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    The Art of Stability | Beth Lewis (Ep. #131 Rebroadcast)

    enMay 30, 2022

    Podcast Summary

    • Emphasizing Conscious Movement and Individualized Approach with Beth LewisFitness expert Beth Lewis integrates various systems and focuses on individualized, conscious movement, drawing inspiration from Bruce Lee's Jeet Kune Do.

      Beth Lewis, a fitness expert, emphasizes the importance of conscious movement and being connected to your body. She integrates various systems like Postural Restoration Institute (PRI), Dynamic Neuro muscular stabilization (DNS), and Functional Range Conditioning (FRC) into her work, extracting what's useful and disregarding what's less helpful. Beth's unique approach, inspired by Bruce Lee's Jeet Kune Do, is to be agnostic to specific systems and focus on what works best for each individual. She met Peter Atia, the podcast host, through a mutual connection and has since become a go-to resource for all things related to strength and stability. Their collaborative work, including in-depth interviews and demonstrative videos, is available to subscribers for further exploration.

    • From Childhood Passion to International Dance CareerFollow your passions, adapt and be resilient to physical and emotional challenges, and trust and collaborate with others to succeed in your field.

      The speaker's passion for dance led her from being a competitive athlete and musician as a child, to touring internationally with a physical theater dance company, and eventually settling in New York. Her natural ability and dedication allowed her to excel in her field, but the physical demands took a toll on her body as she aged. The company she danced for, Pilatellis, is known for its athletic and improvisational style, which requires a high level of trust and collaboration among its members. The speaker's experience demonstrates the importance of following one's passions, even if it means making significant sacrifices, and the value of adaptability and resilience in the face of physical and emotional challenges.

    • Foundational Experience Shaping PerspectiveStarting out as a fitness professional, the speaker learned the importance of safety, basic movement prep, and proper form, setting the foundation for her future philosophy integrating various approaches to improve movement and loading.

      Starting out in New York as a fitness professional, the speaker hustled hard, teaching multiple classes a day and providing one-on-one training sessions. Her philosophy focused on safety and basic movement prep. However, she soon realized the importance of proper form and the potential for injury in popular exercises like squats, deadlifts, and presses. Despite being only 30% of who she is today, this foundational experience shaped her perspective and set her on a path towards integrating various philosophies to improve how people move and are loaded.

    • Exploring out-of-range joint control for better movement abilityFunctional Range Conditioning (FRC) highlights the importance of improving stability and awareness beyond comfortable mid-range for enhanced movement performance

      Our ability to move and perform exercises, like squatting, is influenced by our body's stability and awareness of its own capabilities beyond the comfortable mid-range. The speaker, who struggled to help others perfect their squat technique despite being able to do it herself, discovered this concept through Functional Range Conditioning (FRC). FRC emphasizes the importance of exploring and improving out-of-range joint control to enhance overall movement ability. The speaker's aha moment came when she realized that people can easily maintain a perfect squat position while lying down, but struggle to do so under their own bodyweight due to stability issues. This realization opened up a whole new world of understanding for the speaker, leading her to dive deeper into FRC and its potential benefits.

    • Maintaining muscle control at end rangesFocus on exercises that challenge muscles at their end ranges to improve overall strength and prevent potential pathologies. Prioritize scapular mobility and control for better breathing and stability.

      Our muscles, particularly those in the scapular girdle, can become weak and deconditioned at their end ranges if not regularly used and controlled. This is because our central nervous system is lazy and needs reminders to stay within certain ranges. The importance of scapular mobility and control cannot be overstated as it guides where our shoulders and rib cage should go, allowing for better breathing and stability. By focusing on exercises that challenge our muscles at their end ranges, we can improve our overall strength and prevent potential pathologies. For instance, the tricep kickback exercise, which may seem easy with light weights, can actually reveal weaknesses and the need for greater control. It's crucial to understand that our muscles' strength is not uniform throughout their range of motion and that we should prioritize working in the end ranges to maintain optimal function.

    • Improve mobility and coordination with Controlled Articular RotationsCARs, a component of FRC, can help improve scapulae movement, minimize involvement of head, ribs, and spine, and use isometric input for lasting results.

