organelles

Drp1 cuts off mitophagy

Misfolded mitochondrial proteins can be eliminated by Parkin-dependent mitophagy but how this process selectively removes damaged mitochondrial regions is unclear. Burman et al. reveal that protein aggregates in the mitochondrial matrix trigger a local accumulation of Parkin on the mitochondrial outer membrane, and that the mitochondrial fission protein Drp1 segregates these domains to prevent Parkin accumulation from spreading and directing the elimination of healthy regions of the organelle. This biosights episode presents the paper by Burman et al. from the October 2nd, 2017, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Richard Youle (NINDS, NIH). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research.

Information about cell organelles and how they function. Song on Podcast was taken from one of the best Biology You Tube's I have seen. http://www.youtube.com/watch?v=jqUhWDp73bM is the link to the full clip along with many other excellent clips. Use this podcast anytime, anyplace to help you understand Biology. Every effort was made to ensure accuracy; however, mistakes do get made I encourage everyone to investigate this area of Biology further.