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    E13 - The Evolutionary Lens with Bret Weinstein & Heather Heying | Herd Immunity Won't Save Us | DarkHorse Podcast

    en-usMay 10, 2020

    Podcast Summary

    • Herd Immunity UncertaintiesThe long-term immunity after COVID-19 recovery and achievability of herd immunity through natural infection are uncertain, and binary thinking of opening up versus staying closed should be replaced with a focus on the complexities of the situation.

      The consensus around herd immunity as a solution to the COVID-19 crisis is evaporating due to uncertainty about immunity after recovery and the conflation of herd immunity achieved through natural infection versus vaccination. The speakers emphasized that we don't know if people who have had the virus and recovered are immune in the long term, and herd immunity may not even be achievable through natural infection. Furthermore, they warned against the dangerous fragmentation of our collective will to fight the crisis, with some pushing for immediate reopening without considering the unknowns and risks involved. The speakers emphasized that this virus is new to humans, and we don't have a clear understanding of how it will continue to change. Therefore, it's crucial to separate the binary thinking of opening up versus staying closed and focus on the complexities of the situation.

    • Balancing Caution and Costs in COVID-19 PolicyWe need a comprehensive approach to understand the impact of reopening on infection rates and the validity of various hypotheses about the virus, while acknowledging the reality of the pandemic's health and economic impact.

      We are facing a significant decision between two policy approaches regarding the COVID-19 pandemic: one favoring caution and medical/epidemiological advice, and the other considering the costs of continued lockdowns versus the potential consequences of reopening. However, our current collective discussion lacks a non-polarized, comprehensive approach to understanding the situation. We need to address important questions, such as the impact of reopening on infection rates and the validity of various hypotheses about the virus's origins and nature. Ultimately, it's crucial to acknowledge the reality of the pandemic and its impact on health and the economy while remaining open to new information and perspectives. The virus, as a living organism, is exploring possibility space to ensure its survival, and our policy decisions should be informed by this understanding.

    • Risk of giving COVID-19 more room to evolveFocus on limiting virus spread to prevent long-term costs and setbacks, not just short-term benefits or costs

      The ongoing debate about reopening society during the COVID-19 pandemic involves a significant risk. By pushing for a quick return to normalcy, we may be unintentionally giving the virus more room to evolve and potentially become a permanent fixture in human populations, similar to the flu. This could result in substantial long-term costs and setbacks for humanity. Instead, our focus should be on limiting the virus's ability to spread and infect as many people as possible, to minimize its opportunities to discover new ways of infecting us. We need to shift the public discussion towards the importance of considering the long-term consequences of our actions, rather than just the short-term benefits or costs. The false dichotomy of lockdown versus no lockdown needs to be challenged, and we should aim for a more nuanced understanding of what easing restrictions could look like while still prioritizing safety.

    • Understanding the Complexity of the COVID-19 PandemicMaintain a critical perspective and question official narratives, prioritize individual well-being and economic recovery.

      The current environment is complex and nuanced, with various levels of influence shaping our understanding of the COVID-19 pandemic. While some institutions, like the intelligence community, assert a scientific consensus that the virus was not man-made or genetically modified, other reports, such as the one from Science Magazine, raise questions about potential conflicts of interest and the withdrawal of NIH grants for collaborative research between the US and China on bat coronaviruses. This inconsistency highlights the importance of maintaining a critical perspective and questioning official narratives when they contradict personal research or common sense. Furthermore, the discussion emphasizes the need to prioritize individual well-being and economic recovery, as excessive reliance on masks and fear of the mainstream media may hinder personal growth and societal progress.

    • Debate over COVID-19 origins continues despite intelligence community's natural explanationExperts challenge consensus on COVID-19 origins, NIH funding decision adds confusion, openness to all hypotheses essential for scientific progress

      While the intelligence community in the US maintains that the origins of COVID-19 are natural, the scientific community's consensus on this matter is being challenged by some experts. The NIH's decision to pull funding for a long-standing research collaboration between the US and China on coronaviruses in bats adds to the confusion, as it goes against the clear message from the intelligence community. Furthermore, the monolithic stance of the tenured Research 1 University virology community on the unmodified virus origin theory raises questions, especially when contrasted with alternative hypotheses that are gaining traction among those outside of this community. As scientists, we must remain open to all hypotheses, even if we may personally prefer a certain explanation. The distinction between what is and what ought to be is crucial, and an evolutionary perspective can help us challenge and change things that are not in our best interests. The ongoing debate highlights the importance of critical thinking and scientific rigor in understanding complex issues.

    • Censorship of dissenting voices during crisesCensorship can limit explanations, potentially leading to inaccurate understandings. Be aware of incentives and pressures that may suppress doubts or alternative hypotheses.

