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    Mara Labs Podcast

    Each week, scientists David Roberts and John Gildea and their guests will break down everything from complicated formulas behind supplement science to simple steps to improve your health - one day at a time.
    en44 Episodes

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    Episodes (44)

    Episode 301: Holistic and Whole Body Dentistry with Dr. Jesse Myers

    Episode 301: Holistic and Whole Body Dentistry with Dr. Jesse Myers
    In this episode, David Roberts and Dr. John Gildea interview Dr. Jesse Myers.  Dr. Myers talks about a wide variety of topics including root canals, oral microbiome, how oral health impacts Alzheimer's disease, fluoride and his favorite toothpaste.   
     
    Anti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis
     
    Zhang Y, Huang L, Zhang J, De Souza Rastelli AN, Yang J, Deng D. Anti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:808460. Published 2022 Jan 24. doi:10.3389/fphar.2022.808460
     
    The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis
     
    Kitamoto S, Nagao-Kitamoto H, Jiao Y, et al. The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis. Cell. 2020;182(2):447-462.e14. doi:10.1016/j.cell.2020.05.048
     
     
    Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota
     
    Teng Y, Ren Y, Sayed M, et al. Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota. Cell Host Microbe. 2018;24(5):637-652.e8. doi:10.1016/j.chom.2018.10.001
     
    Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: A clinical and microbiological study
     
    Nagasri M, Madhulatha M, Musalaiah SV, Kumar PA, Krishna CH, Kumar PM. Efficacy of curcumin as an adjunct to scaling and root planning in chronic periodontitis patients: A clinical and microbiological study. J Pharm Bioallied Sci. 2015;7(Suppl 2):S554-S558. doi:10.4103/0975-7406.163537
     
    The impact of the stone age diet on gingival conditions in the absence of oral hygiene
     
    Baumgartner S, Imfeld T, Schicht O, Rath C, Persson RE, Persson GR. The impact of the stone age diet on gingival conditions in the absence of oral hygiene. J Periodontol. 2009;80(5):759-768. doi:10.1902/jop.2009.080376
     
    Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors
     
    Dominy SS, Lynch C, Ermini F, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. Sci Adv. 2019;5(1):eaau3333. Published 2019 Jan 23. doi:10.1126/sciadv.aau3333
     
    Secreted gingipains from Porphyromonas gingivalis increase permeability in human cerebral microvascular endothelial cells through intracellular degradation of tight junction proteins
     
    Nonaka S, Kadowaki T, Nakanishi H. Secreted gingipains from Porphyromonas gingivalis increase permeability in human cerebral microvascular endothelial cells through intracellular degradation of tight junction proteins. Neurochem Int. 2022;154:105282. doi:10.1016/j.neuint.2022.105282
     
    Recipes:
    Zereshk Pollo 
     
     
     
    Regenerative Panang Curry
     
     
    Mara Labs Podcast
    enFebruary 15, 2023

    Episode 226: Why You Likely Need More Salt, Not Less

    Episode 226: Why You Likely Need More Salt, Not Less

    So, in this podcast, Dr. John Gildea uses his 20 years of research in salt and kidneys to clarify many misconceptions about salt and it's impact on things like blood pressure. It was a fascinating and informative podcast for me to record, and one hope you will enjoy it!

    Mara Labs Podcast
    enNovember 30, 2022

    Episode 220: Sulforaphane 101 - The Good Molecule In Broccoli

    Episode 220: Sulforaphane 101 - The Good Molecule In Broccoli

    John Gildea and David Roberts discuss the basics of sulforaphane.  They highlight the confusion in the broccoli supplements due to how brands choose to call the precursor to sulforaphane, which is called glucoraphanin.  They also highlight how sulforaphane is converted from glucoraphanin.  And discuss some of the main benefits of sulforaphane.

    2:00 – The difference between cell culture, animal and human studies

    5:00 – how sulforaphane is made from broccoli

    5:45 – Some organic seeds produce no sulforaphane

    6:50 – What does BrocElite bring to the market?

    8:00 – All but one other supplement has glucoraphanine – the precursor to sulforaphane.  This needs to be converted in the gut

    9:30 – if the enzyme myrosinase is added, it is a protein and gets degraded.

    10:40 – if you have sulforaphane in the capsule, it gets into your bloodstream.  If you have glucoraphanin, it may not

    12:50 – Sulforaphane benefit of pain relief via anti-inflammation

    14:00 – Fasting also gives the same benefits on pain as sulforaphane

    15:30 – Sulforaphane benefit of brain health benefit from BDNF

    19:15 – Sulforaphane benefit of Phase II detox

    22:50 – The difference between a flush, cleanse and detox

    25:00 – increase Nrf-2 by using molecules that work in synergy with sulforaphane

    Mara Labs Podcast
    enJuly 06, 2022
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