      Controlled Articular Rotations (CARs), a key component of Functional Range Conditioning (FRC), can help improve mobility and coordination by encouraging consistent movement of the scapulae, while minimizing involvement of the head, ribs, and spine. FRC uses isometric input and progressive angular isometric loading to help the brain accept and own new ranges of motion, making it beneficial for both rehabilitation and performance. Despite the challenges, consistent practice is necessary for lasting results. FRC was developed by Dr. Andreo Spina, a chiropractor, and includes both manual therapy and strength application components.

    • Integrating FRC and PRI into weight trainingFRC and PRI techniques improve movement control, coordination, and proprioception during weight training, preventing injuries and enhancing functionality.

      Functional range conditioning (FRC) and Postural Restoration Institute (PRI) techniques, when integrated into weight training, can significantly improve movement control, coordination, and proprioception. FRC involves teaching people to hold and release tension in their body, while PRI focuses on addressing asymmetries caused by natural patterns of compression and rotation. The speaker, who adopted these methods in his training, reported better performance, fewer injuries, and increased client acceptance after initial resistance. These techniques can help prevent repetitive injuries and improve overall functionality.

    • Proper breathing impacts movement and overall well-beingInefficient breathing can lead to physical issues like rib flare, anterior tilt, and symptoms such as plantar fasciitis, knee pain, and anxiety. Focus on wide and deep breathing and address underlying imbalances for improved health and functionality.

      Proper breathing plays a crucial role in efficient movement and overall well-being. Poor breathing patterns, such as favoring one side or shallow breathing, can lead to various physical issues like rib flare, anterior tilt, and even symptoms like plantar fasciitis, knee pain, and anxiety. These problems may arise due to external stressors like sitting for long periods, staring at screens, or wearing heavy footwear, which can disrupt our natural movement patterns and relationship with gravity. To mitigate these issues, focusing on wide and deep breathing, as well as addressing any underlying imbalances, can significantly improve overall health and functionality.

    • Maintaining the brain-foot connectionPractice toe yoga, assess foot mobility, transition to minimalist shoes, and observe children's natural movements to improve brain-foot communication and overall foot health.

      The connection between our brain and our feet is crucial for optimal movement and overall health. Neglecting toe mobility and foot exercises can lead to a loss of sensation and function, impacting our ability to effectively support our body weight and transmit force. To maintain this connection, practicing toe yoga and assessing foot mobility are simple yet effective ways to improve communication between the brain and feet. Additionally, transitioning to minimalist shoes or going barefoot can help reintroduce the feet to the ground and promote better overall foot health. Observing children's natural developmental patterns can also provide insight into the importance of proper movement and loading.

    • Re-learning lost neuromuscular abilitiesThe DNS system helps individuals re-learn developmental steps for improved movement patterns as adults. Every person is unique, requiring individualized focus on distal or rib cage control, or even training knee valgus as a natural occurrence.

      Our neuromuscular abilities, which we are born with, are remarkable and crucial for efficient movement. Unfortunately, many people lose these abilities by the time they are six years old due to sedentary lifestyles. The DNS (Developmental Neurolasty) system, which originated from a school in Prague, aims to help individuals re-learn developmental steps they may have missed, leading to improved movement patterns as adults. However, it's essential to recognize that every person is unique, and a one-size-fits-all approach doesn't exist. Some people may benefit from focusing on distal control or rib cage control, while others may need to tap into their parasympathetic side. Regarding knee valgus, a common issue where the knee caves in during movements like lunges, some believe it should be avoided at all costs. However, functional movement expert Mike Robertson suggests training it as it's a natural occurrence in life and can help individuals understand and manage any discomfort or pain associated with it. In summary, it's crucial to approach movement with a holistic perspective, considering each person's unique needs and abilities.

    • Optimizing Movement for Adaptability and ResilienceEnsure subconscious movements are safe, assess individuals for potential issues, and provide alternative options to determine optimal movement patterns

      Movement in everyday life should be as subconscious as possible for optimal reactivity, adaptability, and resilience. However, it's essential to ensure that these subconscious movements are safe and not leading to injury. Posture is not inherently good or bad; it depends on the individual's options and ability to adapt. Sitting for extended periods, especially in a fixed position, can lead to strain. While some people may tolerate load well, others may be more susceptible to injury due to environmental stressors. Assessing individuals and addressing any potential issues is crucial to promoting adaptability and preventing discomfort. There's no definitive answer to distinguishing between problematic movement patterns and adaptations, but providing alternative options can help determine the best course of action. Additionally, addressing vestibular issues and considering an individual's symptomatic presentation can contribute to a more comprehensive approach to promoting optimal movement and reducing discomfort.

