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    How to Optimize Testosterone & Estrogen

    enApril 12, 2021
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    Podcast Summary

    • Achieving Hormone Optimization through Behaviors, Nutrition, Exercise, and SupplementationTaking on specific behaviors, nutrition, exercise, and supplementation can improve overall wellbeing and impact estrogen and testosterone levels. Anabolic steroids are not the only way to impact sex steroid hormones, and other factors like exercise, cold exposure, and breathing patterns can play a role as well.

      Hormone optimization can be achieved through specific behaviors, nutrition, exercise, and supplementation tools. The concept of Salutogenesis in the allopathic medicine field emphasizes that taking on particular behaviors can promote wellbeing above where you would be if you were not doing those behaviors. Estrogen and testosterone ratios have profound influence on feelings of wellbeing, optimism, anxiety, and reproduction. Anabolic steroids are heavily used and abused in the sports community, but there are also many steroids that are not anabolic steroids that can impact sex steroid hormones. Specific types of exercise, cold exposure, and breathing patterns can impact sex steroid hormones, both estrogen and testosterone.

    • Understanding Hormones and Their FunctionsHormones such as estrogen and testosterone are essential for the proper functioning of the body. These hormones are produced by different glands and can impact our behavior, mood, and overall health. Checking hormone levels with a doctor can help identify any imbalances.

      Hormones such as estrogen and testosterone are produced by glands in the body, including the pineal gland, the hypothalamus, the gonads, and the thyroid gland. Aromatase enzymes in body fat and the testes can convert testosterone into estrogen, which is important for hormone optimization. Pre-pubescent females have low estrogen levels, while puberty causes levels of estrogen to skyrocket before dropping during menopause. Testosterone levels fluctuate across the lifespan, with competition playing a powerful role in activating it. Testosterone also reduces anxiety, promotes novelty, and promotes competitive behavior by changing the threshold for stress in the amygdala. Variations in hormone levels occur across individuals, and consulting with a medical doctor, specifically an endocrinologist, is recommended for hormone examination.

    • The Relationship between Hormones and Sexual BehaviorTestosterone is important for stress reduction, competition, and mating in males, while females rely on it for reproductive behavior. Both estrogen and testosterone are crucial for male libido. Vitamin B6 can reduce the refractory period.

      Testosterone plays a crucial role in reducing stress and anxiety in males of a species and promoting forging type behaviors, novel seeking, and mating. Competition itself can increase testosterone, and dopamine and testosterone work together. In females, testosterone increases their libido and seeking out of reproductive behavior, while estrogen promotes consensual receptivity. In males, both estrogen and testosterone are important for libido, while sex itself can increase testosterone levels depending on ejaculation. Prolactin release sets the refractory period in males, which can be reduced through vitamin B6 intake.

    • Impact of Sexual Behavior and Parenthood on Hormone LevelsSexual activity can increase testosterone levels, but becoming a parent can lead to a decrease in testosterone and increase in cortisol and estradiol levels, ultimately leading to a potential change in physical appearance.

      Sexual behavior can increase testosterone levels, with actual intercourse resulting in far greater increases than mere observation. Ejaculation does not adjust testosterone levels, but abstinence or sex after a week or more can lead to a 400% increase in testosterone levels. DHEA can increase both testosterone and estrogen, with the extent of increase depending on individual hormone levels and the presence of aromatase. Becoming a parent results in a decrease in testosterone levels, increased cortisol, and doubled estradiol levels due to an increase in prolactin. This hormone can suppress sex steroid hormones and increase categories of other hormones. This phenomenon, along with a decrease in physical activity, can result in a phenomenon known as the dad bod in both males and females.

    • The Impact of Father's Smell on Parenting Hormones and PheromonesA father's availability and contact with the baby's smell can impact parenting hormones. Illness and pro-inflammatory cytokines decrease desire for sex. Parenting can change hormone levels due to smell or pheromones with established effects such as the Libutti and Bruce effects in animals.

