Introducing: The Ultimate Human with Gary Brecka

This week’s conversation is with Dr. Colleen Cutcliffe, the CEO and Co-Founder of Pendulum Therapeutics.

Colleen’s extensive background includes a doctorate in Biochemistry and Molecular Biology from Johns Hopkins University, and over 20 years of experience managing and leading teams in biotech, pharma, and academia.

In 2013, Colleen left her position as Senior Manager of Biology at Pacific Biosciences to start Pendulum, a company on a mission to improve health through first of its kind research and development in the gut microbiome.

Pendulum’s next generation probiotics are pioneering ways for people to transform their health and wellness by unlocking the power of the gut microbiome.

I’ve been studying gut health and the microbiome for a long time now, and it’s clear that Pendulum is on the forefront of creating meaningful change for people.

I was fascinated to learn more about the topic from Colleen, and I hope you leave this conversation with a better understanding of the gut microbiome, and some applied insights on how improving your gut health can improve your life.

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For more information and shownotes from every episode, head to findingmastery.net.

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"Our bacteria control our behavior." - Dr. Gundry
If you enjoyed this episode, check out show notes, video, and more at http://lewishowes.com/521

Tim Gray - Entrepreneur & Health Optimization Expert

Our guest this week is Tim Gray. Tim is a seriously interesting person and deeply committed biohacker/health optimization expert. As you’ll learn, Tim and T.A. met by happenstance at Baby Bathwater—an entrepreneurial event hosted in Croatia—where they quickly realized their shared enthusiasm for science, technology, and longevity. Tim’s approach to health optimization stems from his passion and commitment to everything he does; what Tim calls his “all-in or nothing” mentality.

As an entrepreneur, Tim is a specialist in psychology, neuro marketing, cognitive hypnotherapy, conversion rate optimization and SEO. His expertise in digital marketing is rooted in his own experiences as the founder of a very successful e-commerce business, and over 13 years experience of search engine marketing and psychology. He has a keen interest in body language and human behavior led him to study and gain various Oxford University recognized qualifications, including a Diploma in Cognitive Hypnotherapy (HPD), a Master Practitioner certification in NLP (Neuro Linguistic Programming) and NVQ in Business Management. His growing interest in optimal health, having a sharp and clear mind (and “biohacking”) has also led him to open the first Hyperbaric Oxygen Therapy clinic in London.

In this episode of How to Live to 200, T.A. explores some really interesting and less popular areas with Tim. We ask and answer questions on biohacking, mercury poisoning, gut bacteria, and more. Here’s a sample of what we cover:

• How Tim used the Ketogenic diet and Bulletproof Coffee to kickstart his journey to biohacking and health optimization
• Why Tim doesn’t like the term “biohacker”
• What symptoms allow him to easily detect mercury toxicity in strangers
• What tests Tim recommends to measure your mercury levels
• What foods to avoid if you’re worried about mercury toxicity
• What farm-raised salmon can do to your body and brain
• Should you have your old fillings removed?
• Tim’s personal gut microbiome optimization techniques
• What Tim data currently tracks and how he decides what to pay attention to
• How you can use Hyperbaric Oxygen Therapy to thrive
• How do you learn to enjoy your current moment while still striving for improved health

There’s so much great info packed into this episode, so don’t be surprised if you need to take a second listen to capture all of Tim’s knowledge.

About Tim

• Tim Gray’s Twitter
• London Biohacking Meetup
• Hyperbaric Oxygen Therapy

Show Links

• Hyperbaric Oxygen Therapy Center (3 highlighted links under “about”)
• Biohacker London
• healthoptimisation.com
• Baby Bathwater Institute
• IGF-1 hormone
• Living Supplements ALA
• Doctor's Data hair mineral analysis tests
• Christopher Shade's Mercury Tri-Test
• Personal Science
• BioLab Organic Acids Test
• uBiome
• Genova Diagnostics Comprehensive Digestive Stool Analysis (CDSA)
• Symprove gut bacteria supplement
• Chuckling Goat kefir
• RESTORE gut supplement
• Teemu Arina
• Oura Ring
• Aniracetam
• The Mercury Diaries, David Forsyth
• Amalgam Illness, Diagnosis and Treatment, Dr. Andy Cutler
• The Obstacle is the Way, Ryan Holiday
• Stop the Thyroid Madness, Janie Bowthorpe

View the Show Notes Page for This Episode

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Nir Barzilai, Director of the Institute for Aging Research at the Albert Einstein College of Medicine, is back for his third appearance on The Drive. In this episode, Nir divulges insights into lifespan and healthspan through the lens of his extensive research on centenarians as well as the latest from the TAME trial (Targeting/Taming Aging with Metformin), a multi-center study investigating the concept that the multi-morbidities of aging can be delayed in humans. He discusses common gene variants found in centenarians, important pathways for longevity, and ultimately what we can learn from centenarians about extending lifespan while also trying to improve healthspan. Additionally, Nir goes into depth on metformin as a longevity tool for humans, including studies with positive and negative results. He discusses the impact metformin can have on exercise for both strength training and cardiovascular training, as well as future research facilitated by data from the TAME Trial. He also touches on epigenetic clocks and concludes with his take on the usefulness of NAD precursors as a potential gero-protective agent.

We discuss:

• Insights from genetic studies of centenarians and twins [3:00];
• Genes with protective variants that aid longevity [13:00];
• The relationship between growth hormone and IGF-1 [22:45];
• Use of growth hormone as a longevity tool [34:00];
• Longevity genotypes: the role of APOE e2, Lp(a), Klotho, and CETP [41:45];
• The correlation between high TSH and longevity [46:30];
• Important pathways for longevity [52:00];
• Insights from centenarian studies, nature vs. nurture, and more [59:00];
• The contraction of morbidity that comes with improved healthspan [1:08:00];
• Defining healthspan [1:13:13];
• Unique perspectives and positive attitudes of centenarians [1:17:30];
• Lessons to take away from centenarians [1:24:00];
• Metformin overview: history, studies, and potential for gero-protection [1:28:45];
• The TAME trial (Targeting Aging with Metformin) [1:39:00];
• The challenge of studying metformin in animals models [1:46:45];
• How data from the TAME trial could provide insights into biomarkers of aging and facilitate a future study on proteomics [1:53:30];
• The search for biomarkers to identify who can benefit from treatment [2:00:30];
• The impact of metformin on exercise, and finding the right indication for the use of metformin [2:10:30];
• Are NAD precursors geroprotective? [2:21:30]; and
• More.

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