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    #189: Evidence Free Medicine (Bret Weinstein & Heather Heying DarkHorse Livestream)

    en-usAugust 30, 2023

    Podcast Summary

    • Discussing free speech, Orwell, Huxley, and gut healthDoctors Bret Weinstein and Heather Hine emphasized the importance of free speech, discussed the impact of Orwell and Huxley, and highlighted the significance of gut health and the role of microbes in shaping the immune system, even before birth. They recommended Seed, a probiotic that supports gut, skin, and heart health, and is free from major allergens.

      During the Dark Horse Podcast livestream number 189, doctors Bret Weinstein and Heather Hine discussed various topics including the importance of free speech, the influence of Orwell and Huxley, and the role of developmental hormones. They encouraged listeners to join their community on Locals for exclusive content. The doctors also highlighted the importance of gut health and the role of microbes in shaping the immune system, even before birth. They promoted Seed, a probiotic that supports gut, skin, and heart health, and is free from major allergens. The probiotic is engineered to maintain viability through the digestive tract and does not require refrigeration. Seed's daily symbiotic supports micronutrient synthesis and has been reported to improve digestive function in 24 to 48 hours.

    • Macadamia Nuts: A Delicious and Nutritious SnackMacadamia nuts are a tasty, long-growing nut with numerous health benefits, including satiety, heart health, and collagen production. House of Macadamias offers various products for different diets.

      Macadamia nuts, despite being high in fat and low in carbs, are a delicious and nutritious snack with numerous health benefits. These benefits include being satiating, good for heart health, and aiding in natural collagen production and fat loss. Macadamias are also rare and expensive due to their long growing time. House of Macadamias, a company dedicated to making this nut accessible to everyone, offers a variety of products including salted macadamias, macadamia nut oil, and macadamia nut milk. These products are perfect for various diets such as vegan, keto, and paleo. Our favorite House of Macadamias product is their simple salted macadamia nuts, which are made with Namibian sea salt and are highly recommended. Macadamia nuts are a worthy investment due to their taste and health benefits.

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    • Shift towards prioritizing free speech on social mediaElon Musk's acquisition of Twitter leads to less content moderation, raising concerns about misinformation and hate speech while ensuring open discourse.

      The tech industry is experiencing a shift towards prioritizing free speech following Elon Musk's acquisition of Twitter. This change is reflected in the Washington Post's admission that social media companies are receding from their role as watchdogs against political misinformation and are updating their policies to allow for more open discourse. However, it's important to note that while Musk's stance on free speech is clear, there are concerns about the potential consequences of this shift, particularly regarding the spread of misinformation and hate speech. The safety team at Twitter has emphasized their responsibility to ensure open, accurate, and safe political discourse, indicating that they will still be implementing some form of content moderation. Overall, this development underscores the significant impact that individual economic competitors can have on industry standards and the importance of balancing free speech with safety and accuracy.

    • Elon Musk's complex stance on Twitter's free speechMusk aims to balance free speech and societal constraints, but ambiguous tweets create confusion. Hiring more people may indicate a renewed commitment, but implications are unclear.

      Elon Musk's stance on free speech at Twitter is complex and nuanced, as he balances the desire to uphold free speech principles with the need to navigate legal and societal constraints. Musk's tweets on the topic have contained ambiguous language, leading to confusion and debate. The context of political discourse and varying laws in different jurisdictions add to the complexity. Musk faces a challenging task as he runs Twitter as a business while also ensuring free speech remains a priority, despite potential backlash from governments and users. The recent hiring of more people at Twitter may indicate a renewed commitment to upholding free speech, but the implications of this move remain to be seen. Overall, Musk's approach to free speech at Twitter highlights the ongoing debate and tension between protecting individual expression and maintaining social order.

    • Twitter's commitment to free speech under new leadershipConcerns about Twitter's content moderation policies under new leadership, with potential international pressure and legal precedents shaping the outcome.

      There is ongoing debate about Twitter's commitment to free speech under new leadership, with concerns that it may follow the lead of other tech companies in implementing stricter content moderation policies. Some argue that this could be a response to international pressure, while others see it as a step back from Twitter's historic role as a platform for open dialogue. The Washington Post article mentioned in the discussion suggests that Facebook and YouTube have also eased their content moderation policies, but it remains unclear to what extent this is true and whether it is a reaction to Twitter's actions or other factors. Regardless, there are legal precedents and ongoing debates about the extent to which private companies can be held to the same free speech standards as public entities. Ultimately, the outcome of these developments will depend on how Twitter and other tech companies navigate the complex intersection of free speech, content moderation, and international regulations.