      Father's availability and contact with the baby's smell impact the level of hormones that promote parenting behaviors. Illness and pro-inflammatory cytokines like IOL six decrease the desire for sex and reduce levels of testosterone and estrogen, making them bad for sex steroid hormones. The mere act of parenting can change hormone levels due to smell or pheromones. Well-established pheromone effects in animals include the Libutti, Bruce, Whitten, and Vandenberg effects. The Libutti effect shows that the presence of males changes the oscillation cycle of females. The Bruce effect causes pregnant animals to abort or reabsorb their fetus if a novel male replaces the father for 48 hours.

    • The Science of Human Pheromones and Its EffectsHuman pheromones from sweat and urine can have an impact on menstrual cycles and puberty. The vomeronasal equivalent in humans is a combination of smell and taste, and detecting a partner's t-shirt based on pheromone effects is statistically significant.

      The presence of pheromone effects in humans is still a controversial topic, but studies have shown that pheromones from sweat and urine can modulate menstrual cycle patterns and accelerate or delay puberty. Additionally, the pheromones from male urine can cause a re-introduction of the estrous cycle and a spontaneous abortion of the fetus. Although there is no well-identified pheromone organ in humans, studies have shown that the vomeronasal equivalent in humans is a combination of smell and taste. Furthermore, the accuracy of detecting a partner's t-shirt based on pheromone effects is above statistical significant threshold, indicating the reality of pheromone effects in humans.

    • The Impact of Breathing on Hormones and Mate AttractionBreathing through the nose can improve sleep and hormone optimization, while chemicals in perfumes can mimic pheromones to attract mates. Learning proper breathing techniques can optimize hormone levels and reduce sleep apnea incidences.

      Chemical compounds built into perfumes can be designed to attract mates by mimicking pheromones. In the animal world, taste and smell are crucial for mating, and the Fleming response is a well-documented phenomenon. Apnea, or under-breathing during sleep, can negatively impact hormone levels and is associated with reductions in estrogen and testosterone. However, adjusting breathing patterns while awake can improve sleep and hormone optimization. Breathing through the nose, not the mouth, can improve cosmetic features of the face and optimize hormone levels. Learning to breathe in particular ways can have a significant impact on sleep, reduce the incidence of sleep apnea, and boost various hormones in the body.

    • The Importance of Nose Breathing for Hormonal Balance and Sleep Quality.Proper nose breathing can boost testosterone and estrogen balance while reducing cortisol and apnea. Practice nose breathing throughout the day and during sleep to optimize hormonal levels and improve overall health.

      Breathing properly through the nose can positively impact hormones like testosterone and estrogen, while mouth breathing has negative effects on the attractiveness of one's face and jaw. Studies show that reducing or eliminating apnea in sleep can significantly increase testosterone and balance estrogen to testosterone ratios in males and females. This is achieved by decreasing cortisol levels, which can be achieved through proper breathing. Therefore, it is essential to practice nose breathing during waking hours and while sleeping to optimize hormone levels and reduce the negative effects of apnea on the body.

    • The Benefits of Nasal Breathing and Morning Light Exposure.Nasal breathing during exercise can improve breathing and lung capacity, while morning light exposure can affect hormone levels, including fertility and sex drive. Understanding these relationships can lead to better health optimization strategies.

      Nasal breathing during exercise can have numerous positive effects, including reducing apnea and increasing lung capacity. By dilating the nasal passages, individuals can experience easier breathing through their nose. Additionally, viewing bright light within the first hour of waking can have a direct effect on hormone levels, including fertility and libido. The relationship between light, dopamine, and sex steroids is powerful and has been observed in seasonal breeding animals. Understanding these relationships can lead to a deeper understanding of how to optimize light viewing behavior for overall health.

    • How Animal Fur Color and Seasonal Breeding is Linked to Dopamine and HormonesThe color of animal fur and their breeding patterns are related to dopamine levels, which in turn affects sex hormone levels. Optimizing light exposure early in the day can help boost dopamine levels and balance hormones.

      The color of animals' fur is related to their tendency to breed, which is linked to the levels of sex steroid hormones. Dopamine is the link between these, and it increases all three. This means that animals breed more in the summer months when there is more daylight and less in the winter months, which also affects humans' mood and behavior. To optimize testosterone and estrogen levels, it is crucial to get sufficient light exposure in the eyes early in the day, which increases dopamine levels. It is also important to avoid bright light exposure in the middle of the night, as it suppresses dopamine release and affects testosterone and estrogen levels. Taking care of light viewing behavior is important before considering other ways to optimize hormone levels.

