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    The Role of the Gut Microbiome in Human Health - With Dr. Will Bulsiewicz

    enJune 13, 2022

    Podcast Summary

    • Understanding the Impact of Diet and Social Connections on Microbiome HealthEating a fiber-rich diet and maintaining social connections are essential for a healthy microbiome. Research into the microbiome can lead to personalized nutrition and improved hormonal health.

      Our microbiome is constantly evolving and is influenced by the food we eat and the people around us. In this podcast episode, Dr. Will Bulsiewicz, a New York Times bestselling author, discussed the importance of fiber in maintaining a healthy microbiome and identified factors that can harm gut microbes. He also emphasized the significance of social connections in microbiome health. Dr. Bulsiewicz also shared insights on how research into the microbiome can lead to personalized nutrition and discussed the role of the microbiome in hormonal health. Overall, this conversation deepened the understanding of the microbiome's importance and provided practical insights for caring for it. Additionally, the Resetter podcast's host, Dr. Mindy, announced the launch of her Reset Academy, which offers support and guidance for individuals looking to adopt fasting and healthier lifestyles.

    • The Importance of Gut Microbes and Their Impact on Our HealthGut microbes transform food, produce beneficial compounds, and impact digestion, metabolism, immune system, and brain health. Neglecting their importance has historical roots, but recognizing their role leads to actions that support their health and improve overall well-being.

      Our gut microbes play a crucial role in our overall health and well-being. They transform food into essential nutrients and produce compounds that positively impact our digestion, metabolism, immune system, and brain health. However, we have historically neglected the importance of taking care of our microbiomes. This is partly due to the historical narrative that has preconditioned us to focus on individual organs rather than the interplay between our diet, lifestyle, and gut microbes. By recognizing the importance of our microbiomes and the products they produce, we can prioritize actions that support their health and ultimately improve our own. This shift in perspective is the new frontier in health and wellness, and it's an exciting time to be part of this revolution in understanding the human body. Join the Reset Academy community at doctormindypels.com to learn more and take the first step towards unlocking your fullest potential.

    • From Enemies to Friends: Our Changing Perspective on Gut MicrobesAdvancements in technology led to the discovery of 38 trillion anaerobic gut microbes, friends that aid digestion, produce essential chemicals, and maintain health.

      Our understanding of microbes, particularly those in our gut, has undergone a significant transformation. For much of history, microbes were seen as harmful, even causing the top causes of death before the discovery of penicillin. However, with advancements in technology, we've come to realize that most microbes in our gut are anaerobic and cannot be grown on culture plates. This means that we had limited understanding of their functions. With the advent of DNA sequencing in 2006, we discovered that there are 38 trillion microbes in our gut, working in teams to help us digest food, produce necessary chemicals, and keep us healthy. These microbes are not our enemies, but rather our friends, and their absence can lead to digestive issues, among other health problems. In essence, our perspective on microbes has shifted from viewing them as harmful to recognizing their essential role in maintaining human health.

    • The gut microbiome's role in health and diseaseA healthy gut microbiome is crucial for overall wellbeing, linked to chronic digestive symptoms and other health issues like high blood pressure, high cholesterol, diabetes, obesity, psoriasis, sinus infections, and migraines. Its unique to each person, and a loss of functionality in combination with genetics can lead to specific medical conditions.

      Our gut microbiome plays a crucial role in our health and wellbeing, yet it is not yet fully integrated into conventional medical care. As a gastroenterologist, I have seen firsthand how a compromised gut microbiome can lead to chronic digestive symptoms, but also to other health issues such as high blood pressure, high cholesterol, type 2 diabetes, obesity, psoriasis, sinus infections, and migraine headaches. The microbiome is unique to each individual, and it's not a simple matter of being "unhealthy" leading to specific diseases. Instead, there may be a pattern of loss of functionality in the gut microbiome that, in combination with a person's genetic code, can manifest as specific medical conditions. The science is there, but it will take time for educational paradigms to shift and for the medical community to fully embrace the importance of the gut microbiome in health and disease.

    • Genetics and Microbiome: Interconnected Factors in HealthGenetics and microbiome interact to influence health, with both genetic and environmental factors shaping the microbiome, which can impact disease risk later in life.

