biofabrication

Mark Skylar-Scott is one of the world’s foremost experts on the 3D printing of human tissue, cell by cell. It’s a field better known as bioprinting. But Skylar-Scott hopes to take things to a level most never imagined. He and his collaborators are working to bioprint an entire living, working human heart. We’re printing biology, Skylar-Scott tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Episode Reference Links:

• Skylar-Scott Lab

Connect With Us:

• Episode Transcripts >>> The Future of Everything Website
• Connect with Russ >>> Threads or Twitter/X
• Connect with School of Engineering >>> Twitter/X

Chapters:

(00:00:00) Introduction

Host Russ Altman introduces the episode, guest Mark Skylar-Scott and his work bioprinting the heart.

(00:02:15) What is Bioprinting & Tissue Engineering?

Explanation of bioprinting and its distinction from traditional 3D printing. Overview of the technology and its applications in tissue engineering and how to get the cells for this purpose.

(00:06:37) Engineering the Cells of the Heart

The 11 different cell types of the heart that are being created, and the steps involved in printing them, scaffolding them, and how they form tissue.

(00:12:23) Building Hearts: Size and Growth Considerations

The scale of bio-printed hearts, potential strategies for growth and integration, & technical challenges in controlling cell growth and development. 

(00:15:05) Scaling Up Cell Production

The importance of scaling up cell production for efficient experimentation. Exploration of the transition from laboratory research to clinical implementation. 

(00:18:40) Vascularization: The Key to Functional Bioprinted Organs

Critical importance of creating a comprehensive vascular network & the challenges of integrating capillaries and ensuring nutrient delivery to all cells. 

(00:23:00) Ethical Considerations in Bioprinting

Examination of the ethical issues surrounding the use of human cells in bioprinting, focusing on consent and the potential for inequality in access due to cost.

(00:26:12) The Future of Bioprinting: Timeline and Field Dynamics

Projections about the timeline for the clinical application of bio-printed organs and the state of collaborative competition within the fabrication field. 

(00:28:28) Conclusion

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads or Twitter/X

Connect with School of Engineering >>> Twitter/X

(1:05) - Machine Learning Understands the Human Gut

(15:43) - A  Major Step Forward in Organ Biofabrication

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As always, you can find these and other interesting & impactful engineering articles on Wevolver.com.

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INTRODUCTION

Have you ever thought about making your packaging grow… without water and extra energy? Yes, literally… That’s the wonder of mycelium! 

Meghan, the Mushroom Packaging manager of Ecovative Design, will take you through this fascinating sustainable solution they are developing for 15 years.  

You will learn 

• how custom-molded packaging can grow with mycelium
• what kind of ecological based material is used for the process
• why this protective packaging can be confidently claimed as home compostable 

and much more!

I enjoyed how Meghan explains all this with passion and simple analogies. And what if I told you that you can even give it a try to build something useful and beautiful for yourself with a GIY kit? Let’s discover what could that all enable for you!

WHERE TO FIND MEGHAN, ECOVATIVE AND MUSHROOM PACKAGING?

Their websites: https://ecovative.com/ & https://mushroompackaging.com/

Their YouTube Channel: https://www.youtube.com/c/ecovative with fascinating videos

Their social media:

For Mushroom Packaging

• mostly here: https://www.instagram.com/mushroompackaging/ (check the GIY and license brands’ activities)
• https://www.linkedin.com/company/mushroompackaging/
• https://www.facebook.com/mushroompackaging

For Ecovative

• https://www.instagram.com/ecovative/
• https://www.linkedin.com/company/ecovative-design/
• https://www.facebook.com/ecovative/
• https://twitter.com/ecovative

ABOUT MEGHAN OLSON FROM ECOVATIVE DESIGN

As manager, Meghan leads the Mushroom Packaging team, where she is responsible for all commercial activities in North America, and supporting the growing global network of MycoComposite licensees, with direct oversight over both sales and licensing funnels.

Meghan has a M.S. in Mechanical Engineering and a dual B.S. in Mechanical Engineering and Design, Innovation & Society from Rensselaer Polytechnic Institute. She has been a fan of Ecovative for more than a decade, ever since being introduced by her late mentor Burt Swersey, who also mentored Ecovative's founders at RPI and championed the company from day one. Meghan was thrilled to join the Ecovative team in late 2019, a role to which she brings business development experience from another local technology company, Vyv (formerly Vital Vio). She began her career in a fluid system design role at GE Power, immediately after earning her M.S. focused on additive manufacturing of composites. At Ecovative, Meghan is focused on overseeing the commissioning of the newest Mushroom Packaging production facility and onboarding new partners and clients. 

