movement disorders

Today on the show, a new understanding of Parkinson's disease.

Parkinson's disease is one of the most common neurodegenerative disorders — right after Alzheimer's disease. It's familiar to many as a movement disorder: people with the disease develop difficulties with voluntary control of their bodies. But the real story is much more complicated.

This week, we speak with Kathleen Poston, a Stanford neurologist who is at the forefront of efforts to redefine Parkinson's disease and related disorders based on their underlying biology — not just their symptoms. As Poston says: "The biology is the disease." 

Join us to learn about exciting advances in our ability to detect the brain pathology driving these disorders much earlier, even before symptoms arise, and how this is opening doors for early intervention and — hopefully — prevention.

Learn More

• Poston Lab at Stanford Medicine
• Lewy Body Dementia Research Center of Excellence at Stanford
• Understanding Parkinson's Disease: Stanford's Dr. Kathleen Poston on latest advances (CBS News Bay Area - Video)
• A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research (The Lancet - Neurology, 2024)
• International Working Group Proposes New Framework for Defining Parkinson Disease Based on Biology, Not Symptoms (Neurology Live article)

Episode Credits

This episode was produced by Michael Osborne at 14th Street Studios, with production assistance by Morgan Honaker. Our logo is by Aimee Garza. The show is hosted by Nicholas Weiler at Stanford's Wu Tsai Neurosciences Institute and Knight Initiative for Brain Resilience. 

Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neuroscience to a wider audience.

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Helen Bronte-Stewart is a neurologist and an expert in movement disorders, like Parkinson’s. She says new approaches, such as closed-loop deep-brain stimulation, and new digital health technologies that chart subtle changes in movement are reshaping the field, leading to new understandings and new treatments for this once-untreatable disease. To modulate behavior, you first have to measure it, Bronte-Stewart tells host Russ Altman. It’s the future of movement disorders in this episode of Stanford Engineering’s The Future of Everything podcast.

Connect With Us:

Episode Transcripts >>> The Future of Everything Website

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In this podcast episode on tardive dyskinesia (TD), Joseph P. McEvoy, MD, interviews Leslie, a patient who was diagnosed with TD 10 years ago. She describes her journey to an accurate diagnosis, the impact that TD has on her daily life, and her advice for patients and providers affected by TD.

Presenters:

Joseph P. McEvoy MD
Professor
Psychiatry and Health Behavior
Psychiatrist
Augusta University
Augusta, Georgia

Leslie

This content is based on a CE/CME program supported by independent educational grants from Neurocrine Biosciences, Inc.

For more programs in this series, visit:
https://bit.ly/3dUCVi6

In this first of 6 podcast episodes on tardive dyskinesia (TD), Drs Greg W. Mattingly and Jonathan M. Meyer have a discussion on identifying TD in clinical practice—including how to effectively screen patients during telehealth appointments. They cover who should be screened and how often, informal vs formal screening, and the valuable insight that family/caregiver reports can provide in the identification process. Additional conversation sheds light on differentiating TD from other movement disorders, including tics and tremors, and the role of primary care and other specialty providers in helping to identify TD. The experts round out the podcast with a focus on the impact of TD on both patient and caregiver quality of life—even mild TD can have an enormous influence over emotional, social, and mental well-being—bringing home the point that screening for and identifying TD early on is very important for patient outcomes.

Presenters:

Greg W. Mattingly, MD
Associate Clinical Professor
Psychiatry
Washington University School of Medicine
St Louis, Missouri
President
St Charles Psychiatry Associates
St Charles, Missouri

Jonathan M. Meyer, MD
Voluntary Clinical Professor
Department of Psychiatry
University of California, San Diego
Psychopharmacology Consultant
Balboa Naval Medical Center First Episode Psychosis Program
State of Nevada Project ECHO First Episode Psychosis Program

This content is based on a CE/CME program supported by independent educational grants from Neurocrine Biosciences, Inc.

For more programs in this series, visit: 
https://bit.ly/3AhRXau

Early intervention is critical to treating neurodevelopmental disorders, like cerebral palsy. But just how early can we diagnose them?

