In this weeks episode I have the world leading expert on NITRIC OXIDE to guest Dr Nathan Bryan. Dr Bryan has published over 100 scientific papers on Nitric Oxide and is the author of FUNCTIONAL NITRIC OXIDE NUTRITION alongside 4 other books.
Dr Bryan has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and provide the basis for new preventive or therapeutic applications.
What does Nitric Oxide do in the body?
Nitric oxide or NO is considered one of the most important molecules produced in humans. This simple molecule controls oxygen and nutrient delivery to every cell in the body, it regulates cellular communication and even has anti-microbial properties that protect our body from invading pathogens. In fact, this molecule is so important it was named "Molecule of the Year" by Science Magazine in 1992 and in 1998 a Nobel Prize in Physiology or Medicine was awarded to the three US Scientists responsible for its discovery.
ADEQUATE NO PRODUCTION IS REQUIRED FOR OPTIMAL HEALTH AND DISEASE PREVENTION
Loss of nitric oxide production is recognized as the earliest event in the onset and progression of most if not all chronic diseases, including the number 1 killer of men and women worldwide, cardiovascular disease. There are two ways the body normally makes NO. One is from the amino acid L-arginine. The enzyme that converts L-arginine into nitric oxide becomes dysfunctional. This is due to many factors including aging, oxidative stress, poor diet, lack of physical exercise, smoking, diabetes, high sugar diet, etc. The other pathway is from nitrate and nitrite found naturally in some foods. Each pathway contributes about 50% of the total NO production and one can compensate for the other. However, when NO production from both pathways becomes limiting, then that is when health problems start to occur.
What you will learn in this interview:
- How our bodies produce nitric oxide and it's role as a signaling molecule that sets many cascade of reactions in the body
- Why mouth wash may be destroying your nitric oxide production and how that affects everything from blood pressure, to dementia to gut health to immune health to cardiovascular health.
- Why athletes will benefit from optimising their nitric oxide levels
- What the Nitric oxide synthase enzyme is and why it uncouples and what affects this has as we age.
- Endolethial dysfunction and it's connection to Nitric oxide
Why topical use of Nitric oxide creams can prevent aging skin, wrinkles, rosacea and why how Dr Bryan used it on his father who has non healing skin wounds from being a paraplegic and how this led to his wound healing study trials and his skin care range that will revolutionize your skin care. - What fluoride in the water does to our Nitric oxide status and it's affects on thyroid, as a neurotoxin and how it damages thyroid tissue.
TEN FACTS ABOUT NITRIC OXIDE (NO)
- Nitric oxide is one of the most important molecules produced in the human body.
- NO is a potent vasodilator that keeps your arteries open and clean from plaque build-up.
- Nitric oxide is made by every cell in your body; however, production declined by 10-12% per decade starting in the early 20s. By age 40-50, we make only 50%.
- Loss of NO production is associated with all major cardiovascular risk factors.
- Prescription drugs, such as proton pump inhibitors, NSAIDS, and Cholesterol lowering Statin drugs block the production of NO
- Loss of NO production is due to the inability to convert L-arginine into NO so products that contain L-arginine or L-citrulline are not always effective at restoring NO production
- NO has been shown to support healthy lowering blood pressure.
- NO may help improve the aging function and make you feel younger.
- NO is responsible for blood vessel dilation in the sex organs and is critical for optimal sexual function.
- Foods like beets and green leafy vegetables are rich in nitrite and nitrate that can be converted to NO when consumed.
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BIO
Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research. He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute. After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. During his tenure as faculty and independent investigator at UT, his research focused on drug discovery through screening natural product libraries for active compounds. His nine years at UT led to several discoveries which have resulted in over a dozen issued US and international patents and many more pending worldwide.
Specifically, Dr. Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He was the first to demonstrate and discover an endocrine function of nitric oxide via the formation of S-nitrosoglutathione and inorganic nitrite. Through the drug discovery program in natural product chemistry, Dr. Bryan discovered unique compositions of matter than can be used to safely and effectively generate and restore nitric oxide in humans. This technology is now validated in six published clinical trials. He is also a successful entrepreneur who has commercialized his nitric oxide technology through the formation of Human, to the Power of N, Inc (formerly Neogenis Labs) where he is a Founder and inventor. Dr. Bryan has been involved in nitric oxide research for the past 18 years and has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in many chronic diseases. Dr. Bryan has published a number of highly cited papers and authored or edited 5 books. He is an international leader in molecular medicine and nitric oxide biochemistry.
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