      While genetics play a role in many health conditions, they are not the sole determinant. The microbiome, the community of bacteria in our bodies, also plays a significant role in the manifestation of diseases and conditions. This means that if you receive a genetic diagnosis, it would be beneficial to also consider your microbial profile. The microbiome is influenced by both genetic and environmental factors, and is passed down from both parents, although the exact proportions are not yet fully understood. Research suggests that factors like mode of delivery, diet, and antibiotic exposure can impact the development of a healthy gut microbiome in newborns, potentially leading to metabolic and immune issues later in life. Additionally, the microbiome can be influenced by the level of connection in relationships, with more connected partners sharing more microbes. This malleability of the microbiome underscores the importance of considering both genetics and microbiome in understanding and addressing health conditions.

    • Breast milk supports newborn's microbiome with HMOsBreast milk's HMOs feed beneficial bacteria, promoting gut health. Factors beyond individual control, like stress and relationship issues, can negatively impact the gut microbiome.

      Breast milk plays a crucial role in supporting a newborn's developing microbiome through the presence of human milk oligosaccharides (HMOs). These oligosaccharides, which are essentially the breast milk equivalent of dietary fiber, are designed to feed and fuel beneficial bacteria, such as bifidobacteria. The presence of these bacteria is important for the baby's gut health. Additionally, the speaker suggests that the health of one's microbiome can be influenced by factors beyond individual control, such as ongoing stress and conflict in relationships, which can negatively impact the gut microbiome. Therefore, it's essential to address these underlying issues to promote optimal gut health.

    • Impact of mental and emotional wellbeing on gut healthAddressing the root causes of stress or trauma can positively impact gut health. Consider the whole person, not just diet.

      Our mental and emotional wellbeing plays a significant role in our gut health. A woman in the discussion shared her experience of how leaving a job that caused her stress led to her ulcerative colitis going into remission. The speaker emphasized that we are more than just the sum of our diet and that addressing the root cause of stress or trauma in our lives can have a positive impact on our gut microbiome. She also announced a new fitness program, PowerSync 60, designed to help individuals address their unique hormonal needs while working out. The discussion also touched on the controversial topic of fiber. While some advocate for high-fiber diets, others, like the carnivore diet, suggest avoiding it altogether. The speaker acknowledged the complexity of the issue and agreed that plant toxins can be problematic but also emphasized the importance of considering the whole person and addressing underlying stressors or traumas. In summary, the key takeaway is that our mental, emotional, and physical health are interconnected, and addressing the root causes of stress or trauma can have a positive impact on our gut health. It's important to consider the whole person and not just focus on diet alone.

    • Study shows fiber's importance for lowering risk of diseases and longer lifespanConsuming recommended daily fiber intake linked to lower risk of heart disease, cancer, stroke, and type 2 diabetes, longer lifespan, but many people are deficient

      Despite fiber being sometimes portrayed negatively, it's essential for good health. A study published in The Lancet in 2019, compiled all available data about dietary fiber and found that people who consume more fiber have a lower risk of heart disease, certain types of cancer, stroke, and type 2 diabetes. These conditions are leading causes of death in the US. The study, which included over 120 million person-years of data, showed that fiber intake is linked to longer lifespan. However, despite its numerous benefits, many people are deficient in fiber, with 19 out of 20 people likely being deficient. The recommended daily intake for men is 38 grams. To understand the truth about fiber and other health-related topics, we must rely on science, which allows us to piece together observations and test hypotheses. Science may not provide absolute truths, but it offers valuable insights into the workings of the universe.

    • The Importance of Fiber in Our Diet and Its Impact on HealthDespite the recommended daily fiber intake, most Americans consume less. A deficiency can increase risk of heart disease, cancer, and decrease longevity. Diets rich in legumes and whole grains, high in fiber, can improve health.

