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    • Menopause: The End of Menstrual Cycles and SymptomsMenopause marks the end of menstrual periods and can bring symptoms like hot flashes and night sweats. Perimenopause, the time before menopause, can last up to 6 years. HRT can be a controversial treatment, with benefits and risks depending on individual circumstances.

      Menopause is a significant stage in a woman's life characterized by the end of menstrual periods due to the loss of ovarian function. The perimenopause, the time before menopause, can last several years and is marked by irregular periods and the onset of symptoms like hot flashes and night sweats. Menopause typically begins around age 51, and the perimenopause can last up to 6 years or more. It's essential to note that not all women experience symptoms, but for those who do, hormone replacement therapy (HRT) can be a controversial and complex treatment option. While some studies have linked HRT to increased breast cancer risk, the author of one such study, Joanne Manson, now believes that the benefits of HRT for women suffering from bothersome symptoms outweigh the risks. It's crucial for women to consult with healthcare professionals to determine the best course of action for their individual circumstances.

    • Understanding Menopause: From Taboo to Informed Decision-MakingOne in ten women may find menopause burdensome enough to leave their jobs. Seek professional help for symptoms, which can range from mild to severe. Hormone therapy is an option for some women with moderate to severe symptoms, but not all. Consult healthcare professionals for informed decision-making.

      The menopause, a natural transition in a woman's life, has seen a significant shift in how it's perceived and approached. In the past, it was often taboo and women were encouraged to suffer in silence. However, it's crucial for women to seek help for menopausal symptoms, which can range from mild to severe. The scientific understanding of menopause and its symptoms has evolved, with risk factors identified such as race, ethnicity, smoking, body mass index, comorbidities, and stress. While it's difficult to predict who will experience bothersome symptoms, recent studies suggest that up to 1 in 10 women may find the transition so burdensome that they have to leave their jobs. The pendulum of hormone therapy use has swung widely, from routine use in the 1980s and 1990s to a complete rejection in the past decade. Today, hormone therapy is considered appropriate for some women with moderate to severe symptoms, but not all. It's essential for women to consult healthcare professionals for informed decision-making about hormone therapy or non-hormonal treatments. The conversation around menopause has come a long way, but there's still much to learn and discuss.

    • Menopause symptoms impact daily life and health81% of women experience sleep disturbances, anxiety, and brain fog during menopause, but only a quarter seek treatment, leading to potential metabolic issues and disrupted daily activities.

      The symptoms of menopause are prevalent and impact a large percentage of women, with 81% reporting sleep disturbances, 65% experiencing anxiety, and 68% dealing with brain fog, among other symptoms. However, only 20-25% of these women consider their symptoms burdensome enough to seek treatment. Menopause is gaining more attention due to its impact on the economy and the increasing female workforce. The advocacy and activism of the patient population also play a significant role in bringing more attention to this neglected topic. The symptoms of menopause, which can disrupt sleep and daily activities, can lead to metabolic problems such as weight gain, higher risk of abnormal cholesterol, and diabetes. Despite the severity of these symptoms, menopause has not been as well-understood or discussed as other health topics, such as pregnancy and childbirth.

    • Taking Menopause Symptoms SeriouslyConsidering lifestyle factors and carefully weighing benefits and risks of treatment options are crucial for managing menopause symptoms effectively. A high-quality diet can reduce the risk of symptoms like hot flashes, sleep disturbances, brain fog, anxiety, and depression.

      Menopause symptoms should not be trivialized or ignored, despite being a natural part of life. Women experiencing symptoms that interfere with their quality of life, disrupt sleep, or cause adverse impacts should take them seriously and consider seeking treatment. However, the decision to treat should involve careful consideration of the benefits and risks, as all medications, including hormone therapy and antidepressants, come with potential side effects. Additionally, lifestyle factors, such as weight and diet, can play a significant role in menopause symptoms. New research suggests that maintaining a high-quality diet can reduce the risk of symptoms like hot flashes, sleep disturbances, brain fog, anxiety, and depression. This cross-sectional study found that overweight individuals had an 80% higher chance of brain fog or headaches, a 60% greater chance of depression or low mood, and around a 40% greater chance of hot flushes. Therefore, addressing lifestyle factors and considering the benefits and risks of treatment options are crucial for managing menopause symptoms effectively.

    • Lifestyle modifications for menopause symptomsRegular exercise, a plant-based diet, avoiding triggers, and trying soy products may help reduce menopause symptoms for some women

      While there is no magic pill for alleviating hot flashes and night sweats related to menopause, making certain lifestyle modifications can be beneficial for some women. Regular physical activity, ideally at least 30 minutes of moderate or vigorous exercise five days a week, and a plant-based diet rich in fruits, vegetables, whole grains, fish, and low in red meat, saturated fat, fried foods, and alcohol are recommended. Identifying and avoiding triggers, such as alcohol and spicy foods, can also help reduce symptoms. Soy products may be worth trying for some women, as they have shown potential benefits for some. Unfortunately, supplements and specific nutrients have not been proven to consistently alleviate symptoms. It's important to remember that each woman's response to these lifestyle modifications can vary.

