping air travel safe.

Thank you for tuning in, and we hope you enjoy this episode from the archives.

Chapter Time Stamps:

(00:00:50) ACAS X Origins

Russ Altman sets the stage by revisiting a conversation from 2020 with Professor Mykel Kochenderfer, a pioneer in aeronautics and astronautics at Stanford University. They discuss Mykel's groundbreaking research leading to the creation of the Airborne Collision Avoidance System, ACAS X.

(00:03:10) Ensuring Trustworthy Autonomous Vehicles

Exploring the challenges in building trustworthy autonomous systems, Mykel discusses the complexities of imperfect sensor systems, uncertainty in predicting future trajectory, and the trade-off between safety and operational efficiency.

(00:07:20) Dynamic Programming: The Key to ACAS X

Mykel explains the role of dynamic programming in ACAS X, transforming complex computations into tractable tasks through offline modeling and a lookup table, balancing safety and efficiency.

(00:10:30) Balancing Safety and Efficiency

Russ and Mykel delve into the intricate balance between safety and operational efficiency in ACAS X, highlighting the need for AI systems to make sound decisions even in rare, low-probability scenarios.

(00:14:15) ACAS X Implementation and Use Cases

Mykel elaborates on the role of ACAS X in aviation safety, detailing its advisory nature and its integration with air traffic control systems, while addressing the potential automation in specific aircraft models.

(00:17:40) Broadening Horizons: Urban Air Mobility

Exploring the expansion of ACAS X to urban air mobility systems, Russ and Mykel discuss the challenges of modeling and validating models for a wide range of aircraft, and the importance of incorporating human expertise.

(00:21:05) Global Collaboration and AI Consensus

Mykel emphasizes the collaborative nature of ACAS X implementation, involving different stakeholders, such as the FAA, Eurocontrol, and ICAO, and the role of AI in reaching a consensus on safety objectives.

(00:23:30) The Journey Ahead

As the conversation draws to a close, Mykel reflects on the evolution of ACAS X, its future applications, and the fusion of AI and human wisdom shaping the skies of tomorrow.

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Guest David Rehkopf is an expert in population health who says that where we live is one of the strongest influences on how long we live. While we know diet and health care are important, it has been tough to tease out what about these places allows people to live longer and healthier lives. By examining environmentally induced changes in DNA, we may be able to more quickly and more accurately quantify what aspects of environments promote longer, healthier lives, Rehkopf tells host Russ Altman in this episode of Stanford Engineering’s The Future of Everything podcast.

Chapter Time Stamps:

(00:00:00) Introduction

Host Russ Altman delves into the fascinating world of longevity with Dr. David Rehkopf from Stanford University. Discover the surprising links between government policies, corporate practices, and their impact on health.

(00:02:14) The Quest for Centenarians

Explore Dr. Rehkopf's research on centenarians in Costa Rica and how these long-lived individuals offer insights into the factors influencing longevity.

(00:06:20) Unraveling the Genetics of Longevity

Learn how genetic factors play a role in determining how long we live, and how centenarians possess unique genetic signatures that may hold the key to extended lifespans.

(00:09:45) Lifestyle and Environment

Discover the impact of lifestyle choices and environmental factors on longevity. From the benefits of traditional diets to the potential effects of infectious disease exposure, the picture becomes clearer.

(00:10:55) The Role of Exercise

Dive deeper into the significance of physical activity on long-term health and how regular exercise can contribute to increased lifespan and overall well-being.

(00:11:40) Social Connections and Longevity

Explore the intricate relationship between social connections, community engagement, and the potential impact on living longer and healthier lives.

(00:13:30) Government Policies and Health

Dr. Rehkopf sheds light on the influence of government policies, such as the Earned Income Tax Credit (EITC), on health outcomes. Find out how these policies can positively impact maternal health and sickness absence rates.

(00:15:20) The Power of Public Health Initiatives

Learn about the importance of public health initiatives in promoting healthy behaviours, preventing diseases, and potentially extending the human lifespan.

(00:16:05) Access to Healthcare

Explore the crucial role of accessible healthcare in longevity, and how disparities in healthcare access can affect different populations.

(00:18:30) Work-Life Balance

Delve into the concept of work-life balance and its potential impact on employee health and happiness in the long run.

(00:19:45) Corporate Wellness Programs

Learn about the various corporate wellness programs and initiatives aimed at improving employee well-being and how they might influence longevity.