      The average consumption of fiber in both men and women in the United States is significantly lower than the recommended amount, which is 25 grams per day for women and 38 grams per day for men. This deficiency, according to scientific research, can increase the risk of our top five causes of death. Yet, instead of emphasizing the importance of increasing fiber intake, there are books being written suggesting that fiber may be the problem. The science, based on over 120 million years of data, shows that a diet rich in legumes and whole grains, which are high in fiber, can reduce the risk of heart disease, cancer, and increase longevity. Furthermore, menopausal women have a set of bacteria in their microbiome that breaks down estrogen, and maintaining a healthy balance of this bacteria is crucial for hormonal health. The gut microbiome plays a significant role in estrogen metabolism and utilization, and an imbalance can lead to various estrogen-related health conditions, including endometriosis, endometrial hyperplasia, and hormonally motivated cancers. Dietary fiber, which is essential for a healthy gut microbiome, can help rebalance these conditions and reduce the risk of breast cancer. It is important to note that the average American consumes more than their body weight in meat annually, but the argument is that the small amount of legumes consumed is the problem. This does not make logical sense.

    • Understanding Menopause goes beyond hormones, it's about hormones and metabolismPersonalized nutrition company Zoe uses data from thousands of women to create tailored dietary recommendations for managing menopause symptoms and maintaining metabolic balance, combining microbiome analysis, continuous glucose monitoring, and self-reported food intake and feelings.

      Menopause is more than just hormonal changes. It's the intersection of hormones and metabolism. Breast, ovarian, and endometrial cancers have been linked to injury to the gut microbiome and hormonal imbalances. Unfortunately, women's health is underfunded for research, leaving many questions unanswered about how to eat optimally during this stage of life. A personalized nutrition company called Zoe is using data from thousands of women to create tailored dietary recommendations to help manage symptoms and maintain metabolic balance during menopause. Their approach combines microbiome analysis, continuous glucose monitoring, and self-reported food intake and feelings. This data is then used to provide personalized recommendations, contributing to a robust network of knowledge that benefits all participants. Their first publication, led by world-class researcher Sarah Berry, aims to address the specific dietary needs of women during perimenopause and menopause, with a focus on reducing symptoms and maintaining metabolic balance. This exciting research has the potential to provide much-needed answers for women seeking to optimize their health during this critical life stage.

    • Impact of diet and other factors on microbiomeIn just 4 weeks, we can significantly shift our microbiome through optimizing diet, exercise, sleep, and mood, with companies like Zoe offering tools to help us understand our unique needs and track progress.

      Our diet, along with other factors like exercise, sleep, and mood, significantly impacts our microbiome, which is constantly evolving. Within approximately 4 weeks, we can cause a noticeable shift in our microbiome through optimizing these factors. This idea of taking control of our choices to benefit our microbiome is exciting, as companies like Zoe are developing technologies to help us understand our unique needs and track progress over time. It's essential to remember that our microbiome is not a static entity but a dynamic system that can be influenced for the better. Furthermore, practicing gratitude is a theme for this year on The Resetter podcast, and I'd like to ask the speaker about her gratitude practice and what she's grateful for today.

    • Eating a variety of plant-based foods benefits gut health and overall well-beingConsuming fermented plant foods increases gut diversity and reduces inflammation, while a supportive network of loved ones contributes to personal growth

      Incorporating a variety of plant-based foods, particularly those rich in fiber, resistant starches, polyphenols, and prebiotics, is essential for a healthy microbiome and overall well-being. Gratitude and support from loved ones also play a significant role in personal growth and improvement. A study from Stanford University supports this by showing that consuming fermented plant foods increases gut microbiome diversity and reduces inflammation in the body. To learn more about this topic and access valuable resources, visit The Plant Fed Gut website (theplantfedgut.com) and follow The Gut Health MD on Instagram and Facebook. Don't miss Mindy's new cookbook, "The Fiber Fueled Cookbook," coming out on May 17th.

    • A roadmap to better gut healthLearn about food intolerances, low FODMAP and low histamine protocols, and how to ferment and sprout foods at home for improved gut health.

      The "Fiber Fields Cookbook" is more than just a collection of recipes. It serves as a roadmap to better gut health, with the first half focusing on understanding food intolerances and their management through low FODMAP and low histamine protocols. The second half of the book teaches readers how to ferment and sprout foods at home. This cookbook is currently available at various bookstores, including Amazon, but the speaker encourages supporting local bookstores when possible. The conversation between the speaker and the listener aligns perfectly with the themes of the cookbook, making it an excellent resource for anyone looking to improve their gut health. If you're interested in learning more about this topic, consider checking out the "Fiber Fields Cookbook" and sharing your thoughts with others. Remember, every little bit helps in supporting local businesses and promoting healthier living.