    • Game theory and free speech in the tech industryLeaders in restrictive speech risk losing competitive advantage, but smaller platforms face challenges in attracting users due to network effects and established content libraries.

      In the tech industry, companies like Twitter and Meta, with mega-influence, must be cautious about their actions due to the cascading implications. Musk, as a leader in restrictive speech, risks losing his competitive advantage if he slows down, allowing Meta to catch up and appear more free. This dynamic, known as game theory, can significantly impact market share and free speech. However, this argument primarily applies to companies of equivalent size, such as Twitter, YouTube, and Facebook. For smaller platforms, like Rumble and Locals, actively promoting free speech, the challenge lies in attracting a large enough audience to compete with the established giants. Network effects play a significant role, as audiences benefit from the existing libraries and resources on platforms like YouTube. In the case of non-controversial content, such as instructional videos, the depth of the library can make it difficult for competitors to attract users. Ultimately, the weight class issue comes down to the difficulty of moving established content and audiences to new platforms.

    • Free Speech Battle: YouTube vs RumbleYouTube's dominance faces challenge from Rumble due to its free speech stance, but YouTube's size and user base remain advantages. Healthcare's boundary-pushing procedures spark debate on ethics and reality.

      The ongoing battle between YouTube and alternative platforms like Rumble centers around speech rights and the legacy inertia that keeps users on established platforms. Rumble's primary competitive advantage is its commitment to protecting free speech, which could potentially dethrone YouTube. However, YouTube's size and user base give it an advantage, and it should pay close attention to the evolving landscape. Meanwhile, in the realm of healthcare, a doctor in Austin, Texas, is performing nonbinary surgeries, including the creation of artificial genitalia for individuals who wish to retain both sets. The debate around these procedures raises questions about the boundaries of medical ethics and the definition of reality. While some view these surgeries as a means of expressing individual identity, others argue that they are based on delusions and have no basis in reality. The doctor's ability to perform these procedures raises concerns about the medical community's role in validating and normalizing these practices. These developments highlight the importance of open dialogue and critical thinking in various domains, from technology to healthcare. As society continues to grapple with complex issues, it's crucial to maintain a balanced and informed perspective.

    • Evidence-free medicine in gender identity discussionsDoctors perform surgeries lacking scientific basis due to fear of being labeled transphobic, ignoring chromosomes' role in sex determination and promoting a harmful notion of changing sex through surgeries.

      The current state of gender identity discussions and related medical practices can be described as "evidence-free medicine." The argument's power to silence logical debate and criticism is so strong that doctors can perform surgeries that lack a solid scientific basis, such as creating non-binary or multiple sets of genitalia, without facing significant consequences. This situation is postmodern and utopian in nature, with a social goal of reeducating society to accept non-binary identities and a technical solution of altering human genitalia. Despite the lack of scientific evidence, these practices continue due to the fear of being labeled transphobic. It's essential to acknowledge that chromosomes do not determine sex but rather the gametes produced, and the idea that people can change their sex through surgeries is a flawed and harmful notion. We should challenge these practices and focus on promoting a healthy, evidence-based approach to understanding and addressing gender identity issues.

    • Embrace yourself and let the mind healRecognize mind's healing power, focus on changing mindset, society's restrictions not reason for distress, understand personal challenges, and remember children's development is complex

      It's essential to embrace ourselves as we are and recognize the mind's capacity to heal and adapt. The mind is a marvelous healing organ, and many people with dysphoria find that they grow out of it. The body, being complex and largely uncontrollable, is best left alone, and we should focus on changing our minds instead. Society's restrictions on gender roles should not be a reason for distress, as we all live in societies with varying degrees of freedom. The process of development involves reconciling ourselves to the cards we're dealt, and while wishing to be the other sex may be challenging, it's essential to understand that there are far worse challenges people face and overcome. The idea that children should be denied mental and physical maturation through surgical and hormonal interventions is a contentious issue, and it's important to remember that the children themselves are not the ones driving this movement. Instead, it's the adults who are advocating for such interventions and labeling those who disagree as morally defective.

    • The COVID-19 response created an authoritarian environment that discouraged debate on transgender interventionsThe fear of repercussions from the authoritarian response to COVID-19 led to the widespread acceptance of transgender interventions without solid evidence, prioritizing population-level interventions over individual health.