PODCAST MUSIC

Special thanks to Joachim Regout who made the jingle. Have a look at his work here. 

I am happy to bring a sample of our strong bonds on these sound waves. Since I was a child, he made me discover a wide range of music of all kinds. I am also delighted he is a nature lover and shares the Look4Loops 'out of the box philosophy'. He is an inspiring source of creativity for me. 

In this live Youtube interview, I had the pleasure of getting to the co-founders (also husband and wife) for 3D Biotechnology Solutions, Ana Millás and Pedro Massaguer. 3DBS is the first Brazilian startup that brought bioprinters to its local research institutions and market, and now it is gearing up to expand its global market including that of the United States. Some of the major talking points of this episode include Ana and Pedro's early journey as biotech cofounders in Brazil, their funding strategies, market product fit, and their strategies in dealing with the local innovation ecosystem and regulatory agencies. We also dig a little deeper on their new hybrid bio fabrication bioprinter that combines electrospinning and extrusion-based bioprinting to generate unique tissue engineering capability for its customers

Follow 3DHEALS:

https://www.instagram.com/3dheals/
https://linktr.ee/3dheals

Follow our guests:

https://www.instagram.com/3dbiotechnologysolutions/

Show Notes: https://3dheals.com/made-in-brazil-interview-with-the-co-founders-of-bioprinting-startup-3d-biotechnology-solutions

More on our Guests:

Ana Millás

As a biologist, Millás holds her PhD and Master’s degree from the Department of Materials Engineering and Bioprocesses at the School of Chemical Engineering of State University of Campinas/UNICAMP. Post-doctoral degree at School of Pharmaceutical Sciences - University of São Paulo. Ana has made part of her research in internationally renowned research centers and institutions, among them, at Cornell University in the United States and Nottingham Trent University and The Electrospinning Company in UK. She has an amazing experience in the amazon forest, also experience in the textile industry. As the R&I Director at 3D Biotechnology Solutions startup, she focused her research on the development of 3D skin in vitro models, vascularized tissues and cartilage reconstruction using the technologies of electrospinning and 3D bioprinting.

Pedro Massaguer

Business Developement, is a specialist in Strategic Business Management. He completed a Master's and Doctorate in the Science and Technology Policy program at the state University of Campinas (UNICAMP). He has experience in innovative technology-based projects, business development, and strategic planning in the area of Biotechnology. He is the CEO of 3D Biotechnology solutions and also partner of In Situ Cell Therapy and Labtermo Microbiology Consultancy.

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

A short interview with 3DHEALS2020 bioprinting panel speaker, Jordan Miller, co-Founder and CEO of Volumetric, and Professor at Rice University. Volumetric's light-based bioprinting platform was featured on the cover Science last year. In this episode, Jordan shared what motivated him to tackle tough problems like organogenesis for transplant, his perspective on how biology, art/design, and 3D printing have always worked together in the field of tissue engineering, his thoughts on how his background and vascularization projects can help the COVID19 pandemic, plus his late experience as a graduate of YC Class 2020. Full written interview is here. 

Jordan Miller is an Assistant Professor of Bioengineering at Rice University and Co-Founder of Volumetric, a Houston-based startup focused on next-generation biomaterials and biofabrication technologies. Miller received his bachelor’s degree in Biology from MIT in 2003 and earned his Ph.D. in Bioengineering from Rice University in 2008. His primary interests combine synthetic chemistry, 3D printing, microfabrication, and molecular imaging to direct cultured human cells to form more complex organizations of living vessels and tissues for research in regenerative medicine. Precisely engineered in vitro systems at the molecular, micro- and meso-scale are well suited to decouple the relationship between tissue architecture and cell function. These systems are now permitting comprehensive closed-loop design and optimization of large-scale engineered tissues through refinement with computer models of mass transport and assessment of their therapeutic potential in vivo. 

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

En el tercer episodio de Moda Circular, entrevistamos a Edith Medina de Biology Studio en México.
  
