genotype

Have you ever wondered why some people seem to thrive on certain diets while others struggle to find the right balance? The answer might lie in our genes. Nutrigenomics is the study of how our individual genetic makeup interacts with the food we eat, influencing everything from our metabolism to nutrient absorption to our overall well-being. In this episode we’ll explore this interaction and explain how you may benefit by “eating according to your genes”. 

Image by Gerd Altman

Shownotes: yournutritionprofs.com

Do you have a nutrition question you'd like us to answer? Let us know! Contact Us on our website or any of the following ways:

yournutritionprofs@gmail.com

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In this episode, Emily Heil, PharmD, MS, BCIDP, AAHIVP; Laila Woc-Colburn, MD; and Trevor Van Schooneveld, MD, FSHEA, FACP, discuss their approach to managing infections involving Pseudomonas aeruginosa with difficult-to-treat resistance, including: 

• Mechanisms of β-lactam resistance
• Effect of resistance mechanism on susceptibility to antipseudomonal agent
• 2023 IDSA guidance recommendations 
• Activity against newer antipseudomonal β-lactams in the United States
• The latest clinical data by antimicrobial regimen:

              - Ceftolozane/tazobactam
              - Ceftazidime/avibactam
              - Imipenem/cilastatin/relebactam
              - Cefiderocol

• Applying antimicrobial stewardship principles

Program Director:

Trevor Van Schooneveld, MD, FSHEA, FACP  
Professor, Division of Infectious Diseases
Program Director, Infectious Diseases Fellowship
Medical Director, Antimicrobial Stewardship Program
University of Nebraska Medical Center
Omaha, Nebraska

Faculty:

Emily Heil, PharmD, MS, BCIDP, AAHIVP
Associate Professor
Department of Pharmacy
University of Maryland  
School of Pharmacy
ID Clinical Pharmacy Specialist
University of Maryland Medical Center|
Baltimore, Maryland

Laila Woc-Colburn, MD
Associate Professor
Division of Infectious Diseases
Emory University School of Medicine  
Atlanta, Georgia

Content based on a CME program supported by an educational grant from Merck & Co., Inc., Rahway, NJ, USA.

Follow along with a downloadable slideset at: https://clinicaloptions.com/CE-CME/infectious-disease/cmv-prevention-in-sot-recipients/26139

Link to full program: https://bit.ly/40HyvPy

On this episode of Ruff Talk VR we are joined with Lasse Tassing, Jaime Monedero March, and Mark Olsen of Bolverk Games to talk about their newest VR game Genotype - available now on the official Meta Quest store! This game packs a thrilling story in with fun gameplay in this narrative story adventure. Listen as we get to know some of the team behind this game, what it was like to make Genotype, what's next for the game, and more!

Discord: https://discord.gg/9JTdCccucS

Patreon: https://www.patreon.com/rufftalkvr

Gaming Showcase: https://www.rufftalkvr.com/p/2024-ruff-talk-vr-gaming-showcase/

Tabor Radio: https://www.buzzsprout.com/2216985

If you enjoy the podcast be sure to rate us 5 stars and subscribe! Join our official subreddit at https://www.reddit.com/r/RuffTalkVR/

Get 20% OFF @manscaped + Free Shipping with promo code RUFFTALKVR at MANSCAPED.com!

Genotype Website: https://www.playgenotype.com/

Genotype Store Link: https://www.meta.com/experiences/6694982853879859/

In Genotype, you explore an Antarctic research base overrun by monstrous beasts, wielding high-tech gloves that print living organisms you can use as weapons and survival tools.

- Print creatures and use them as weapons to fight off aggressive beasts.
- Transform into other beings to move through vents, and use them as tools to clear environmental obstructions.
- Upgrade your creatures' DNA to enhance their capabilities, and customize your GRAID gloves to increase your survival chances.
- Enjoy high-fidelity graphics that take full advantage of the Meta Quest platforms' graphical potential.
- Immerse yourself in an emotional narrative with fully voice-acted characters.
- Dive into a world with truly alien sound design and atmospheric synth-scapes.

You play as Evely, an intern at an Antarctic weather station. During a routine expedition, Evely falls through the ice into the mysterious Snowdrop Initiative laboratories. Luckily, the facility's last human survivor, William, can guide her to save herself — and the entire planet.

