enzyme

Lupus is a long-term autoimmune disease that can cause inflammation and pain in any part of someone’s body. Those with lupus see their immune system attack healthy tissue.

For this episode, we have three guests: Roger Sutton, Ph.D., professor of cell physiology and molecular biophysics in the School of Medicine, and two members of his lab, MD/Ph.D. student, Johanna Villarreal and Ph.D. student, Joey McCord. The three of them talk to us about lupus -- diagnosis, symptoms, treatment -- and their research on lupus.

Organization mentioned:
Lupus Research Alliance
Lubbock Lupus Group (Facebook)
Lubbock Lupus Group (Instagram)

Today’s episode is one you will not want to miss. Just when I think I have a lot thrown at me, I meet someone that really puts it into perspective. Sarah Prebianca is a wife to Connor, mom of two beautiful girls (Camilla, 4 and Georgia, 2). Their 2 year old, Georgia suffers from a debilitating, extremely rare, genetic disease  (Lesch-Nyhan Disease). It has turned their lives upside down - countless hospital admissions, health scares, trauma, and days where it felt like there was no hope for them.  Through the difficult times, she learned to lean into her faith like never before. Sarah chooses to thrive as you will learn all about in this episode. 

To help with Georgie’s fundraising on Go Fund Me - HOPE For A Cure: LND Gene Therapy Research Fund

Follow Sarah  on IG @mrs.sarahprebianca

If you enjoyed this episode, make sure and give us a five star rating  and leave us a review on iTunes, Podcast Addict, Podchaser and Castbox.

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Follow me on Social Media:

• Amy on IG
• Amy on Facebook

Resources:

• AmyLedin.com
• Lean Bodies Consulting (LBC)
• LBC University

Amy Ledin Bio: The Co-Owner and Operator at Lean Bodies Consulting. Amy Ledin has been in the online wellness space for over a decade. Her coaching in this space has led to her passion in helping women build strong personal integrity. Fighting cancer for now close to 7 years, Amy loves sharing her mindset hacks and strategies that helped her through her fight to not just be a survivor, but an overcomer.

#5for50 #5for50FamilyEdition #AmyLedin #AmyLedin.com #ErikLedin #LeanBodiesConsulting #LBC #Kamele #KamelePerez

DISCLAIMER: The opinions, beliefs, and viewpoints expressed by the hosts and guests on this podcast do not necessarily represent or reflect the official policy, opinions, beliefs, and viewpoints of Disenyo.co LLC and its employees.

DMK founder and idea man, Danné Montague-King stops by the podcast this month to visit with host, Michelle D'Allaird-Brenner. Listen in on their conversation about his professional origins, innovative formulations, and the inside scoop to his latest passion project. 

In this episode, Michelle and Danné discuss…

[02:17] Coming out on top. 

[06:04] His history coming into the industry. 

[10:02] Anything can be changed. 

[13:22] There is no secret ingredient. 

[17:26] Education is more important than anything else. 

[20:00] What it means to be DMK-certified. 

[27:45] The up and coming “stemzyme.”

[29:30] What keeps Danné going after 50 years.

[33:06] If something doesn’t work, that means a component is missing. 

[36:05] Believing in yourself at all costs. 

[39:16] Four questions for Danné. 

[42:27] “The Maybelline Prince”

[45:16] “Skin Health: Surgical Alternatives to Healthy Skin, Anti-Aging and Scar Revision”

Follow DERMASCOPE:

Instagram: @dermascope

Facebook: facebook.com/dermascope

TikTok: @dermascope 

Additional Links:

Visit our website at DERMASCOPE

Learn more about this podcast at The Aesthetic Report  

Get your subscription here. 

Herzlichen Dank an unsere WERBEPARTNER:

www.carnivoro.de Supplemente rund um die Carnivore Ernährung

Mit dem Gutscheincode CARNITARIER erhältst du 10 % Rabatt auf deinen ersten Einkauf! 

Affiliate Link: www.carnivoro.eu/carnitarierin

www.kaufnekuh.de Fleisch aus artgerechter Haltung mit fairen Preisen für Landwirte

Mit dem Gutscheincode CARNITARIER erhältst du 10 € Ermäßigung auf deinen Einkauf ab 50 €.

Moritz Schäfer erklärt, dass Dehnungsstreifen auch ohne Schwangerschaft und ohne Dehnung der Haut auftreten können.

