zoonosis

Simon and Heather join TWiEVO to discuss their analysis of the evolutionary history of ACE2 usage by coronaviruses in the Sarbecovirus genus.

Hosts: Nels Elde and Vincent Racaniello

Guests: Simon Anthony and Heather Wells

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Links for this episode

• Evolutionary history of sarbecovirus ACE2 binding (bioRxiv)
• Bombali virus in bats (Nat Micro)
• Herpesviruses in Puerto Rican bats (bioRxiv)
• Adenovirus and herpesvirus in great apes (PLoS One)
• Time stamps by Jolene. Thanks!

Music on TWiEVO is performed by Trampled by Turtles

Send your evolution questions and comments to twievo@microbe.tv

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Raul Rabadan

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Links for this episode

• Rabadan Laboratory
• Understanding Coronavirus (Amazon)
• Topological Data Analysis for Genomics and Evolution (Amazon)
• Recombination and mutation shaped SARS-CoV-2 (bioRxiv)
• Bat CoV with cleavage site insertion (Curr Biol)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine.

Hosts: Vincent Racaniello

Guests: John Mackenzie, Jon Epstein, Eun-Chung Park, and Linfa Wang

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Intro music is by Ronald Jenkees.

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Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.

Host: Vincent Racaniello

Guest: Christian Drosten

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Links for this episode

• Das Coronavirus podcast
• Identification of SARS-CoV in Germany (NEJM)
• 29 nt deletion in genome of SARS-CoV (Sci Rep)
• 382 nt deletion in genome of SARS-CoV-2 (bioRxiv)
• Virological assessment of COVID-19 patients (Nature)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

This week, coronavirus infection in big cats, how new diseases emerge in the first place, whether face masks work against coronavirus, can Covid-19 spread through the air, can you catch Covid from urine, and is previous TB a risk factor for severe coronavirus disease? Also, will wearing a face mask protect other people from you, is 5G a risk for Covid-19, and can coronaviruses be carried in semen? Join Dr Chris and Azania as they Ask the Naked Scientist... Like this podcast? Please help us by supporting the Naked Scientists

A TWiV foursome provides an update on the SARS-CoV-2 pandemic, including antibody testing kits, FDA emergency approval of convalescent sera, and answer listener questions about the dangers of mail delivery and take out foods, decontamination of PPE, diagnostic testing, and much more.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Links for this episode

• Coronavirus test kit
• Rapid SARS-CoV-2 serological assay (medRxiv)
• Is Dr. Fauci in trouble? (NY Times)
• FDA approves emergency use of convalescent serum (FDA)
• Image by Michele Banks
• Letters read on TWiV 594
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Vincent, Elio and Michael discuss the stability of human coronaviruses on surfaces and in aerosols, and peptidoglycan production by a mosaic consisting of a bacterium within a bacterium within an insect.

Links for this episode:

• Human coronavirus 229E infectivity on common surfaces (mBio)
• Aerosol and surface stability of SARS-CoV-2 (medRxiv)
• Peptidoglycan synthesis by a insect-bacteria mosaic (Cell)
• Letters read on TWiM 213

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

 

El ser humano se ha considerado tan por encima de los demás seres vivos de la naturaleza, que cree que puede utilizarlos o manejarlos a su antojo. Consecuencia de ello son las frecuentes epidemias o pandemias, enfermedades de animales que de vez en cuando se vuelven transmisibles a los humanos. Aquí algunos ejemplos, la explicacion de la zoonosis y también algunas medidas preventivas para los que tienen mascotas, ganado o incluso cazan animales salvajes.

Ori Lieberman joins Vincent to discuss COVID-19, the disease caused by SARS-CoV-2, gleaned from his experience during clinical rotations in medical school.

Hosts: Vincent Racaniello

Guest: Ori Lieberman

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Intro music is by Ronald Jenkees.