      The cultural shift in 2020 towards transgender interventions for children in major hospitals in the US can be linked to the authoritarian, censorious environment created by the response to COVID-19. Doctors and medical professionals were discouraged from questioning or debating these interventions due to the fear of repercussions similar to those experienced during the COVID-19 pandemic. The environment was described as one that discourages meaningful debate and encourages the demonization of those who ask questions. This shift in culture led to the widespread acceptance of transgender interventions, despite the lack of solid evidence to support their use. The doctor's account highlights the concern that public health initiatives, which often prioritize population-level interventions over individual health, can lead to the imposition of interventions from the top down, with little regard for individual well-being or scientific evidence. While transgender ideology and the COVID-19 response are distinct issues, the doctor's account sheds light on how the authoritarian response to COVID-19 may have facilitated the widespread acceptance of transgender interventions.

    • Public health arguments can override individual medical decisionsAwareness of public health interventions' impact on individual health is crucial, as they can inadvertently increase transmission or hide product risks.

      Public health arguments can be used to override individual medical decisions, creating potential issues and ethical dilemmas. Pharma companies may desire this, as it allows them to bypass doctors and sell drugs or treatments that might not be effective or safe. For instance, public health campaigns against symptom reducers in infectious diseases can inadvertently increase transmission, while the "flatten the curve" argument turns individual health into a population concern. Pharma companies are aware of these triggers and may try to eliminate control groups in studies to hide the potential risks of their products. The public health trigger is another such leverage point for them. It's essential to be aware of these dynamics and consider the potential consequences of public health interventions on individual health and well-being.

    • Impact of top-down medical interventions on doctors' autonomy and patient careTop-down medical interventions, such as those in transgender treatment, can restrict doctors' autonomy, create a perpetual patient base for pharmaceutical companies, and have potential long-term consequences on patients' health and wellbeing.

      The concept of standard of care in medicine can be used to justify top-down decision-making, displacing doctors and their professional judgment. This is evident in the case of transgender medical treatment, which is seen as riding on the wave of public health mandates. This top-down approach not only restricts doctors' autonomy but also creates a perennial patient base for pharmaceutical companies. A physician in an article from 2023 raises concerns about the impact of affirmed gender identities on children, suggesting that it can lead to self-hatred and increased suicide rates. Furthermore, the use of puberty blockers, which are known to affect the hypothalamus, a crucial part of the brain responsible for controlling emotions and hormonal functions, raises ethical concerns about the potential long-term consequences of shutting down this system. Overall, the discussion highlights the importance of considering the potential consequences of top-down medical interventions and the need for a more nuanced approach to healthcare.

    • The Hypothalamus and Its Role in Motivation and Sex HormonesThe hypothalamus, a crucial part of the brain, generates sex hormones through the release of gonadotropin releasing hormone (GnRH). Its damage can impact various systems, and synthetic GnRH analogs have risks, including hormonal inhibition.

      The hypothalamus, a complex system in the brain, plays a fundamental role in various aspects of human life, including motivation. Its damage can lead to significant impacts on different systems in the body, such as the reproductive system. The hypothalamus produces gonadotropin releasing hormone (GnRH), which in turn releases sex hormones. GnRH analogs, synthetic versions of this hormone, can be used to treat conditions like prostate cancer and, off-label, as puberty blockers. However, their use comes with risks, including the potential for inhibiting the production of sex hormones. The complex nature of the hypothalamus and its role in various systems highlights the importance of understanding the intricacies of biological systems and the potential consequences of interfering with them.

    • Understanding Cat's Unique Health ChallengesObserving behavior changes, understanding species-specific physiology, and maintaining consistent hormone levels are crucial for cat health.

      Our cat's behavior and health can present us with unexpected challenges. In the first instance, our cat managed to trick an elderly neighbor into believing he was homeless, leading to unwanted weight gain. In contrast, another time, he developed a thyroid tumor, which caused him to lose weight and become uncomfortable. However, the unique anatomy of a cat's thyroid gland allowed for a successful treatment using radioactive iodine. The thyroid gland in cats is divided into two parts, and when one part develops a tumor, it overproduces hormones, causing the other part to shut down. By administering radioactive iodine, the tumorous part is destroyed, leaving the healthy part to produce the necessary hormones. This treatment not only cured the cat but also highlighted the importance of understanding the unique physiology of different species. Moreover, the discussion emphasized the significance of consistent hormone levels in maintaining health. Gonadotropin releasing hormone agonists work by flooding the body with synthetic hormones, which in turn shuts down the body's production of its own hormones. This understanding of the hormonal system and its response to sustained doses can lead to better management of various health conditions. Overall, these experiences with our cat taught us the importance of observing changes in behavior and health, understanding species-specific physiology, and being attentive to the significance of consistent hormone levels.