    • Overcoming complex movement patterns takes time and patienceCommunicating the long-term benefits of addressing underlying issues like rib flare and locked QLs can motivate individuals to commit to a focused approach, despite the lack of instant gratification.

      Addressing movement patterns and underlying issues requires patience and consistency. The discussion highlights a case where a person with significant rib flare and locked lower back muscles (QLs) was able to make progress through a focused approach on breathing, compressive work, and addressing gait patterns. However, unwinding these patterns takes time and may not always feel good in the moment. Motivating individuals to commit to this process can be challenging, as some may prefer more traditional training methods that provide instant gratification. Effective communication involves explaining the long-term benefits and potential limitations of various approaches. Common traits among individuals who respond well to this type of intervention include a willingness to believe in the process and a desire for long-term improvements, even if they are incremental.

    • Consistent practice and attention to detail lead to significant improvementsPaying attention to small details and consistently practicing can lead to major improvements in physical abilities, even during a pandemic. Prioritize training for optimal health in old age.

      Paying attention to small details and consistently practicing can lead to significant improvements in physical abilities, even if progress seems slow or elusive at first. This was evident in the speaker's personal experience with overcoming hamstring control issues, which required focused attention and patience to overcome. Successful individuals, whether training for major competitions or simply striving for optimal health in old age, must be diligent in their efforts to master the fundamentals. Moreover, the COVID-19 pandemic has shown that effective training can be done remotely, requiring clear communication and demonstration from trainers to ensure proper form and execution. This has been a valuable adaptation for many individuals, particularly those who may not have had the opportunity to work with trainers in person before. Ultimately, the goal should be to prioritize training for the Centenarian Olympics – the pursuit of maintaining optimal health and strength well into old age. This involves addressing various systems, such as strength, stability, movement, and control, and can be achieved through consistent practice and attention to detail.

    • Combining guided instruction and self-practice for effective agingIncorporating both guided instruction and self-practice helps build strength, coordination, and independence for aging, focusing on functional movements and efficient breathing.

      Incorporating a combination of guided instruction and self-practice leads to better learning and improved functionality. This approach allows individuals to review and understand concepts on their own, while also receiving guidance and feedback from experts. This method can be particularly effective for exercises like deadlifts and split leg work, which require strong hip stability and functional movement. The ultimate goal is to help individuals build the strength and coordination needed to perform daily tasks and activities with ease, even as they age. Another key principle is the importance of maintaining independence and mobility as we age. This can include being able to carry groceries, climb stairs, and even continue to dance or engage in other physical activities. To achieve this, it's important to focus on exercises that challenge coordination, balance, and reaction time, in addition to building overall strength. Throughout the aging process, it's essential to prioritize functional movement and efficient breathing, as these skills will enable us to maintain our independence and continue to enjoy the activities we love. By incorporating a variety of exercises and challenging activities, we can set ourselves up for a strong foundation for a healthy and active life in our later years.

    • Train and improve balance for a better futureAssess vestibular discrepancies, enhance proprioception, prioritize balance training, focus on getting up from the floor, and ensure safety and improved quality of life in old age

      Balance, which is essential for dealing with gravity effectively, can be trained and improved at any age. This improvement is crucial as declining balance can significantly impact daily life and safety as we age. The training process involves assessing any underlying vestibular discrepancies and implementing exercises to enhance proprioception, such as closing eyes to work on lower leg adaptiveness. Neglecting balance training can lead to more significant challenges in the future, so it's essential to prioritize it. A key exercise to focus on is the ability to get up from the floor using minimal support, as this becomes increasingly difficult with age. This not only ensures safety but also enhances overall quality of life. By starting balance training now, individuals can set themselves up for a better future, allowing them to enjoy activities and time with loved ones when they are older.

    • Join children in physical activities by participating fullyFully engage in kids' activities by getting on the floor, using proper muscles, and staying flexible for better results and a more connected experience.

      Engaging in physical activities with children requires more than just observing from a distance. It's essential to participate fully by getting on the floor and using your own support to move around. This not only increases your likelihood of doing it regularly but also fosters a more connected and refined experience. Another crucial aspect is the importance of flexibility and reflexivity over rigidity. Bracing strategies, such as relying too heavily on the rectus abdominis muscles, can limit your options and make it harder to respond to unexpected situations. Instead, focus on using muscles like the hamstrings to maintain proper posture and alignment. Furthermore, incorporating exercises that engage multiple muscle groups, like kneeling curls, can provide better results and overall benefits. By keeping an open mind and being willing to explore new ways of approaching fitness, you can enhance your physical abilities and enjoy the process.

    • Technique and focus on neurological down-regulation are crucial for chronic pain and fitnessEffective hamstring control and back pain relief come from proper rowing technique, starting with tension in the catch position and utilizing legs for power, while maintaining finesse and relaxation.

      Proper technique and focus on neurological down-regulation are crucial for addressing chronic pain and improving overall fitness. The speaker's personal experience with hamstring control and back pain highlights the importance of accessing and using these muscles effectively. Rowing, an often overlooked exercise, can be particularly beneficial for those experiencing back pain as it encourages movement in the back and engagement of the legs. The key to mastering the rowing stroke lies in understanding the sequence of events, starting with creating tension in the catch position and utilizing the legs for the majority of the power. By focusing on finesse and relaxation at the appropriate times, individuals can improve their technique and reap the benefits of this full-body exercise.

    • Effective and injury-free rowing requires proper relaxationRelax grip, abs, ribs for ease of movement and pain-free rowing. Focus on strapless rowing, hand and knee relaxation, coordination, consistent speed, and low-impact hip strength training for runners.

      Proper relaxation is crucial for effective and injury-free rowing. Tension in the grip, abs, and ribs can hinder the ease of movement and cause pain. The bar should feel almost nothing, and the focus should be on relaxing the entire body. The use of strapless rowing and learning to relax the hands and knees were game changers for the speaker in managing QL pain. Additionally, coordination and maintaining a consistent speed are essential for beginners before adding power and weight. Rowing can be used as a form of high-intensity training, but focusing on proper technique and coordination before increasing speed is important. Rowing is beneficial for runners as it provides a low-impact alternative to build hip strength and endurance. The difference between concentric and eccentric strength within a muscle is another area of interest for the speaker, who plans to demonstrate it in the gym.

    • Maintaining scapular protraction and focusing on eccentric strength for optimal performance and longevityProper scapular protraction and eccentric strength are essential for optimal performance and injury prevention in various physical activities. Focus on controlling descent and maintaining form to enhance overall performance and longevity.

      Maintaining proper scapular protraction and focusing on eccentric strength are crucial for optimal performance and longevity in various physical activities, including archery and hiking. The difference between a good and great archer lies in their ability to keep their scapula protracted during the shot sequence, ensuring no slide back of the bow and maintaining a relaxed arm. Eccentric strength, which is often overlooked, is essential for controlling the descent and preventing injury. Improving midline adaptability, flexibility, and control are also important for enhancing overall performance and longevity. The inability to maintain proper form during movements, such as bodyweight split squats, can indicate underlying issues with body control and flexibility. While flexibility is important, control and proper form take priority.

    • Proper alignment and engagement during exercises for back comfort and effective hamstring stretchesFocus on engaging lumbar and lower thoracic areas for proper stretch, incorporate low-intensity aerobic workouts, remember training should be a learning experience, and encourage children to play and move regularly for essential motor skills development.

      Proper body alignment and engagement during exercises, such as touching your toes, is crucial for avoiding back discomfort and effectively stretching hamstrings. It's essential to focus on engaging your lumbar and lower thoracic areas to achieve a proper stretch, rather than just relying on hip flexibility. Additionally, incorporating more low-intensity, aerobic workouts, like zone two training, can improve overall fitness and mental focus. It's important to remember that feeling like you're at the brink of exhaustion during workouts isn't necessary, and training should be a learning experience rather than a constant stressor. Finally, encouraging children to play and move regularly from a young age can help them develop essential motor skills and improve overall fitness.