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    Timecodes:

    00:00 Intro

    00:15 Jonathan’s Intro

    00:50 Quickfire round

    01:40 Jonathan’s accident 

    04:00 Unpacking clindamycin

    11:40 Antibiotic-associated diarrhea 

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    22:20 Jonathan’s gut at 7 days 

    27:50 Fermented foods

    27:00 Tips for building your gut back up

    41:30 Benefits vs. risks

    48:00 Summary 

    51:20 Outro

    Mentioned in today’s episode:

    Post-antibiotic gut mucosal microbiome reconstitution is impaired by probiotics and improved by autologous FMT from Cell

    Saccharomyces boulardii: What makes it tick as successful probiotic? From the Journal of Fungi

    Follow ZOE on Instagram.

    Episode transcripts are available here.

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    Audio Timecodes:

    00:00  Introduction

    01:14    Quick Fire Questions

    03:27   What is Inflammation?

    07:40   Why is too much inflammation bad for you?

    09:06  This is at the core of most diseases…

    19:07    How blood sugar levels affect inflammation

    24:22   What is the role of Gut and the gut barrier?

    15:22 How does food affect inflammation?

    23:47    What is the role of Gut and the gut barrier?

    28:06   Gut microbes love good food!

    30:09   Inflammation and Gut Microbes: A two-way Street

    35:00   More plants and fermented food will reduce inflammation

    40:15    We need microbiome diversity

    45:45   Non-Dietary Approaches to Reduce Inflammation

    47:57    Benefits of Time-Restricted Eating

    52:01    Summary

    Mentioned in todays episode:

    Gut microbiota targeted diets modulate human immune status from Cell

    The Big IF Study: What did we find? From ZOE

    PREDICT: The world's largest in-depth nutritional research program from ZOE

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    Episode transcripts are available here.

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    Welcome back to the Empowered Nutrition podcast! In this episode, Dr. Pal Manickam welcomes Erin Skinner, a registered dietitian, for an enlightening discussion on the significance of circadian rhythm, nutrition, and gut health in maintaining metabolic and digestive well-being. Together, they explore the benefits of fasting, aligning eating patterns with daylight hours, the importance of fiber for a healthy gut microbiome, and the integration of conventional medicine with nutrition for optimal health outcomes.

    Episode Highlights:

    1. Understanding Circadian Rhythm and Metabolic Health:
    • Dr. Pal Manickam and Erin Skinner highlight the impact of circadian rhythm on metabolic processes and discuss the benefits of eating within the sun to sunset window.
    • They emphasize that aligning eating patterns with daylight hours can enhance metabolism and improve overall metabolic health.
    1. The Role of Fiber in Gut Health:
    • Erin emphasizes the importance of fiber diversity in promoting a healthy gut microbiome.
    • They discuss the alarming trend of insufficient fiber intake in the population and underscore the significance of incorporating an adequate amount of fiber in the diet.
    1. Nutrition and Gut Health for Vegetarians:
    • Erin shares valuable insights on nutrition and gut health for vegetarians.
    • She emphasizes the importance of protein diversity and suggests incorporating fermented foods like kimchi and sauerkraut to improve gut diversity.
    1. Combining Conventional Medicine with Nutrition:
    • Dr. Pan Monica and Erin stress the significance of combining conventional medicine with nutrition for holistic health outcomes.
    • They discuss the need for acknowledging the essential role of food in addition to medical interventions for optimal well-being.

    Best Quotes:  "We just abused the plan that was provided to us, and that is the replication of what we see in terms of GI diseases."

    Conclusion: Dr. Pal Manickam and Erin Skinner provide valuable insights into the importance of circadian rhythm, fasting, nutrition, and gut health for metabolic and digestive wellness. They emphasize the benefits of aligning eating patterns with daylight hours, incorporating fiber in the diet, and the role of protein diversity and fermented foods in vegetarian nutrition. By combining conventional medicine with nutrition, individuals can achieve holistic health and well-being.

    Check out the full interview on Youtube!

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