      During times of crisis, there is a significant push to silence dissenting voices and maintain a narrow narrative. This was discussed in relation to the case of Dr. Kyle Sadel, who lost his job for expressing suspicions about ventilator treatment for COVID-19 patients on YouTube. The censorship of voices, whether by federal agencies or private corporations, can lead to a winnowing of possible explanations and a potentially inaccurate understanding of the situation. This is not always about courage or simple coercion, but rather a complex web of incentives and pressures that can lead individuals to suppress their doubts or alternative hypotheses. The concept of self-deception being more powerful than simple deception was also mentioned, as it can be easier to convince oneself of a certain belief before trying to convince others. It's important to be aware of this dynamic and strive for open and honest dialogue, even when dealing with partial truths or conspiracy theories.

    • Considering the frequency and expected value of seemingly unusual circumstancesInvestigate thoroughly before jumping to conclusions based on incomplete information. Unusual circumstances may not be as rare or significant as they initially appear.

      When evaluating seemingly unusual or suspicious circumstances, it's crucial to consider the expected value and frequency of the phenomenon in question before jumping to conclusions. The speaker shares an example of the origins of the COVID-19 pandemic and how the proximity of a fish market and a virology lab in Wuhan led to conspiracy theories. However, upon further investigation, the speaker discovered that virology labs studying coronaviruses from bats were not uncommon, and Wuhan actually had several such labs. Therefore, the apparent proximity of the fish market and the lab was not an unlikely coincidence. The speaker emphasizes the importance of gathering facts and data before making assumptions and avoiding hasty conclusions based on incomplete information.

    • Exploring the Origin of COVID-19: Mapping Out PossibilitiesCreate a flowchart to estimate likelihoods of COVID-19 origin possibilities, skepticism towards lab-created hypothesis, and consider excess deaths for a comprehensive understanding of pandemic impact

      During the discussion, the importance of mapping out various possibilities and estimating their likelihoods regarding the origin of the COVID-19 virus was emphasized. The speaker suggested creating a flowchart with percentages and updating it regularly. They expressed their skepticism towards the lab-created hypothesis but acknowledged the existence of intermediate possibilities. The conversation then shifted to the concept of excess deaths, which is used to account for deaths that may not be directly attributed to COVID-19 but are still related to the pandemic. By comparing death counts from one year to another, excess deaths can help provide a more accurate understanding of the impact of the virus on mortality rates.

    • Understanding the impact of the pandemic on mortality ratesExcess deaths data reveals the total number of deaths during a time period, comparing it to historical data helps estimate pandemic-related fatalities, not all excess deaths are directly from COVID-19, and excess deaths can also uncover new health conditions related to the virus.

      Excess deaths data can provide valuable insights into the impact of events like the COVID-19 pandemic on mortality rates. By comparing the number of deaths in a given time period to the expected number based on historical data, excess deaths can help estimate the number of deaths directly or indirectly related to the pandemic. However, it's important to note that excess deaths don't necessarily mean all those people died from COVID-19. Some may have died from related causes or other unknown reasons. Additionally, excess deaths can reveal previously unidentified conditions or complications linked to the virus. For instance, there have been reports of a new inflammatory condition in children that may be linked to COVID-19, which could show up in excess deaths data even if the children don't die from the condition. Overall, excess deaths data is a useful measure for understanding the full impact of the pandemic on mortality rates.

    • COVID-19 may cause long-term lung damage and rapidly mutateCOVID-19 may cause lung damage and mutate rapidly, impacting long-term health and complicating the global response

      COVID-19, caused by the SARS-CoV-2 virus, may be more dangerous than previously thought. Even those who recover without symptoms may have visible lung damage, indicating potential long-term health consequences. The virus is also rapidly mutating, leading to debates about when a new strain should be classified as a different variant. With so many mutations happening in every infected person, it's likely that new strains are constantly emerging and then dying out without being recognized. Some strains may be more virulent than others, but determining this requires ongoing research. The question of how many strains exist is not straightforward, as every infected person may host multiple strains, and some of these may not survive long enough to be identified. The ongoing evolution of the virus adds complexity to the global response, emphasizing the importance of continued research and vigilance.

    • Mutation process in viruses like SARS-CoV-2Mutations can make the virus more effective, leading to new strains and complicating containment efforts, but not all mutations are harmful.

      The mutation process in viruses like SARS-CoV-2 plays a crucial role in their evolution and survival. While most mutations may not have any significant impact on the virus's functionality, some may accidentally innovate something that makes it more effective, increasing its chances of spreading to new hosts. This process of natural selection can lead to the emergence of new strains, some of which may be more difficult to control. The virus's ability to mutate and adapt to new environments also complicates efforts to contain its spread, as a strain that thrives in one region could be easily transmitted to another where it may be more successful. It's important to note that not all mutations are detrimental to humanity, and some may even make the virus less harmful. However, given the potential consequences of a more virulent strain, it's essential to remain vigilant and continue researching ways to prevent and treat COVID-19. The mutation process is a double-edged sword, offering the virus a means of survival and adaptation but also posing a significant threat to public health.