    • The Impact of a Diverse Athletic Background on Learning and DevelopmentHaving a diverse athletic background can improve learning abilities and coordination, but individuals with specialized sports backgrounds might face challenges due to ingrained movement patterns. Developing midline stability and coordination is essential, and a comprehensive membership program can provide access to exclusive content and resources.

      Having a diverse athletic background as a child can significantly impact one's learning abilities and movement patterns as an adult. The speaker shared his personal experience of participating in multiple sports and how it shaped his learning and development. He also mentioned that individuals with specialized sports backgrounds might face challenges due to their ingrained movement patterns. The speaker also emphasized the importance of having good midline stability and coordination, which can be developed through various physical activities. Furthermore, the speaker mentioned the benefits of having a comprehensive membership program for his podcast, which includes access to exclusive content, discounts on recommended products, and monthly Q&A sessions. He also reminded listeners that the podcast is for general informational purposes only and should not be used as a substitute for professional medical advice. Overall, the discussion highlighted the importance of having a diverse athletic background and the potential impact it can have on one's learning and development, as well as the benefits of accessing exclusive and in-depth content through a membership program.

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    We discuss:

    • How Peter keeps track of his takeaways from each podcast episode [5:15];
    • Luc van Loon episode: fat utilization, muscle protein synthesis, dietary protein, aging and inactivity, and more [8:45];
    • Behavioral changes that have come about from the conversation with Luc van Loon [23:45];
    • Courtney Conley episode: importance of toe strength and the impact of dedicated foot training [26:45];
    • Olav Aleksander Bu episode: the importance of VO2 max for lifespan, and the practicalities of measuring and improving VO2 max [36:45];
    • Behavioral changes that have come about from the conversation with Olav [56:00];
    • Alex Aravanis episode: liquid biopsies for cancer detection [1:01:30];
    • Colleen Cutcliffe episode: the importance of gut bacteria balance, and the potential therapeutic uses of probiotics, particularly Akkermansia [1:16:45];
    • Mark Rosekind: the significant issue of road fatalities and injuries, their causes, and practical safety measures to reduce risks [1:27:00]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enJune 03, 2024

    #303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.

    #303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.

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    Dena Dubal is a physician-scientist and professor of neurology at UCSF whose work focuses on mechanisms of longevity and brain resilience. In this episode, Dena delves into the intricacies of the longevity factor klotho: its formation and distribution in the body, the factors such as stress and exercise that impact its levels, and its profound impact on cognitive function and overall brain health. Dena shares insights from exciting research in animal models showing the potential of klotho in treating neurodegenerative diseases as well as its broader implications for organ health and disease prevention. She concludes with an optimistic outlook for future research in humans and the potential of klotho for the prevention and treatment of Alzheimer’s disease.

    Disclosure: Peter is an investor in Jocasta Neuroscience, a company working to develop klotho as a therapy for people with Alzheimer’s disease.

    We discuss:

    • Dena’s fascination with aging and how she came to study klotho [3:30];
    • Biological properties of klotho: production, regulation, decline with age, and factors influencing its levels [11:45];
    • Potential benefits of klotho on brain health [22:00];
    • The relationship between soluble klotho protein, platelet factors, and cognitive enhancement [33:45];
    • The role of platelet factor 4 (PF4) and it’s interaction with GluN2B in mediating cognitive enhancement [46:45];
    • Benefits of klotho observed in a mouse model of Parkinson’s disease [55:45];
    • Benefits of klotho observed in a mouse model of Alzheimer’s disease [1:03:00];
    • Promising results of klotho in primate models, and the importance of finding an appropriate therapeutic dose before moving to human trials [1:08:00];
    • Speculating why a single klotho injection has such long-lasting effects [1:25:30];
    • Potential cognitive benefits of klotho in humans, the impact of the KL-VS genetic variant on klotho levels, and the need for human trials to confirm these effects [1:27:45];
    • The interaction between the KL-VS genetic variant and APOE4 and how it impacts risk of Alzheimer’s disease [1:34:45];
    • The significance of klotho levels: studies linking lower levels to increased mortality and the broader implications for organ health and disease prevention [1:47:15];
    • Measuring klotho levels and determining an individual’s KL-VS status [1:52:15];
    • The promising potential of klotho for Alzheimer’s disease treatment, and the importance of philanthropy for funding research [1:58:00]; and
    • More.