To survive, you must use the GRAID gloves to print creatures. As you explore the facility, you will find ways to print new creatures, and to modify and upgrade the ones you have access to.

You will have to adapt, and use the creatures to battle hostile monsters, reach otherwise inaccessible places, and clear the way to venture deeper into the Snowdrop facility.

You hold the fate of the world in your hands. Don’t shake... and never mind the penguins.

In this episode, Daniel R. Kuritzkes, MD, discusses considerations for rapid initiation of antiretroviral therapy in patients who are newly diagnosed with HIV, including:

• Recommended regimens
• Management of patients previously receiving PrEP
• Timing of laboratory testing

Presenter:

Daniel R. Kuritzkes, MD
Harriet Ryan Albee Professor of Medicine
Harvard Medical School
Chief, Division of Infectious Diseases
Brigham and Women’s Hospital
Boston, Massachusetts

To download the slides: 
https://bit.ly/3odUA9C

To view the full online program: 
https://bit.ly/3ZjSFhg

In this episode, Jill Blumenthal, MD, MAS, and William R. Short, MD, MPH, AAHIVS, address key considerations when evaluating ART safety and tolerability in pregnant people, those trying to conceive, and transgender individuals, such as:

• Approaching patients trying to conceive on nonpreferred ART regimens (eg, 2-drug regimens like LA CAB and RPV)
• Optimizing the use of the Antiretroviral Pregnancy Registry
• Addressing unique barriers to ARV adherence in transgender individuals with HIV (eg, drug formulation considerations for ARV medications and gender-affirming hormone therapy, sperm banking or egg harvesting, drug coverage considerations)

Faculty: 
Jill Blumenthal, MD, MAS
Associate Professor of Medicine
Infectious Diseases and Global Public Health 
University of California, San Diego
San Diego, California

William R. Short, MD, MPH, AAHIVS
Associate Professor of Medicine
Division of Infectious Diseases 
Department of Medicine  
Perelman School of Medicine at the University of Pennsylvania 
Philadelphia, Pennsylvania

Link to full program:
http://bit.ly/3PM3nYe

Link to downloadable slides: 
http://bit.ly/3WgYycz

NBA great Alonzo Mourning returned home from the Sydney Olympics after winning the gold medal feeling ill. He surprisingly was diagnosed shortly after with kidney disease. Scientists have discovered his type of kidney disease is linked to having genetic variants of the APOL1 gene – ones that 13% of people with African ancestry carry. Dr. Ogo Egbuna leads clinical development for the team researching APOL1-mediated kidney disease at Vertex where they’re investigating a small molecule therapy to target its underlying cause.

Produced by Bloomberg Media Studios and Vertex Pharmaceuticals. 
 

Featured guests:

Alonzo Mourning is a retired NBA player, the Vice President, Player Programs for the Miami Heat, an advocate for kidney disease research, and a beneficiary of a kidney transplant.

David Friedman is an Associate Professor of Medicine, Harvard Medical School and a Principal Investigator and Nephrologist at Beth Israel Deaconess Medical Center. He's researched and consulted for Vertex Pharmaceuticals.

Janice Lea  is a Professor of Medicine and Clinical Director of Nephrology at Emory University School of Medicine.

Ogo Egbuna is Vice President, Clinical Development at Vertex Pharmaceuticals Read more about Vertex's approach to targeting kidney disease.

Produced by Bloomberg Media Studios and Vertex Pharmaceuticals. 
 

You can think of the “D” in HDV as standing for difficult, disadvantaged, and dangerous. Hepatitis delta virus (HDV) is difficult to diagnose, is often diagnosed in disadvantaged patient populations, and leads to dangerous sequelae.

Listen as Dr. Kosh Agarwal and Dr. Graham R. Foster and discuss challenges and opportunities for linking patients to care after a positive test for HDV.