    • Menopause supplements: A form of 'life insurance'Menopause supplements may help mitigate symptoms and risks, acting as 'life insurance', but standard multivitamins and healthy lifestyle are essential.

      Menopause supplements, while not definitively proven to prevent all health issues related to menopause, can be seen as a form of "life insurance" due to their potential benefits. These supplements can help mitigate symptoms and risks associated with menopause, such as bone density loss and increased heart disease risk. However, they often come at a higher cost than standard multivitamins. The evidence suggests that taking a standard multivitamin is beneficial for overall health, but it should not replace healthy lifestyle behaviors. Hormone Replacement Therapy (HRT) is a common treatment for menopause symptoms. It works by replacing the declining estrogen levels, which can cause hot flashes, night sweats, and vaginal dryness. HRT can be estrogen alone for women who have had hysterectomies or estrogen plus progestin for those who haven't, to protect against uterine cancer. HRT comes in pill and patch forms, with pills increasing the risk of blood clots due to their direct impact on the liver. The recent conversation around HRT also includes progesterone and testosterone, which can be used in combination for certain women to address specific symptoms.

    • Delivery methods and hormones matter for menopausal womenBioidentical hormones delivered via patch, spray, or gel are generally safer than oral conjugated estrogen for menopausal women. Testosterone use in women is controversial due to limited conclusive evidence of benefits, but many still seek it out.

      When it comes to hormone therapy for menopausal women, the method of delivery and type of hormones used can significantly impact safety and effectiveness. The patch, spray, or gel application of bioidentical estradiol and micronized progesterone are generally considered safer than oral conjugated estrogen due to a lower risk of blood clots. Bioidentical hormones have a chemical structure identical to naturally produced hormones. However, it's essential to differentiate between FDA-approved and compounded hormones. Regarding testosterone, its use in women is controversial due to limited conclusive evidence of significant improvements in sexual function and libido. Many women still seek testosterone therapy, often in the form of low-dose FDA-approved products for men or custom compounded menopause therapy. The controversy stems from earlier reports linking hormone replacement therapy to increased health risks, which led to a significant reduction in its use. However, more recent studies, such as the one led by Joanne, published in the Journal of the American Medical Association in 2017, have provided updated advice on hormone therapy safety and benefits.

    • Menopausal symptoms relief vs risks for women in their forties and fiftiesHormone therapy can provide significant relief from menopausal symptoms for women in their forties and fifties, but individual health factors should be considered, and consulting a healthcare professional is essential for an informed decision. The patch and transdermal forms may have a better risk-benefit profile compared to the pill form.

      For women in their forties or fifties experiencing bothersome menopausal symptoms, the benefits of hormone therapy are generally more significant than the risks. However, it's crucial to consider individual health factors and consult a healthcare professional for an informed decision. The patch and transdermal forms of estrogen and micronized progesterone are likely to have a better risk-benefit profile compared to the pill form used in the Women's Health Initiative trial. Women should not endure menopausal symptoms unnecessarily. The findings from the Women's Health Initiative trial, which focused on preventing chronic diseases in older postmenopausal women, were often misinterpreted to discourage hormone therapy use in younger women. It's essential to understand that the risks and benefits vary greatly depending on age and specific health conditions.

    • Making informed decisions about HRT during menopauseWomen should consider their overall health, risk factors, and symptoms when deciding to continue or stop HRT during menopause. Regular check-ups and discussions with healthcare providers are important.

      The decision to continue or stop hormone replacement therapy (HRT) during menopause is an individual one that depends on a woman's overall health, risk factors, and symptoms. Women with severe symptoms and low risk of breast cancer may benefit from continuing HRT, while those with an intact uterus and higher risk of breast cancer are generally recommended to stop within 5 years. However, each woman's experience is unique, and many find that their symptoms significantly decrease or disappear when they try to come off HRT. It's important to have regular check-ups and discussions with healthcare providers to make informed decisions about HRT use.

    • Noticeable benefits of HRT for menopause symptoms take around 4 weeksHRT can help reduce menopause symptoms, but it takes time to notice benefits, regular exercise and diet are crucial for weight management, HRT may aid in preventing some weight gain and fat accumulation, but not entirely.

      Hormone replacement therapy (HRT) can help alleviate symptoms of menopause, such as hot flashes and night sweats, but it's important to note that the benefits may not be immediate and can take around 4 weeks to become noticeable. Additionally, HRT may not prevent all weight gain or body composition changes during menopause. Regular physical activity and a healthy diet are essential in managing weight and metabolic risk factors. The PEPI trial suggests that HRT can help lessen weight gain and abdominal fat accumulation, but it does not eliminate these changes entirely. Overall, a combination of lifestyle modifications and HRT can help improve symptoms and maintain overall health during menopause.