Sie entstehen, wenn es ein hormonelles Ungleichgewicht der anabolen und katabolen Hormone auftritt. Dazu kommt dann oft auch ein Nährstoffmangel und ein Proteinmangel. Moritz empfiehlt dagegen auf seinen Insulinhaushalt zu achten, ausreichend Nährstoffe zu sich zu nehmen, auch in Form von verschiedenen Collagenarten. Mit Enzymen zu supplementieren ist ebenfalls sehr hilfreich. Und einen Wiederaufbau der Haut hält er durchaus für möglich. 

Moritz Schäfer könnt Ihr auf Instagram erreichen unter @mo.magnon. Seine private allgemeine Webseite zu Themen rund um die Gesundheit lautet www.momagnon.com. 

Das Buch könnt Ihr als E-Buch auf der Seite www.stretchmarksecret.com runterladen. Mit folgendem Rabattcode erhaltet ihr 20 % Nachlass: fleischzeit20

Hört mal rein in den Podcast!

Ihr findet uns auf Instagram unter:

@fleischzeitpodcast

@fastencoachdave

@carnitarierin

Andreas Website:

www.carnitarier.de

Haftungsausschluss:

Alle Inhalte im Podcast werden von uns mit größter Sorgfalt recherchiert und publiziert. Dennoch übernehmen wir keine Haftung für die Richtigkeit, Vollständigkeit oder Aktualität der Informationen. Sie stellen unsere persönliche subjektive Meinung dar und ersetzen auch keine medizinische Diagnose oder ärztliche Beratung. Dasselbe gilt für unsere Gäste. Konsultieren Sie bei Fragen oder Beschwerden immer Ihren behandelnden Arzt.

Haftungsausschluss:

Alle Inhalte im Podcast werden von uns mit größter Sorgfalt recherchiert und publiziert. Dennoch übernehmen wir keine Haftung für die Richtigkeit, Vollständigkeit oder Aktualität der Informationen. Sie stellen unsere persönliche subjektive Meinung dar und ersetzen auch keine medizinische Diagnose oder ärztliche Beratung. Dasselbe gilt für unsere Gäste. Konsultieren Sie bei Fragen oder Beschwerden immer Ihren behandelnden Arzt.

Small molecules are a pillar of human health, making up a majority of the drugs we have in our healthcare arsenal. Many of these drugs are obtained by utilizing synthetic chemistry to modify the composition of some small molecule found in nature. Derivatives of tropane alkaloids, for example, alleviate neuromuscular disorders and are derived from a chemical found in nightshade plants. However, sourcing these plants have become exceedingly difficult as climate change, the pandemic, and geopolitics ravage the supply chain. Looking to overcome these challenges, Prashanth recapitualed the biochemical pathway that makes these tropane alkaloids in yeast. In the most complex feat of metabolic engineering to date, Prashanth can make these life-saving drugs in a bioreactor, insulated from the issues that make them expensive and in short-supply.

About the Author

• Prashanth is a graduate student at Stanford University and published this work in the lab of Professor Christina Smolke. Christina and her team are world experts in metabolic engineering and broke multiple records in generating yeast that perform complex biosynthesis.
• Prashanth’s love of science was fostered by his teacher who encouraged him to combine his fascination with biology and his unique perspective on chemistry.

Key Takeaways

• Drugs are often sourced from natural sources like plants that have extremely precarious supply chains.
• The same biosynthetic pathways that makes the drug in plants can be recapitulated in yeast so that the small molecule can be brewed anywhere.
• Moving this biosynthetic pathway from one organism to another is not easy and still requires a ton of novel biology to be discovered in order to succeed.
• Here, Prashant had to hunt for new enzymes, cut-out wasted chemical reactions, and engineer ways to move the molecule and proteins to the specific parts of the cell.

Translation

• Scaling these microbes to make them economically viable first requires maximizing the amount of drug that each yeast can make.
• Directed evolution of useful enzymes, importing new molecular transporters, and optimizing growth conditions will be used to spin-out this microbe.
• The strain will be licensed through Stanford to pharmaceutical companies.

First Author: Prashanth Srinivasan

Paper: 

Biosynthesis of medicinal tropane alkaloids in yeast

This week we hear all about a bristlebird rescue mission, World Dance Day and plastic-eating enzymes…

Thirty years ago, Dr. Arnold had an idea: to breed molecules in the laboratory the way we breed animals - to bring out the traits we want in them. The molecules she was particularly interested in were enzymes, which are essential to life, and which she knew could be used to make environmentally friendly materials, including bio-fuels, cleaning products, and pharmaceuticals. Her idea worked right away. It’s now called “directed evolution,” and it has had huge implications for industry. In 2018, it earned her a Nobel Prize in Chemistry (only the fifth ever awarded to a woman). She talks here about the science, but also about the bumps in her life that helped her become an original thinker.

(c ) American Academy of Achievement 2019

Matt Gallant is an entrepreneur, a poker champion, an ex-rock guitarist, a strength and conditioning coach with a degree in kinesiology, the CEO of a company called BiOptimizers, and a guy who send me e-mails like this:

"Subject line: probiotic enema

Break open a handful of capsules and ferment in coconut water...reaches peak power around 4-5 hours of fermentation. However you live in a cooler climate so it might take longer. You can drink it, and if it's still sweet then you can go longer. When it starts to become a bit acidic, that's when it is at it's peak. For enema, retention time should be 15-20 minutes. I like doing the Batman enema. I'll go upside down with the Om Swing so it really works it's way down. I tend to do this after two days of fasting so it really takes care of old bad bacteria..."

As you can imagine, this dude thinks outside the box when it comes to nutrition and health. He is also joined on today's podcast by , a natural bodybuilder, vegetarian and low-protein diet advocate. Wade is a 3-time All Natural Bodybuilding Champion, advisor to the American Anti-Cancer Institute, director of Education at BiOptimizers Nutrition and a vegetarian for over 13 years. He is also the author of several books including the best-selling books “Staying Alive in a Toxic World”.

During our discussion, you'll discover:

-The reason Matt does probiotic and digestive enzyme enemas...[9:25]

-The full-head laser light therapy treatment Matt does on his body each morning...[14:40]

-What you need to look for if you are going to use an ionizing water plate to alkalinize your water...[16:30]

-The method Wade uses to breathe in 10 kilograms of oxygen each morning...[22:20]

-Why Wade consumes Branched Chain Amino Acids (BCAA's) each morning...[25:15]

-How Wade maintains and builds muscle on a low-protein, vegetarian diet...[32:40]

-Why can't your body just digest food all on it's own without an enzyme...[37:00]

-The 13 different types of digestive enzymes, and how to know when you should take which...[45:20]

-A muscle-building hack you can use by breaking open digestive enzymes and probiotics and adding them to a shake or smoothie...[50:20]

-Why BiOptimizers only has one single strain in their probiotic formula...[53:50] -What happens if you take digestive enzymes on an empty stomach...[57:50]

-How to use digestive enzymes combined with salt as a potent meat tenderizer...[63:25]

-The groundbreaking enzyme study that showed hematoma recovery to go from 15.6 days to 6.6 days, swelling from 10 days to 4 days, restriction of movement from 12.6 days to 5 days, inflammation from 10.5 days to 3.8 days and unfit for training status from 10.2 days to 4.2 days...[64:45]

-The biggest mistakes most people make when using digestive enzymes...[68:00]

-Whether you should take digestive enzymes before, during or after a meal...[71:55]

-Matt's step-by-step protocol for giving yourself a highly effective probiotic enema...[74:15]

-And much more!

Resources from this episode: -Bioptimizers website where you can find Matt and Wade's probiotic and MassZymes P3-OM digestive enzyme blends <--click for discount -OmSwing Yoga swing -The Power Of When podcast about Wolves, Dolphins, Lions and Bears -Vielight Neuro (10% discount code is “GREENFIELD”) -Kangen water machine for alkanizing and structuring water -Website with study: "Double-Blind Clinical Study Using Certain Proteolytic Enzymes Mixtures In Karate Fighters" -Website with study: "Therapy Of Ankles Join Distortions With Hydrolytic Enzymes; Results Of Double-Blind Clinical Trials" -Traumatic Injury In Athletes paper -Website with study: Enzyme Therapy And Sports Injuries

Do you have questions, thoughts or feedback for Matt or me? Leave your comments at BenGreenfieldFitness.com and one of us will reply!

See omnystudio.com/listener for privacy information.

Discussion of the oral MEK inhibitor trametinib in cancer treatment. .

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