(00:21:05) Hybrid Work Models and Longevity

As the world adapts to the pandemic-driven hybrid work models, Dr. Rehkopf discusses the potential long-term effects on workforce health and well-being.

(00:23:40) The Road Ahead

In this final chapter, we speculate on the future of longevity research and how understanding the intricate connections between government, corporations, and individual choices can shape a healthier and longer life for all.

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As anyone with chronic disease knows, access to health care doesn’t always equate with equitable health care outcomes, says guest Alyce Adams, an expert in innovations in health policy. Too often, care delivery breaks down along racial and socioeconomic lines. Our focus should be on better outcomes for all people, she says. Adams now develops interventions to help communities and health systems improve care delivery — and health equity — as she tells host Russ Altman in this episode of Stanford Engineering’s The Future of Everything podcast.

Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode and welcomes Professor Alyce Adams from Stanford University to discuss how new approaches in communities and health systems are improving care delivery for traditionally underserved populations.

(00:01:29) Unraveling Health Disparities

They discuss the disparities present in healthcare, particularly among underrepresented populations, and the importance of integrating patient voices in research.

(00:02:42) Addressing Socioeconomic Factors

The role of socioeconomic factors in health disparities and how they influence access to quality care. The discussion also examines efforts to eliminate barriers and provide equitable healthcare.

(00:04:15) Cultural Competence in Medicine

The conversation shifts to the significance of cultural competence in healthcare delivery. Prof. Adams explains the need for healthcare professionals to understand and respect diverse cultural backgrounds to ensure effective patient care.

(00:07:50) Bridging the Knowledge Gap

Insights into understanding patient knowledge and disease understanding, focusing on the example of tobacco use. The efforts to integrate patient and caregiver perspectives early in the research process are discussed.

(00:09:15) Empowering Patient Decision-Making 

The discussion explores strategies to empower patients in their healthcare decisions. Prof. Adams explains the importance of personalized care plans that align with patient values and priorities.

(00:11:30) Digital Health Literacy 

The increasing role of digital health tools and the importance of health literacy in utilizing these technologies effectively. The challenges of ensuring equitable access to digital health resources are also addressed.

(00:15:10) Qualitative Methods in Research

Insights into qualitative research methods and their significance in understanding patient experiences and priorities. The need for collaboration with community partners to shape research questions is emphasized.

(00:17:05) The Power of Patient Stories 

The conversation discusses the impact of patient narratives in healthcare research. Prof. Adams explains how patient stories provide valuable context and humanize data, leading to more comprehensive and patient-centric research outcomes.

(00:20:30) Building Patient-Centric Algorithms  

The development of AI algorithms to assess patient risk and facilitate decision-making for clinicians. Prof. Adams discusses the challenges of encoding priorities in these algorithms while considering potential biases.

(00:22:12) Algorithmic Transparency 

The discussion delves into the importance of algorithmic transparency and its role in building trust between patients and AI-driven healthcare systems. Prof. Adams explains the need for clear and interpretable AI models.

(00:27:45) Ethical Considerations in AI Implementation

The conversation explores ethical considerations in implementing AI technologies in healthcare. Prof. Adams discusses the potential risks and benefits and the importance of continuous evaluation and oversight.

(00:30:15) Engaging Policy Makers

The episode concludes with an optimistic view of policymakers' receptivity to research insights. Prof. Adams explains the importance of proactive engagement and communication in policy decisions.

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Chaitan Khosla is a chemical engineer who says that the world’s most advanced drug factories are not behemoths of the industrial age, but microscopic bacteria. These tiny creatures have evolved enzymatic assembly lines that ingest raw materials and churn out valuable other molecules, like life-saving antibiotics. By engineering new microbes, we hope to create next-generation drugs, Khosla tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Chapter Show Notes:

(00:00:43) Introduction to Assembly Lines and Antibiotics

Russ welcomes Professor Khosla and introduces the intriguing world of bacterial assembly lines and their crucial role in antibiotic synthesis. He emphasizes the significance of antibiotics and their intricate molecular structures.

(00:06:19) Enzymatic Assembly Lines: The Automotive Analogy

Drawing an analogy between assembly lines in nature and automotive assembly lines, discussion highlights the remarkable efficiency and meticulous organization of bacterial assembly lines.

(00:08:17) The Scale of Antibiotic Assembly Lines

Russ Altman and Chaitan Khosla delve into the scale of antibiotic assembly lines, using erythromycin as a prime example. They explore the multitude of enzymes involved in the assembly line process.

(00:10:34) Challenges in Antibiotic Synthesis

The conversation centers around the challenges faced by human chemists in synthesizing antibiotics compared to the remarkable efficiency and complexity of bacterial assembly lines.

(00:12:00) Uncovering Nature's Engineering Marvels

Russ Altman and Chaitan Khosla discuss the awe-inspiring engineering feats found in nature's assembly lines, exploring the intricacies of their construction and their functional significance.

(00:15:15) Expanding the Search for Assembly Lines

Russ Altman and Chaitan Khosla broaden the scope of assembly line research, discussing the potential for discovering novel assembly lines in previously unexplored organisms and environments.

(00:19:00) The Mystery of Orphan Assembly Lines

Russ Altman and Chaitan Khosla explore the enigmatic world of orphan assembly lines, discussing the fascination and curiosity surrounding these assembly lines whose functions remain unknown.

(00:22:00) Decoding the Language of Genes

Russ Altman and Chaitan Khosla delve into the process of deciphering the genetic code to unravel assembly line functions. They discuss the techniques and strategies employed in this intricate decoding process.

(00:24:00) Leveraging Artificial Intelligence in Assembly Line Analysis

The hosts discuss the application of artificial intelligence and machine learning in analyzing assembly line data, showcasing the potential of these technologies to accelerate the discovery of assembly line functions.

(00:26:00) A Window into Nature's Medicine Cabinet

Russ Altman and Chaitan Khosla explore the remarkable potential of assembly lines in antibiotic discovery, unveiling how studying these assembly lines can unlock nature's vast repertoire of medicinal compounds.

(00:28:32) Novel Insights from Recent Assembly Line Discoveries

Russ Altman and Chaitan Khosla highlight the groundbreaking insights gained from recent assembly line discoveries, discussing the exciting prospects and implications of these findings.

(00:30:30) Conclusion and Show Wrap-up

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Neuroscientist Kalanit Grill-Spector studies the physiology of human vision and says that the ways computers and people see are in some ways similar, but in other ways quite different. In fact, she says, rapid advances in computational modeling, such as deep neural networks, applied to brain data and new imaging technologies, like quantitative MRI and diffusion MRI, are revolutionizing our understanding of how the human brain sees. We’re unraveling how the brain “computes” visual information, as Grill-Spector tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Chapter Time Stamps:

(00:01:30) Episode introduction: Exploring the fascinating field of cognitive neuroscience and brain development with Kalanit Grill-Spector.

(00:02:45) Dr Grill-Spector's background and research interests: The intersection of cognitive neuroscience, psychology, and computer science.

(00:04:00) The crucial role of experience in shaping brain development: Understanding how environmental factors influence neural specialization.

(00:09:55) The development of word processing regions in the brain: Investigating the emergence and evolution of brain regions associated with reading and word recognition.

(00:11:30) The evolution of word specialization and its implications: Exploring how the brain acquires the ability to read and process words.

(00:14:20) Shift in research focus to studying brain development in infants: Exploring the critical early phases of brain development and the impact of experience on neural circuits.

(00:16:40) Pokemon, Brain Representation, and Perception: The surprising findings on the continued development of word and face processing regions. Discovering the extended period of specialization and plasticity in these brain areas.

(00:19:10) Unexpected decline in specialization for body parts, particularly hands: Examining the trade-off between different cognitive abilities as brain regions specialize.

(00:22:00) Understanding the potential impact of experience on brain organization: Examining how environmental factors shape the neural pathways and cognitive capabilities.

(00:25:00) Investigating the influence of Pokemon on brain representation and perception: Analyzing the effects of exposure to specific visual stimuli on brain organization.

(00:27:15) The unique characteristics of Pokemon stimuli: Exploring how visual features, animacy, and stimulus size affect brain responses.

(00:29:00) Specificity of brain representation for Pokemons: Uncovering whether the brain develops distinct neural pathways for Pokemon stimuli.

(00:31:45) Comparing the effects of word learning: Understanding the potential trade-offs in brain specialization.

(00:32:45) Technical challenges in studying infant's brains: Discussing the need for new tools and analysis methods to study developing brains.

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Guest Debra Kaysen is a psychologist specializing in treatment of post-traumatic stress disorder (PTSD) who says that promising new cognitive and behavioral therapies are, quite literally, giving people “their lives back.” These therapies work without drugs to help patients manage their disease and its symptoms and, perhaps, even cure PTSD. We’re providing tools to change how they think, Kaysen tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

For interested listeners, Kaysen offers a list of PTSD resources:

Resources

• Previous TFoE episode with Shaili Jain on treatments for PTSD
• https://istss.org/public-resources/trauma-basics
• https://istss.org/public-resources/find-a-clinician
• https://adaa.org/learn-from-us/from-the-experts/blog-posts/consumer/what-youre-feeling-ptsd-what-do-help

Free apps from the VA for PTSD and other related concerns

• https://www.ptsd.va.gov/appvid/mobile/
• https://www.abct.org/get-help/

For a Cognitive Processing Therapy (CPT) trained therapist

• https://cptforptsd.com/cpt-provider-roster/

Stanford’s PTSD clinic

• https://med.stanford.edu/psychiatry/patient_care/ptsd.html

International resource for a Prolonged Exposure (PE) trained therapist

• https://www.med.upenn.edu/ctsa/find_pe_therapist.html

Chapter Timestamps:

(00:00:00) Introduction to Trauma Therapy and Digital Mental Health

 Russ Altman introduces the topic of trauma therapy and discusses the advancements in digital mental health.

 (00:01:45) Support Apps for Trauma Survivors

Debra Kaysen explores the use of mobile applications as a means of support for sexual assault survivors in the immediate aftermath of trauma.

(00:03:15) Overcoming Barriers

Finding Therapists: Debra Kaysen highlights the challenges survivors face in finding therapists and the potential of apps to bridge that gap.

(00:05:10) Bridging the Gap: Challenges in Accessing Support

Debra Kaysen discusses the difficulties survivors face in accessing timely support and how apps can provide a solution.

(00:08:00) The Power of Telehealth for PTSD Treatment

Debra Kaysen emphasizes the effectiveness of telehealth in treating post-traumatic stress disorder (PTSD) and its growing acceptance in the field.

(00:10:15) Equivalence of Telehealth and In-Person Therapy

Debra Kaysen shares her personal experience of providing therapy to her patients via telehealth and highlights its equivalence to in-person sessions.

(00:12:30) Exploring Asynchronous Therapy with Text Messages

Debra Kaysen delves into the use of text messages as a form of asynchronous therapy for PTSD treatment, offering flexibility and convenience.

(00:14:20) Enhancing Support: Immediate Response and Accessibility  

Debra Kaysen discusses the immediate response and accessibility benefits of asynchronous therapy with text messages.

(00:16:00) Building Trust and Establishing Rapport  

Debra Kaysen emphasizes the importance of building trust and establishing rapport in digital therapy settings.

(00:18:00) Honesty and Reduced Fear of Judgment 

Russ Altman discusses the potential for reduced fear of judgment in digital therapy, allowing individuals to be more open and honest in their communication.

 (00:20:00) Exploring Effective Therapeutic Techniques

Debra Kaysen explores various therapeutic techniques used in trauma therapy and their effectiveness in promoting healing.

(00:24:15) Long-Term Outcomes and Prevention

Debra Kaysen explores the long-term outcomes of trauma therapy, highlighting its potential to prevent symptom recurrence and equip individuals with lifelong resilience skills.

(00:26:00) Empowering Individuals: Coping Strategies

Debra Kaysen discusses empowering individuals with effective coping strategies to navigate future traumas.

(00:28:00) Sustaining Progress: Follow-up and Resilience

Debra Kaysen discusses the importance of follow-up care and how trauma therapy helps individuals develop resilience.

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Hi everyone, Russ here, we’re running a best-of episode this week to re-share a conversation I had in 2021 with Karen Liu, an associate professor of computer science here at Stanford Engineering. The conversation is relevant today because, as we all know, AI is having a moment, and robotics is an important part of that. Karen and her lab have a goal of enabling robots to contribute in caregiving roles - think of tasks like helping medical patients get dressed each day - and they’re using physics-based simulations to do that. I hope you’ll take some time to tune into this discussion, it’s a timely and relevant one given larger societal conversations about AI. Enjoy!

Chapter Time Stamps:
(00:00:00) Introduction 

Russ Altman interviews Karen Liu, a Stanford professor in computer science, to explore the advancements in exoskeleton technology and their impact on human augmentation.

(00:01:12) Defining Exoskeletons

Karen Liu provides an overview of exoskeletons as wearable devices that enhance human capabilities and become an integral part of the wearer's body.

(00:02:30) Wearable Devices and Human Augmentation 

The discussion delves into the concept of wearable devices augmenting human abilities, drawing parallels to popular culture references such as Iron Man.

(00:05:40) Incorporating Sensors and Cameras

Karen Liu explains how sensors and cameras are integrated into exoskeletons to understand the wearer's environment, enabling the exoskeleton to anticipate future actions.

(00:07:55) Parallels with Self-Driving Car Technologies

Exploring similarities with self-driving cars, the conversation highlights how exoskeletons can leverage environmental awareness to guide the wearer's movements.

(00:09:20) Modeling Human Behavior and Intentions

The discussion shifts to the modeling of human behavior and predicting user intentions to ensure exoskeleton assistance aligns with user expectations and maintains their independence.

(00:11:30) Ensuring User Safety and Comfort 

The focus turns to designing exoskeletons that prioritize user safety and comfort, considering factors such as ergonomics and personalized adjustments.

(00:13:45) Real-Time Adaptive Assistance

The conversation explores the potential for exoskeletons to dynamically adapt assistance levels in real time based on the wearer's needs and changing circumstances.

(00:15:20) Balancing Assistance and User Independence

The importance of finding the right balance between providing assistance and preserving user independence is discussed, ensuring that exoskeletons empower rather than hinder.

(00:17:05) Ethical Considerations and Accessibility

The discussion touches upon ethical considerations surrounding exoskeleton technology, including accessibility, affordability, and ensuring equal opportunities for all users.

(00:18:30) Optimizing Performance and Efficiency

The conversation dives into strategies for optimizing the performance and efficiency of exoskeletons, including advancements in energy management and battery technologies.

(00:19:45) User Feedback and Iterative Design

Karen Liu highlights the significance of user feedback and iterative design processes in refining exoskeleton technology to better meet user needs and preferences.

(00:20:30) Future Possibilities and Advancements 

Looking ahead, the conversation explores potential advancements in exoskeleton technology, including advancements in artificial intelligence and personalized exoskeleton designs.

(00:22:00) Collaborations and Interdisciplinary Research

The importance of interdisciplinary collaborations in advancing exoskeleton technology is discussed, emphasizing the need for expertise from various fields.

(00:23:10) Summary and Key Takeaways

Russ Altman summarizes the main points discussed throughout the episode, highlighting key takeaways for listeners to reflect upon.

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Guest Bill Mitch says it’s no secret the world is running short of fresh water. As a civil and environmental engineer, he sees wastewater as a potential solution, if only we can eliminate the impurities. Mitch designs systems to remove toxic chemicals from wastewater to enable its reuse as a drinking water supply. It’s not easy, but it costs half as much as desalinating seawater, Mitch tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Show Notes & Chapters: The future of Wastewater

(00:00:05) Introduction

Russ introduces the podcast and guest, William Mitch, who discusses the future of wastewater treatment.

(00:00:38) Nitrogen in Wastewater Treatment

Russ and William kick off the conversation with an insightful discussion on the issues surrounding the nitrogen cycle in wastewater treatment. They discuss the nitrogen cycle, the role of nitrogen in wastewater treatment, and the challenges of removing it from wastewater, including the current technologies being used.

(00:02:28) The Basics of Wastewater Treatment

Mitch explains the fundamental process of wastewater treatment, highlighting the initial step of removing solids and the biological process of removing organic matter.

(00:07:35) Understanding Biochemical Oxygen Demand (BOD)

Mitch explains the concept of BOD, its importance in water treatment, and how technology has evolved to measure it.

(00:10:19) The Challenge of Nitrogen Removal

Discussion about the difficulties and processes involved in removing nitrogen from wastewater, focusing on the traditional and newer approaches.

(00:14:02) Energy Consumption in Wastewater Treatment

Mitch talks about the substantial energy demand involved in wastewater treatment, especially in the nitrogen removal process.

(00:17:32) Research on Nitrogen Removal

Mitch discusses his lab's research on a more energy-efficient process for nitrogen removal from wastewater, explaining the concept of anammox bacteria and their role in this process.

(00:20:49)  Phosphate Removal and Regulation

Mitch talks about the lack of regulatory pressure for phosphorus removal from water and its potential future implications.