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Ralph Baric joins TWiV to dissect the coronavirus pandemic caused by SARS-CoV-2, including discussion on community spread, asymptomatic infections, origin of the virus, transmission, vaccine development, and much more.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

Guest: Ralph Baric

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Links for this episode

• Aerosol and surface stability of SARS-CoV-2 (medRxiv)
• Clinical course and risk factors for COVID-19 (Lancet, pdf)
• Face mask use during SARS-CoV outbreak (EID)
• COVID-19 and Italy (Lancet)
• Letters read on TWiV 591
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

While today’s research often has a bias of being primarily for the benefit of humankind, there are many pathogens that negatively affect other organisms on Earth. Today, we’ll discuss zoonosis and how transfer of a pathogen from one organism to another can shape global health. Let’s learn to be scientifically conversational.

Vincent and Rich update the current situation with COVID-19 and SARS-CoV-2, including fatality ratios, virus spreading outside of China, immunity to infection, vaccines, antivirals and much more.

Hosts: Vincent Racaniello and Rich Condit

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Links for this episode

• WHO CoV sitreps
• How to Prepare for the Coronavirus (NY Times)
• Multiple shedding routes of SARS-CoV-2 (Emerg Microbes Inf)
• Cruise ship a/c could promote virus spread (Purdue news)
• Image credit
• Letters read on TWiV 589
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus.

Hosts: Nels Elde and Vincent Racaniello

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• Distinct CoV name needed (Lancet)
• Proximal origin of SARS-COV-2 (virological)
• CoV spillovers not rare (Goats and Soda)
• SARS-CoV-2 phylodynamics analysis (virological)
• Bat CoV surveillance in China (PLoS Path)
• Image credit
• Time stamps by Jolene. Thanks!

Science Picks

Nels - Alejandro Sanchez TED Talk
Vincent - WHO SARS-CoV-2 Sitrep

Music on TWiEVO is performed by Trampled by Turtles

Send your evolution questions and comments to twievo@microbe.tv

The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

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Links for this episode

• WHO CoV sitreps
• Epidemiology of COVID-19 (China CDC)
• COVID-19 incubation period (J Med Virol)
• China clinical trials for COVID-19 (Nature)
• Furin cleavage site in SARS-CoV-2 spike (virology blog)
• Proximal origin of SARS-CoV-2 (Virological)
• Pangolin photos (Nat Geo)
• Letters read on TWiV 588
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Kathy - The deep sea
Rich - World's oldest message in a bottle
Dickson - Coronavirus: A visual guide
Vincent - Recent NSABB meeting Videocasts Day 1 Day 2

Listener Picks

Stephen - This podcast will kill you
Neva - China's surveillance
Sophia - WHO online courses

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

The TWiM team reviews the coronavirus outbreak that began in Wuhan, China, and the finding that an IRF deficiency underlies Whipple’s disease. 

• 2019-nCoV case tracking (JHU)
• Clinical features of infection with 2019-nCoV (Lancet)
• Early transmission dynamics of 2019-nCoV (NEJM)
• Isolation of 2019-nCoV (NEJM)
• TLR4 defect in Whipple’s disease (eLife)

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Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

Send your microbiology questions and comments to twim@microbe.tv

The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

• ASV 2020
• Real time tracking of 2019-nCoV (JHU)
• Estimation of 2019-nCoV R0 (Int J Inf Dis)
• WHO Sitreps on 2019-nCoV
• Coronavirus overtakes SARS (SCMP)
• HHS press conference
• Discovery of 2019-nCoV (bioRxiv)
• Rich CoV genes in bats (PLoS Path)
• Early 2019-nCoV transmission dynamics (NEJM)
• Clinical features of early 2019-nCoV patients (Lancet)
• Remdesvir for MERS-CoV (Nat Commun)
• Transmissibility of 2019-nCoV (Imperial Coll, pdf)
• Comparison of R0 of pathogens (Guardian)
• Forecast of 2019-nCoV (WHO, Univ Hong Kong, pdf)
• Quammen on 2019-nCoV (NY Times)
• Benefits of handwashing (NY Times)
• Asymptomatic 2019-CoV transmission (NEJM)
• Summary of TWiV 584
• Surgical vs N95 masks (JAMA)
• Letters read on TWiV 585
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Pandemic
Alan - Educated by Tara Westover
Rich - Star Trek: Picard
Dickson - Highest Resolution Image Ever Taken of Surface of the Sun
Kathy - Scientists make vampire bats ‘glow’ to simulate vaccine spread
Vincent - Virology Lectures 2020

