metabolites

Discover the astonishing intricacies of microbial ecosystems and their potential to improve healthcare.  Guest KC Huang is many things: A bioengineer. A microbiologist. An inventor. But mostly he’s an expert on the ecology of the human gut. He and his collaborators have developed a device that can sample bacterial DNA and create a living map of the gut microbiome from mouth to … ah, well … you know. Every step of the way, he says, we play host to trillions of guests we know very little about. It’s time we got to know them, Huang tells host Russ Altman on this episode of Stanford Engineering’s The Future of Everything podcast.

Chapter Timestamps:

(00:00:00) Introduction

Russ introduces the gut microbiome and its impact on health. The potential for engineering ourselves through microbiome manipulation.

(00:00:57) Overview of Gut Microbiome

Russ Altman introduces the guest, KC Huang. KC provides an overview of the gut microbiome and its impact on health and everyday life.

(00:05:21) Challenges in Studying the Gut Microbiome

KC Huang discusses the challenges in studying the gut microbiome, including the limited data and the difficulty in accessing the ecosystem.The unique interface between human cells and gut microorganisms is emphasized.

(00:07:02) Poop as a Data Source

Russ Altman humorously mentions the collection of poop for research purposes. The difficulties in studying the bowel's internal microbiome are discussed.

(00:08:53) Diversity of Gut Microorganisms

KC Huang addresses the diversity of microorganisms in the gut microbiome. The challenges of characterizing the complex ecosystem are highlighted.KC Huang corrects a common misconception about the location of the gut microbiome. The gut microbiome as an external influence on the human body is explained.

(00:10:45) The Impact of Gut Microbiome Beyond Bowel Movements

Russ Altman mentions the gut microbiome's influence on brain function, diet, exercise, and more. The far-reaching effects of the gut microbiome are introduced.KC Huang addresses the connection between the gut microbiome and brain function. The constant interaction between microorganisms and the brain is emphasized.

(00:12:22) Impact of Gut Microbiome on Sleepiness

The relationship between post-meal sleepiness and gut microbiome activity is mentioned. The gut as a source of constant growth and activity is explained.

(00:13:19) The Device for Studying the Gut Microbiome

KC Huang introduces an innovative device designed to study the gut microbiome by collecting samples at different points in the gut. The device's simplicity and capabilities for multi-dimensional analysis are highlighted.

(00:17:32) Exercise and Its Effect on Body Temperature

The role of exercise in increasing body temperature and its potential influence on the gut microbiome is explored. Possible connections between exercise, temperature, and gastrointestinal effects are mentioned.

(00:21:55 ) The Student Survey on Microbiome Therapies

KC Huang shares the results of a student survey about microbiome-based therapies, highlighting changes in perception after studying the field. The evolving excitement and uncertainty surrounding the field's future are mentioned.

(00:23:52) The Need to Embrace Ecosystem Complexity

KC Huang emphasizes the importance of embracing the complexity of the gut microbiome ecosystem. The limitations of reductionist approaches in the field are highlighted.

(00:28:20) Complexity with a Thousand Species

KC Huang explores the challenges of dealing with complex microbial ecosystems containing thousands of species. The significance of interactions between these species is discussed.

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

Connect with Russ >>> Threads or Twitter/X

Connect with School of Engineering >>> Twitter/X

Guests: Dr. Lance Baumgard, Iowa State University and Dr. Jim Drackley, University of Illinois at Urbana-Champaign

Our Real Science Exchange pubcast always has leading scientists and industry professionals discussing the latest ideas and trends, and tonight we have two very well-known guests. Dr. Lance Baumgard and Dr. Jim Drackley join us to discuss cow management and the dogma that has developed over the years. 

Dr. Baumgard kicks off by explaining the dogma of the transition period - two metabolites reduce the animal’s immune system and predispose them to health disorders. (5:38) 

Dr. Drackley continued by saying he was influenced by research that could show in a clinical case of ketosis, there is an underlying subclinical, perhaps inflammatory pressure, causing the problem. (20:39) 

Dr. Baumgard mentioned utilizing ketones comes at a metabolic disadvantage: a loss of energy. So what could cows be doing if they’re able to increase their feed intake enough so they don’t have to make ketones? (27:18) 

Dr. Drackley said the million-dollar question is if inflammation is the key, what do we do about it? How do we prevent it or treat it? (31:38) 

Dr. Baumgard explained his thought process is that if even healthy cows have some level of immune activation going on in the transition period, some of this subclinical hypocalcemia that’s occurring in the transition period could be caused by immune activation. (43:50)

Dr. Drackley said as we select for high-milk production, perhaps part of that is enhanced ability to use ketones. The idea of a tenant of high milk production is you’ve got the time of lower insulin and high growth hormone driving lactation. Those are all tied up with genetic selection.  (46:40) 

Dr. Baumgard wrapped up by saying from a producer or veterinarian perspective, it’s easy to treat and get out, but what really needs to take place is a full examination; where did this immune activation come from? (54:56)

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In this episode of Your Infinite Health, LeNae and Dr. Trip addresses some of the most common myths surrounding testosterone, especially the one about it causing heart attacks.

Testosterone is a hormone that has been the subject of much discussion and debate in recent years, with many claims being made about its potential benefits and drawbacks. In particular, the idea that testosterone causes heart attacks has become a widespread myth, one that needs to be corrected.

It's important to understand that testosterone requirements are not the same for everyone and may be affected by age, physical activity, and other factors. And while engaging in exercise can increase testosterone consumption, it is not a cause of heart disease. On the contrary, testosterone has been found to play a role in preventing cardiovascular disease, dementia, and diabetes.

For anyone considering testosterone therapy, it's important to understand that regular monitoring and follow-up are essential for achieving optimal results. It's also important to be aware that other hormones and metabolites can affect testosterone's effectiveness, and that some people may require higher levels of testosterone due to impaired androgen receptors.

While testosterone replacement therapy can help optimize cholesterol levels over time, it's also possible to experience excessive levels of testosterone, leading to synthetic androgen stimulation. Women, in particular, may experience side effects such as changes in voice and hair growth, while men may experience excessive levels of testosterone as well.

Ultimately, maintaining an optimal testosterone level can have a wide range of benefits, ranging from improved focus and stamina to reduced risk of cardiovascular disease. In order to achieve these benefits, it's important to work closely with a physician, undergo regular check-ins, and have an understanding of what optimal testosterone levels are for you.

Dr. Trip Goolsby & LeNae Goolsby are the co-founders of the Infinite Health Integrative Medicine Center, and are also the co-authors of the book “Think and Live Longer”.

Takeaways

1. Testosterone requirements vary depending on age.
2. Testosterone is not the cause of heart attacks.
3. Do regular lab tests with your physician.

Connect

Dr. Trip Goolsby & LeNae Goolsby are the co-founders of the Infinite Health Integrative Medicine Center, and are also the co-authors of the book “Think and Live Longer”.

Take a breath and breathe out. What you just exhaled is the subject of this podcast. It is a story of over 140 thousand molecules and what we are learning about them and what a single breath might tell us about our health. Dr. Biology catches up with bioanalytical chemist Heather Bean. The two explore the world of metabolomes and metabolites, what they are, how we use them today and the future for these molecules when it comes to diagnosing and treating diseases.

Learn more: Human Breath Atlas
Visit: The Bean Lab

If you have not already, subscribe to the podcast so you can be notified about new episodes.

In this episode, Ayesha discussed a new blood test developed by researchers at the University of Oxford that can detect cancers and even if they’ve metastasized. The test is based on measuring metabolites produced by tumor cells in blood samples using nuclear magnetic resonance (NMR) spectroscopy. The researchers found that the test could identify cancer among healthy people, those with localized cancer and individuals with cancer that has metastasized. The test could help detect cancers even before the use of conventional imaging-based methods.

The editorial team also discussed Bayer’s commitment to 100 percent green packaging for its consumer products by 2030. The target is part of the company’s sustainability program, which includes shifting to renewable energy sources and sustainably sourcing recyclable and reusable paper materials. Bayer’s most popular consumer products like Aspirin, Aleve and Claritin will all have green packaging by the target year, which will also include recycling information that is consumer friendly. Other pharmaceutical companies like AstraZeneca, GSK and Biogen also have similar sustainability programs, reflecting the growing awareness of the pharmaceutical industry’s large carbon footprint and the importance of efforts to reduce it.

Read the full articles here: 

Cancer Blood Test Developed by University of Oxford Researchers Can Detect Metastasis

Bayer Commits to 100 Percent Green Packaging by 2030

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Lack of energy, blood sugar imbalances, low immunity are some of the symptoms of an Adrenal Gland acting up.

Dr. Yim talks about adrenals that are hyper or hypo, turned around and just plane tuckered out. The fall out of chronic stress is a taxed adrenal gland, Dr Yim gives practical and understandable information on how they get that way and what you can do to rebuild adrenals that have been overworked

The body has systems that work together, if one gets out of balance the whole body is impacted. Even the break down of wastes (metabolites) can be negatively impacted by tired out adrenals.

Steroid hormones start with cholesterol. Cortisol needs cholesterol. Naturopathic medicine likes getting to the cause and one of the tests Dr. Yim uses is new to the clinic.

CHI Test gives a comprehensive look at steroid and precursor production for a better more fine tuned program.

Salivary hormone test-taking samples at different times of day, either with saliva.

Include in program for rebuilding the adrenals:

Lifestyle
Meditation-Top Ten Meditation Techniques
Beth's Favourite-Seven Sighs
John's Favourite-Nature sound and mindfulness

Nutrients
IV Therapy-B Vitamins, 5, 6 and Vitamin C, Zinc, Magnesium
Ginseng-Adaptogen and Stimulating
Ashwaganda-used when overproducing cortisol, calms it down
Rhodiola-Adaptogen

Vitamins/Minerals
Pantothenic Acid - B5 need to add other B vitamins so balance isn't thrown off
B Complex
Zinc