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    The Peter Attia Drive
    enMay 27, 2024

    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

    View the Show Notes Page for This Episode

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    Julia Wattacheril is a physician scientist and director of the Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) program at Columbia University Irving Medical Center. In this episode, Julia delves deep into the complex world of liver health, beginning with a foundational overview of liver physiology. She provides an in-depth look at how alcohol impacts liver function, breaking down the metabolism of ethanol and its detrimental effects. Julia then shifts the focus to understanding liver function tests and optimal enzyme levels, providing a detailed explanation of AST and ALT and elucidating why fluctuations in these levels may or may not be concerning. She provides a primer on the four major stages of liver disease, discussing risk and emphasizing the importance of early diagnosis. Julia highlights the role of liver disease in increasing the risk of cancer and cardiovascular disease and covers in detail the various strategies for diagnosing, treating, and preventing the progression of liver disease.

    We discuss:

    • Julia’s training, the importance of liver health, and the challenges and innovations of hepatology [3:15];
    • The complex and crucial functionality of the liver, its four most essential functions, and more [8:45];
    • Liver injuries: historical and evolving understanding of causal factors, and the progression to liver diseases and cancer [13:15];
    • How the liver metabolizes nutrients and what happens in the presence of excess calories or alcohol [24:45];
    • Methods of diagnosing liver disease and how insights guide treatment and management strategies [33:30];
    • The poisonous nature of ethanol to the liver [40:30];
    • Varied responses to alcohol, damaging effects of alcohol beyond the liver, and the process of advising patients on their alcohol consumption [47:15];
    • Understanding liver enzymes AST and ALT—interpreting levels, lifestyle factors that affect them, and diagnostic approaches [58:30];
    • Interpreting liver function tests for fatty liver disease, and the challenges of diagnosing liver pathologies, particularly in children versus adults [1:13:15];
    • Comprehensive liver health assessments via imaging and various diagnostic tools to prevent overlooking potential liver pathologies [1:18:45];
    • Potential impact of recreational drugs, statins, and other medications on liver function test results [1:26:45];
    • Shifting nomenclature from NAFLD to MASLD to reflect accuracy in the underlying pathophysiology and understanding of liver diseases [1:30:30];
    • Pathophysiology of MASLD, the need for proactive screening, and the significance of liver fat percentage as an indicator of metabolic health [1:36:30];
    • The importance of screening for rare conditions alongside common metabolic diseases associated with fatty liver accumulation [1:42:45];
    • Practical strategies for managing MAFLD [1:45:30];
    • The impact of fructose consumption on liver health and the challenges of disentangling its effects from other factors like obesity and insulin resistance [1:52:45];
    • The potential of GLP-1 agonists for the treatment of MASLD [1:57:45];
    • How the four stages of liver disease have evolved [2:00:30];
    • Increased cancer and heart disease risk associated with early-stage MAFLD [2:05:15];
    • Emerging drugs and therapies for addressing fat accumulation and fibrosis related to MAFLD [2:12:15];
    • Peter’s major takeaways [2:18:45]; and
    • More.

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    The Peter Attia Drive
    enMay 20, 2024

    #301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it

    #301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it

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    In this “Ask Me Anything” (AMA) episode, Peter delves into the often misunderstood concept of inflammation. He first defines inflammation and differentiates between acute inflammation and chronic inflammation, the latter of which is linked to aging and a plethora of age-related diseases. Peter breaks down the intricate relationship between chronic inflammation, obesity, and metabolic health, and highlights the signs that might suggest someone may be suffering from chronic inflammation. From there, the conversation centers on actionable advice and practical steps one can take to manage and minimize chronic inflammation. He explores how diet plays a crucial role, including the potential benefits of elimination diets, and he examines the impact of lifestyle factors such as exercise, sleep, and stress management. Additionally, he discusses the relevance of food inflammatory tests and concludes by examining the potential benefits and drawbacks of drugs and supplements in managing inflammation.