Presenters:

Kosh Agarwal, MD
Consultant Hepatologist and Transplant Physician
Institute of Liver Studies
King's College Hospital NHS Foundation Trust
London, United Kingdom

Graham R. Foster, FRCP, PhD
Professor of Hepatology
The Liver Unit
Consultant Hepatologist
Queen Mary University of London
London, United Kingdom

Link to full program:
https://bit.ly/3tlxa0H

In this episode from the series “Key Decisions in HIV Care,” W. David Hardy, MD, and Josep M. Llibre, MD, PhD, discuss important considerations for ART use in the context of virologic failure and resistance, including:

• A discussion of the definitions of the following: highly treatment experienced, complex ART, multidrug-resistant HIV, and limited treatment options
• The scope of the problem, including data from the CNICS cohort
• DHHS and EACS guideline recommendations on the management of virologic failure and drug resistance, including recommendations for the use of genotypic and phenotypic genotyping and proviral DNA sequencing
• Construction of an optimized background regimen with discussion of the OPTIONS, DAWNING, NADIA, and VIKING-3 trials
• Novel treatment options, including ibalizumab and data from TMB-301/-311, fostemsavir and data from BRIGHTE, and lenacapavir and data from CAPELLA

Presenters:

W. David Hardy, MD
Scientific and Medical Consultant
Adjunct Clinical Professor of Medicine
Division of Infectious Diseases
Keck School of Medicine of USC
Los Angeles, California

Josep M. Llibre, MD, PhD
S­enior Consultant Physician and Clinical Researcher
Infectious Disease and “Fight against AIDS and Infectious Diseases Foundation”
Hospital Universitari Germans Trias i Pujol
Badalona
Barcelona, Spain  

Content based on an online CME program supported by educational grants from Gilead Sciences, Inc.; Janssen Therapeutics, Division of Janssen Products, LP; and ViiV Healthcare.

Follow along with the slides at: 
https://bit.ly/3z9AtL0

Link to full program:
https://bit.ly/2TXTYWx

Join Marcia for Part 1 of this genetics episode covering a total of 13 papers. In this one, she talks about papers from October 2021, related to transcriptomics, especially genes that are differentially expressed In Alzheimer’s disease, and some studies with vertebrate and invertebrate AD model organisms and risk loci. Tune in to learn more! 

Sections in this episode:  

Transcriptomics/Gene expression changes (2:45)

Model organisms (17:21)  

Risk alleles/variants (22:16)  

Methods (27:09)  

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You can find the numbered bibliography for this episode by clicking here, or the link below:

https://drive.google.com/file/d/1T7h0KF--qwGt31ygyXV_NMAktRDw7CWH/view?usp=sharing

To access the folder with all the bibliographies for 2021 so far, follow this link (it will be updated as we publish episodes and process bibliographies), or click the following link below:

https://drive.google.com/drive/folders/1N1zx_itPkCDNYE1yFGZzQxDDR-NiRx3p?usp=sharing

You can also join our mailing list to receive a newsletter by filling this form. 

Or tweet at us: @AMiNDR_podcast  

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Follow-up on social media for more updates!

Facebook:  AMiNDR  

Twitter: @AMiNDR_podcast

Instagram: @AMiNDR.podcast

Youtube: AMiNDR Podcast

LinkedIn: AMiNDR Podcast

Email: amindrpodcast@gmail.com  

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Please help us by spreading the word about AMiNDR to your friends, colleagues, and networks! Another way you can help us reach more listeners who would benefit from the show is by leaving us a review on Apple Podcasts or wherever you listen to podcasts. It helps us a lot and we thank you in advance for leaving a review! 

Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Marcia Jude, edited by Michelle Grover, and reviewed by Kate Van Pelt and Anusha Kamesh. The bibliography was generated by Anjana Rajendran and the wordcloud was created by Sarah Louadi (www.wordart.com). 

Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer’s Disease papers into episodes each month. For October 2021, the sorters were Jacques Ferreira, Christy Yu, Kate Van Pelt, Eden Dubchak, Kira Tosefsky, Dana Clausen, Ellen Koch and Elyn Rowe.

Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, Jacques Ferreira, and Shruti Kocchar for keeping everything running smoothly.

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.   

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w   

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If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.  

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*About AMiNDR: *  

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!" 

This week, Casey answers a listener question - 'Should I be eating for my genotype?' Inside, you'll learn some genetics basics before moving onto what, if any, value a nutrigenomic test has to offer (spoiler: minimal), and what strategies you can pursue to individualize your diet. Check it out!

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Klaus Rabe discusses a study that looks at ADRB2 polymorphisms and drug efficacy in preventing COPD exacerbations in patients from the POET trial.

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