zoonosis

The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

• Support Viruses & Cells Gordon Conference
• Outbreak at the Smithsonian
• Outbreak (TWiV 501)
• Latest Ebola virus outbreak, DRC (WHO)
• Summary of Ebola virus outbreaks (CDC)
• Ebola virus nomenclature (ICTV)
• Ebola virus distribution map (CDC)
• Polarization of vaccinia virus membrane proteins (bioRxiv)
• Image credit
• Letters read on TWiV 507

Weekly Science Picks

Alan - Puzzled Escape Games
Rich - An Extremely Detailed Map of the 2016 Election
Dickson - Parker Solar Probe
Kathy - Ancient earth globe and connected Dinosaur database
Brianne - STEMM education should get HACD
Vincent - Free tuition for all NYU medical students

Listener Pick

Heather- GoFarm blog

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World.

Host: Vincent Racaniello

Guests: Sabrina Sholts, Jon Epstein, and Ed Niles

Become a patron of TWiV!

Links for this episode

• Sabrina Sholts
• Jonathan Epstein
• EcoHealth Alliance
• Outbreak at the Smithsonian
• ASM partners with Smithsonian (bLog Phase)
• Vincent as museum object (AMNH)
• Video of this episode (YouTube)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Guest: Vincent Munster

At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses.

Become a patron of TWiV!

Links for this episode

• Rocky Mountain Laboratory
• Munster Laboratory
• Small town, big science (TWiM 140)
• Image credit

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Jeremy Luban, Aaron Lin, and Ted Diehl

Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.

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Links for this episode

• Ebola virus glycoprotein with increased infectivity (Cell)
• Effect in cells of Ebola virus mutations from West African outbreak (Cell)
• Ebola virus in semen for over 500 days (Clin Inf Dis)
• Puzzling origin of 2014 Ebola virus outbreak (J Virol)
• Mutant Ebola virus may have caused explosive outbreak (Goats and Soda)
• Virus Genomics and Evolution website

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 1:05:40

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm 1:35

Register for the 2017 ASM Grant Writing Online course.

Weekly Science Picks

Jeremy – Real time tracking of Ebola virus evolution
Ted - The Brain Scoop
Aaron - Kate Rubins sequencing DNA on ISS (video)
Alan – A Sand County Almanac by Aldo Leopold
Rich –  Vendee Globe
Kathy – Axios
Vincent – Vendors from above by Loes Heerinck

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, and Paul Duprex

Guests: Ralph Baric, Felix Drexler, Marion Koopmans, and Stacey Schultz-Cherry

From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases.

Become a patron of TWiV!

Links for this episode

• EIDA2Z meeting
• MERS-CoV infection of Alpaca (EID)
• Origins of HAV in small mammals (PNAS)
• WHO recommendations on influenza vaccine composition
• Collaborative Cross mice
• Video of this episode at YouTube

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Check out the graduate and postdoctoral programs at the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Deadline for applying to the graduate program is 1 December 2016. For more information about the Department, please visit http://bit.ly/micromssm

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello and Alan Dove

Guest: David Quammen

Four years after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen.

Watch this episode at YouTube

Become a patron of TWiV!

Links for this episode

• David Quammen's website
• Spillover by David Quammen
• Threading the NEIDL (TWiV 200)
• The NEIDL at Boston University

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and non­fiction series from the world's best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE.

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Ralph Baric and Vineet Menachery

Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses  to infect human cells and cause disease in mice.

Links for this episode

• Zoonotic potential of SARS-like bat viruses (Nature)
• SARS-CoV susceptibility loci via collaborative cross (PLoS Genetics) 47:00, 57:25
• Ebright and Wain-Hobson quotes (Nature) 1:17:20
• Misleading press release (UNC) 1:24:45
• Super powerful SARS 2.0 (not!) (Motherboard)
• SARS-like bat virus can jump without mutating (not!) (Daily Mail) 1:26:30
• Photo credit
• Letters read on TWiV 364 1:47:40

This episode is sponsored by Mt. Sinai Department of Microbiology (2:10), ASM Education (33:25), and the 32nd Clinical Virology Symposium (1:51:30)

Timestamps by Jennifer. Thanks!

Weekly Science Picks 1:53:00

Kathy - California Dept of Public Health
Rich - Leafy greens on space station
Vincent - Mechanical keyboards and TWiV on Perfect your podcast

Listener Picks

Jesse - Networking for Nerds by Alaina G. Levine
Russell - Worldmapper

Send your virology questions and comments to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich discuss the virus behind rose rosette disease, and fatal human encephalitis caused by a variegated squirrel bornavirus.

Links for this episode

• Virology tenure-track position at NIH (pdf) 7:00
• Voinnet investigation is a Swiss Federal secret (twitter) 12:25
• Rose rosette disease in Ft. Worth (Star Telegram) 29:35
• Rose rosette virus discovered (J Gen Virol) 34:25
• Emeravirus (ViralZone) 33:55
• Eriophyid mites (MI Botanical Garden) 32:40
• Mite vector of rose rosette disease (U Florida) 34:55
• Image credit
• Squirrel bornavirus associated with human encephalitis (NEJM) 38:40
• Poll: How do you consume podcasts? 1:21:40
• Letters read on TWiV 347 8:10, 59:40

This episode is sponsored by ASM GAP and ICAAC/ICC

Time stamps by Jennifer. Thanks!