    • Optimizing Sleep and Light Viewing Behavior for Hormone Optimization.Paying attention to sleep patterns and avoiding light exposure at night helps regulate sex steroid hormone levels, which reduces anxiety. Cold exposure through ice baths or cold showers also helps regulate hormones and optimize lifestyle.

      Optimizing sleep patterns and light viewing behavior can have a positive effect on sex steroid hormone levels, which can in turn help reduce anxiety and other issues. The relationship between temperature, day length, and sunlight is also closely tied to hormone levels. Cold exposure, such as ice baths or cold showers, can have positive effects on sex steroid hormones through rebound vasodilation and neural effects. Understanding the science behind these phenomena can help individuals make informed decisions about their lifestyle choices and hormone optimization.

    • The Connection Between Brain Neurons and GonadsCooling neurons that control blood flow can increase testosterone or estrogen levels, while excessive heat is not good for the gonads. Exercise can optimize testosterone levels, benefiting both males and females.

      The gonads, ovaries, and testes are heavily vascularized and have a connection to the neurons in the brain that produce gonadotropin-releasing hormone. Cooling neurons that control vasoconstriction and vasodilation through exposure to cold can increase testosterone or estrogen levels by reducing the entry of blood or lowering it. Excessive heat is not good for the gonads as proteins in sperm are heat-sensitive. Exercise, whether weight training or endurance work, can increase testosterone levels in males and females, but the basis for this effect is not fully understood by scientists. Optimizing testosterone levels has numerous positive effects in both males and females.

    • How Heavy Weight Training Can Increase Testosterone LevelsHeavy weight training without going to failure can cause a boost in testosterone for up to 48 hours. Neural engagement and feedback signals can lead to the production of more testosterone or increased receptor activity. However, over-exertion can increase cortisol levels and lower testosterone.

      Heavy weight training, but not weight training to failure, leads to the greatest increases in testosterone in males and females for about a day or up to 48 hours. The engagement of neurons that recruit high threshold motor units in muscle when moving heavy loads provides a feedback signal to the gonad to produce more testosterone or to increase receptor activity. The optimal protocols for increasing testosterone through weight training are not fully understood, but it is clear that working too hard can increase cortisol levels and reduce testosterone.

    • The Science of Testosterone and ExerciseHeavy weight training without going to failure increases testosterone levels. Follow it up with endurance training and high-intensity interval training. Limit endurance exercise to 75 minutes to avoid increased cortisol levels. Menopause symptoms involve reduced estrogen levels and may require supplemental estrogen.

      Weight training with heavy loads, but not to failure, is the best scientifically supported solution to increase testosterone levels. Endurance activity should be done after weight training to optimize testosterone levels as endurance activity performed first leads to a decrease in testosterone. High intensity interval training increases testosterone levels, but endurance exercise beyond 75 minutes leads to a reduction in testosterone levels due to increases in cortisol. Limiting the endurance exercise to 75 minutes or less and not making it too intense is one way to keep cortisol from increasing. Menopause is characterized by a reduction in estrogen levels, and physicians often prescribe supplemental estrogen to combat its symptoms.

    • Alternative Menopausal TreatmentsBlack cohosh, Panax ginseng and Purearia mirifica offer modest to potent relief for menopausal symptoms. Discuss treatment options with a physician, especially if there is a family history of breast cancer.

      There are potential options besides standard estrogen therapy for menopausal symptoms, including compounds such as black cohosh and Panax ginseng. Quality peer reviewed studies have shown modest improvements in symptoms associated with menopause with these compounds. Purearia mirifica has been found to be very potent in reducing menopausal symptoms in comparison to estrogen replacement therapy. It's important to discuss any supplement options with a physician, especially if there is a concern about supplementing estrogen with a breast cancer background in the family.

    • The Importance of Proper Hormone Balance and SupplementationMaintaining proper zinc, magnesium, and vitamin D levels can promote healthy hormone production. Consult a doctor before taking any hormone-related compounds to avoid negative side effects. Opioid use negatively impacts sex hormones. It is recommended to consult with a doctor for proper supplementation and get regular blood work to ensure healthy hormone levels.

