cd8

Al Singer joins immune to discuss mice that have their T cell immune system reversed, revealing the molecular basis for T cell lineage fate determination in the thymus.

Hosts: Vincent Racaniello, Cynthia Leifer, Steph Langel, and Brianne Barker

Guest: Al Singer

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Links for this episode

• T cell FlipFlop mice reveal lineage determination (Nat Immunol)
• Time stamps by Jolene. Thanks!

Music by Steve Neal.
Immune logo image by Blausen Medical

Send your immunology questions and comments to immune@microbe.tv

Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

Guest: Jon Yewdell

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Links for this episode

• T cell targets in COVID-19 patients (Cell)
• SARS-CoV-2 seroconversion in humans (Nat Med)
• Convergent antibody responses to SARS-CoV-2 infection (bioRxiv)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

The Immune team explains that short chain fatty acids produced by microbial fermentation of fiber rewire metabolism to enable the production of memory T cells.

Hosts: Vincent Racaniello, Stephanie Langel, and Cynthia Leifer

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Links for this episode

• CD8+ T cell memory needs microbiome derived fatty acids (Immune)
• Image credit: Principles of Virology 4e
• Time stamps by Jolene. Thanks!
• Letters read on Immune 25

Weekly Science Picks

Stephanie - This Week in Neuroscience
Cindy - Graduate Abuse by Derek Lowe
Vincent - Funding ends for seeking new viruses

Music by Steve Neal. Immune logo image by Blausen Medical.

Send your immunology questions and comments to immune@microbe.tv

Lynda Coughlan joins the weekly virtual bus companions for a discussion of a host defense peptide from frogs that destroys influenza virus, and mouse models for acute and chronic hepacivirus infection.

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Guest: Lynda Coughlan

 

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Links for this episode

• Linda on Virus Watch and BSGCT
• Anti-influenza peptide from frogs (Immunity)
• Magainins (Wikipedia)
• Urumi
• Kathy's defensin paper (PLoS Path)
• World Hepatitis Day
• Mouse model for hepacivirus infection (Science)
• Letters read on TWiV 452

Weekly Science Picks

Kathy - US rivers as subway map
Lynda - No Time to Lose: A Life in Pursuit of Deadly Viruses by Peter Piot
Alan - Apollo-era computers found in dead engineer’s basement
Vincent - 110 NFL Brains, research article in JAMA and The best science is often accidental

Listener Pick

Stig - Security Now! and The Gene by Siddhartha Mukherjee
Ricardo - John Oliver on Vaccines

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVites read listener questions and comments about public engagement in science, vaccines, RNAi, reprogramming CD8 cells to treat cancer, rabies, and much more.

Links for this episode

• Viral gifts
• Controlling plant viruses by vector control (Ann Rev Phyto)
• Flavivirus RNAi suppressor (J Virol)
• Entre probetas podcast (iTunes)
• Hedgehog central
• Reprogramming T cells for leukemia therapy (NEJM)
• Petri Dish podcast
• On Your Mind podcast
• Letters read on TWiV 264

Weekly Science Picks

Kathy - Sorting algorithms visualized
Alan - Stratodean
Rich - Art in Science by Polyxeni Potter
Vincent - Pixel Genes

Listener Pick of the Week

Judi - Olympus BioScapes Winner

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hello In this edition of the podcast I will discuss a paper published by Demotte and collaborators published this year in the journal Immunity "Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes" vol 28, pag 414 of April 2008. In this paper the authors show that LacNAC can compete for galectin-3 binding freeing TCR from TIL to colocalize with CD8 and allow the recovery of efector functional on ex vivo freshly isolated TIL from ovarian cancer and gastric cancer. See you next time.

Olá Malta De volta com uma nova edição que espero seja do vosso apreço. http://www.immunity.com/content/article/abstract?uid=PIIS1074761308000708