Weekly Science Picks 1:17:05

Alan - National Immunization Awareness Month (Twitter campaign)
Rich - Rosie Revere, Engineer by Andrea Beaty
Vincent - iPhone owns podcasts (9to5Mac)

Listener Pick of the Week

Sandra - World Zoonoses Day graphic
Peter - Mammal-carnivorous plant mutualism (bat and shrew)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The eTWiVicators review evidence that the HIV-1 group O epidemic began with a single cross-species transmission of virus from western lowland gorillas.

Links for this episode

• Traces of ATCV-1 associated with laboratory contamination (PNAS)
• ATCV-1 findings not explained by contamination (PNAS)
• Origin of HIV-1 group O epidemic in western lowland gorillas (PNAS)
• INNO-LIA
• Principles of Microbial Diversity
• Image credit: John
• Letters read on TWiV 327

Weekly Science Picks

Alan - California bill to eliminate personal vaccine exemptions
Rich - Kepler observatory (Kepler-186f)
Kathy - USGS disease map
Dickson - Philosphy of Microbiology by Maureen O'Malley
Vincent - Nautilus

Listener Pick of the Week

Ken - Life in our phage world (online, book party); All about that base
Neal - Gilles van Cutsem at CROI
Ricardo - Flow hive

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Vincent, Elio, and Michele review a study of the viruses and bacteria in commensal rats in New York City.

Visit microbeworld.org/twim for complete show notes. Thanks for listening!

Host: Vincent Racaniello

Guest: Linfa Wang

Vincent visits the Australian Animal Health Laboratory in Geelong, Australia and speaks with Linfa about his work on bats and bat viruses.

Links for this episode

• Hendra virus vaccine (Emer Inf Dis)
• Comparison of bat genomes (Science)
• Endogenous retroviruses in bats (Retrovirol)
• The Bat Pack
• Bats in Geelong (YouTube)
• Video of this episode - view at YouTube

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Dickson Despommier

Vincent and Dickson discuss evidence that the malaria parasite originated in gorillas.

Links for this episode:

• Great apes and zoonoses (Science)
• Source of human malaria (PNAS)
• Origin of human malaria parasite in gorillas (Nature)
• Ape Plasmodium in Cameroon not infecting humans (PNAS)
• No Plasmodium in greater spot-nosed monkey (Int J Parasit)
• TWiP 13: Toxoplasmosis
• Image credit
• Letters read on TWiP 62

Contact

Send your questions and comments (email or mp3 file) to twip@twiv.tv

Subscribe

Subscribe to TWiP (free) in iTunes, by the RSS feed or by email

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Matt Frieman

Matt joins the TWiV team to discuss the discovery of a SARS-like coronavirus in bats that can infect human cells, and what is going on with MERS-coronavirus.

Links for this episode

• SARS-like virus in bats binds ACE2 (Nature)
• Bat SARS-like virus that infects human cells (virology blog)
• Coronavirus infections update (WHO)
• Lack of MERS coronavirus antibodies in humans (EID)
• Mice not susceptible to MERS-CoV (J Gen Virol)
• MERS-CoV case imported into Spain
• MERS-CoV like virus in European hedgehogs (J Virol)
• DPP4 amino acids positively selected in bats (Virol J)
• Image credit: Richie Frieman
• Letters read on TWiV 258

Weekly Science Picks

Kathy - Optical illusion (YouTube)
Alan - Amboceptor
Matt - Reply all by Richie Frieman (audio sample)
Vincent - The microbiology of beer

Listener Pick of the Week

Cassie - NeatoShop
Peter - Synapse evolution with Seth Grant (BSP 101)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Vincent, Dickson, Alan and Rich discuss an estimate of the number of different mammalian viruses on Earth.

Links for this episode:

• Estimate of unknown viral diversity in mammals (mBio)
• How many viruses on Earth? (virology blog)
• Letters read on TWiV 249

Weekly Science Picks

Alan - Extreme macrophotography
Dickson - Baloney detection kit
Rich - Mutant silkworms spin colored silk (original article)
Vincent - FlightRadar24

Listener Pick of the Week

Jenn - Ebola by William Close
Jenn - Eleven Blue Men by Berton Roueche
Nissin -Profiles in Science

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Matt Frieman

Matt joins Vincent, Alan, and Rich to summarize what we know and what we do not know about the MERS coronavirus.

Links for this episode:

• MERS-CoV update (WHO)
• MERS-CoV evolution (epidemic)
• Sick camel linked to MERS-CoV death (7Days)
• MERS-CoV hospital outbreak (NEJM)
• MERS-CoV French hospital cluster (Lancet)
• MERS-CoV family cluster (NEJM)
• Matt on MERS-CoV on the Voice of Russia
• Letters read on TWiV 239

Weekly Science Picks

Matt - The Kid Should See This
Alan - Cassini to photograph Earth 
Vincent -Cockroaches! (YouTube)
Rich - Sydney Brenner (Web of Stories)

Listener Pick of the Week

Ebrahim - Virus Hunter by CJ Peters and Mark Olshaker

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Vincent, Alan, Dickson and Welkin review how a virus regulates the severity of mucocutaneous leishmaniasis, virophage control of antarctic algal host-virus dynamics, and human metapneumovirus infection in gorillas.