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    993: Johann Hari | The Skinny on 'Magic Pill' Weight-Loss Drugs

    en-usMay 21, 2024

    Podcast Summary

    • Understanding the Complex Relationship Between Food, Obesity, and the Human BrainProcessed foods have an addictive nature that can hinder healthy eating choices, and obesity drugs like ozempic may offer potential benefits but also carry risks.

      Learning from this episode of The Jordan Harbinger Show is the complex relationship between food, obesity, and the human brain. Johann Hari shares his personal journey of struggling with weight and health, leading him to explore the effects of processed foods on our brains and the rise of obesity drugs like ozempic. The surprising discovery from a study on people who were previously exposed to an unhealthy American diet is that they refused to eat healthy food once they had a taste of junk food, even when they were starving. This phenomenon highlights the addictive nature of processed foods and the importance of understanding the psychology behind obesity beyond just calorie intake. The conversation also touches on the potential risks and benefits of using obesity drugs like ozempic and the larger implications for public health.

    • New weight loss drugs: Ethical dilemmas and health concernsNew weight loss drugs offer significant weight reduction but come with potential side effects and ethical concerns, requiring a nuanced approach to understanding their implications.

      The discovery of new weight loss drugs, which promise significant body weight reduction, raises complex ethical, health, and societal questions. The speaker's personal experience of witnessing the stark contrast between his expectations and reality at a Hollywood party led him to explore the potential benefits and risks of these drugs. He learned that these drugs can lead to substantial weight loss, but also come with potential side effects and ethical concerns, such as the impact on people with eating disorders and body positivity progress. After a year-long investigation, the speaker remains conflicted about the drugs, emphasizing the need for a nuanced and thoughtful approach to understanding their implications.

    • A brief history of diet drugs and their health risksThe pursuit of quick weight loss through diet drugs has a long history of health risks, from blindness and fever to primary pulmonary hypertension. Consider the long-term effects before using.

      The history of diet drugs, including Ozempic, is marked by a series of grim discoveries and consequences. From the early use of explosive powder Denis Trufano, which led to blindness and fever, to more recent drugs like fenfen that caused primary pulmonary hypertension, the pursuit of quick weight loss has often come with serious health risks. The allure of certainty and instant results can overshadow the complex realities and potential harms of these drugs. It's important to consider the long-term effects and potential unintended consequences before turning to diet drugs for weight loss.

    • Considering the benefits and risks of new obesity drugsNew obesity drugs can reduce the risk of heart attacks, strokes, and diabetes-related causes, but they come with potential risks. Consult healthcare professionals and consider individual circumstances before making a decision.

      While there are valid concerns about the potential risks and side effects of new obesity drugs, it's important to consider the potential benefits as well. These drugs have shown promising results in reducing the risk of heart attacks, strokes, and diabetes-related causes, similar to the effects of bariatric surgery. However, the benefits come with potential risks, and it's crucial to be aware of both sides. The drugs, like Fen-phen, have a history of causing severe side effects, but they also offer significant health improvements for some individuals. Ultimately, the decision to use these drugs should be made in consultation with healthcare professionals and based on an individual's unique circumstances and risk factors. The truth about the science of obesity and its impact on health is complex, and it's essential to acknowledge both the benefits and risks.

    • Considering the Risks and Consequences of Weight Loss DrugsWeight loss drugs come with significant risks, including muscle mass loss and malnutrition, and long-term consequences should be carefully considered.

      The decision to use weight loss drugs comes with significant risks and considerations. Dr. Max Pemberton, a leading British doctor, stated that he would rather be HIV positive than diabetic due to the severe impact diabetes has on one's health and quality of life. Obesity is linked to various health issues such as cancer, dementia, heart disease, and stroke. Some individuals choose to take weight loss drugs to lose excess weight, while others, like Sharon Osbourne, aim for an unrealistic "super skinny" look. However, the risks of these drugs include muscle mass loss, leading to conditions like sarcopenia and frailty in old age. Moreover, the drugs can also lead to malnutrition, making it challenging to build back muscle. It's crucial to weigh the risks and benefits carefully and consider the long-term consequences of weight loss methods.

    • Impact of drugs on sense of satiety and weight lossUsing certain drugs can lead to significant weight loss by increasing satiety, but risks include malnutrition and chronic under-eating

      The use of certain drugs can significantly impact a person's sense of satiety, leading to a dramatic decrease in food intake and subsequent weight loss. This individual shared his personal experience of losing 42 pounds in a little over a year through the use of these drugs, but emphasized the potential risks of malnutrition and chronic under-eating. The drugs work by making people feel much fuller much faster, allowing them to consume significantly fewer calories than before. However, this rapid weight loss comes with its own challenges, including the need for careful monitoring to ensure adequate nutrition. The speaker also touched upon the importance of willpower in managing weight and the complex relationship between willpower and the factors contributing to obesity. The explosion of obesity in recent decades highlights the significance of understanding the role of satiety and the potential impact of drugs on this phenomenon.

    • Processed Foods Alter Our Ability to Feel FullProcessed foods change our eating habits, leading to overconsumption and obesity by disrupting our natural satiety signals

      The drastic shift from consuming whole, natural foods to processed or ultra-processed foods in our diets has led to an unprecedented obesity epidemic. This change, as seen in experiments like the "Cheesecake Rats" study, alters our ability to feel full and know when we've had enough. The processed foods, which didn't exist before, undermine our natural nutritional wisdom. This experiment showed that rats, when given the choice, would consume excessive amounts of processed foods and refuse to eat their natural healthy food. Similarly, humans, once exposed to these processed foods, may lose touch with their natural satiety and overeat, leading to obesity. The food industry has taken away our sense of fullness, and recent developments in medicine aim to restore it.

    • Processed foods leave us feeling unsatisfied and craving moreProcessed foods can create an insatiable hunger due to their lack of fiber and addictive flavor profiles, leading to a need for artificial solutions.

      Processed foods can leave us feeling unsatisfied and craving more due to their lack of fiber and the way they're engineered with a blend of fat and protein to create addictive flavor profiles. This is according to Johan Hari, who shared his personal experience of feeling truly full for the first time after giving up junk food. He also mentioned that these foods create an insatiable hunger in us, and the drugs designed to curb this hunger are merely an artificial solution to an artificial problem. A professor named Michael Lowe emphasized this point, stating that processed food is the root cause of our unnatural hunger. Instead, we should focus on finding fulfillment in other areas of life, like good relationships or hobbies. This episode was brought to you by Article, offering chic designer furniture at affordable prices with a 30-day guarantee, and Industrious, providing flexible workspaces for professionals.

    • The challenges of making healthy choices in an unhealthy environmentUnderstanding the complex factors contributing to obesity and approaching weight-related discussions with care and education is key to maintaining a healthy weight.

      Our environment, filled with junk food and sugary drinks, can make it challenging for individuals to make healthy choices despite their best efforts and willpower. Biological, psychological, and social factors all contribute to obesity and the difficulty of maintaining a healthy weight. Willpower can be likened to an umbrella in a storm, providing some protection but ultimately breaking down in extreme conditions. It's crucial to approach weight-related discussions with care and understanding, focusing on education and empowerment rather than shame or hopelessness. The complex nature of obesity requires a comprehensive approach that acknowledges the various contributing factors.

    • Experience of weight stigma and its impact on mental and physical healthWeight stigma, particularly against women, can lead to damaging mental and physical health consequences, including internalized negative self-image and avoidance of one's own body. However, recognizing and addressing the harm caused by the stigma while also acknowledging the importance of addressing health risks associated with obesity is crucial.

      The stigma against overweight individuals, particularly women, has long been prevalent in media and society, leading to damaging consequences for their mental and physical health. Shelley, a woman from Britain, shared her experience of being bullied and shamed for her weight starting from a young age. This included being humiliated by her teacher and school nurse, and facing daily insults from her peers. The constant stigma led Shelly to internalize negative self-image and avoid looking at her own body. However, she later discovered the body positivity movement in the US and brought it to Britain, inspiring a modest body positivity movement. Unfortunately, Shelley herself faced a dilemma when she realized the scientific evidence showing the physical harm caused by her excessive weight. She struggled to reconcile this with her belief in fighting stigma, leading to a complex and personal struggle. Despite these challenges, Shelly remains proud of her activism and continues to advocate for body positivity while acknowledging the importance of addressing the health risks associated with obesity.

    • Understanding the Complexity of Body Image and HealthAddressing body positivity and health concerns requires love, compassion, and understanding of past experiences of shame and bullying.

      The body positivity movement and concerns about obesity-related health harms are not mutually exclusive. A woman shared her personal experience of how losing weight saved her life from heart problems, emphasizing the importance of addressing both stigma and health concerns with love and compassion. The analogy of the AIDS crisis and the gay community's initial reaction to health advice illustrates how past experiences of shame and bullying can make it difficult for individuals to receive well-intended health advice without perceiving it as further stigma. It's crucial to understand this perspective while continuing to promote health and longevity for all.

    • Jeff Parker's Transformative Weight Loss Journey with DrugsJeff Parker's story highlights the significant health improvements weight loss drugs can bring, but it's essential to acknowledge the risks and continue advocating for body positivity and addressing the root causes of obesity.

      As we strive towards promoting body positivity and addressing the obesity crisis, it's crucial to recognize the transformative impact of weight loss drugs on individuals' lives. Jeff Parker's story serves as a powerful example of the dramatic health improvements these drugs can bring. However, it's essential to acknowledge the risks involved and continue advocating for a movement against stigma. The physical reality of carrying excess weight poses health risks, and it's crucial to address this reality with honesty and compassion. We must also consider the underlying causes of obesity, such as our food system, and work towards long-term solutions. Ultimately, we want to protect people from both bullying and illness, and the key question is whether we want to live in a world where we only manage symptoms with drugs or tackle the root causes.

    • Historical and cultural biases towards weight loss and medicationRecognize that biases towards weight loss and medication are not based on objective reality, but rather on historical and cultural constructs. Focus on addressing root causes of obesity and creating a supportive environment for various means of health improvement.

      Our attitudes towards weight loss and the use of drugs like Ozempic are deeply rooted in historical and cultural biases. These biases can lead us to view weight loss achieved through healthy means as virtuous, while weight loss achieved through medication as "cheating." This mindset can create feelings of guilt or unfairness, particularly for those who have struggled with weight loss through diet and exercise alone. It's important to recognize that these biases are not based on objective reality, but rather on historical and cultural constructs. Instead of viewing weight loss as a moral issue or a competition, we should focus on working together to address the root causes of obesity, such as the availability and affordability of healthy food options and the normalization of sedentary lifestyles. By shifting our perspective, we can create a more supportive and inclusive environment for those seeking to improve their health through various means, including medication.

    • Balancing symptom relief and root cause solutionsAddressing symptoms and root causes aren't mutually exclusive. Prioritizing survival through symptom relief can lead to opportunities for addressing deeper issues and creating lasting change.

      Addressing the symptoms of a problem, such as using medication to manage obesity, is not contradictory to dealing with the deeper causes. In fact, prioritizing the symptom can be crucial for survival, allowing individuals to live long enough to contribute to and benefit from addressing the root causes. This was emphasized through the speaker's friend's experience with breast cancer and the importance of immediate action to save a life. Additionally, the speaker's conversation with Jeff Parker highlighted the need for both short-term solutions and long-term environmental change. This perspective can be applied to various issues, including health, gun control, and environmental concerns. Ultimately, it's essential to find a balance between addressing symptoms and tackling the underlying causes while recognizing the importance of survival for continued progress.

    • Understanding the root causes of unhealthy eating habitsExploring past traumas and psychological drivers can provide insights for addressing unhealthy eating habits effectively and long-term.

      Addressing the symptoms of unhealthy eating habits, such as obesity, through methods like medication or surgery, may not be sufficient. Underlying psychological drivers, including past traumas, can contribute to these habits. Johan Hari shared his personal experience with this, revealing how he was unable to resist ordering fried chicken at a KFC despite being on weight loss medication. He also mentioned the connection between sexual abuse and weight gain, which he plans to explore further in a future episode. Overall, it's crucial to understand and address the root causes of unhealthy eating habits for effective and long-term solutions.

    • Obesity and emotional trauma60% of severely obese women experienced sexual abuse or assault, revealing obesity's complex and deeply rooted causes

      Obesity is often a coping mechanism for deeper emotional traumas. In an experiment, Dr. Felitti found that 60% of severely obese women had gained weight as a result of sexual abuse or assault. This discovery challenged the common perception that obesity is simply a matter of personal choice or lack of willpower. Instead, it revealed that the root causes of obesity can be complex and deeply rooted in past experiences. By asking not "what's wrong with you," but "what happened to you," healthcare professionals may be able to better understand and address the underlying causes of obesity. This approach could lead to more effective and sustainable treatments, as well as a greater understanding of the true nature of this widespread health issue.

    • GLP-1 drugs work by mimicking a natural hormone and signaling to the brain and gut to stop eatingGLP-1 drugs help people lose weight by mimicking a natural hormone, staying in the system longer, and potentially resetting the brain's resistance to weight loss.

      GLP-1 drugs, while helping people lose weight, work in a complex way that is not yet fully understood. These drugs mimic a natural hormone in the body, GLP-1, which signals to the brain and gut that a person has eaten enough and should stop eating. However, the artificial version of GLP-1 stays in the system much longer than the natural version, leading to feelings of fullness and reduced appetite. While it was initially thought that the drugs primarily worked in the gut, it is now clear that they have effects on the brain as well. The drugs may help "reset" the brain's resistance to weight loss, making it easier for people to lose weight and keep it off. However, the exact mechanism is not yet known. The potential benefits of these drugs are significant, with 47% of Americans expressing interest in using them, and their impact on the economy potentially comparable to the invention of the smartphone. However, the long-term effects and potential risks are still being studied.

    • Potential economic implications of weight loss drugsWeight loss drugs could impact industries, but long-term safety concerns, including thyroid cancer risk, warrant ongoing research and consideration

      The widespread use of weight loss drugs in the United States could have significant economic implications, potentially leading to changes in industries like food manufacturing and air travel. While these drugs have been shown to be effective in the short term for diabetics, there are concerns about long-term safety, particularly regarding the risk of thyroid cancer. The exact risk increase is contested, but some studies suggest it could be up to 75%. It's important to remember that thyroid cancer is relatively rare, but the potential increase is a cause for concern, especially given the history of other drugs with hidden risks, like Fen-phen. The debate around the safety of these drugs highlights the need for ongoing research and careful consideration of the risks and benefits. Ultimately, it's crucial that we address the underlying causes of obesity, such as unhealthy diets and sedentary lifestyles, in addition to treating the symptoms.

    • Obesity's Active Role in Health RisksObesity increases cancer risk and other health issues, leading to 678,000 annual deaths in the US. Consult a doctor before considering weight loss drugs, and process emotions instead of feeding off them for better health.

      Obesity is not just an inert condition, but an active one that sends signals through the body, increasing the risk of cancer and other health issues. Obesity is a leading cause of cancer in both Britain and the US, and the decision to take weight loss drugs is a complex one with significant risks and benefits. The stakes are high, as 678,000 Americans die each year due to obesity-related illnesses. It's essential to be well-informed and consult a doctor before making a decision. Additionally, being addicted to drama and holding onto negative emotions can negatively impact mental and emotional health. It's crucial to recognize and process emotions instead of feeding off them to maintain a healthy perspective on life.

    • The impact of processed foods on our health and relationship with foodProcessed foods can negatively affect our health and deepen unhealthy eating habits due to cultural pressures and personal experiences. Gut health and diversity play a crucial role in overall well-being, and fat shaming can hinder health improvement efforts.

      Our relationship with food and our health is deeply interconnected, and the processed foods that have become so prevalent in our diets can have detrimental effects on both. Dr. Johann Hari shares his personal experience with food addiction and the cultural pressures that contribute to unhealthy eating habits. He also discusses the impact of processed foods on our gut health and the importance of gut diversity. Furthermore, Hari emphasizes the harmful effects of fat shaming and how it can hinder efforts to improve health and well-being. Overall, the conversation highlights the need for a more compassionate and holistic approach to understanding and addressing issues related to food, health, and body image.

    • Addressing Obesity as a Serious Health ConcernObesity contributes to various health issues, including cancer, autoimmune disorders, and dementia. It's important to prioritize health and wellness, and approach weight loss as a serious health concern, not just a cosmetic issue. Avoid addiction to weight loss drugs and consider the financial burden of healthcare.

      Obesity not only affects physical health issues like high blood pressure, inflammation, and joint problems, but it also contributes to diseases such as cancer, autoimmune disorders, and dementia. The speaker emphasizes the importance of addressing obesity as a health concern and not just a cosmetic issue. Additionally, the speaker shares a personal experience of a Uber driver struggling to afford a diabetes drug for his wife, highlighting the financial burden of healthcare. The speaker also warns against the potential dangers of addiction to weight loss drugs and the impact it could have on overall well-being and quality of life. Overall, the message is to prioritize health and wellness, and to approach weight loss and obesity as a serious health concern.