    • Exploring natural remedies for menopause symptomsLimit alcohol, try soy and tofu, consider HRT for severe symptoms, discuss testosterone with a doctor, and find the right healthcare provider for effective treatment.

      There are various ways to alleviate menopause symptoms beyond just relying on medication. Limiting alcohol consumption and incorporating real foods like soy and tofu into your diet are potential natural remedies. Soy can benefit some women greatly, but it may not have any effect on others. HRT, particularly in the form of estradiol patches, can be effective for women in their forties or fifties with bothersome symptoms, as the benefits are likely to outweigh the risks. Testosterone is a controversial topic and not yet approved by the FDA, but it may be worth discussing with a doctor if experiencing specific issues. Lastly, finding the right doctor and persisting in the search for effective treatment is crucial, as help is available and there are ways to significantly alleviate menopause symptoms.

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    Timecodes:

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    Satchin’s books:



    Books by our ZOE Scientists:



    Studies referenced in today’s episode: 


    Have feedback or a topic you'd like us to cover? Let us know here.

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    Timecodes:

    00:00 Tim Spector's tribute to Michael

    01:01 Introduction

    01:55 Quick Fire Questions

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    Michael Mosley’s book 'Just One Thing' is available to buy here

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    Timecodes:

    00:00 Introduction

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    Timecodes:

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    Timecodes

    00:00 Introduction

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    If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your membership.

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    Timecodes

    00:00 Introduction

    01:20 Quickfire questions

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    Mentioned in today's episode:

    Omega-3 polyunsaturated fatty acids and inflammatory processes: Nutrition or pharmacology? in the British Journal of Clinical Pharmacology

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    If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your membership.

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    Timecodes:

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    Is there a nutrition topic you’d like us to explore? Email us at podcast@joinzoe.com, and we’ll do our best to cover it. 

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    If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your membership.

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    Timecodes:

    00:00 Introduction

    01:26 Quickfire questions

    03:08 What are spices?

    03:43 Polyphenols in spices

    07:25 Spices and your health

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    14:49 Anti-inflammatory benefits of spices

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    Studies related to today’s episode:


    Is there a nutrition topic you’d like us to explore? Email us at podcast@joinzoe.com, and we’ll do our best to cover it.

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    Follow Dr. Federica Amati on Instagram 

    If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your membership.

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    Timecodes

    00:00 Introduction

    01:17 Quickfire questions

    03:32  The first window of opportunity is before you are born

    06:04 It takes two to tango: equal roles in conception

    07:25 The science behind sperm health and diet

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    16:25 Nutritional needs in the second trimester of pregnancy

    17:20 Preventing allergies during pregnancy

    20:30 Nutrition in childhood and adolescence

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    25:10 The impact of ultra-processed foods on teenagers

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    36:00 Longevity supplement myths

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    46:05 Preparing for healthy aging and avoiding 'Sniper Alley'

    50:10 How to eat right in your 70s and beyond

    54:22 Protein needs as you age

    56:30 Becoming a ZOE member is like having a nutritionist in your pocket!

    59:20 Summary

    Mentioned in today's episode:


    Books:


    Is there a nutrition topic you’d like us to explore? Email us at podcast@joinzoe.com, and we’ll do our best to cover it. 

    Episode transcripts are available <a...

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    Tim Spector is one of the world’s top 100 most-cited scientists, a professor of epidemiology, and scientific Co-Founder at ZOE. Tim trained originally in rheumatology and epidemiology. 

    Make smarter food choices for your body: zoe.com/podcast

    Follow Tim on Instagram.

    If you want to uncover the right foods for your body, head to zoe.com/podcast, and get 10% off your personalised nutrition program.

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    Timecodes

    00:00 Introduction

    01:21 Quickfire questions

    03:08 What is osteoporosis?

    06:10 Why might our bones become more fragile as we age?

    08:10 Your skeleton renews itself all the time

    10:30 Does menopause cause osteoporosis?

    12:48 What's it like living with osteoporosis?

    15:16 How common is osteoporosis in males?

    16:04 What are the symptoms of osteoporosis and at what age should you get checked?

    21:40 Some chilling statistics about osteoporosis

    23:10 Common myths about the effects of calcium and vitamin D on osteoporosis

    27:50 What is the latest science on vitamin D supplementation?

    34:10 Can vitamin D and calcium ensure children’s bone density is healthy?

    34:55 Osteoporosis treatment options, including new drugs    

    37:20 The impacts of HRT on bone density

    39:30 What are the downsides to some of these treatments?

    43:00 Does physical activity help to prevent fractures?

    44:30 Lifestyle impacts: diet and nutrition

    49:40 Can exercise make your bones stronger?

    55:20 Ideal exercises to prevent osteoporosis

    57:10 Cyrus and Tim’s top 3 actions to improve bone health

    59:10 Summary

    Mentioned in today's episode:


    Relevant studies:

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