Listener Pick

Edward - Virus snowflake designs
Anthony - Microbe Hunting Autism to Zika

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove,Rich Condit, Kathy Spindler

Guest: Ralph Baric

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Links for this episode

• ASV 2020
• WHO coronavirus sitreps
• CIDRAP article on coronavirus vaccines
• Phylogenetic analysis of 2019-nCoV
• ACE2 is 2019-nCoV receptor (bioRxiv)
• Visual explainer of Huanan market (SCMP)
• Clinical features of 2019-nCoV patients (Lancet)
• Familial cluster of pneumonia caused by 2019-nCoV (Lancet)
• SARS-CoV 29 nt deletion reduces replication (Sci Rep)
• NSABB
• 2019 TWiV World Tour t-shirt
• Letters read on TWiV 584
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - Library plug-in for Firefox or Chrome
Rich - Sounds of the Solar Wind (Parker Solar Probe)
Dickson - Stunning wildlife photos
Kathy - Incomplete list of things that blow the minds of intro bio students
Vincent - Mosquito photographs by Alex Wild (and anti-pick)

Listener Pick

Justin - YadaYadaYada virus

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle.

Download TWiV 582 (71 MB .mp3, 118 min)
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Links for this episode

• ASV 2020
• NJ ready to remove religious vaccine exemptions (Patch)
• New virus causing pneumonia in China (NY Times)
• New China virus is coronavirus (NY Times, ProMedMail)
• Weekly influenza cases (CDC)
• Future of influenza vaccines (Vaccines)
• Household influenza vaccine study (Int J Epidemiol)
• African swine fever (USDA)
• African swine fever infographics (one, two)
• Race for African swine fever vaccine (Scientist)
• 3D structure of African swine fever virus (J Biol Chem)
• Letters read on TWiV 582
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Rich - Mayo Clinic - Ken Burns; Patient Care and Health Information
Dickson - Australia Fires; Insect ecology; Smoke and aerosols
Kathy - runcible
Vincent - Without a Vaccine, These Are Your Odds

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Subscribe (free): iTunes, Google Podcasts, RSS, email

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Links for this episode

• Please take the TWiV listener survey
• ASV 2019 Satellite Symposia
• Crowdfunding for EV-D68 research
• Outbreak (exhibit, TWiV 501)
• Four Corners hantavirus outbreak (Wikipedia)
• Death at the Corner (Atlantic)
• Hantavirus infection by US state (CDC)
• Hantavirus US cases and mortality (CDC)
• Hantavirus international cases (CDC)
• Belmont hantavirus death (NYTimes)
• Intestinal dysmotility following flavivirus infection of mice (Cell)
• Image credit
• Letters read on TWiV 527
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Alan - Zooming into Sagittarius A, ESO video
Rich- Orbits and Ice Ages: A History of Climate
Dickson- National Geographic Best Photos 2018
Kathy- HealthMap Vaccine Finder
Vincent - Taylor Custom

Listener Pick

Neal- The Yoda of Silicon Valley

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.

Hosts: Vincent Racaniello and Brianne Barker

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Links for this episode

• Pan American Society for Clinical Virology San Diego and Houston Regional Meetings
• It's not SARS 2.0 (TWiV 364)
• Bats out of hell (TWiV 183)
• Bombali virus, a new Ebolavirus (Nat Micro)
• Asymptomatic Ebolavirus infections (virology blog)
• Bat-borne mumps virus (Cell Rep)
• Image credit
• Letters read on TWiV 517
• Timestamps by Jolene. Thanks!

Weekly Science Picks

Brianne - Ed Yong on AFM
Vincent - Goggles Optional podcast (especially #243)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv