zoonosis

TWiV reviews the latest virology news, how infection with a plant virus causes insect to grow long wings, and reverse zoonoses of 2009 H1N1 pandemic influenza viruses in US swine.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Angela Mingarelli

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• The New City by Dickson Despommier
• Midwife gave children pellets instead of vaccines (NY Times)
• Vaccine derived poliovirus circulation in Indonesia (WHO)
• 9th case of measles in Philadelphia (City of Philadelphia)
• Measles exposure warning northern Virginia (Virginia DOH)
• China lab sequenced SARS-CoV-2 genome 2 weeks before release (WSJ)
• Wisconsin bill to restrict gain of function experiments (Science)
• Virus infection of insects causes long wings (PNAS)
• Reverse zoonoses of influenza H1N1 virus in swine (PLoS Path)
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Concerto for Horn and Hardart, P. Schickele
Angela – ChatGPT4
Brianne – How mRNA Vaccine Works, Why We Need Two Doses of mRNA Vaccine
Rich – Evolutionary basis for the human diet: consequences for human health by P. Andrews, R.J. Johnson
Vincent – Virology Lectures 2024

Listener Picks

Geoff and Anonymous – Dickson Despommier wants our cities to be like forests

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV explains a study showing that ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews, and development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Kathy Spindler

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• MicrobeTV Discord Server
• MicrobeTV store at Cafepress
• Become a member of ASV (asv.org)
• Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
• The New City by Dickson Despommier
• Brett Lindenbach passes (Yale Medicine)
• Virome of small mammals (Cell)
• Epstein-Barr virus nanoparticle vaccine (Cell Host Micr)
• Letters read on TWiV 1073
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Summary of Global Climate Action at COP 28 and Notable Deaths 2023: Music
Kathy – Two APODS  Winter solstice, 183 Days in the Sun and the Same color illusion
Vincent – The American Academy of Microbiology discusses gain-of-function research of concern (GOFROC) and enhanced potential pandemic pathogens (ePPP)

Listener Picks

Gregory – Climate Change – A revised prediction – Steven Chu
John – Detergent packs are kinda wishy-washy (Technology Connections)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other origins, and his work on the virosphere.

Host: Vincent Racaniello

Guest: Eddie Holmes

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

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Links for this episode

• MicrobeTV Discord Server
• Huanan Seafood Market early COVID-19 epicenter (Science)
• SARSr-CoV-2 in Malayan Pangolins (PLoS Path)
• Zoonotic risk of farmed animals (Cell)
• Virusea at bat-tick interface (Microb Genom)
• Influenza H3N8 virus in southern China (J Virol)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Vincent travels to the University of Pennsylvania to meet up with Susan, Rick, Gigi and David to discuss the origin of SARS-CoV-2, how the FBI might have reached its conclusion on the matter, and public and political perception of scientific risk.

Host: Vincent Racaniello

Guests: Susan Weiss, Rick Bushman, Gigi Gronvall, and David Joanson

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• MicrobeTV Discord Server
• Huanan Seafood Market early COVID-19 epicenter (Science)
• Spillover market with Michael Worobey (TWiV 876)
• Unclassified intelligence on SARS-CoV-2 origins (IC)
• Conspiracy theories about COVID-19 (Foreign Policy)
• COVID-19 not from lab leak (Globe and Mail)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Vincent travels to Montreux, Switzerland and the 16th International Nidovirus Symposium, where he speaks with Maria von Kerkhove, the face of COVID-19 for the World Health Organization, and Kanta Subbarao, Director of the WHO Collaborating Centre on Influenza in Melbourne.

Host: Vincent Racaniello

Guests: Kanta Subbarao and Maria von Kerkhove

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• MicrobeTV Discord Server
• Nidovirus Symposium, Montreux
• WHO Collaborating Centre for Influenza, Melbourne
• Maria von Kerkhove (Wikipedia)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid.

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Download TWiV 995 (74 MB .mp3, 123 min)
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

•Register for ASV 2023
•MicrobeTV Discord Server
• More evidence for SARS-CoV-2 spillover (Zenodo)
•Polio cases linked to nOPV2 (Science; GPEI statement)
•nOPV2 on TWiV 756
•Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe)
•Stability of nOPV2 in children (npj Vaccines)
•2A changes compensate for 5′-UTR disruptions (Virology)
•HBV shifts from naked to enveloped (Nat Comm)
•Letters read on TWiV 995
•Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath
Angela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons
Brianne – Science Museums Take Stock of 1.1 Billion Objects from Around the World
Vincent – Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York

Listener Picks

Gary – Tony Fauci on PBS
Stefanie – What Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Dr. Keith Sumption, Ph.D. is Chief Veterinary Officer and Leader of the Animal Health Program at the Food and Agriculture Organization of the United Nations ( FAO - https://www.fao.org/home/en ) as well as their Director of the Joint Centre for Zoonoses and Anti-Microbial Resistance (CJWZ). The Food and Agriculture Organization of the United Nations is an international organization that leads international efforts to defeat hunger and improve nutrition and food security. The FAO comprises 195 members and helps governments and development agencies coordinate their activities to improve and develop agriculture, forestry, fisheries, and land and water resources. It also conducts research, provides technical assistance to projects, operates educational and training programs, and collects agricultural output, production, and development data. Dr. Sumption has worked on disease ecology at the interaction of wildlife, domestic and the environment for more than 30 years. Dr. Sumption holds a Doctor of Philosophy (PhD) from the University of Reading, gained following 3 years of field and molecular epidemiology research upon African Swine Fever in southern Africa, and veterinary medicine (Vet.MB) and Natural Sciences degrees from the University of Cambridge in the United Kingdom. Dr. Sumption has served as Executive Secretary of European Commission for the Control of Foot-and-Mouth Disease (EuFMD), where he has been responsible for developing strategy, negotiating funding and managing implementation of the Commission's work programs, which now involve over 80 countries, and reports to the member states of the Commission and FAO Regional Conference and Department (AGD) for progress. Prior to FAO, Dr. Sumption was a research group leader and Master’s program Coordinator at the Centre for Tropical Veterinary Medicine (CTVM), University of Edinburgh, managing projects on African high impact tick borne and contagious diseases including heartwater , theilerioses, mycoplasmoses (CBPP and CCPP), and viral Transboundary Animal Diseases TADS (rinderpest , PPR and sheep and goat pox) and as a seconded technical officer to the United Kingdom Department for International Development (DFID), leading work to define demand and impact of research at the primary animal health care level in Kenya, for almost 2 years. 

IN THE SPOTLIGHT is a quarterly feature where we revisit past Talking Apes episodes that focus on highly critical issues. For our March 2023 instalment we're featuring our Season 1 episode with disease detective Dr Tony Goldberg, accompanied by three brand new podcasts exploring disease ecology and the links between animal health, human health, and the environment. 

Zoonotic diseases occur when viruses, bacteria, or parasites jump between humans and animals. Dr Goldberg explores how these diseases take a toll on us and apes like us.  In this episode he tells us about his quest to understand them, how we live with them, and his adventures in Africa trying to track down and eradicate a scary infection that almost wiped out an entire population of rescued chimpanzees.

Tony's episode was originally aired in March 2021 at the heart of the Covid-19 pandemic which threw the world into turmoil, not only within our personal lives, but economically, culturally, and politically.  The pandemic brought to light zoonosis as a critical, prevalent issue and a constant existential threat to us all.

Also in this special ZOONOSIS IN THE SPOTLIGHT season throughout March, don't miss our incredible new two-part conversation with award-winning science writer David Quammen, and finally a look at life on the frontlines of zoonotic and anthroponotic disease with mountain gorilla veterinarian Dr Gladys Kalema-Zikusoka; from heart of Uganda’s gorilla country, the Bwindi Impenetrable Forest. Visit our website to find out more. 

Click here to visit Tony's website. 

Talking Apes is an initiative of the nonprofit GLOBIO.
Official website: talkingapes.org
Instagram: @talkingapes_podcast
Twitter: @talking_apes
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TWiV discusses a new henipavirus from fruit bats in Madagascar, and attenuation of SARS-CoV-2 Omicron disease in mice caused by genome mutations outside of the spike protein coding region.

Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, and Brianne Barker

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Research assistant position at FDA (pdf)
• Beijerinck virology prize (KNAW)
• Nipah virus vaccine (TWiV 618)
• Novel henipavirus from Madagascar (J Viral)
• Spike-independent Omicron attenuation in mice (Cell Rep)
• Letters read on TWiV 933
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Small groups: 3.  Modern Jazz Quartet. Signature song: Skating in Central Park. Signature album: Django.
Brianne – To Prevent a Martian Plague, NASA Needs to Build a Very Special Lab
Kathy – Physics Girl – Overnight in the Most Remote Camp on Earth
Vincent – Lab leaders wrestle with paucity of postdocs

Listener Picks

Gary – Stan Kenton Orchestra
Miguel – Microsoft Premonition

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk.

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Monkeypox multi-country outbreak risk assessment (pdf, ECDC)
• Monkeypox update (ProMedMail)
• Monkeypox virus genome sequences (Nextstrain)

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost.

Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Climate change and viral zoonosis risk (Nature)
• COVID-19 mRNA boost effect on memory B cells (Nature)
• Letters read on TWiV 896
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Toots Thilelemans
Amy – Largest comet ever identified
Vincent – Scientific review articles as antivaccine disinformation

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber’s bats in Hungary.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guests: Elke Muhlberger, Adam Hume, and Gabor Kemenesi

Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Elke on TWiV 200 and Threading the NEIDL
• Infectious Lloviu virus from bats in Hungary (Nat Commun)
• Infectious Lloviu virus from DNA (PloS Path)
• Letters read on TWiV 891
• Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – APod Stars and Globules in the Running Chicken Nebula
Kathy – BioRender Poster Builder
Rich – The Sins of Our Fathers: An Expanse Novella (The Expanse) by James S. A. Corey
Vincent – Baumgartner Restoration

Listener Pick

J – Time, Einstein, and the coolest stuff in the Universe

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Kathy Spindler

Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• Biden preliminary report on virus origins (NY Times)
• Window on SARS-CoV-2 origins closing (Nature)
• WHO Committee members on TWiV 760
• Origins of SARS-CoV-2 review (Cell)
• Comirnaty? Really Pfizer? (FDA)
• Why the weird name for Pfizer vaccine (Quartz)
• US vaccine names (CDC)
• More coronaviruses from rodents in China (J Viral)
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – The Brilliant Abyss by Helen Scales
Kathy – Solar System ball drop
Rich – Dr. Fox effect
Alan – Patty Wagstaff virtual airshow cockpit video
Vincent – Office Hours

Listener Picks

Karen – The Dog Will See You Now
Alicia – Bio-Rad GTCA Song

Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv

Laurie Garrett, author of The Coming Plague, joins TWiV for a wide-ranging discussion of infectious disease and public health, including emerging infections, the role of wildlife markets in spillovers, and missteps in handling the COVID-19 pandemic.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Laurie Garrett

Subscribe (free): iTunes, Google Podcasts, RSS, email

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Links for this episode

• Lauriegarrett.com
• The Coming Plague
• Betrayal of Trust
• Trump sabotaged coronavirus response (Foreign Policy)
• ASV Vaccine Town Hall
• Timestamps by Jolene. Thanks!

Weekly Picks

Brianne – A Pivotal Mosquito Experiment Could Not Have Gone Better
Kathy – Microbiology at the Movies
Vincent – When a Good Scientist Is the Wrong Source

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• ASV vaccine town halls 15:10
• Porcine deltacoronavirus in Haitian children (medRxiv)
• Canine coronavirus from Malaysian pneumonia patient (Clin Inf Dis)
• No shift, measles (TWiV 340)
• The Cancer Thief (TWiV
• Letters read on TWiV 759
• Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Ants: workers of the world
Amy – Let The Record Show by Sarah Schulman
Rich – QAnon resembles the games I design
Alan – Librivox
Vincent – Stratechery

Listener Picks

Fernando – The 60-year old scientific screwup that helped COVID kill

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Tony Schountz joins TWiV to explain the work of his laboratory showing that deer mice can be infected with and transmit SARS-CoV-2, and how his colony of Jamaican fruit bats is being used to understand their response to virus infections.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler and Brianne Barker

Guest: Tony Schountz

Subscribe (free): iTunes, Google Podcasts, RSS, email

Become a patron of TWiV!

Links for this episode

• SARS-CoV-2 infection of deer mice (bioRxiv)
• Infection of Jamaican fruit bats with MERS-CoV (Sci Rep)
• Immunological control of virus infections in bats (Front Immunol)
• Transmission of bat influenza viruses in bats (Nat Micro)
• Letters read on TWiV 668
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Virus Masks
Kathy – UV in the vineyards (video)
Rich - Great White Shark Attack
Vincent - Smart WiFi garage door opener

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv