Logo
    Search

    Qualy #26 - What is Peter looking to achieve and monitor with his blood glucose monitor?

    enSeptember 18, 2019

    Podcast Summary

    • Subscriber-exclusive Qualys podcast episodesThe Qualys podcast offers short, exclusive episodes for subscribers, focusing on important blood glucose monitoring tools and experiences.

      The Qualys podcast, produced by Peter A Diamonds, offers exclusive, short episodes featuring the best questions and topics discussed in previous podcasts. These episodes are released Tuesday through Friday and can only be accessed through a private subscriber-only podcast feed. The podcast aims to help new listeners and those who may have forgotten previous discussions. The host, Peter A Diamonds, expressed his attachment to the G6 blood glucose monitor and CGM, emphasizing their importance for monitoring blood sugar levels. He shared his experience of forgetting to wear his Aura Ring and feeling distressed without the data it provided. If listeners enjoy the quality episodes and want access to more subscriber-exclusive content, they can visit peteratiamd.com to subscribe. Occasionally, high-quality episodes are released in the main feed for all listeners to enjoy.

    • Managing Diabetes with Technology: A Personal StoryA continuous glucose monitor (CGM) acts as a powerful tool for individuals with diabetes, providing real-time feedback and driving internal competitiveness to maintain healthy glucose levels.

      Technology, specifically the use of a continuous glucose monitor (CGM), plays a significant role in helping the speaker manage their behavior and control their glucose levels. The speaker shares how they used to live a disciplined life but fell off track around three years ago and now rely on the CGM to prevent them from giving in to temptations and maintain their health. The CGM acts as a powerful tool, driving their internal competitiveness and providing real-time feedback, which helps them avoid spikes in glucose levels and make healthier choices. While the speaker acknowledges that they still slip up occasionally, the CGM remains an essential part of their daily routine to manage their diabetes effectively.

    • Understanding our body's response to food and activity with real-time feedbackContinuous glucose monitors (CGMs) provide valuable real-time information, but their affordability and accessibility for non-diabetic consumers are limited due to regulatory restrictions, aiming to empower individuals to better manage their health and well-being.

      Understanding our body's response to food and activity requires feedback, just like driving a car. Wearing continuous glucose monitors (CGMs) provides valuable real-time information, allowing individuals to make informed decisions and minimize potential harm. However, the current FDA-approved CGMs, like the Dexcom G6, are medical devices, and their affordability and accessibility for non-diabetic consumers remain limited due to regulatory restrictions. The challenge is to find a way to make these devices more consumer-friendly without compromising their accuracy or potential misuse for insulin dosing. Ultimately, the goal is to empower individuals to better manage their health and well-being through continuous, accessible, and accurate feedback.

    • Limiting Effectiveness of Real-time CGM DevicesReal-time CGM devices are essential for diabetes management, but their effectiveness can be hindered by removing real-time capabilities or providing broad ranges. Affordability and development of real-time insulin monitoring are key to optimal diabetes care.

      Real-time continuous glucose monitoring (CGM) devices are valuable tools for managing diabetes due to their accuracy and immediate feedback. However, there are deliberate ways to limit the effectiveness of these devices, such as removing their real-time capabilities or providing broad ranges, which can hinder their precision and usefulness. Ideally, CGMs would become affordable enough for widespread use, allowing individuals to prioritize real-time, high-precision monitoring for optimal diabetes management. Additionally, the lack of a continuous insulin monitor is a notable gap in diabetes care technology. Despite efforts to develop real-time insulin monitoring in the past, it remains an unmet need in the field.

    • Measuring Real-Time Insulin Levels at Point of Care is ChallengingTraditional insulin measurement methods are complex and impractical for quick, on-the-spot measurements. Low glucose levels and low glucose variability from CGM devices can serve as indicators for low insulin levels, but further research is needed for real-time insulin measurement.

      Measuring insulin in real-time at a point of care device is currently challenging due to the complexities involved in the assay process. Insulin is not as easily measurable as glucose, and traditional methods such as radio immune assays and ELISAs require multiple steps and washing processes, making them impractical for quick, on-the-spot measurements. While some companies are exploring the use of continuous glucose monitoring (CGM) data to impute insulin changes, this approach would require significant data and validation to build an accurate regression curve. In the absence of real-time insulin measurement, a good proxy for low insulin levels is a low glucose level and low glucose variability. The CGM device can provide these reports, and entering a low glucose variability state may indicate a low insulin level. However, it's important to note that this is not a definitive measurement and should be used as a guide rather than a definitive indicator. Further research and development are needed to make real-time insulin measurement a reality, and it may be some time before we see a reliable, point-of-care solution for insulin measurement.

    • Understanding A1C test limitationsThe A1C test has limitations and should be used in conjunction with other metrics like CGM for a more accurate and effective approach to diabetes management. It doesn't provide info on glucose variability and accuracy depends on red blood cell life assumption.

      While the A1C test is commonly used to measure average blood glucose levels over a prolonged period, it has limitations and should be interpreted in conjunction with other metrics. The A1C test does not provide information on glucose variability, which is important in understanding insulin profiles and effective glucose management. The test's accuracy is dependent on the assumption that red blood cells live for 90 to 120 days, and any deviation from this range can result in over or under estimation of average glucose levels. Furthermore, the A1C test does not directly measure average glucose levels but instead infers them based on the A1C value. In contrast, continuous glucose monitoring (CGM) provides both average glucose levels and glucose variability, allowing for a more comprehensive understanding of insulin profiles. Ultimately, the speaker believes that while the A1C test has its uses, it should not be relied upon as the sole metric for managing diabetes, and other metrics such as CGM should be considered for a more accurate and effective approach to diabetes management.

    • CGM vs A1C: More Accurate Blood Sugar InformationCGM offers more precise blood sugar data than A1C tests, potentially replacing them in future medical assessments.

      Continuous glucose monitoring (CGM) can provide more accurate and meaningful information about blood sugar levels compared to the A1C test. The speaker, who is a prediabetic himself, shared that his average blood glucose levels based on CGM readings suggest an A1C between 4.5 and 5, which is a significant difference from his actual A1C readings ranging from 5.6 to 6.0. He expressed his hope that in the future, CGM may replace the A1C test entirely, making it a trivial part of medical examinations or insurance assessments. However, it's important to remember that this podcast is for informational purposes only and should not be considered medical advice. Always consult with a healthcare professional for any medical concerns. The speaker also disclosed potential conflicts of interest and encouraged listeners to visit his website for more information.

    Recent Episodes from The Peter Attia Drive

    #307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.

    #307 ‒ Exercise for aging people: where to begin, and how to minimize risk while maximizing potential | Peter Attia, M.D.

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    In this special episode, Peter addresses the common questions about starting or returning to an exercise routine over the age of 50. Individuals in this age group have frequently reached out with questions about whether it's too late to start exercising and often express concern over a lack of prior training, a fear of injury, or uncertainty about where to begin. Peter delves into the importance of fitness for older adults, examining all four pillars of exercise, and provides practical advice on how to start exercising safely, minimize injury risk, and maximize potential benefits. Although this conversation focuses on people in the “older” age category, it also applies to anyone of any age who is deconditioned and looking to ease into regular exercise.

    We discuss:

    • Key points about starting exercise as an older adult [2:45];
    • Why it’s never too late to begin exercising and incorporating the four pillars of exercise [5:45];
    • The gradual, then sharp, decline in muscle mass and activity level that occur with age [10:00];
    • The decline of VO2 max that occurs with age [15:30];
    • Starting a training program: exercise variability, movement quality, realistic goals, and more [18:30];
    • Improving aerobic capacity: the malleability of the system, the importance of consistency, and setting long-term fitness goals [25:15];
    • Starting cardio training: base building, starting with low volume, and zone 2 training [30:45];
    • The critical role of VO2 max in longevity [36:45];
    • How to introduce VO2 max training to older or deconditioned individuals [46:15];
    • Options for performing zone 2 and VO2 max training [53:45];
    • The ability to make gains in strength and muscle mass as we age [57:00];
    • How to implement strength training for older individuals [1:01:00];
    • Advice for avoiding injury when strength training [1:07:30];
    • Risk of falls: the devastating consequences and the factors that increase fall risk [1:12:15];
    • Mitigating fall risk: the importance of foot and lower leg strength, ankle mobility, and balance [1:19:45];
    • Improving bone mineral density through resistance training [1:24:30];
    • The importance of protein in stimulating muscle protein synthesis, especially in older adults [1:31:00];
    • Parting advice from Peter [1:34:00]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enJune 24, 2024

    #306 - AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more

    #306 - AMA #60: preventing cognitive decline, nutrition myths, lowering blood glucose, apoB, and blood pressure, and more

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    In this “Ask Me Anything” (AMA) episode, Peter provides insights on a broad range of important topics. He delves into the prevention of cognitive decline, the link between cardiovascular disease and Alzheimer's disease, and methods to lower blood glucose, insulin, and apoB. He also addresses nutrition-related queries, exploring the impact of dietary habits on weight loss and longevity, how a person can identify the best diet for themselves, and common nutrition myths. Additional discussions include optimal blood pressure, daily step goals, the benefits of standing versus sitting desks, and much more.

    If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #60 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

    We discuss:

    • Overview of topics and episode format [1:40];
    • Preventing cognitive decline [5:00];
    • How to lower blood glucose and insulin [13:30];
    • The relationship between lipids, CVD, and Alzheimer’s disease, and whether statins can increase the risk of neurodegenerative disorders and AD [23:15];
    • Reducing apoB levels through exercise and diet [31:45];
    • Pharmacological options for lowering apoB [38:00];
    • How nutrition impacts longevity via metabolic health, muscle mass, BMD and more [40:15];
    • How can someone determine the best diet for themselves? [43:45];
    • Nutrition myth: All weight loss is good [46:45];
    • Nutrition myth: Metabolic rates are dramatically different among individuals based on genetics [49:00];
    • Nutrition myth: Losing weight after a brief period of overeating is impossible [53:45];
    • Nutrition myth: GLP-1 agonists are a replacement for a healthy lifestyle [57:45];
    • Nutrition myth: There is a single best diet for weight loss [1:03:00];
    • Nutrition oversimplification: All calories are created equal [1:05:45];
    • Daily step goals [1:06:45];
    • The benefits of standing versus sitting throughout the day [1:10:45];
    • How to identify the most impactful and easiest-to-implement ways to improve your health [1:12:30];
    • The critical importance of emotional health [1:14:30];
    • Why supplements should be considered as supportive aids rather than primary solutions in one’s strategy to improve longevity [1:18:00];
    • Strategies for reducing high blood pressure [1:20:45];
    • Peter’s biggest frustrations with "mainstream health advice" [1:28:00];
    • Peter’s chaotic, yet cherished, morning routine [1:31:00]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enJune 17, 2024

    #305 ‒ Heart rate variability: how to measure, interpret, and utilize HRV for training and health optimization | Joel Jamieson

    #305 ‒ Heart rate variability: how to measure, interpret, and utilize HRV for training and health optimization | Joel Jamieson

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    Joel Jamieson is a conditioning expert who developed Morpheus to give people a smarter way to build their conditioning regimen and improve their recovery. In this episode, Joel dives deep into the world of heart rate variability (HRV), explaining its scientific foundation, how it measures the balance between the sympathetic and parasympathetic nervous systems, the various methods of measurement, and how it can guide healthier lifestyle choices and improved training performance. He explores the nuances of HRV calculation, the impact of aging on HRV, and the roles of genetics, exercise, and other lifestyle factors in this process. He also covers Morpheus, the innovative training tool that won Peter over after his initial skepticism, highlighting its practicality and effectiveness in guiding training and optimizing fitness outcomes.

    We discuss:

    • Heart rate variability (HRV): evolution, science, and practical applications of HRV in athletic training [4:00];
    • Methods of measuring HRV: EKG, wrist-based sensors, and more [11:30];
    • How HRV is calculated from the data [22:30];
    • The role of the autonomic nervous system (ANS) in regulating HRV [25:45];
    • The decline in HRV with age, and the mitigating effects of fitness and other lifestyle factors [33:30];
    • The role of genetics in HRV, the modifiability of HRV, and a comparison of VO2 max and HRV as predictors of mortality [37:00];
    • How aging affects HRV and sympathetic drive, and the importance of spontaneous movement and exercise in maintaining the body's adaptability [43:30];
    • How Morpheus measures HRV using RMSSD and normalizes it to a 100-point scale for easier interpretation [49:45];
    • The Morpheus system: development, integration with various metrics, and personalized daily training recommendations to optimize fitness and recovery [51:30];
    • The benefits of morning HRV readings for assessing daily readiness compared to overnight HRV measurements [1:03:00];
    • Why Morpheus recommends using a chest strap rather than an arm band [1:10:00];
    • The impact of consistent exercise, stress, alcohol, and other lifestyle factors on HRV [1:11:15];
    • Optimizing zone 2 training with Morpheus [1:18:15];
    • Using heart rate recovery (HRR) as an indicator of athletic conditioning and the balance between aerobic and anaerobic systems [1:22:45];
    • The importance of tracking HRV trends over time rather than focusing on data from a given day [1:29:00];
    • Effect of GLP-1 agonists on heart rate and HRV [1:34:45];
    • Where HRV belongs in the hierarchy of health metrics [1:42:00];
    • Parting thoughts [1:46:30]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enJune 10, 2024

    #304 – NEW: Introducing quarterly podcast summaries - Peter shares his biggest takeaways on muscle protein synthesis, VO2 max, toe strength, gut health, and more

    #304 – NEW: Introducing quarterly podcast summaries - Peter shares his biggest takeaways on muscle protein synthesis, VO2 max, toe strength, gut health, and more

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    In this quarterly podcast summary (QPS) episode, Peter introduces a new format aimed at summarizing his biggest takeaways from the last three months of guest interviews on the podcast. Peter shares key insights from each episode, covering diverse topics such as protein and muscle building with Luc van Loon, toe strength with Courtney Conley, VO2 max with Olav Aleksander Bu, liquid biopsies for cancer with Alex Aravanis, gut health and probiotics with Colleen Cutcliffe, and road safety with Mark Rosekind. Additionally, Peter shares any personal behavioral adjustments or modifications to his patient care practices that have arisen from these engaging discussions.

    If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the episode #304 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

    We discuss:

    • How Peter keeps track of his takeaways from each podcast episode [5:15];
    • Luc van Loon episode: fat utilization, muscle protein synthesis, dietary protein, aging and inactivity, and more [8:45];
    • Behavioral changes that have come about from the conversation with Luc van Loon [23:45];
    • Courtney Conley episode: importance of toe strength and the impact of dedicated foot training [26:45];
    • Olav Aleksander Bu episode: the importance of VO2 max for lifespan, and the practicalities of measuring and improving VO2 max [36:45];
    • Behavioral changes that have come about from the conversation with Olav [56:00];
    • Alex Aravanis episode: liquid biopsies for cancer detection [1:01:30];
    • Colleen Cutcliffe episode: the importance of gut bacteria balance, and the potential therapeutic uses of probiotics, particularly Akkermansia [1:16:45];
    • Mark Rosekind: the significant issue of road fatalities and injuries, their causes, and practical safety measures to reduce risks [1:27:00]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enJune 03, 2024

    #303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.

    #303 - A breakthrough in Alzheimer’s disease: the promising potential of klotho for brain health, cognitive decline, and as a therapeutic tool for Alzheimer's disease | Dena Dubal, M.D., Ph.D.

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    Dena Dubal is a physician-scientist and professor of neurology at UCSF whose work focuses on mechanisms of longevity and brain resilience. In this episode, Dena delves into the intricacies of the longevity factor klotho: its formation and distribution in the body, the factors such as stress and exercise that impact its levels, and its profound impact on cognitive function and overall brain health. Dena shares insights from exciting research in animal models showing the potential of klotho in treating neurodegenerative diseases as well as its broader implications for organ health and disease prevention. She concludes with an optimistic outlook for future research in humans and the potential of klotho for the prevention and treatment of Alzheimer’s disease.

    Disclosure: Peter is an investor in Jocasta Neuroscience, a company working to develop klotho as a therapy for people with Alzheimer’s disease.

    We discuss:

    • Dena’s fascination with aging and how she came to study klotho [3:30];
    • Biological properties of klotho: production, regulation, decline with age, and factors influencing its levels [11:45];
    • Potential benefits of klotho on brain health [22:00];
    • The relationship between soluble klotho protein, platelet factors, and cognitive enhancement [33:45];
    • The role of platelet factor 4 (PF4) and it’s interaction with GluN2B in mediating cognitive enhancement [46:45];
    • Benefits of klotho observed in a mouse model of Parkinson’s disease [55:45];
    • Benefits of klotho observed in a mouse model of Alzheimer’s disease [1:03:00];
    • Promising results of klotho in primate models, and the importance of finding an appropriate therapeutic dose before moving to human trials [1:08:00];
    • Speculating why a single klotho injection has such long-lasting effects [1:25:30];
    • Potential cognitive benefits of klotho in humans, the impact of the KL-VS genetic variant on klotho levels, and the need for human trials to confirm these effects [1:27:45];
    • The interaction between the KL-VS genetic variant and APOE4 and how it impacts risk of Alzheimer’s disease [1:34:45];
    • The significance of klotho levels: studies linking lower levels to increased mortality and the broader implications for organ health and disease prevention [1:47:15];
    • Measuring klotho levels and determining an individual’s KL-VS status [1:52:15];
    • The promising potential of klotho for Alzheimer’s disease treatment, and the importance of philanthropy for funding research [1:58:00]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enMay 27, 2024

    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

    #302 - Confronting a metabolic epidemic: understanding liver health and how to prevent, diagnose, and manage liver disease | Julia Wattacheril, M.D., M.P.H.

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    Julia Wattacheril is a physician scientist and director of the Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) program at Columbia University Irving Medical Center. In this episode, Julia delves deep into the complex world of liver health, beginning with a foundational overview of liver physiology. She provides an in-depth look at how alcohol impacts liver function, breaking down the metabolism of ethanol and its detrimental effects. Julia then shifts the focus to understanding liver function tests and optimal enzyme levels, providing a detailed explanation of AST and ALT and elucidating why fluctuations in these levels may or may not be concerning. She provides a primer on the four major stages of liver disease, discussing risk and emphasizing the importance of early diagnosis. Julia highlights the role of liver disease in increasing the risk of cancer and cardiovascular disease and covers in detail the various strategies for diagnosing, treating, and preventing the progression of liver disease.

    We discuss:

    • Julia’s training, the importance of liver health, and the challenges and innovations of hepatology [3:15];
    • The complex and crucial functionality of the liver, its four most essential functions, and more [8:45];
    • Liver injuries: historical and evolving understanding of causal factors, and the progression to liver diseases and cancer [13:15];
    • How the liver metabolizes nutrients and what happens in the presence of excess calories or alcohol [24:45];
    • Methods of diagnosing liver disease and how insights guide treatment and management strategies [33:30];
    • The poisonous nature of ethanol to the liver [40:30];
    • Varied responses to alcohol, damaging effects of alcohol beyond the liver, and the process of advising patients on their alcohol consumption [47:15];
    • Understanding liver enzymes AST and ALT—interpreting levels, lifestyle factors that affect them, and diagnostic approaches [58:30];
    • Interpreting liver function tests for fatty liver disease, and the challenges of diagnosing liver pathologies, particularly in children versus adults [1:13:15];
    • Comprehensive liver health assessments via imaging and various diagnostic tools to prevent overlooking potential liver pathologies [1:18:45];
    • Potential impact of recreational drugs, statins, and other medications on liver function test results [1:26:45];
    • Shifting nomenclature from NAFLD to MASLD to reflect accuracy in the underlying pathophysiology and understanding of liver diseases [1:30:30];
    • Pathophysiology of MASLD, the need for proactive screening, and the significance of liver fat percentage as an indicator of metabolic health [1:36:30];
    • The importance of screening for rare conditions alongside common metabolic diseases associated with fatty liver accumulation [1:42:45];
    • Practical strategies for managing MAFLD [1:45:30];
    • The impact of fructose consumption on liver health and the challenges of disentangling its effects from other factors like obesity and insulin resistance [1:52:45];
    • The potential of GLP-1 agonists for the treatment of MASLD [1:57:45];
    • How the four stages of liver disease have evolved [2:00:30];
    • Increased cancer and heart disease risk associated with early-stage MAFLD [2:05:15];
    • Emerging drugs and therapies for addressing fat accumulation and fibrosis related to MAFLD [2:12:15];
    • Peter’s major takeaways [2:18:45]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enMay 20, 2024

    #301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it

    #301 - AMA #59: Inflammation: its impact on aging and disease risk, and how to identify, prevent, and reduce it

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    In this “Ask Me Anything” (AMA) episode, Peter delves into the often misunderstood concept of inflammation. He first defines inflammation and differentiates between acute inflammation and chronic inflammation, the latter of which is linked to aging and a plethora of age-related diseases. Peter breaks down the intricate relationship between chronic inflammation, obesity, and metabolic health, and highlights the signs that might suggest someone may be suffering from chronic inflammation. From there, the conversation centers on actionable advice and practical steps one can take to manage and minimize chronic inflammation. He explores how diet plays a crucial role, including the potential benefits of elimination diets, and he examines the impact of lifestyle factors such as exercise, sleep, and stress management. Additionally, he discusses the relevance of food inflammatory tests and concludes by examining the potential benefits and drawbacks of drugs and supplements in managing inflammation.

    If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #59 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

    We discuss:

    • Defining inflammation (and the cultural impact of Napoleon Dynamite) [1:45];
    • Acute vs chronic inflammation [8:00];
    • The connection between chronic inflammation, aging, and age-related diseases [11:00];
    • The impact of inflammation on metabolic health [18:30];
    • Understanding and diagnosing chronic inflammation: blood tests and other approaches, and challenges with measurement [20:00];
    • Factors that contribute to low-level chronic inflammation [28:00];
    • Minimizing inflammation through diet [29:45];
    • The important role of fiber for gut health and inflammation [33:45];
    • A closer look at the impact of trans fats and saturated fats on overall health [34:45];
    • Why Peter prefers dietary fiber from food sources over supplements [38:30];
    • Debunking “superfoods”: emphasizing proven methods over marketing claims for reducing inflammation [39:00];
    • Is there any value in over-the-counter food inflammatory tests? [42:30];
    • Food elimination diets: how they work, symptoms and markers to watch, challenges and limitations [45:15];
    • Identifying dietary triggers for gut-related symptoms through low-FODMAP diets like the “carnivore diet” [51:15];
    • Dairy: the complex role of dairy on inflammation and individual responses [55:00];
    • Wheat: the complexities and conflicting evidence around wheat's inflammatory effects [57:45];
    • How exercise influences inflammation [1:02:00];
    • How sleep quality and duration impacts inflammation [1:07:00];
    • The potential impact of chronic psychological stressors on inflammation [1:13:00];
    • The impact of oral health on inflammation and overall well-being [1:15:00];
    • The role of medications in managing chronic inflammation [1:18:15];
    • Supplements: evaluating the efficacy of various anti-inflammatory supplements [1:22:15];
    • Parting thoughts and takeaways [1:27:00]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    The Peter Attia Drive
    enMay 13, 2024

    #300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

    #300 - Special episode: Peter on exercise, fasting, nutrition, stem cells, geroprotective drugs, and more — promising interventions or just noise?

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    In this special edition celebrating 300 episodes of The Drive, Peter discusses a variety of popular topics and health interventions and classifies them based on their level of evidence and relevance using the following categories: proven, promising, fuzzy, noise, and nonsense. Peter first delves into the topic of geroprotective molecules, covering rapamycin, metformin, NAD and its precursors, and resveratrol. Next, he explores the significance of metrics like VO2 max and muscle mass, as well as emerging concepts like blood flow restriction and stem cells. The conversation extends to nutrition, addressing questions surrounding long-term fasting, sugar consumption, sugar substitutes, and the contentious role of red meat in cancer. Peter not only provides his current stance on each topic—most of which have been covered in great detail in the previous 300 episodes—but also reflects on how his opinion may have evolved over the years.

    We discuss:

    • Defining the categories of “proven, promising, fuzzy, noise, and nonsense” [3:15];
    • Rapamycin [9:30];
    • Metformin [17:00];
    • NAD and its precursors [24:30];
    • Resveratrol [32:45];
    • The importance of VO2 max, muscle mass, and muscular strength for lifespan [38:15];
    • Blood flow restriction (BFR) training [44:00];
    • Using stem cells to treat osteoarthritis or injury [51:30];
    • Fasting as a tool for longevity (and why Peter stopped his fasting protocol) [55:45];
    • The energy balance theory [1:06:30];
    • The idea that sugar is poison [1:12:00];
    • The idea that sugar substitutes are dangerous [1:22:15];
    • The debate on red meat and cancer [1:28:45]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death

    Special episode with Dax Shepard: F1 and the 30th anniversary of Ayrton Senna’s death

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    This is a special episode of The Drive with Peter’s friend and fellow car enthusiast Dax Shepard. In this podcast, which commemorates the 30th anniversary of the death of Brazilian Formula One legend Ayrton Senna, Dax sits down with Peter to better understand what made Senna so special and why Peter remains an enormous fan. This conversation focuses on Senna’s life, the circumstances of his death, and his lasting impact and legacy on the sport of F1.

    We discuss:

    • Peter’s interest in motorsports began as a child [2:30];
    • The drama and dangers of F1 [6:00];
    • What made Senna special [13:00];
    • What Senna meant to Brazilians [24:00];
    • The cause of the fatal crash [28:15];
    • Why Peter is obsessed with Senna [40:30];
    • Being the best versus having the best record [43:30];
    • Senna’s unique driving style and incredible intuition about automotive engineering [46:30];
    • Back to the day of the dreadful race [53:00];
    • What Peter believes caused the crash [1:02:45];
    • Views on dying young, in the prime of life [1:13:00];
    • Senna lives on in his foundation and in safety changes adopted by F1 [1:21:00];
    • Statistics aren’t enough for fandom, and why people like who they do [1:24:15];
    • The biggest difference between F1 today and F1 in the 80s [1:28:30];
    • Senna’s driving superpower [1:30:30];
    • The fastest drivers currently in F1 [1:38:30];
    • Current F1 obsessions [1:45:00];
    • How hard it is to do what the top F1 drivers do [1:50:15];
    • Dax’s love of motorcycles and his AMG E63 station wagon [1:52:15];
    • Awesome Senna mementos from Etsy [2:01:15];
    • What makes specialists interesting, and Max’s devotion to F1 [2:10:15];
    • What Senna might have done if he had not died that day [2:14:00];
    • Michael Schumacher and Max Verstappen are also top F1 drivers [2:17:30];
    • Interlagos in Sao Paulo Brazil is always an incredible experience [2:18:45]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    #299 ‒ Optimizing muscle protein synthesis: the crucial impact of protein quality and quantity, and the key role of resistance training | Luc van Loon, Ph.D.

    #299 ‒ Optimizing muscle protein synthesis: the crucial impact of protein quality and quantity, and the key role of resistance training | Luc van Loon, Ph.D.

    View the Show Notes Page for This Episode

    Become a Member to Receive Exclusive Content

    Sign Up to Receive Peter’s Weekly Newsletter

    Luc van Loon is an internationally renowned expert in skeletal muscle metabolism. In this episode, Luc starts with an exploration of the roles of insulin and triglycerides in endurance exercise, highlighting their impact on skeletal muscle metabolism, and he offers profound insights into the significance of protein in this context. He elucidates how different protein types and forms influence muscle protein synthesis rates, exploring the nuances of protein absorption, digestibility, amino acid quality, and their implications for performance and recovery. Delving deeper, he differentiates between animal and plant protein sources, unraveling the distinctive properties of various protein types, from the differences between whey and casein to the emerging trends in collagen protein supplementation. Moreover, Luc dissects the intricate connections among physical activity, lean muscle mass, muscle protein synthesis induced by resistance training, and dietary protein.

    We discuss:

    • Luc’s background and insights about fuel selection during exercise [3:30];
    • Fuel utilization during endurance exercise [9:30];
    • Fat metabolism, intramuscular lipids, and the nutritional dynamics of endurance sports [17:15];
    • The optimal window for replenishing intramuscular fat stores and glycogen post-exercise [25:15];
    • Luc’s interest in protein metabolism and exploration of amino acids' dual role as building blocks and signaling molecules in driving muscle protein synthesis [32:15];
    • How protein metabolism differs between sedentary individuals and those engaged in predominantly strength training or endurance training [38:45];
    • The basics of how proteins are digested and absorbed, and how muscle protein synthesis is measured [50:30];
    • How factors like food texture, cooking methods, and protein composition impact muscle protein synthesis, and the importance of protein distribution throughout the day [59:45];
    • Differences in whey and casein proteins, and the ability of ingested protein to stimulate muscle protein synthesis [1:03:30];
    • Dietary protein distribution and quantity for the maximization of muscle protein synthesis [1:09:00];
    • Muscle loss with age and inactivity and the importance of resistance exercise to maintain type II muscle fibers [1:17:15];
    • Differences between whey and casein proteins, and the importance of both quantity and quality of protein sources [1:28:30];
    • Optimizing muscle protein synthesis: exercise, timing of protein intake, protein quality, and more [1:37:00];
    • How to preserve muscle while trying to lose weight [1:46:00];
    • Anabolic resistance and overcoming it with physical activity [1:55:45];
    • Importance of protein intake and physical activity in hospitalized patients [2:06:30];
    • Reviewing the efficacy of collagen supplements [2:13:30];
    • Plant-based diets: how to ensure a balance of amino acids, and other considerations [2:20:30];
    • Future research: understanding protein metabolism in the brain [2:23:45]; and
    • More.

    Connect With Peter on TwitterInstagramFacebook and YouTube

    Related Episodes

    41: Back with a Bang: Tackling Type 1 Diabetes Together

    41: Back with a Bang: Tackling Type 1 Diabetes Together

    In this week's unmissable episode of We Are T1D: Type 1 Diabetes, Mike and Jack return with the kind of authenticity and humor that only two Londoners living with T1D can deliver. From the highs and lows of blood sugar levels to the cheeky banter that comes with a hypo, this duo covers it all.

    Mike shares a poignant moment of celebration as his father beats cancer, while Jack boasts a triumphant 90% in-range week. They tackle the challenges of cold weather on blood sugar management and the temptations of post-holiday treats, all while maintaining their signature blend of real talk and laughs.

    Listeners are in for a treat as they play "Guess the Carbs" with Mike and Jack's meals, offering a chance to join in on the fun and potentially win some T1D swag. Plus, the pair dive into community struggles and wins, sharing stories that range from hypo mishaps during intimate moments to triumphs over holiday indulgences.

    Tune in for a dose of relatability, inspiration, and a reminder that you're not alone in your T1D journey. Whether you're looking for advice, a good laugh, or just some company, Mike and Jack have got your back. Don't miss out on this episode – it's a heart-warming, gut-busting, and eye-opening rollercoaster that only the We Are T1D podcast can provide.

    New episodes go out every Sunday!
    Follow/Subscribe to be first to know
    also rate and review - we love reading them!

    48: From Chicago Suburbs to T1D Champion: Sammi's Story of Strength (@type1samfit)

    48: From Chicago Suburbs to T1D Champion: Sammi's Story of Strength (@type1samfit)

    In this heartwarming and eye-opening episode of We Are T1D: Type 1 Diabetes, hosts Mike and Jack welcome Sammi, a Type 1 warrior from the Chicago suburbs, for a cross-continental chat that's as enlightening as it is entertaining. Sammi shares her journey from a soccer-playing teen to a T1D powerhouse, revealing the ups and downs of managing diabetes amidst a whirlwind of hormonal changes, including the challenges and triumphs of pregnancy with T1D.

    The trio dives deep into the complexities of diabetes management, from the fear of lows to the intricacies of insulin pump therapy. Sammi, with her omnipod and Dexcom in tow, provides invaluable insights into the world of automated insulin delivery and the learning curve that comes with it. The conversation takes a turn from the serious to the squirrely as Sammi recounts her struggle with unwelcome furry mechanics in her car.

    Listeners are invited to join the "wins of the week" celebration, with Mike's pre-bolusing success and Sammi's impressive in-range achievements. But it's not just about the blood sugar victories; the episode also explores the importance of asking for help, the impact of diabetes on relationships, and the power of community support.

    From gym fears to the financial strains of healthcare in America, this episode covers it all, including a discussion about how different exercises impact blood sugar and the benefits of a protein-rich diet. Mike, Jack, and Sammi keep it real, sharing laughs, personal anecdotes, and even a few tech troubles, reminding us all that life with T1D is unpredictable but manageable with the right mindset.

    - Follow The Podcast https://www.instagram.com/wearet1d
    - Follow Mike https://www.instagram.com/t1d_mike
    - Follow Jack https://www.instagram.com/t1d_jack
    - Follow Sammi https://www.instagram.com/type1samfit
    - Share your story and join the community at https://wearet1d.com

    Don't miss out on this episode's blend of humor, honesty, and heartfelt advice. Subscribe/Follow, Rate, and Review to support the show and connect with the T1D family.

    Embrace the journey, take the highs with the lows, and tune in for a dose of camaraderie and encouragement. Catch you on the flip side!

    Stay connected, stay informed, and keep living boldly with Type 1 Diabetes.

    40: Cat-astrophic Start: A Type 1 Diabetic's New Year

    40: Cat-astrophic Start: A Type 1 Diabetic's New Year

    As the clock struck midnight and we welcomed the new year, many of us set resolutions hoping to improve our lives. But for those living with type one diabetes, the turn of the year doesn't just bring new goals; it brings the continuous challenge of managing a chronic condition. This is the world that Mike and Jack invite us into on the 'We Are T1D Podcast'.

    In their latest episode, these two Londoners share their experiences of navigating the festive season with the added complexity of diabetes. Mike recounts his frustrating New Year's Day at work, while Jack deals with the antics of his new kitten, Wotsit, which adds a layer of humor and relatability to the episode.

    The duo doesn't shy away from discussing the tough parts of diabetic life with the listeners, including struggles with insulin resistance and the impact of illness on blood sugar levels. They also delve into the technological aspects of diabetes management, comparing fingerprick tests to CGM readings, and the adjustments needed to maintain control.

    But it's not all about the struggles. Mike and Jack celebrate the wins, too. They share the victories of staying in range over the holidays and the sense of achievement that comes with it. The podcast is a blend of real talk, advice, and encouragement, wrapped up with a good dose of British banter.

    As you listen to their conversation, you can't help but feel a part of their community. They remind us that while diabetes is an individual journey, no one has to walk it alone. Whether you're a fellow type one diabetic, a friend, or family member, or just someone interested in understanding the condition, this episode is a must-listen.

    So grab your favorite low-carb snack, settle in, and tune into the 'We Are T1D Podcast'. It's a dose of reality, a touch of empathy, and a burst of laughter, all rolled into one. And who knows? You might just find the motivation to tackle your New Year's resolutions, diabetic or not.

    Listen to the episode now and join Mike and Jack as they kick off another year of living boldly with type one diabetes.

    • Follow The Podcast https://www.instagram.com/wearet1d
    • Follow Mike https://www.instagram.com/t1d_mike
    • Follow Jack https://www.instagram.com/t1d_jack
    • Get your wins on the podcast at https://wearet1d.com
    • Email Us: wearet1dpodcast@gmail.com

    New episodes go out every Sunday!

    Make sure to Subscribe or Follow, Rate and Review to help others find the podcast.

    #144 Flatten Your Glucose Levels with Jessie Inchauspe

    #144 Flatten Your Glucose Levels with Jessie Inchauspe

    Today we’re talking all about why the most important molecule in your body, glucose, is a double edged sword and how flattening sugar levels in your bloodstream is key to less cravings, improved mood, better weight control and less risk of cardiovascular disease, dementia and depression.


    My guest is Jessie Inchauspé, (in chow spe) who is on a mission to translate cutting-edge science into easy advice to help people improve their physical and mental health by knowing more about their glucose levels.


    Jessie holds a degree in mathematics from King's College London, a degree in biochemistry and her first book, Glucose Revolution, she shares her discovery about the essential role of blood sugar and the surprising hacks to optimise it while still eating the foods we love.


    Today we talk about:

    • The importance of adequate glucose
    • Why blood glucose variability and the velocity of change in your blood glucose is important to know
    • How excess sugar impacts your mitochondria, DNA, inflammation, oxidative stress and glycation levels
    • Why keeping Insulin levels steady is important
    • Glucose flattening hacks
    • How the order of food consumption impacts blood sugar
    • Why curry is good for breakfast
    • Vinegar before meals
    • And how a post dinner walk could be good for sleep and cravings


    A bit of housekeeping, we discuss normal ranges of glucose in mmol/l as 4.0-7.0 fasted and under 8.0 2 hours after eating. But, your individual target range for your blood sugar levels may be different, especially if you have a metabolic condition and your healthcare team will agree with you what that should be. Do not use this podcast episode or any other material from The Doctor’s Kitchen as a replacement for medical advice.


    It’s important to remember that glucose isn’t everything. As we say at the end of the pod, just because your glucose level is flat does not necessarily mean that you’re eating the healthiest diet and it should be seen as just one of those many levers that we can use to optimise behaviour change and positively impact our physiology.


    I’m doing a new thing which is our podcast recipe of the week, a recipe that reflects the topic of conversation on the pod! This week’s recipe is my easy ‘Sweet potato chickpea salad with sumac and tahini dressing’  which you can find on the app here: https://apple.co/3G0zC0Z (iphone only, android users please bear with me)


    You can download The Doctor’s Kitchen app for free to get access to all of our recipes, with specific suggestions tailored to your health needs and new recipes added every month. We’ve had some amazing feedback so far and we have new features being added all the time - check it out with a 7 day free trial too.


    Do check out this week’s “Eat, Listen, Read” newsletter, that you can subscribe to on our website - where I send you a recipe to cook as well as some mindfully curated media to help you have a healthier, happier week.


    Check out the recipes and app here: https://apple.co/3G0zC0Z

    Join the newsletter and 7 day meal plan here: https://thedoctorskitchen.com/newsletter/

    Check out the socials here: https://www.instagram.com/doctors_kitchen/



    Hosted on Acast. See acast.com/privacy for more information.


    FITNEST MAMA | Everything you need to know about exercise during pregnancy with gestational diabetes

    FITNEST MAMA | Everything you need to know about exercise during pregnancy with gestational diabetes

    We all know we should be doing exercise, right?
    It’s good for our physical health, mental health and your blood sugar.
    So it's a no brainer to fit it into your day, right?

    Except that ... sometimes life gets in the way and sometimes it can be hard, and how the hell are you meant to know what to do when you're pregnant!

    It's not always simple. 

    It's a bit like with food how we all generally know the gist of what’s good for us (moving our body, eating fruits and vegetables), but the tricky thing is actually knowing HOW to do this, and what specifics to focus on in certain times, again, like pregnancy.

    So I get it.

    You might not know what exercises are safe, or what is best to reduce blood sugar.

    OR you might have a decent idea of what you could or want to be doing, but a busy toddler and a full time job take up almost every moment of your time and regularly get in the way.

    This episode is here to demystify exercise for you.

    I had the pleasure of chatting with Kath Baquie,  a mum of 3, a perinatal physiotherapist, and founder of FitNest Mama. She has SO much wisdom around pre and postnatal exercise and I know you'll get a lot out of listening to this!

    We touch on what is safe and recommended, how to overcome barriers to exercise, and the impact on blood sugar.

    Enjoy x 

     

    Make sure you hit SUBSCRIBE so you don’t miss out on any of my free nutrition tips. 

    And if you found this episode helpful, I would be so appreciative of you leaving me a rating and review - it helps this podcast reach other people like you! 

    You can leave a google review here:  https://g.page/r/CT8DWXBPFFFKEAI/review 

     

    Links and resources:

    Thanks for being here x

     

    Disclaimer: 

    The information in this podcast is provided for informational and educational purposes only, and is not a substitute for individualised medical and nutrition advice. Please speak to your healthcare team before making any changes to your diet and lifestyle. Helena (and any guests) do not accept liability for any harm or damages that occur from following suggestions in these podcast episodes.