Carolina Reis: Reverse Your Biological Age and Increase Your Longevity With These Pro-Aging Hacks! | E228

Podcast Summary

• Exploring the science of aging and skin health with OneSkin's CEO: OneSkin's CEO, Carolina Hice, is using biotechnology to grow human skin in the lab for testing anti-aging products and potentially reversing the aging process.

  Carolina Hice, the cofounder and CEO of OneSkin, shares her passion for understanding the code of life and how it relates to aging and skin health. She grew up with an interest in science, specifically stem cell biology and tissue engineering, which led her to create OneSkin, a biotechnology company focused on growing human skin in the lab for testing anti-aging products. Her mission is to manipulate the genetic code to improve tissue health and potentially reverse the aging process. The conversation also touched on the relationship between skin health and age-related diseases like diabetes, and the importance of healthy skin habits for overall well-being. Overall, this episode highlights the fascinating world of science and the potential for innovation to improve our lives.

• Testing anti-aging skincare products with lab-grown human skin cells: Scientifically validating anti-aging skincare products through lab-grown human skin cells reveals effective solutions for reducing signs of aging and promoting overall health.

  The field of anti-aging skincare is filled with pseudoscience and hype, making it difficult for consumers to determine which products effectively promote age reversal. To address this issue, a company has developed a method to grow human skin cells in the lab and test the efficacy of products on them. By measuring the biological age of the tissue and observing changes after intervention, they can determine if a product is actually reversing aging or accelerating it. This approach not only helps validate the efficacy of existing products but also paves the way for innovation in the anti-aging skincare industry. Furthermore, the skin, being the largest organ in the body, is an essential indicator of overall health. Targeting skin aging through scientifically validated methods not only improves the appearance of the skin but also contributes to the health of the entire body. By focusing on reducing the accumulation of senescent cells, which secrete inflammatory signals that spoil healthy cells and accelerate aging, skincare products can effectively target aging at its root cause. This approach not only reverses the signs of aging on the skin but also supports overall health and well-being.

• The significance of skin health in aging: Effective sunscreen use, choosing repairing and collagen-boosting products, and a healthy lifestyle can reduce inflammation, improve overall health, and maintain a youthful appearance. Be cautious of harmful ingredients in skincare products.

  Our skin, being our largest organ, plays a significant role in our overall health as we age. The accumulation of old cells and inflammation in the skin can lead to systemic inflammation and contribute to aging-related diseases. Both extrinsic factors like sun damage and pollution, and intrinsic factors like cell division and inflammation, can cause skin aging. To protect our skin and combat the effects of aging, it's crucial to use effective sunscreen, look for products that help repair damage and increase collagen production, and maintain a healthy lifestyle. However, not all products on the market are created equal. Consumers should be vigilant and read ingredient lists carefully to avoid harmful chemicals that can do more harm than good. By taking care of our skin and being mindful of the products we use, we can help reduce inflammation, improve our overall health, and maintain a youthful appearance.

• Assessing Skincare Product Safety with Websites: Use websites like EWG and Skinsafe to check ingredient safety, be wary of untested products, and refer to 'clean' ingredient lists for informed choices.

  Consumers can assess the safety of ingredients in skincare products using websites like EWG and Skinsafe. These sites provide risk assessments based on individual ingredients and their concentrations. However, not all products are tested for safety, so it's essential to be cautious of ingredients like fragrances, petroleum derivatives, and plastic-derived ingredients. European regulations are more stringent compared to the US, where companies can sell products with potentially harmful ingredients. To make informed decisions, consumers can also refer to lists of "clean" ingredients curated by organizations like Sephora. Investing time in researching ingredients and their safety can lead to better skincare choices and long-term health benefits.

• Tools for Business Growth: Yahoo Finance and Shopify: Yahoo Finance offers financial news, analysis, and data for investors, while Shopify simplifies online selling. Both are essential for business growth. Embrace aging and focus on prolongevity with platforms like OneSkin.

  Both Yahoo Finance and Shopify provide essential tools for different aspects of business growth. Yahoo Finance empowers investors with comprehensive financial news, analysis, and data, making it a go-to resource for seasoned investors and beginners alike. Shopify, on the other hand, simplifies the process of selling products online, from setting up a store to handling various offerings and customer interactions. It caters to businesses of all sizes and industries, offering easy-to-use features and top-notch support. Moreover, the concept of embracing aging and focusing on prolongevity was discussed, with OneSkin leading the way in this approach. The importance of health and maintaining it as we age was emphasized, and the potential for advancements in areas like diet and skincare to help people look and feel younger for longer was explored. In essence, these platforms and ideas serve as vital resources for entrepreneurs and individuals looking to invest, start a business, or simply enhance their lives by embracing the process of aging.

• Measuring biological age through tissue health: Research shows it's possible to reverse biological age of cells, including skin, through topical treatments. One company claims to reverse skin aging by 2.6 years in 5 days using a peptide.

  While our real age is determined by the year we were born, our biological age is a measure of the health and functionality of our tissues. This means that even if we are a certain age, our skin or other organs may not reflect that age due to lifestyle factors and other influences. Research has shown that it's possible to reverse the biological age of cells, including skin, through topical treatments and other methods. One company, OneSkin, has even claimed to reverse the age of skin by 2.6 years in just 5 days through the use of a peptide in their product. The decision to focus on topical treatments rather than oral supplements or drugs was made for faster consumer access and lower risk, as well as the peptide's ability to penetrate deeper layers of the skin. Lifestyle choices, such as diet and exercise, are believed to account for the vast majority of how we age, with genetics playing a much smaller role.