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    • Processed and ultra-processed foods are a major driver of the obesity epidemic, as they undermine the body's natural ability to feel full and satisfied after eating. Moving from fresh, whole foods to mostly processed foods is strongly linked to the dramatic rise in obesity rates.
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    Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!

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    • Pornography use, especially among adolescents and young adults who grew up with easy access to internet porn, has been linked to erosion of gray matter in the brain's prefrontal cortex, which controls impulse control and decision-making.
    • Porn use has been associated with sexual disorders like erectile dysfunction in young men, as well as difficulties forming emotional bonds and intimacy in relationships.
    • While some psychologists dispute the existence of "porn addiction," neuroscientific evidence shows porn use can lead to compulsive behaviors and brain changes resembling substance addictions.
    • While some political efforts have been made to declare porn a public health crisis, there is little policy action based on scientific evidence to provide resources for treatment and awareness.
    • Connect with Jordan on Twitter, Instagram, and YouTube. If you have something you'd like us to tackle here on Skeptical Sunday, drop Jordan a line at jordan@jordanharbinger.com and let him know!
    • Connect with Michael Regilio at TwitterInstagram, and YouTube, and make sure to check out the Michael Regilio Plagues Well With Others podcast here or wherever you enjoy listening to fine podcasts!

    Full show notes and resources can be found here: jordanharbinger.com/986

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    985: Lives Are at Stake in Bail Reform's Wake | Feedback Friday

    985: Lives Are at Stake in Bail Reform's Wake | Feedback Friday

    When bail reforms free violent offenders and risk others' safety, how can we uphold justice while safeguarding victims? Welcome to Feedback Friday!

    And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in!

    On This Week's Feedback Friday:

    • When bail reforms free violent offenders and risk others' safety, how can we uphold justice while safeguarding victims?
    • You've about had it with your autistic boss' cringeworthy conspiracy theories. How can you disagree respectfully and maintain professionalism?
    • As a cancer patient struggling with massive student loans and disability assistance denial, what legal help and guidance is available for navigating private loan regulations while fighting for survival?
    • You've invented a non-functional plastic object that brings laughter to all who behold its absurdity. You want to protect the IP so you can profit from this stroke of comedic novelty, but you can't ignore the potential environmental impact of manufacturing such an item en masse. What should you do?
    • Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com!
    • Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger.
    • Connect with Gabriel on Twitter at @GabeMizrahi and Instagram @gabrielmizrahi.

    Full show notes and resources can be found here: jordanharbinger.com/985

    This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals

    Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!

    Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!

    984: Susan Casey | Unraveling Mysteries in the Ocean's Darkest Depths

    984: Susan Casey | Unraveling Mysteries in the Ocean's Darkest Depths

    What challenges can the ocean help us meet, and what must we do to safeguard its treasures? The Underworld author Susan Casey dives deep for answers here!

    What We Discuss with Susan Casey:

    • The ocean plays a crucial role in regulating the Earth's climate and serves as the largest carbon sink on the planet, making its preservation essential for mitigating climate change.
    • The ocean is home to a fascinating array of creatures that have adapted to extreme conditions, such as iron-breathing microbes, glass sponges, and jellyfish that can reverse their life cycle.
    • Pollution, including plastics, chemical weapons, and nuclear waste, has severely impacted the ocean ecosystem, with some deep-sea creatures found to have plastic particles embedded in their organs.
    • There are an estimated three million shipwrecks on the ocean floor, preserving valuable historical artifacts and information — such as the Antikythera mechanism, an ancient Greek analog computer.
    • Exploring the ocean can lead to groundbreaking discoveries in medicine, Earth's history, and climate, providing valuable insights for addressing humanity's challenges — provided we safeguard this treasury of knowledge for current and future generations.
    • And much more...

    Full show notes and resources can be found here: jordanharbinger.com/984

    This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals

    Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!

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    Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course!

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    Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!

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    Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course!

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    Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course!

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    Full show notes and resources can be found here: jordanharbinger.com/705

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    • Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger.
    • Connect with Gabriel on Twitter at @GabeMizrahi.

    Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course!

    Like this show? Please leave us a review here -- even one sentence helps! Consider leaving your Twitter handle so we can thank you personally!

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    Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!

    Full show notes and resources can be found here: jordanharbinger.com/918 

    This Episode Is Brought To You By Our Fine Sponsors: jordanharbinger.com/deals 

    Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! 

    Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!