    • Impact of Puberty Blockers on the HypothalamusPuberty blockers' interference with the hypothalamus, a primal part of the brain responsible for emotional responses and hormonal regulation, raises concerns about potential negative consequences on human development and identity.

      The discussion highlights the importance and complexity of the hypothalamus in regulating various hormonal and emotional functions in our bodies. The use of puberty blockers, which shut down the activity of the hypothalamus, raises concerns as it may interfere with fundamental aspects of human nature and development. While some argue that puberty blockers might be less harmful than cross-sex hormones due to the latter's impact on hormonal ratios, the former's interference with the hypothalamus, a primal and ancient part of the brain, raises more significant concerns. The hypothalamus is not just a hormone factory but is responsible for our emotional responses to beauty, music, and more. Interfering with its function could potentially shut down what makes us human. Instead, cognitive interventions, such as helping children understand and reconcile with their identity, are more likely to work without devastating consequences. Ultimately, the complexity of the human body and brain necessitates a cautious and thoughtful approach when considering interventions, especially during critical developmental stages.

    • Interfering with natural puberty can have unintended consequencesAttempting to bypass adolescence can lead to confusion and loss of agency. Prioritize old, tested interventions and trust personal decision-making.

      Interfering with the natural process of growing up, particularly in the context of blocking puberty for trans youth, can have unintended and potentially devastating consequences. The idea that medicine can perfectly simulate the puberty of the opposite sex is an arrogant assumption, as we are not yet at that level of knowledge. Adolescence is a universal stage between childhood and adulthood, and attempting to bypass it can lead to confusion and a loss of agency. Instead, it's important to prioritize interventions that are old, tested, and as downstream as possible. We should not blindly trust those with degrees or prescriptions, but rather trust our own abilities to make informed decisions about our own lives. The current trend of allowing the continuation of these interventions can lead to harm and should be stopped. The idea that people can transition from prepubescent boy to woman or girl to man without experiencing adolescence is a flawed notion. We are not butterflies, and we cannot skip essential stages of our development. It's important to remember that every individual has the right to grow up as normally as possible.

    • Flawed argument for medical intervention in transgender issuesBelief in genitalia and hormones as sole determinants of gender identity can lead to harmful interventions, ignoring individual exploration and self-discovery

      The argument for medical intervention in transgender issues based on the belief that genitalia and hormones are the sole determinants of gender identity is flawed and potentially harmful. This perspective, which can lead to the affirmation of individuals' delusions and even suicide ideation, overlooks the complexity of human development and the importance of encouraging individuals to be true to themselves. The pressure to conform to a particular gender identity through medical intervention, rather than allowing individuals to explore their identities and figure out their paths through modern life, can result in psychological and physiological harm. It's essential to recognize the complexity of human development and the importance of encouraging individuals to be true to themselves, rather than pushing them towards potentially harmful interventions.

    • Expanding Engagement with Live Q&As and Community BuildingEngage with the Dark Horse podcast community through locals, support the podcast through their store and newsletter, and stay tuned for upcoming content featuring Megan Rapinoe and other topics.

      The Dark Horse podcast is expanding its engagement with its audience through live Q&A sessions on their locals and encouraging community building. They also have a store and a weekly newsletter, and recently discussed soccer player Megan Rapinoe's political activism in their newsletter. Exciting things are coming up, and they encourage checking out their sponsors: Seed, House of Academia, and American Heart for Gold. So, join their locals, check out their store and newsletter, support their sponsors, and stay tuned for upcoming content. Megan Rapinoe, an exceptional soccer player and Trump critic, was the topic of their latest newsletter. Their message is to be good to loved ones, eat well, and get outside. So, engage with the community, support the podcast, and take care of yourself.