      Maintaining proper levels of zinc, magnesium, and vitamin D can promote testosterone and estrogen production in proper ratios. However, it is important to consult with a doctor before taking any hormone-related compounds as they can have serious implications. Opioids are known to negatively impact sex steroid hormones, and excessive use can have numerous endocrine syndromes and disruptions. While there is a vast range of products available in the market, from deer antlers to bull testes, to increase testosterone, it is always safer and recommended to consult a doctor for proper supplement doses. It is also advised to get regular blood work done to ensure proper androgen and vitamin D levels.

    • The Impact of Supplement Compounds on AndrogensSupplement compounds like creatine, Tonga Ali, and boron may have benefits for adjusting androgens like testosterone and dihydrotestosterone, but it's important to research extensively and approach them with caution to understand potential side effects.

      Supplement compounds like creatine, Tonga Ali, and boron have been supported by scientific literature for their ability to adjust androgens such as testosterone and dihydrotestosterone. Creatine has evidence of increasing DHT, but its impact on hair loss can depend on individual susceptibility. Tonga Ali has pro-fertility, pro-free testosterone, and subtle aphrodisiac effects, while also being anti-estrogen. Boron is also interesting as research has shown it to increase free testosterone and decrease estrogen levels. While these supplements may have their benefits, it's important to approach them with caution and research extensively to understand their potential side effects on different organs and tissues.

    • Caution in Hormonal ModulationBoron supplementation may increase testosterone, but cautious examination of potential side effects is necessary as androgen and estrogen modulation can increase cancer risk. Testosterone levels should be within a personalized range for specific goals, and careful consideration of active steroids is advised.

      Boron supplementation has some scientific support for freeing up more testosterone, but it is important to be cautious when modulating hormones, especially androgens and estrogens. Any tissue that recycles itself is prone to cancers, and those tissues thrive on androgens and estrogens to create more tumors. It is not the goal to free up all testosterone, but to get free testosterone into a range that works for your particular goals and needs. In addition, there are active steroids that have bioavailability or their metabolites are bioavailable, and they have been shown in a study to have significant increases in muscle mass strength, hypertrophy effects, and other expected androgen increases when given in conjunction with strength training. When considering hormonal optimization, caution and careful examination of side effects is always crucial.

    • The Impact of Hormonal Supplementation on Sports Performance and FertilityHormone supplementation can enhance sports performance and fertility, but effects vary and depend on an individual's hormonal makeup. It's crucial to be aware of potential impacts on gene expression, strength, and anxiety levels.

      Supplementation with hormones can have a significant impact on sports performance and fertility. Hormones like luteinizing hormone may be increased through the use of prescription drugs like HCG. For those interested in increasing for dojo aggressiveness, FADOGI HRESTIS may increase luteinizing hormone levels. However, it's important to note that supplementation effects can be subtle and varied depending on an individual's hormonal makeup. It's crucial for athletes and individuals seeking hormone therapy to be aware of the potential impact on gene expression, strength, and anxiety levels.

    • Approaching Hormone Supplements with CautionBefore taking hormone supplements, consult with a healthcare provider and monitor hormone levels through regular blood tests and ovulation tracking. Opt for supplements that support hormone production instead of creating a significant increase. Be cautious of potential side effects and toxicity.

      Modifying estrogen or testosterone levels through supplements can have both positive and negative effects on the body and should always be approached with caution. It is important to monitor hormone levels through regular blood tests and tracking ovulation cycles. Supplements that support the overall production of these hormones, such as magnesium, T3, and zinc, may be a better option than those that create a significant increase in hormone levels. Some supplements, such as bull by Natalie census, may have liver toxicity and should be used with caution.