• Living Longer: 20% Genes, 80% Lifestyle: Focus on healthy lifestyle choices and skin care to influence 80% of aging process, improve overall health, and extend lifespan.

  While genetics play a role in aging, only 20% of how we age is determined by our genes. The other 80% is within our control through healthy lifestyle choices. The concept of "blue zones" provides valuable insights into this, as these areas have high concentrations of centenarians who live healthily and disease-free for over a century. Their secrets include a Mediterranean-style diet, low stress levels, and strong community connections. Another essential aspect to consider is the importance of skin care as a part of overall health care. Skin span refers to the length of time our skin remains healthy and functional. By focusing on skin health from a preventative perspective, we can keep our skin youthful and resilient, ensuring it continues to protect our bodies effectively. Skin is a vital organ, and neglecting it can lead to serious health issues as we age. In summary, by prioritizing healthy lifestyle choices and taking proper care of our skin, we can significantly impact our aging process and improve our overall health and well-being.

• Focus on whole body skin health, not just the face: Discovering OS1, a peptide that decreases senescent cells, is a game-changer in anti-aging. Prioritize research on elasticity for healthy, youthful skin.

  The skincare industry should focus on the whole body, not just the face, as skin is the largest organ and our overall health is connected to its condition. Senescent cells, damaged cells that stop dividing and start secreting harmful substances, are a major contributor to aging and various chronic diseases, including skin aging. The discovery of OS1, a patented peptide that can decrease the amount of senescent cells by up to 50%, is a game-changer in the fight against aging. By addressing the root cause of aging, skin can become healthier and more functional, resulting in a youthful appearance. Elasticity is an essential aspect of skin health, as it allows the skin to maintain its shape and recover from damage. The skincare industry should prioritize research and development of products that improve skin elasticity and overall health.

• The connection between skin health and mental wellbeing: Aging skin can impact mental health, but maintaining healthy skin can boost confidence and overall wellbeing. The pandemic has emphasized the importance of good skin health, and using effective skincare ingredients like peptides can help stimulate collagen production and maintain youthful-looking skin.

  The health of our skin and our mental wellbeing are interconnected. As we age, the production of collagen, elastin, and hyaluronic acid in our skin decreases, leading to a loss of elasticity and firmness. This can impact our confidence and self-esteem, affecting our mental health. On the other hand, taking care of our skin and maintaining its health can boost our confidence and improve our overall wellbeing. The pandemic has highlighted the importance of good skin health, with many people spending more time on video calls and paying closer attention to their appearance. Furthermore, the use of peptides in skincare products can help stimulate the production of elastin, allowing our cells to do their work and maintain youthful-looking skin for the long term. Similarly, in business, using a powerful hiring platform like Indeed can save time and resources by attracting and hiring the best candidates for the job, allowing business owners to focus on their growth and success.

• Gender-neutral skincare for women and men of all ages: OneSkin's products promote prevention and healthy skin for all ages. Botox may be less effective for younger users, and diverse teams can aid entrepreneurship without a business background.

  OneSkin's gender-neutral skincare products are suitable for all ages, from teenagers to older adults, as they focus on prevention and maintaining healthy, youthful skin. Regarding Botox, while it can help reduce the appearance of wrinkles and fine lines, it's recommended for those who already have signs of aging, as using it too early may make the skin tissue lazy and less effective over time. For those considering entrepreneurship without a business background, being part of a diverse and qualified team, like the all-female scientist team behind OneSkin, can be an asset when seeking funding. However, it's essential to be proactive, learn the necessary skills, and be persistent in pursuing your business goals.

• Foundation of success: Great product, team, and continuous learning: Starting with a solid product, building a diverse team, learning constantly, taking the first step, and staying focused on value can lead to entrepreneurial success and personal fulfillment, despite challenges.

  Having a great product is the foundation for success in entrepreneurship, regardless of one's background or the diversity of the team. Surrounding oneself with complementary people and continuously learning are also crucial. Starting early and taking the first step, even without a clear idea, can lead to pivots and eventual success. Aligning one's purpose with their work can bring fulfillment beyond just financial profits. Despite challenges, particularly for women entrepreneurs in securing funding, persistence and focusing on the product's value can lead to recognition and growth.

• Prioritize skin health and use science-backed skincare for anti-aging and disease prevention: Find passion, prioritize skin health, research safe ingredients, maintain a healthy lifestyle for anti-aging and disease prevention

  Prioritizing skin health and using science-backed skincare products, like OneSkin, in conjunction with maintaining a healthy lifestyle can help reverse the aging process and lower the risk of age-related diseases. Carolina Diaz, the founder of OneSkin, emphasizes the importance of finding passion and purpose in what we do, as profit will follow when we generate value for others. To ensure the effectiveness and safety of skincare products, it's crucial to research ingredients and avoid those with cancer-causing chemicals, hormone disruptors, or petroleum derivatives. A healthy lifestyle includes a nutritious diet, regular exercise, and sunscreen use. By combining these practices, we can potentially lower inflammation levels and fight off diseases associated with aging. Listeners can learn more about OneSkin and subscribe to their newsletter on their website and social media platforms.