    If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #59 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

    We discuss:

    • Defining inflammation (and the cultural impact of Napoleon Dynamite) [1:45];
    • Acute vs chronic inflammation [8:00];
    • The connection between chronic inflammation, aging, and age-related diseases [11:00];
    • The impact of inflammation on metabolic health [18:30];
    • Understanding and diagnosing chronic inflammation: blood tests and other approaches, and challenges with measurement [20:00];
    • Factors that contribute to low-level chronic inflammation [28:00];
    • Minimizing inflammation through diet [29:45];
    • The important role of fiber for gut health and inflammation [33:45];
    • A closer look at the impact of trans fats and saturated fats on overall health [34:45];
    • Why Peter prefers dietary fiber from food sources over supplements [38:30];
    • Debunking “superfoods”: emphasizing proven methods over marketing claims for reducing inflammation [39:00];
    • Is there any value in over-the-counter food inflammatory tests? [42:30];
    • Food elimination diets: how they work, symptoms and markers to watch, challenges and limitations [45:15];
    • Identifying dietary triggers for gut-related symptoms through low-FODMAP diets like the “carnivore diet” [51:15];
    • Dairy: the complex role of dairy on inflammation and individual responses [55:00];
    • Wheat: the complexities and conflicting evidence around wheat's inflammatory effects [57:45];
    • How exercise influences inflammation [1:02:00];
    • How sleep quality and duration impacts inflammation [1:07:00];
    • The potential impact of chronic psychological stressors on inflammation [1:13:00];
    • The impact of oral health on inflammation and overall well-being [1:15:00];
    • The role of medications in managing chronic inflammation [1:18:15];
    • Supplements: evaluating the efficacy of various anti-inflammatory supplements [1:22:15];
    • Parting thoughts and takeaways [1:27:00]; and
    • More.

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    The Peter Attia Drive
    enMay 13, 2024

    #300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

    #300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

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    In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO2 max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years.

    We discuss:

    • Defining the categories of “proven, promising, fuzzy, noise, and nonsense” [3:15];
    • Rapamycin [9:30];
    • Metformin [17:00];
    • NAD and its precursors [24:30];
    • Resveratrol [32:45];
    • The importance of VO2 max, muscle mass, and muscular strength for lifespan [38:15];
    • Blood flow restriction (BFR) training [44:00];
    • Using stem cells to treat osteoarthritis or injury [51:30];
    • Fasting as a tool for longevity (and why Peter stopped his fasting protocol) [55:45];
    • The energy balance theory [1:06:30];
    • The idea that sugar is poison [1:12:00];
    • The idea that sugar substitutes are dangerous [1:22:15];
    • The debate on red meat and cancer [1:28:45]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death

    Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death

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    This is a special episode of The Drive with Peter’s friend and fellow car enthusiast Dax Shepard. In this podcast, which commemorates the 30th anniversary of the death of Brazilian Formula One legend Ayrton Senna, Dax sits down with Peter to better understand what made Senna so special and why Peter remains an enormous fan. This conversation focuses on Senna’s life, the circumstances of his death, and his lasting impact and legacy on the sport of F1.

    We discuss:

    • Peter’s interest in motorsports began as a child [2:30];
    • The drama and dangers of F1 [6:00];
    • What made Senna special [13:00];
    • What Senna meant to Brazilians [24:00];
    • The cause of the fatal crash [28:15];
    • Why Peter is obsessed with Senna [40:30];
    • Being the best versus having the best record [43:30];
    • Senna’s unique driving style and incredible intuition about automotive engineering [46:30];
    • Back to the day of the dreadful race [53:00];
    • What Peter believes caused the crash [1:02:45];
    • Views on dying young, in the prime of life [1:13:00];
    • Senna lives on in his foundation and in safety changes adopted by F1 [1:21:00];
    • Statistics aren’t enough for fandom, and why people like who they do [1:24:15];
    • The biggest difference between F1 today and F1 in the 80s [1:28:30];
    • Senna’s driving superpower [1:30:30];
    • The fastest drivers currently in F1 [1:38:30];
    • Current F1 obsessions [1:45:00];
    • How hard it is to do what the top F1 drivers do [1:50:15];
    • Dax’s love of motorcycles and his AMG E63 station wagon [1:52:15];
    • Awesome Senna mementos from Etsy [2:01:15];
    • What makes specialists interesting, and Max’s devotion to F1 [2:10:15];
    • What Senna might have done if he had not died that day [2:14:00];
    • Michael Schumacher and Max Verstappen are also top F1 drivers [2:17:30];
    • Interlagos in Sao Paulo Brazil is always an incredible experience [2:18:45]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

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