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    In this episode, my guest is Dr. Layne Norton, Ph.D., one of the world’s top experts in nutrition and training for physical fitness. We discuss how to evaluate scientific evidence and the validity of different practices aimed at achieving fat loss, muscle strength and hypertrophy, microbiome health, vitality, and longevity. We explore many hotly debated topics, including fasting, seed oils, saturated fats, sugar, red meat, artificial/low-calorie sweeteners, and GLP-1 agonists (e.g., Ozempic). Additionally, we delve into the timing of protein and carbohydrate intake relative to fasting and exercise, fat loss and sleep, and the benefits of dietary protein and fiber on overall health. We also discuss how to accelerate hypertrophy and fat loss, improve strength, whether we need to train to “failure,” how to enhance exercise recovery, and how to manage pain. We cover training before versus after age 50, whether metabolism changes with age, and the connection between muscle health and longevity. We also address why certain behaviors and supplements might work for some people but not others. Listeners to this episode will benefit greatly from Layne’s science-based expertise on a wide range of topics, including health, nutrition, and fitness. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Mateina: https://drinkmateina.com/huberman Eight Sleep: https://www.eightsleep.com/huberman Maui Nui: https://mauinuivenison.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Layne Norton 00:01:49 Sponsors: Mateina, Eight Sleep, Maui Nui 00:06:39 Science-Based Evidence, Mechanism vs. Outcome 00:14:31 Meta-analysis, Methods, Evidence Quality 00:22:45 Evidence Hierarchy, Randomized Controlled Trials, Cohort Data 00:33:53 Sponsor: AG1 00:35:05 “Don’t Turn Your Brain Off”; Protein Synthesis 00:42:01 Protein Synthesis, Refractory Response; Resistance Training   00:46:05 Protein Intake, Intermittent Fasting & Training 00:54:52 Tool: Total Protein Intake, Distribution & Protein Synthesis 01:00:25 Muscle Quality, Protein Remodeling, Muscle Growth 01:05:34 Sponsor: LMNT 01:06:46 Early vs. Late Time-Restricted Eating; Fasting Blood Glucose & HbA1c 01:10:30 Carbohydrate Timing, Individual Response, Placebo; Tool: Tracking Diet 01:19:50 “The Norton Method”; Tool: Consistency 01:25:16 Resistance & Cardiovascular Training; Competition; Immune System & Rest 01:33:50 Mind & Body Effects, Stress; Belief Effects 01:41:30 Training to Failure, Reps in Reserve, Hypertrophy & Strength Training 01:50:24 Fatigue & Training to Failure, Speed, Strength Training 01:59:06 Tool: Training After 50, Consistency 02:09:12 Fat Cells, Diabetes, Exercise 02:16:50 Metabolism & Age-Related Changes?, Appetite 02:23:17 Ozempic, Mounjaro, GLP-1 Agonists, Lean Mass, “Food Noise” 02:33:42 GLP-1 Agonists, Judgement & Obesity 02:40:19 Sugar, Excess Calories, Body Weight 02:49:16 Satiety, Sugar & Calorie Budget 02:54:56 Tool: Individualization, Context & Diet Psychology 02:57:22 Seed Oils, Butter, Olive Oil 03:06:56 Red Meat, Carcinogenic?; Simple Diet; Fiber Benefits 03:13:43 Saturated Fat, Cholesterol; Seed Oils 03:18:41 Artificial & Low-Calorie Sweeteners, Insulin, Appetite 03:29:06 Artificial & Low-Calorie Sweeteners, Gut Microbiome; Cancer 03:37:58 Tools: Training Recovery, Glycogen Replenishment; Stress & Activity 03:45:56 Collagen Supplementation, Skin & Nails, Whey Protein 03:57:00 Evidence-Based Approach 04:01:41 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enAugust 12, 2024

    Dr. Martha Beck: Access Your Best Self With Mind-Body Practices, Belief Testing & Imagination