En este episodio hablamos de:

• Biofabricación
• La historia de la creación de Biology Studio
• La labor educativa que hace Biology Studio para conectar comunidades indigenas con estudiantes de los talleres de Biology Studio
• El valor reflexivo de trabajar con materiales
• Sostenibilidad en la moda a partir de materiales renovables

Puedes seguir a Biology Studio en los siguientes enlaces:

Pagina web
https://biologystudio.com.mx/

Instagram
https://www.instagram.com/biologystudio/

Facebook
https://www.facebook.com/biologystudio/

Puedes mantenerte al tanto de las noticias de Moda Circular siguiendonos en los siguientes canales:

Instagram
https://www.instagram.com/circular.fashion/

Facebook
https://www.facebook.com/circulrfashion/

Edith Medina 
Bio

Pionera en el campo del bioarte en México, se especializa en materiales
biológicos y biofabricación con aplicaciones al diseño, el arte y la ciencia.
Tiene estudios complementarios de Arte y Biología en la Universidad Oberta de Cataluña, de Etnografía de Objetos en la Plataforma de la Universidad de Harvard y de Arte y Nuevos Medios en el Instituto Nacional de Bellas Artes.

Desde hace más de diez años su trabajo se desarrolla a partir de procesos
biológicos, en los que la experimentación con bacterias, hongos y
elementos naturales juegan un papel importante para el desarrollo de
nuevas materialidades en los campos del arte, la moda y el diseño.
Ha colaborado con museos, universidades e institutos de investigación en
México, España, Colombia, Centroamérica e Inglaterra. Es fundadora y
directora creativa de BiologyStudio, primer estudio mexicano en vincular
arte, diseño y biología, donde actualmente se encuentra experimentando
nuevas opciones materiales.

Check out this informative interview between Dr. Mayasari Lim (Roosterbio/3DHEALS) and Adam Feinberg, Professor at Carnegie Mellon University, CTO and co-founder at FluidForm. Learn how Adam first got into 3D printing and bioprinting (years ago!), and how his team at CMU discovered the FRESH technique. Adam also shared his view on how to stay critical of convention and learn to think outside of the box. Adam will be speaking at the Organogenesis/Bioprinting panel at 3DHEALS2020 in June 2020. 

Guest Biography: 

Dr. Adam Feinberg is CTO and co-founder of FluidForm. The core technology of FRESH printing was developed in his Regenerative Biomaterials and Therapeutics lab at Carnegie Mellon University (CMU), where he is a Professor in the Departments of Biomedical Engineering and Materials Science and Engineering. His group develops materials-based, engineering strategies to control the self-organization and assembly of various cell types into tissues. Adam earned his Bachelor of Science in Materials Science and Engineering from Cornell University, and his MS and PhD in Biomedical Engineering from the University of Florida. He performed his postdoctoral work at the School of Engineering and Applied Science at Harvard University. He holds more than 20 US patents and patent applications, has authored over 45 publications, and is a member of the Materials Research Society, American Chemical Society, Society for Biomaterials, Biophysical Society, Biomedical Engineering Society, and the American Heart Association.

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

A fun interview with Rachel the Commercial Innovation Manager of ISS/CASIS on her earlier life as a scientist at NASA Ames Research Center, on why working with ISS/CASIS is even more relevant today to all of us, and how it has already had early successes in the commercialization of a few late projects. Rachel also shared with us the challenges we are facing towards scaling such activities and what it is like to attend a party of a rocket launch.  Her full written interview is published here. Rachel will be speaking at 3DHEALS2020 (and answering questions) on microgravity/ISS for 3D printing directly.

Rachel Clemens has focused her career on advancing life science research and product development through experiments in space. In her current role as a Commercial Innovation Manager at the ISS US National Lab, she brings life science research to low earth orbit. She leads partnership development with life science companies – she finds that every sector, from start-ups to big pharma, can benefit from research in space. She is eager to entertain even the craziest of ideas and passionate about finding new solutions to Earth-bound problems. 

After earning a PhD in Molecular Biology from Oregon Health and Science University, Rachel became a Scientist at NASA Ames Research Center leading research on how microgravity affects host-immune systems and microbial pathogenesis. In addition to her current role at the National Lab, Rachel volunteers as a Scientific Project Manager at the Rare Genomics Institute, which connects rare disease patients around the world and provides tools and support to the greater rare disease community. She is based in San Francisco, CA where she blazes trails on foot, conquers hills by bike, and bravely hosts dinner parties in her micro-studio.

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

Join me for a fascinating conversation with 3DHEALS2020 speaker, Kevin Caldwell, CEO and co-founder of Ossium Health, a startup building a bone marrow bank, and providing solutions to more available bone marrow transplant and other related cell therapies. Learn more about Kevin's personal journey as an entrepreneur, how such a bone marrow/stem cell band from organ donors can help biofabrication and tissue engineering, and the bioethical concerns with cell therapy and tissue engineering. The video version of this interview can be found here. Stay tuned for more in-depth written interview with Kevin at 3DHEALS.com.