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    Heather’s newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com

    Our book, A Hunter-Gatherer’s Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://a.co/d/dunx3at

    Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org

    *****

    Mentioned in this episode:

    Laumer et al 2024. Active self-treatment of a facial wound with a biologically active plant by a male Sumatran orangutan. Scientific Reports, 14(1), p.8932. https://www.nature.com/articles/s41598-024-58988-7

    County Highway: https://www.countyhighway.com

    Thousands Believe Covid Vaccines Harmed Them. Is Anyone Listening? https://www.nytimes.com/2024/05/03/health/covid-vaccines-side-effects.html

    Chris Martenson on the NYT: https://twitter.com/chrismartenson/status/1787602191114526836

    Benn et al 2023. Randomized clinical trials of COVID-19 vaccines: Do adenovirus-vector vaccines have beneficial non-specific effects?. Iscience, 26(5): https://portal.findresearcher.sdu.dk/en/publications/randomized-clinical-trials-of-covid-19-vaccines-do-adenovirus-vec

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    Never Alone: The 223rd Evolutionary Lens with Bret Weinstein and Heather Heying

    Never Alone: The 223rd Evolutionary Lens with Bret Weinstein and Heather Heying

    In this 223rd in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we talk about the state of the world through an evolutionary lens.

    In this episode, we discuss science and religion, materialism and other ways of understanding our world. Can analysis and quantification explain everything? Can narrative, intuition, and creativity? All are or should be part of the scientific process; science is incomplete with only one mode. We also discuss models, how they fail, how difficult they are to assess, and what one recent climate model has to say about the role of air pollution in Earth’s temperature. Enlightenment values require that we use our freedom to inquire about all things that we are curious about. Also: happy Beltane!

    *****

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    *****

    Mentioned in this episode:

    Third Man Syndrome and Shackleton: https://twitter.com/brianroemmele/status/1785827941718614291

    Clearer skies may be accelerating global warming: https://www.science.org/content/article/clearer-skies-may-be-accelerating-global-warming
     
    Hodnebrog et al 2024. Recent reductions in aerosol emissions have increased Earth’s energy imbalance. Communications Earth & Environment, 5(1):166: https://www.nature.com/articles/s43247-024-01324-8

    Nature editorial: What happens when climate change and the mental-health crisis collide? https://www.nature.com/articles/d41586-024-00993-x

    Animation about mental health and climate change: https://www.imperial.ac.uk/grantham/publications/all-publications/the-impact-of-climate-change-on-mental-health-and-emotional-wellbeing-current-evidence-and-implications-for-policy-and-practice.php

    Growing up is hard to do (do not pay others to do your thinking for you): https://naturalselections.substack.com/p/growing-up-is-hard-to-do

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    We're Beating the WHO – With Dr. Kat Lindley

    We're Beating the WHO – With Dr. Kat Lindley

    Dr. Kat Lindley is the President of the Global Health Project. Bret Talks to her about the state of the World Health Organization Pandemic Treaty.

    Find Dr. Lindley on X: @KLVeritas (https://twitter.com/KLVeritas)

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    Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.

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    Why Darwin was Right: The 222nd Evolutionary Lens with Bret Weinstein and Heather Heying

    Why Darwin was Right: The 222nd Evolutionary Lens with Bret Weinstein and Heather Heying

    In this 222nd in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we talk about the state of the world through an evolutionary lens.

    In this episode, we discuss evolution, and how we know that it is true. We discuss the different kinds of beliefs that people have—beliefs that attempt to reconcile with reality, vs beliefs that reconcile with social standing and comfort. If your beliefs put you on the outs with your friends, do you change your beliefs, or your friends? Are you willing to give up the cocktail party for reality? We also discuss research published in 2000 and funded by Fauci’s NIAID, which demonstrated that it was possible to make chimeric coronaviruses, swapping the spike protein from one to a different species entirely. Finally: sex-biased gene expression, in which genes are expressed differently in the two sexes, in anatomical systems as varied as brain, kidneys, and liver.
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    Our book, A Hunter-Gatherer’s Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://a.co/d/dunx3at

    Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org

    *****

    Mentioned in this episode:

    Kennedy 2023. The Wuhan Cover-Up and the Terrifying Bio-Weapons Arms Race: https://www.skyhorsepublishing.com/9781510773981/the-wuhan-cover-up/

    Kuo et al 2000. Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier. Journal of virology, 74(3):1393-1406: https://journals.asm.org/doi/full/10.1128/jvi.74.3.1393-1406.2000

    Rodríguez-Montes et al 2023. Sex-biased gene expression across mammalian organ development and evolution. Science 382(6670), p.eadf1046: https://www.science.org/doi/10.1126/science.adf1046

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