    Dr. Martha Beck: Access Your Best Self With Mind-Body Practices, Belief Testing & Imagination
    In this episode, my guest is Dr. Martha Beck, Ph.D., a Harvard-trained sociologist, bestselling author, and one of the world’s foremost experts on personal exploration and development.  Dr. Beck shares specific frameworks and practices to tap into your unique and deepest desires, core truths, and best life direction—all elements that comprise your authentic self. She also explains how to align your work and relationships of all kinds with your true self and how to embrace the discomfort and process of leaving unhealthy relationships. We discuss how to deal with negative thoughts and emotions, grapple with societal norms, and improve body awareness to gauge your inner truth. We also discuss codependency and self-abandonment - and how to exit and recover from these experiences.  By the end of the episode, you will have learned numerous practical tools to access your best self and live a richly fulfilling life.  Access the full show notes for this episode at hubermanlab.com. Dr. Beck's Wayfinder Life Coach Training: https://marthabeck.com/life-coach-training Thank you to our sponsors AG1: https://drinkag1.com/huberman BetterHelp: https://betterhelp.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Waking Up: https://wakingup.com/huberman Timestamps 00:00:00 Dr. Martha Beck 00:01:34 Sponsors: BetterHelp, Helix Sleep & LMNT 00:05:34 Tool: Perfect Day Exercise 00:15:31 “Clear Eyed”, Male vs. Female 00:23:31 Family & Work; Directed Attention & Miracles 00:30:21 Sponsor: AG1 00:32:10 Unease, Restlessness & Guilt; Life Worth, Fear 00:37:22 Accessing the Subconscious; Compassionate Witness Self 00:46:16 Finding Self, Suffering, Anxiety; Tool: “KIST”, Self-Parenting 00:54:01 Self, Radiance, Death; Awakening 00:59:14 Suffering & Compassionate Attention 01:02:10 Challenging Internal Thoughts, Understanding Truth, Body & Mind; 01:08:44 Sponsor: Waking Up 01:10:20 Western Society & Pressure 01:18:30 Tool: Sensing Truth in Body; Meditation, “Stopping the World” 01:25:02 Energy, Magnetoreception, Pet’s Death 01:33:49 Lying to Ourselves, Addiction 01:38:18 Tool: “Integrity Cleanse”, Lies; The Light 01:47:32 Relationship with Loss; Love, Self-Abandonment & Codependency 01:55:10 Romantic Relationships; Jobs & Family 02:02:06 Hurting Others, Relationship Imbalance 02:06:55 Tool: True Empathy 02:11:26 “Happiness is an Inside Job”, Codependency 02:18:58 Live Your Joy, Western Society 02:24:41 Relationships, Love & Integrity, “Feeling Good By Looking Weird” 02:30:42 “I Like It!”, Punk Rock Music, Love 02:34:24 Honesty & Essential Self; Helping People & Healers 02:42:12 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enAugust 05, 2024

    AMA #18: Cold Therapy Advice, Skin Health Tips, Motivation, Learning Strategies & More

    AMA #18: Cold Therapy Advice, Skin Health Tips, Motivation, Learning Strategies & More
    Welcome to a special edition of the 18th Ask Me Anything (AMA) episode, part of Huberman Lab Premium. This episode is a recording of the live stream AMA, exclusive to our Premium members. We've decided to make the full-length version available to everyone, including non-members of Huberman Lab Premium. Huberman Lab Premium was launched for two main reasons. First, it was launched in order to raise support for the main Huberman Lab podcast — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation and other donors. If you're not yet a member but enjoyed this full-length livestream AMA, we invite you to join Huberman Lab Premium. By subscribing, you'll gain access to exclusive benefits including our regular monthly full-length AMA episodes, AMA transcripts, podcast episode transcripts, early access to live events and more. Additionally, a significant portion of your membership proceeds contributes to advancing human scientific research. You can learn more about the research we were able to support in our Annual Letter 2023. If you're a Huberman Lab Premium member, you can access the transcript for this AMA episode here. Timestamps 00:00 Introduction & Announcements 00:15 Supporting Mental & Physical Health Research 01:56 Exciting New Research Initiatives 03:39 Skin Health & Appearance 14:46 Cold Therapy Benefits & Guidelines 21:18 Self-Motivation Strategies 27:05 Understanding REM Sleep 28:45 Morning Routine: Exercise & Cold Exposure 29:17 The Importance of REM Sleep 29:49 Non-Sleep Deep Rest (NSDR) Protocols 31:27 REM Sleep Rebound & Compensation 32:55 Impactful School Strategies for Learning 34:19 Meditation & Micro Gaps in Learning 39:13 Physical Activity & Learning 41:01 Exploring Shilajit & Testosterone 47:51 Writing Process & Overcoming Obstacles 51:32 Addiction & Recovery Resources 53:47 Closing Remarks & Gratitude Disclaimer & Disclosures
    Huberman Lab
    enAugust 02, 2024