    • Discussing ways to minimize COVID-19 becoming permanent and protecting oneselfConsider individual risks and make informed decisions, and combine individual actions with collective expert discussion to combat COVID-19 spread

      We need a group of intelligent, educated, and unbiased individuals to have an open discussion about how to minimize the likelihood of COVID-19 becoming permanent in the human population. Individuals can also take steps to protect themselves by understanding the risks associated with different activities. For instance, working in an ICU or performing procedures on infected patients carries a high risk, while living in your house or walking in a suburban yard with no people in sight has a low risk. Touch exposures, such as opening a door frequently or hugging people, also have varying levels of risk depending on the number of people who have touched the surface before you. It's essential to consider these risks and make informed decisions, rather than relying on one source of information. Additionally, the exponential decay of viral particles means that even if someone sick with COVID-19 delivers a package to your door, the chance of the virus spreading is low. Overall, a combination of individual actions and a collective discussion among experts is necessary to combat the spread of COVID-19.

    • The risk of getting COVID-19 from a contaminated surface decreases over timeWearing masks, being outside, and handling packages carefully can help reduce the risk of COVID-19 infection. The likelihood of getting sick from a contaminated surface is higher within 5 minutes than hours later.

      The risk of contracting COVID-19 from a contaminated surface decreases significantly over time. The expert suggests that the likelihood of getting sick from a surface touched by an infected person within 5 minutes is much higher than if the same surface was touched hours later. However, masks and being outside offer protection, and handling delivered packages carefully can also minimize risk. The expert also shared surprising statistics from Johns Hopkins researchers, stating that COVID-19 is now the leading cause of death in the United States and that 0.2% of New Yorkers have died from it. These numbers highlight the severity of the pandemic, even if the accuracy of these statistics is debated. Ultimately, the expert emphasizes that while there is no certainty in navigating the pandemic, taking precautions such as wearing masks, being outside, and handling packages carefully can help reduce the risk of infection.

    • Constitutional questions amidst the COVID-19 pandemicThe pandemic raises complex constitutional issues, with the balance between public health and individual freedoms requiring careful consideration and thoughtful dialogue.

      The ongoing COVID-19 pandemic and the resulting lockdown measures have led to a significant loss of life and raised constitutional questions. While the fatality rate may decrease with a higher percentage of the population being infected, the loss of life is still staggering, with 1 in 500 New Yorkers having died in the last few months. The constitutional implications of the lockdown are complex, with some arguing that the government's expanded powers during times of mass risk are justified, while others believe it to be unconstitutional. However, it's important to remember that the Constitution is a living document, and discretion is key in making it work. The government's actions must be warranted, and overreach should be avoided. These are unprecedented times, and finding a balance between public health and individual freedoms is a challenge that requires careful consideration and thoughtful dialogue.

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    Hodnebrog et al 2024. Recent reductions in aerosol emissions have increased Earth’s energy imbalance. Communications Earth & Environment, 5(1):166: https://www.nature.com/articles/s43247-024-01324-8

    Nature editorial: What happens when climate change and the mental-health crisis collide? https://www.nature.com/articles/d41586-024-00993-x

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    Find Dr. Lindley on X: @KLVeritas (https://twitter.com/KLVeritas)

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    Why Darwin was Right: The 222nd Evolutionary Lens with Bret Weinstein and Heather Heying

    Why Darwin was Right: The 222nd Evolutionary Lens with Bret Weinstein and Heather Heying

    In this 222nd in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we talk about the state of the world through an evolutionary lens.

    In this episode, we discuss evolution, and how we know that it is true. We discuss the different kinds of beliefs that people have—beliefs that attempt to reconcile with reality, vs beliefs that reconcile with social standing and comfort. If your beliefs put you on the outs with your friends, do you change your beliefs, or your friends? Are you willing to give up the cocktail party for reality? We also discuss research published in 2000 and funded by Fauci’s NIAID, which demonstrated that it was possible to make chimeric coronaviruses, swapping the spike protein from one to a different species entirely. Finally: sex-biased gene expression, in which genes are expressed differently in the two sexes, in anatomical systems as varied as brain, kidneys, and liver.
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    Mentioned in this episode:

    Kennedy 2023. The Wuhan Cover-Up and the Terrifying Bio-Weapons Arms Race: https://www.skyhorsepublishing.com/9781510773981/the-wuhan-cover-up/

    Kuo et al 2000. Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: crossing the host cell species barrier. Journal of virology, 74(3):1393-1406: https://journals.asm.org/doi/full/10.1128/jvi.74.3.1393-1406.2000

    Rodríguez-Montes et al 2023. Sex-biased gene expression across mammalian organ development and evolution. Science 382(6670), p.eadf1046: https://www.science.org/doi/10.1126/science.adf1046

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