In this episode, Xtalks is marking World Parkinson’s Day (April 11) and Parkinson’s Awareness Month, which are observed every year to help raise awareness about the disease and the individuals living with it. To learn more about new Parkinson’s disease research, Ayesha discussed a new study by researchers at Rush University Medical Center that shows statins may help decrease the risk of parkinsonism in older adults. Hear about how parkinsonism relates to Parkinson’s disease and how the neuroprotective effects of statins could prevent Parkinson’s and related conditions.

The editorial team also discussed a new rapid molecular test developed by UK-based Genedrive PLC that can help physicians select the best antibiotic to treat babies with to prevent hearing loss. Gentamicin is the preferred treatment for newborns with infections like sepsis but about one in 500 babies have a genetic variant that makes them susceptible to gentamicin-induced hearing loss. Find out how the new genetic test can produce results in less than half an hour to help clinicians quickly determine the best course of treatment, and its rollout across a couple of NICUs in England.

Read the full articles here: 

Parkinson’s Awareness Month: Statins May Lower Parkinsonism Risk in Older Adults 

Genedrive’s Genetic Test Can Prevent Hearing Loss in Babies Through Personalized Treatment 

For more life science and medical device content, visit the Xtalks Vitals homepage.

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In this episode, Diana Perkins, MD, MPH, and Martha Sajatovic, MD, discuss the impact of tardive dyskinesia on social and functional domains and the benefits of proper assessment and treatment of tardive dyskinesia in improving patient quality of life in these areas.

Presenters:

Diana Perkins, MD, MPH
Professor of Psychiatry 
University of North Carolina School of Medicine
Chapel Hill, North Carolina 

Martha Sajatovic, MD
Professor of Psychiatry and Neurology
Departments of Psychiatry and Neurology
Case Western Reserve University School of Medicine
Cleveland, Ohio

Link to full program:
https://bit.ly/3GkJmUS

In this episode, John M. Kane, MD, and Rebecca S. Roma, MD, discuss clinical assessment of extrapyramidal symptoms (EPS), antiparkinsonian drugs, and tardive dyskinesia (TD). They review differentiating between TD and EPS, identify tools for diagnosing TD, and provide some important clinical pearls and evidence-based reasons for choosing different medications for treating EPS and TD.

Presenters:

John M. Kane, MD
Professor and Chairman
Department of Psychiatry
Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
Glen Oaks, New York

Rebecca S. Roma, MD
Medical Director
REACH, LLC
Pittsburgh, Pennsylvania

Link to full program:
https://bit.ly/2RM8hfM

Symptoms of Parkinson's disease develop slowly over several years, and can include shaking, stiffness, difficulty with walking, balance and coordination.  Marianne shares what is known about the disease, symptoms, and current treatment.

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Lewy Body Disease (LBD) is the second most common form of dementia, caused by protein deposits in the brain.  Learn about how LBD affects the body and the course of the disease.

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In life, taking the first steps can be the hardest, but with love and support from people like our next guest, putting one foot in front of the other becomes a mission.  On today's episode of the Live, Learn and Play Podcast, we sit down with Carrie Andrews, Jayden's Mom, to discuss his adoption, challenges and successes, and the strength from being in a wheelchair all day to walking and talking a mile a minute.  

Dr. Kisha Young, MD, Ph.D. sits down to talk with Kate about her passion for her practice and her patients. 

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Judy Hensley, PhD, PT began her career in Physical Therapy at the University of Kansas, later earning a Master's level at the University of Indianapolis and culminating with a Doctoral Degree at Rocky Mountain University of Health Professionals.  She was the first in the state of Kansas to receive her Board Certification as an Orthopedic Clinical Specialist in 1996.  She is also a certified manual therapist from the University of St. Augustine.  She was an adjunct instructor for Rockhurst University for six years. She has taught continuing education courses in the area and for the Kansas Physical Therapy Association and has been a mentor to many students, as well as therapists she worked with and trained. Last year, she had the opportunity to co-write a chapter, Movement Issues with Chronic Ill and Chronic Pain Patients, for the book, Integrative Medical Nutrition Therapy: Principles and Practices.