    Dr. Peter Attia: Supplements for Longevity & Their Efficacy

    Dr. Peter Attia: Supplements for Longevity & Their Efficacy
    In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.  We discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.  Finally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.  Listeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Levels: https://levels.link/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps 00:00:00 Dr. Peter Attia, NAD Pathway 00:02:31 Sponsors: LMNT, Levels & Eight Sleep 00:06:38 Categories of Longevity Approaches 00:17:22 Peter’s Supplements; Rapamycin & Research Data 00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho 00:30:35 Sponsor: AG1 00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan 00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan 00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol 00:53:31 Perform with Dr. Andy Galpin Podcast 00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health 01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes 01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program 01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance 01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits 01:30:38 Longevity, NR & NMN Supplementation, Inflammation 01:41:00 Rapamycin & Immune Function 01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor  01:55:24 Radiation & Cancer Risk 01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline 02:07:12 Tool: Exercise Timing & Energy Levels 02:11:22 Peter’s Supplements 02:18:46 Andrew’s Supplements 02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy  02:26:52 NAD Pathway Supplementation for Longevity? 02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter Disclaimer
    Huberman Lab
    enJuly 29, 2024

    Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity

    Dr. Stacy Sims: Female-Specific Exercise & Nutrition for Health, Performance & Longevity
    In this episode, my guest is Dr. Stacy Sims, Ph.D., an exercise physiologist, nutrition scientist, and expert in female-specific nutrition and training for health, performance, and longevity. We discuss which exercise and nutrition protocols are ideal for women based on their age and particular goals. We discuss whether women should train fasted, when and what to eat pre- and post-training, and how the menstrual cycle impacts training and nutrition needs. We also explain how to use a combination of resistance, high-intensity, and sprint interval training to effectively improve body composition, hormones, and cardiometabolic health, offset cognitive decline, and promote longevity.  We also discuss supplements and caffeine, the unique sleep needs of women based on age, whether women should use deliberate cold exposure, and how saunas can improve symptoms of hot flashes and benefit athletic performance. Dr. Sims challenges common misconceptions about women’s health and fitness and explains why certain types of cardio, caloric restriction, and low-protein diets can be harmful to women’s metabolic health. Listeners will learn a wealth of actionable information on how to improve their training and nutrition to enhance their health and how to age with greater ability, mobility, and vitality. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui Venison: https://mauinuivenison.com/huberman  Eight Sleep: https://eightsleep.com/huberman   Waking Up: https://wakingup.com/huberman  Timestamps 00:00:00 Dr. Stacy Sims 00:02:24 Sponsors: Maui Nui, Eight Sleep & Waking Up 00:07:03 Intermittent Fasting, Exercise & Women 00:12:50 Cortisol & Circadian Rhythm, Caffeine & Training 00:17:25 Reps in Reserve, Rate of Perceived Exertion (RPE); Age & Women 00:21:06 Pre-Training Meal & Brain, Kisspeptin 00:26:45 Post-Training Meal & Recovery Window 00:29:59 Sponsor: AG1 00:31:48 Hormones, Calories & Women 00:34:24 Women, Strength Improvements & Resistance Training 00:39:10 Tool: Women & Training Goals by Age Range 00:44:16 Women, Perimenopause, Training & Longevity 00:47:14 Women & Training for Longevity, Cardio, Zone 2 00:51:42 Tools: How to Start Resistance Training, Machines; Polarized Training 00:58:23 Perform with Dr. Andy Galpin Podcast 00:59:10 Menstrual Cycle & Training, Tool: Tracking & Individual Variability 01:04:31 Tool: 10-Minute Rule; High-Intensity Training & Menstrual Cycle 01:08:36 “Train Hard & Eat Well”; Appetite, Nutrition & Menstrual Cycle 01:12:22 Oral Contraception, Hormones, Athletic Performance; IUD 01:20:57 Evaluating Menstrual Blood, PCOS; Hormones & Female Athletes 01:26:31 Iron, Fatigue; Blood Testing & Menstrual Cycle 01:29:33 Caffeine & Perimenopause; Nicotine, Schisandra 01:34:24 Deliberate Cold Exposure & Women, Endometriosis; Tool: Sauna & Hot Flashes 01:42:19 Tools: “Sims’ Protocol”: Post-Training Sauna & Performance; “Track Stack” 01:49:37 Women, Hormones & Sleep, Perimenopause & Sleep Hygiene 01:52:54 Supplements: Creatine, Water Weight, Hair Loss; Vitamin D3 01:57:21 Protein Powder; Adaptogens & Timing 02:00:11 Pregnancy & Training; Cold & Hot Exposure 02:06:19 Tool: Women in 50s & Older, Training & Nutrition for Longevity 02:09:38 Tool: Women in 20s-40s & Training, Lactate 02:12:18 Tool: What is High-Intensity Training?, Cardiovascular Sets & Recovery 02:17:22 Training for Longevity, Cellular & Metabolic Changes 02:19:30 Nutrition, 80/20 Rule 02:23:30 Listening to Self 02:26:00 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter  Disclaimer & Disclosures
    Huberman Lab
    enJuly 22, 2024