Guest Biography: 

Kevin E. Caldwell II is the Co-founder, President & CEO of Ossium  Health, where he leads a team that is building the world’s first bone marrow bank. Kevin previously worked in consulting as an Engagement Manager at leading strategy consulting firm 
McKinsey. Prior to that, he served in the Quantitative Research department of the hedge fund Bridgewater Associates. Kevin was trained in Physics and Economics at MIT before receiving his JD from Harvard Law School.

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

A fascinating conversation with upcoming 3DHEALS2020 speaker Dr. Stephanie Willerth on where bioprinting and biofabrication technology is to help with drug development and screening of neurological diseases such as Alzheimer's disease if we can create tissue replacements, "mini-brain", as well as her new bio-ink startup, Axolotl Biosciences.

See the full interview here.

Dr. Willerth holds a Canada Research Chair in Biomedical Engineering at the University of Victoria where she has dual appointments in the Department of Mechanical Engineering and the Division of Medical Sciences as an Associate Professor.

She serves as the Acting Director for the Centre for Biomedical Research at the University of Victoria and on the steering committee of the B.C. Regenerative Medicine Initiative. She also served as the President of the Canadian Biomaterials Society from 2017-2018. Her honors include being named the 2018 REACH award winner for Excellence in Undergraduate Research-inspired Teaching, a Woman of Innovation in 2017, one of the 2015 Young Innovators in Cellular and Biological Engineering and a “Star in Global Health” by Grand Challenges Canada in 2014.  She spent Fall of 2016 on sabbatical at the Wisconsin Institute for Discovery supported by the International Collaboration on Repair Discoveries International Travel Award where she wrote her book “Engineering neural tissue using stem cells” published by Academic Press.

She completed her postdoctoral work at the University of California-Berkeley after receiving her Ph.D. in Biomedical Engineering from Washington University. Her undergraduate degrees were in Biology and Chemical Engineering from the Massachusetts Institute of Technology. Dr. Willerth will be speaking at the upcoming virtual 3DHEALS2020.

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

Fluidform, a bioprinting startup, successfully printed heart valves using the FRESH technique and new biocompatible materials. In this short interview, Mike Graffeo, CEO of Fluidshorm shared with us this amazing technology, challenges and opportunities with regulation, scalability, and commercialization of tissue engineering /regenerative medicine products in general.

Mike Graffeo, CEO, Fluidform

A senior executive with a proven track record in commercialization of innovative medical technology, Mike is a results-oriented, decisive leader with a track record of successfully growing new businesses in both startup and growth organizations. Throughout his career, he has gained extensive experience translating highly complex devices and clinical data into successful businesses, both in the US and globally. Mike holds a BS in Engineering Physics and an MEng in Mechanical Engineering from Cornell University, as well as an MBA from Harvard Business School. Mike will also be speaking at the upcoming 3DHEALS2020 San Francisco on June 5-6th, 2020, along with 40+ other world-class speakers.

See full video, audio, written interview here. 

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw

Dr. Mayasari Lim has been the 3DHEALS bioprinting ambassador since 2017. She was one of a few female bioprinting founders (SE3D), and now she is in her new role at RoosterBio. Hear her thoughts on entrepreneurship, bioprinting startups, future of biotech, and overview of the 3DHEALS2020 biofabrication programming. 

About Our Co-host Dr. Mayasari Lim: 
Dr. Mayasari Lim is the West Coast & APAC Regional Account Manager for RoosterBio and an active contributor to the stem cell and bioprinting community. She was the founder and CEO of SE3D, a startup focused on bringing bioprinting into the classroom to support future workforce development. And previously, she was an assistant professor in Bioengineering at Nanyang Technological University in Singapore with a research focus in stem cell bioprocess engineering, bioprinting, and regenerative medicine. She has also served as an adjunct lecturer at the Fung Institute for Engineering Leadership at UC Berkeley. Dr. Lim obtained her Ph.D. degree in Chemical Engineering at Imperial College London and her B.Sc. in Chemical Engineering at UC Berkeley.

Relevant links:

#3dprinted basketball by Wilson:
https://www.wilson.com/en-us/explore/basketball/airless-prototype

#3dprinting for #performancesports on-demand recording link:
https://3dheals.com/courses/3d-printing-for-performance-sports/

Youtube link:
https://youtu.be/s4nJQVA66Nw