(00:21:30) Public Acceptance of Wastewater Treatment Technologies

Russ probes into the public acceptance of wastewater technologies, specifically potable reuse of wastewater. William discusses the changes in public attitudes towards recycled water over the past decades, the importance of public relations campaigns and community education in shaping these attitudes, and the future of potable reuse facilities.

(00:24:39) The Quality of Potable Reuse Waters vs. Conventional Water Supplies

William discusses a recent study comparing the quality of water from potable reuse plants to conventional water supplies. He reveals that the treated waters were found to be of higher quality than surface waters and comparable in quality to groundwater supplies.

(00:27:00) Chlorinated Taste in Drinking Water

Russ asks William about the common chlorinated taste in drinking water. William explains the chemical reactions that lead to this taste and why it isn't necessarily a red flag for consumers.

(00:28:00) Future of Separate Infrastructures for Potable and Non-Potable Water

They wrap up the conversation discussing the possibility and implications of having separate infrastructures for potable water and water used for other purposes. William explains the logistical challenges and why many utilities are moving towards potable reuse.

(00:29:08) Conclusion

Russ concludes the episode, thanking William for his insights into the future of wastewater, and invites listeners to subscribe, rate, and review the podcast for future episodes.

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Guest Matteo Cargnello approaches the challenge of greenhouse gases from a different perspective. He doesn’t study how harmful chemicals got in the skies, or even the consequences. Instead, Cargnello is using his skills as a chemical engineer to turn them into other benign or useful chemicals. So far, he’s turned greenhouse gases into valuable industrial chemicals, polymers, renewable fuels, and even ethanol. Useful products from greenhouse gases, that's the dream, Cargnello tells host Russ Altman on this episode of Stanford Engineering’sThe Future of Everything.

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Deborah Cullinan’s job is to integrate arts of every form across campus. She says art has the power to heal and may be the answer to many of our present-day societal problems, such as growing political polarization and social isolation borne by the pandemic. Art advances equity, improves health, and enhances well-being for all, she says. Everyone should see themselves as artists—engineers, physicians, political scientists alike. "We all want to have creative lives," Cullinan tells host Russ Altman in this episode of Stanford Engineering’s The Future of Everything podcast.

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Helen Bronte-Stewart is a neurologist and an expert in movement disorders, like Parkinson’s. She says new approaches, such as closed-loop deep-brain stimulation, and new digital health technologies that chart subtle changes in movement are reshaping the field, leading to new understandings and new treatments for this once-untreatable disease. To modulate behavior, you first have to measure it, Bronte-Stewart tells host Russ Altman. It’s the future of movement disorders in this episode of Stanford Engineering’s The Future of Everything podcast.

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Our guest, Christopher Manning, is a computational linguist. He builds computer models that understand and generate language using math. Words are the key component of human intelligence, he says, and why generative AI, like ChatGPT, has caused such a stir. We used to hope a model might produce one coherent sentence and suddenly ChatGPT is composing five-paragraph stories and doing mathematical proofs in rhyming verse, Manning tells host Russ Altman in this episode of Stanford Engineering’s The Future of Everything podcast.

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While DNA may be the blueprint of life, proteins are the workhorses, says Polly Fordyce, a bioengineer, explaining how one of her favorites, kinesin, “walks” in 8-nanometer steps transporting chemical cargo through the body. More remarkable still, Fordyce says, kinesin is just one among thousands of “incredible” proteins that make life happen, as she tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

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Rising temperatures and rainfall from climate change will have a surprising effect on human health, says biologist Erin Mordecai, an expert in diseases borne by mosquitoes, ticks and other living creatures. Such conditions are perfect breeding grounds for parasites that will bring deadly diseases to the U.S. and other places once thought out of reach. Hope may rest in mathematical models to guide smarter environmental policies, as Mordecai tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast. 

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Russ Altman is the Kenneth Fong Professor of Bioengineering, Genetics, Medicine, Biomedical Data Science and (by courtesy) Computer Science at Stanford University. His primary research interests are in the application of computing to problems relevant to medicine. Kim Branson is a senior vice president and Global Head of Artificial Intelligence and Machine Learning at GSK, where he leads the GSK.ai team, a group of nearly 100 machine learning researchers and engineers who are pioneering the application of AI to drug discovery and development. In this conversation with Stanford adjunct lecturer and STVP Director of Principled Entrepreneurship Jack Fuchs, Altman and Branson discuss how ethics and principles can shape innovation at the intersection of AI and drug development.