    Dr. Stuart McGill: Build a Strong, Pain-Proof Back

    Dr. Stuart McGill: Build a Strong, Pain-Proof Back
    In this episode, my guest is Dr. Stuart McGill, Ph.D., a distinguished professor emeritus of spine biomechanics at the University of Waterloo and a world expert on spine anatomy and physiology, back pain, and rehabilitation. We discuss the most common sources of back pain, how back pain can be assessed (including self-assessment techniques), and how to design a personalized recovery plan to reduce back pain. We discuss how to train for lifelong fitness, reduce injury risk, and protect your back and joints based on your age and personal goals. We also discuss how to prevent back pain, build core stability, and explain how “McGill’s Big 3” exercises protect and strengthen the back. Dr. McGill, who is exceptionally fit in his late 60s, describes his low-time investment, personal training routine, and the specific exercises he uses for mobility, strength, and cardiovascular fitness. We also discuss controversial issues in the back pain and rehabilitation field, including how pain originates, the biopsychosocial model of pain, and treatments such as platelet-rich plasma (PRP). This episode provides clear, actionable tools to strengthen, prevent, and remedy back pain and injury so you can be pain-free while enjoying sports, exercise, and daily activities at any age. Access the full show notes for this episode at hubermanlab.com. Watch the clip on back pain relief and spine anatomy that accompanies this episode. Demonstration of The McGill Method Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman BetterHelp: https://betterhelp.com/huberman Waking Up: https://wakingup.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps 00:00:00 Dr. Stuart McGill 00:02:33 Sponsors: Helix Sleep, BetterHelp & Waking Up 00:06:23 What Causes Back Pain?; Genetics, Dog Breed Analogy 00:12:55 Tool: Skeleton & Body Type; Spine Flexibility & Discs 00:20:25 Flexibility & Exercises; Discs & Collagen 00:25:43 Sponsor: AG1 00:27:32 Stress & Tipping Point; Athletic Tradeoffs, Triathletes 00:36:17 Back Pain, Goals & Training Program 00:45:57 Spine Hygiene, Back Pain, Powerlifting 00:53:33 Genetics & Running 00:59:34 Sponsor: LMNT 01:00:46 Rehabilitation & Reducing Volume; Injury 01:07:42 Tool: Training for Lifelong Fitness, Injury & Joints 01:17:40 Pain Types, Biopsychosocial Model of Pain 01:26:15 Coaching, Explosivity & Endurance 01:32:43 Virtual Surgery & Rest, Pain Recovery 01:41:25 Tool: McGill’s Big 3; Building Back Strength & Stability 01:46:39 Inversion Tables & Spine Deloading, Disc Bulge, Tool: Lumbar Support 01:51:09 Tool: Daily Walking; Sitting 01:55:33 Deadlift & Bone Density, Glute-Ham Raise 02:06:20 Training & Age, Osteoporosis, Tool: Deadlift Alternatives 02:16:47 Tools: Biblical Training Week; Spine Stability & McGill’s Big 3; Shrinking & Age 02:24:16 Platelet-Rich Plasma (PRP); Disc Damage 02:27:56 Tools: Biblical Training Week & Strength Exercises, Neck Strength 02:35:24 Tools: Sword Play, Distal Limb Loading, Training for Symmetry 02:42:38 Tools: Biblical Training Week, Mobility & Cardiovascular Exercises, Athletic Panel 02:49:22 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures
    Huberman Lab
    enJuly 15, 2024

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